NO310058B1 - Anvendelse av en hymenopteravgift til fremstilling av et medikament for behandling av DNA-virusinfeksjoner - Google Patents
Anvendelse av en hymenopteravgift til fremstilling av et medikament for behandling av DNA-virusinfeksjoner Download PDFInfo
- Publication number
- NO310058B1 NO310058B1 NO945031A NO945031A NO310058B1 NO 310058 B1 NO310058 B1 NO 310058B1 NO 945031 A NO945031 A NO 945031A NO 945031 A NO945031 A NO 945031A NO 310058 B1 NO310058 B1 NO 310058B1
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- infections
- venom
- drug
- hymenoptera
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 31
- 239000003814 drug Substances 0.000 title claims abstract description 20
- 208000004449 DNA Virus Infections Diseases 0.000 title claims abstract description 9
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- 229940079593 drug Drugs 0.000 title claims description 18
- 241000257303 Hymenoptera Species 0.000 title claims description 9
- 229920001184 polypeptide Polymers 0.000 claims abstract description 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 13
- 239000003783 hymenoptera venom Substances 0.000 claims abstract description 8
- 239000002435 venom Substances 0.000 claims description 16
- 231100000611 venom Toxicity 0.000 claims description 16
- 210000001048 venom Anatomy 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 12
- 239000003659 bee venom Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- 208000036142 Viral infection Diseases 0.000 claims description 8
- 230000009385 viral infection Effects 0.000 claims description 7
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 239000002578 wasp venom Substances 0.000 claims description 6
- 230000035876 healing Effects 0.000 claims description 5
- 230000009467 reduction Effects 0.000 claims description 5
- PZEUTLIKVUEDLB-UHFFFAOYSA-N 2-[[[2-[[6-amino-2-[[2-[[6-amino-2-[[2-[[2-[[2-[[2-[[2-[2-[[1-[2-[[2-[[2-[[2-[[2-[[2-[[6-amino-2-[[2-[[2-[2-[[2-[[2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]acetyl]amino]propanoylamino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]propanoylamino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-(carbamoylamino)propanoyl]-(3-amino-3-oxopropyl)carbamoyl]amino]pentanediamide Chemical compound CCC(C)C(NC(=O)CN)C(=O)NCC(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CO)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C(C)CC)C(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CNC(N)=O)C(=O)N(CCC(N)=O)C(=O)NC(CCC(N)=O)C(N)=O PZEUTLIKVUEDLB-UHFFFAOYSA-N 0.000 claims description 4
- 241000594310 Randia aculeata Species 0.000 claims description 4
- 229940066369 honey bee venom Drugs 0.000 claims description 4
- 230000009885 systemic effect Effects 0.000 claims description 4
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims description 2
- 208000029433 Herpesviridae infectious disease Diseases 0.000 claims description 2
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims description 2
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 2
- 208000009608 Papillomavirus Infections Diseases 0.000 claims description 2
- 208000010531 varicella zoster infection Diseases 0.000 claims description 2
- 238000011200 topical administration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 5
- 239000000243 solution Substances 0.000 description 13
- 241000124008 Mammalia Species 0.000 description 6
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 6
- 229960004150 aciclovir Drugs 0.000 description 6
- 239000013543 active substance Substances 0.000 description 6
- 208000004898 Herpes Labialis Diseases 0.000 description 4
- 206010067152 Oral herpes Diseases 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- 208000001688 Herpes Genitalis Diseases 0.000 description 3
- 201000004946 genital herpes Diseases 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 239000002574 poison Substances 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000005074 Retroviridae Infections Diseases 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 206010042928 Syringomyelia Diseases 0.000 description 1
- 241000256834 Vespula vulgaris Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000002642 intravenous therapy Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000009374 poultry farming Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
- Y10S530/858—Proteins from animals other than mammals or birds insects; venom
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Insects & Arthropods (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK92828A DK82892D0 (da) | 1992-06-24 | 1992-06-24 | Anvendelse af braadgifte fra bier og hvepse til fremstilling af laegemidler til behandling af infektioner |
PCT/DK1993/000208 WO1994000137A1 (fr) | 1992-06-24 | 1993-06-24 | Utilisation d'un venin d'hymenoptere pour la fabrication d'un medicament pour le traitement des infections virales de l'adn |
Publications (3)
Publication Number | Publication Date |
---|---|
NO945031D0 NO945031D0 (no) | 1994-12-23 |
NO945031L NO945031L (no) | 1994-12-23 |
NO310058B1 true NO310058B1 (no) | 2001-05-14 |
Family
ID=8098009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO945031A NO310058B1 (no) | 1992-06-24 | 1994-12-23 | Anvendelse av en hymenopteravgift til fremstilling av et medikament for behandling av DNA-virusinfeksjoner |
Country Status (13)
Country | Link |
---|---|
US (2) | US5827829A (fr) |
EP (1) | EP0653939B1 (fr) |
JP (1) | JP3631245B2 (fr) |
AT (1) | ATE190492T1 (fr) |
AU (1) | AU4312093A (fr) |
CA (1) | CA2138793C (fr) |
DE (1) | DE69328102T2 (fr) |
DK (2) | DK82892D0 (fr) |
ES (1) | ES2147200T3 (fr) |
GR (1) | GR3033698T3 (fr) |
NO (1) | NO310058B1 (fr) |
PT (1) | PT653939E (fr) |
WO (1) | WO1994000137A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999018983A1 (fr) * | 1997-10-15 | 1999-04-22 | Alk-Abelló A/S | Composition et methode de traitement d'une maladie encephalomyelopathique, demyelinisante ou auto-immune |
US6372471B1 (en) * | 1998-10-01 | 2002-04-16 | The Rockefeller University | Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon |
US20040081702A1 (en) | 2000-04-14 | 2004-04-29 | Kim Christopher M. | Bee venom treatment without the sting |
EP2187969A2 (fr) * | 2007-08-17 | 2010-05-26 | Arcion Therapeutics, Inc. | Formulations anesthésiques locales à concentration élevée |
WO2010019953A1 (fr) * | 2008-08-15 | 2010-02-18 | Arcion Therapeutics, Inc. | Préparations anesthésiques locales à concentration élevée |
CN102988263B (zh) * | 2012-12-20 | 2014-08-20 | 中国科学院南海海洋研究所 | 一种具有护唇、美唇功效的蜂毒组合物 |
KR101596344B1 (ko) * | 2013-10-30 | 2016-02-22 | 주식회사 청진바이오텍 | 정제봉독을 이용한 동물의 바이러스성 질환의 예방 및/또는 치료용 조성물 |
US10232048B1 (en) | 2014-11-18 | 2019-03-19 | Divine Api-Logics, LLC | Apitherapy method and composition |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3856936A (en) * | 1973-05-07 | 1974-12-24 | Schuyler Dev Corp | Composition and method for cortisol control |
JPS55149214A (en) * | 1979-05-10 | 1980-11-20 | Toyama Chem Co Ltd | Medical composition consisting of extract from liquid in bee poison gland |
US4822608A (en) * | 1987-09-14 | 1989-04-18 | Vespa Laboratories, Inc. | Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof |
CA1337330C (fr) * | 1989-04-13 | 1995-10-17 | Henning Lowenstein | Methodes et compositions pour le traitement des infections chez les mammiferes au moyen de medicaments renfermant du venin d'hymenopteres, des composants proteiniques ou polypeptidiques derives de ce venin ou des analogues de ces composants |
BR9007904A (pt) * | 1989-12-07 | 1992-09-29 | Strahlen Umweltforsch Gmbh | Processo e composicao para o tratamento de infeccao por hiv de mamiferos |
-
1992
- 1992-06-24 DK DK92828A patent/DK82892D0/da not_active Application Discontinuation
-
1993
- 1993-06-24 AU AU43120/93A patent/AU4312093A/en not_active Abandoned
- 1993-06-24 ES ES93912693T patent/ES2147200T3/es not_active Expired - Lifetime
- 1993-06-24 WO PCT/DK1993/000208 patent/WO1994000137A1/fr active IP Right Grant
- 1993-06-24 AT AT93912693T patent/ATE190492T1/de not_active IP Right Cessation
- 1993-06-24 EP EP93912693A patent/EP0653939B1/fr not_active Expired - Lifetime
- 1993-06-24 JP JP50196594A patent/JP3631245B2/ja not_active Expired - Fee Related
- 1993-06-24 PT PT93912693T patent/PT653939E/pt unknown
- 1993-06-24 DE DE69328102T patent/DE69328102T2/de not_active Expired - Fee Related
- 1993-06-24 DK DK93912693T patent/DK0653939T3/da active
- 1993-06-24 CA CA002138793A patent/CA2138793C/fr not_active Expired - Fee Related
-
1994
- 1994-12-23 NO NO945031A patent/NO310058B1/no unknown
-
1997
- 1997-01-21 US US08/786,518 patent/US5827829A/en not_active Expired - Fee Related
-
1998
- 1998-06-22 US US09/102,335 patent/US5958887A/en not_active Expired - Fee Related
-
2000
- 2000-06-15 GR GR20000401388T patent/GR3033698T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE190492T1 (de) | 2000-04-15 |
DE69328102T2 (de) | 2000-11-09 |
DE69328102D1 (de) | 2000-04-20 |
EP0653939B1 (fr) | 2000-03-15 |
US5827829A (en) | 1998-10-27 |
US5958887A (en) | 1999-09-28 |
DK0653939T3 (da) | 2000-08-28 |
NO945031D0 (no) | 1994-12-23 |
AU4312093A (en) | 1994-01-24 |
WO1994000137A1 (fr) | 1994-01-06 |
EP0653939A1 (fr) | 1995-05-24 |
JPH07508010A (ja) | 1995-09-07 |
GR3033698T3 (en) | 2000-10-31 |
JP3631245B2 (ja) | 2005-03-23 |
DK82892D0 (da) | 1992-06-24 |
ES2147200T3 (es) | 2000-09-01 |
CA2138793A1 (fr) | 1994-01-06 |
NO945031L (no) | 1994-12-23 |
PT653939E (pt) | 2000-08-31 |
CA2138793C (fr) | 2004-03-09 |
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