NO310070B1 - Benzo[g]kinolinderivater, fremstilling herav, farmasöytiske midler og preparater inneholdende disse samt anvendelse av derivatene for fremstilling av medikamenter - Google Patents
Benzo[g]kinolinderivater, fremstilling herav, farmasöytiske midler og preparater inneholdende disse samt anvendelse av derivatene for fremstilling av medikamenter Download PDFInfo
- Publication number
- NO310070B1 NO310070B1 NO980043A NO980043A NO310070B1 NO 310070 B1 NO310070 B1 NO 310070B1 NO 980043 A NO980043 A NO 980043A NO 980043 A NO980043 A NO 980043A NO 310070 B1 NO310070 B1 NO 310070B1
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compound
- acid addition
- free base
- salt form
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9513880.6A GB9513880D0 (en) | 1995-07-07 | 1995-07-07 | Organic compounds |
| GBGB9603988.8A GB9603988D0 (en) | 1996-02-26 | 1996-02-26 | Organic compounds |
| PCT/EP1996/002969 WO1997003054A1 (en) | 1995-07-07 | 1996-07-05 | BENZO[g]QUINOLINE DERIVATIVES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO980043D0 NO980043D0 (no) | 1998-01-05 |
| NO980043L NO980043L (no) | 1998-01-05 |
| NO310070B1 true NO310070B1 (no) | 2001-05-14 |
Family
ID=26307342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO980043A NO310070B1 (no) | 1995-07-07 | 1998-01-05 | Benzo[g]kinolinderivater, fremstilling herav, farmasöytiske midler og preparater inneholdende disse samt anvendelse av derivatene for fremstilling av medikamenter |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5885988A (da) |
| EP (1) | EP0839136B1 (da) |
| JP (1) | JPH11509197A (da) |
| KR (1) | KR19990028757A (da) |
| CN (1) | CN1193964A (da) |
| AR (1) | AR004672A1 (da) |
| AT (1) | ATE201199T1 (da) |
| AU (1) | AU703325B2 (da) |
| BR (1) | BR9609326A (da) |
| CA (1) | CA2224436A1 (da) |
| CO (1) | CO4750662A1 (da) |
| CZ (1) | CZ1698A3 (da) |
| DE (1) | DE69612852T2 (da) |
| DK (1) | DK0839136T3 (da) |
| ES (1) | ES2158327T3 (da) |
| GR (1) | GR3036346T3 (da) |
| HU (1) | HUP9802937A3 (da) |
| IL (1) | IL122854A (da) |
| NO (1) | NO310070B1 (da) |
| NZ (1) | NZ313606A (da) |
| PE (1) | PE1998A1 (da) |
| PL (1) | PL324106A1 (da) |
| PT (1) | PT839136E (da) |
| RU (1) | RU2158738C2 (da) |
| SK (1) | SK1798A3 (da) |
| TR (1) | TR199800011T1 (da) |
| TW (1) | TW357143B (da) |
| WO (1) | WO1997003054A1 (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711043D0 (en) | 1997-05-29 | 1997-07-23 | Ciba Geigy Ag | Organic compounds |
| AU5265599A (en) * | 1998-04-08 | 1999-11-01 | Takeda Chemical Industries Ltd. | Amine compounds, their production and their use as somatostatin receptor antagonists or agonists |
| CA2246791A1 (en) * | 1998-09-01 | 2000-03-01 | Alison Buchan | Treatment of endothelium with somatostatin analogues |
| RU2221785C2 (ru) * | 1998-09-22 | 2004-01-20 | Яманоути Фармасьютикал Ко., Лтд. | Гетероциклическое производное, фармацевтическая композиция, его содержащая, и промежуточный продукт |
| PL346795A1 (en) * | 1998-09-22 | 2002-02-25 | Yamanouchi Pharma Co Ltd | Cyanophenyl derivatives |
| GB9902938D0 (en) * | 1999-02-10 | 1999-03-31 | Novartis Ag | Organic compounds |
| PE20030240A1 (es) * | 2001-07-09 | 2003-04-16 | Novartis Ag | DERIVADOS DE BENZO [g] QUINOLINA |
| FI20031454A0 (fi) | 2003-10-06 | 2003-10-06 | Juvantia Pharma Ltd Oy | Selektiivisiä somatostatiinireseptori 1 ja/tai 4 -agonisteja ja -antagonisteja |
| KR100594234B1 (ko) | 2003-12-05 | 2006-06-30 | 삼성전자주식회사 | 편광 현상을 이용하여 해상도를 향상시킬 수 있는 포토마스크 및 그 제조방법 |
| EP2269610A3 (en) | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| JP4958786B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| MX2007003319A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| EP1799667B1 (en) | 2004-09-20 | 2013-03-20 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| BRPI0611187A2 (pt) | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| TWI404702B (zh) * | 2007-08-31 | 2013-08-11 | Lundbeck & Co As H | 兒茶酚胺衍生物和其前藥 |
| US8067410B2 (en) | 2008-06-27 | 2011-11-29 | H. Lundbeck A/S | Phenolic and catecholic amines and prodrugs thereof |
| EP3634406B1 (en) | 2017-05-12 | 2023-09-06 | Board of Trustees of The Southern Illinois University on behalf of Southern Illinois University Edwardsville | 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof |
| US11912687B2 (en) | 2017-05-12 | 2024-02-27 | Board of Trustees of the Southern Illinois University | 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof |
| CR20200225A (es) | 2017-11-24 | 2020-07-25 | H Lundbeck As | Nuevos fármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson |
| US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
| JP7562562B2 (ja) | 2019-05-21 | 2024-10-07 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ |
| EP3972600B1 (en) | 2019-05-21 | 2026-02-18 | H. Lundbeck A/S | Catecholamine carbamate prodrugs for use in the treatment of parkinson s disease |
| EP3972971A1 (en) | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's diseases |
| JP7641234B2 (ja) | 2019-05-21 | 2025-03-06 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ |
| JP7099717B2 (ja) | 2019-09-30 | 2022-07-12 | 株式会社理研バイオ | ソマトスタチン受容体 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH630902A5 (en) * | 1977-01-24 | 1982-07-15 | Sandoz Ag | Process for preparing novel derivatives of 1,2,3,4,4a,10b-hexahydrobenzo(f)isoquinoline. |
| LU88619I2 (fr) * | 1981-10-16 | 1995-07-10 | Sandoz Ag | QUINAGOLIDE, éventuellement sous forme de sel, par exemple du chlorhydrate |
| SU1109393A1 (ru) * | 1983-04-28 | 1984-08-23 | Ордена Трудового Красного Знамени Институт Физики Ан Бсср | Способ получени 9-диэтиламинобензо/ @ /феноксазинона-5 или его производных |
| HU193979B (en) * | 1984-06-12 | 1987-12-28 | Sandoz Ag | Process for producing naphtoxazine derivatives and pharmaceutical compositions containing them |
| NL8702680A (nl) * | 1986-11-21 | 1988-06-16 | Sandoz Ag | Nieuwe benzogchinolinen en werkwijzen voor het bereiden en toepassen van deze verbindingen. |
| WO1993024471A1 (en) * | 1992-06-02 | 1993-12-09 | Whitby Research, Inc. | Substituted naphthoxazines useful as dopaminergics |
| WO1994021614A1 (en) * | 1993-03-24 | 1994-09-29 | Merck & Co., Inc. | SUBSTITUTED 3-PHENANTHRIDINONE DERIVATIVES AS 5α-REDUCTASE INHIBITORS |
| DE4329776A1 (de) * | 1993-09-03 | 1995-03-09 | Sandoz Ag | Naphthoxazine, ihre Herstellung und Verwendung |
-
1996
- 1996-06-12 TW TW085107047A patent/TW357143B/zh active
- 1996-07-05 DE DE69612852T patent/DE69612852T2/de not_active Expired - Fee Related
- 1996-07-05 TR TR1998/00011T patent/TR199800011T1/xx unknown
- 1996-07-05 AR ARP960103468A patent/AR004672A1/es unknown
- 1996-07-05 EP EP96925672A patent/EP0839136B1/en not_active Expired - Lifetime
- 1996-07-05 PT PT96925672T patent/PT839136E/pt unknown
- 1996-07-05 CZ CZ9816A patent/CZ1698A3/cs unknown
- 1996-07-05 CO CO96035363A patent/CO4750662A1/es unknown
- 1996-07-05 PL PL96324106A patent/PL324106A1/xx unknown
- 1996-07-05 HU HU9802937A patent/HUP9802937A3/hu unknown
- 1996-07-05 AT AT96925672T patent/ATE201199T1/de not_active IP Right Cessation
- 1996-07-05 US US08/983,535 patent/US5885988A/en not_active Expired - Fee Related
- 1996-07-05 ES ES96925672T patent/ES2158327T3/es not_active Expired - Lifetime
- 1996-07-05 CN CN96196551A patent/CN1193964A/zh active Pending
- 1996-07-05 RU RU98102128/04A patent/RU2158738C2/ru active
- 1996-07-05 SK SK17-98A patent/SK1798A3/sk unknown
- 1996-07-05 KR KR1019980700056A patent/KR19990028757A/ko not_active Ceased
- 1996-07-05 WO PCT/EP1996/002969 patent/WO1997003054A1/en not_active Ceased
- 1996-07-05 AU AU66120/96A patent/AU703325B2/en not_active Ceased
- 1996-07-05 PE PE1996000517A patent/PE1998A1/es not_active Application Discontinuation
- 1996-07-05 IL IL12285496A patent/IL122854A/xx not_active IP Right Cessation
- 1996-07-05 DK DK96925672T patent/DK0839136T3/da active
- 1996-07-05 JP JP9505489A patent/JPH11509197A/ja active Pending
- 1996-07-05 NZ NZ313606A patent/NZ313606A/xx unknown
- 1996-07-05 CA CA002224436A patent/CA2224436A1/en not_active Abandoned
- 1996-07-05 BR BR9609326A patent/BR9609326A/pt active Search and Examination
-
1998
- 1998-01-05 NO NO980043A patent/NO310070B1/no not_active IP Right Cessation
-
2001
- 2001-08-07 GR GR20010401198T patent/GR3036346T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL122854A (en) | 2000-12-06 |
| CO4750662A1 (es) | 1999-03-31 |
| AU6612096A (en) | 1997-02-10 |
| EP0839136A1 (en) | 1998-05-06 |
| NO980043D0 (no) | 1998-01-05 |
| CA2224436A1 (en) | 1997-01-30 |
| MX9710530A (es) | 1998-03-31 |
| TR199800011T1 (xx) | 1998-04-21 |
| PE1998A1 (es) | 1998-02-14 |
| KR19990028757A (ko) | 1999-04-15 |
| RU2158738C2 (ru) | 2000-11-10 |
| AR004672A1 (es) | 1999-03-10 |
| AU703325B2 (en) | 1999-03-25 |
| JPH11509197A (ja) | 1999-08-17 |
| HUP9802937A2 (hu) | 1999-10-28 |
| IL122854A0 (en) | 1998-08-16 |
| CZ1698A3 (cs) | 1998-04-15 |
| DE69612852D1 (de) | 2001-06-21 |
| NZ313606A (en) | 1999-07-29 |
| ES2158327T3 (es) | 2001-09-01 |
| EP0839136B1 (en) | 2001-05-16 |
| CN1193964A (zh) | 1998-09-23 |
| GR3036346T3 (en) | 2001-11-30 |
| NO980043L (no) | 1998-01-05 |
| DK0839136T3 (da) | 2001-08-06 |
| DE69612852T2 (de) | 2001-10-04 |
| PL324106A1 (en) | 1998-05-11 |
| PT839136E (pt) | 2001-09-28 |
| HUP9802937A3 (en) | 2002-10-28 |
| ATE201199T1 (de) | 2001-06-15 |
| US5885988A (en) | 1999-03-23 |
| TW357143B (en) | 1999-05-01 |
| WO1997003054A1 (en) | 1997-01-30 |
| BR9609326A (pt) | 1999-05-25 |
| SK1798A3 (en) | 1998-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0839136B1 (en) | BENZO[g]QUINOLINE DERIVATIVES | |
| JPH1059967A (ja) | 新規３−（ピペリド−４−イル）−１，２−ベンゾイソオキサゾール及び３−（ピペラジン−４−イル）−１，２−ベンゾイソオキサゾール化合物、その製造方法、並びにそれを含有する医薬組成物 | |
| RU2191776C2 (ru) | Эрголиновые производные, способ их получения, фармацевтическая композиция | |
| US6355642B1 (en) | Tetrahydrobenzindole compounds | |
| JP4762250B2 (ja) | フェニル−ピペラジンメタノン誘導体 | |
| EP1446399B1 (en) | Piperazine derivatives having sst1 antagonistic activity | |
| CN1041360A (zh) | 新的吡啶基和嘧啶基衍生物 | |
| JPH0723364B2 (ja) | 新規な１−ピペラジンカルボキサミド誘導体 | |
| US4243666A (en) | 4-Amino-2-piperidino-quinazolines | |
| JPH02138266A (ja) | ６‐フェニル‐３‐（ピペラジニルアルキル）‐２，４（１ｈ，３ｈ）‐ピリミジンジオン誘導体 | |
| JPH037257A (ja) | ピリジン誘導体及びそれを有効成分とする向精神剤 | |
| KR20010042904A (ko) | 광학 활성 테트라하이드로벤즈인돌 유도체 | |
| JPH0225481A (ja) | ２―［（４―ピペリジニル）メチル］―１，２，３，４―テトラヒドロイソキノリン誘導体、その製造方法およびその治療への適用 | |
| JP5193033B2 (ja) | ヒスタミンｈ３受容体薬剤、製剤及び治療的使用 | |
| CN101384260A (zh) | 哌嗪衍生物 | |
| US5081128A (en) | 2,3-dihydro-1h-isoindole derivatives and their application in therapy | |
| JP2864489B2 (ja) | 喘息治療剤 | |
| JP2004231514A (ja) | ５−ｈｔ７受容体結合能を有し、かつ代謝的に安定なテトラヒドロベンズインドール誘導体 | |
| MXPA97010530A (en) | Benzo (a) quinol derivatives | |
| JPH04103572A (ja) | ４―フェニル―２―（１―ピペラジニル）ピリジン誘導体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN JANUARY 2003 |