NO309966B1 - Anvendelse av rapamycin og derivater derav - Google Patents
Anvendelse av rapamycin og derivater derav Download PDFInfo
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- NO309966B1 NO309966B1 NO965238A NO965238A NO309966B1 NO 309966 B1 NO309966 B1 NO 309966B1 NO 965238 A NO965238 A NO 965238A NO 965238 A NO965238 A NO 965238A NO 309966 B1 NO309966 B1 NO 309966B1
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- Prior art keywords
- rapamycin
- disease
- compound
- glutamate
- cell death
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- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- 235000014593 oils and fats Nutrition 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
- SEPKUNXLGWMPHL-UHFFFAOYSA-N quinoxaline-2,3-dione Chemical compound C1=CC=CC2=NC(=O)C(=O)N=C21 SEPKUNXLGWMPHL-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US833795P | 1995-12-07 | 1995-12-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO965238D0 NO965238D0 (no) | 1996-12-06 |
| NO965238L NO965238L (no) | 1997-06-09 |
| NO309966B1 true NO309966B1 (no) | 2001-04-30 |
Family
ID=21731060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO965238A NO309966B1 (no) | 1995-12-07 | 1996-12-06 | Anvendelse av rapamycin og derivater derav |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0778023B1 (fr) |
| JP (1) | JPH09183727A (fr) |
| KR (1) | KR970032856A (fr) |
| CN (1) | CN1112925C (fr) |
| AR (1) | AR008747A1 (fr) |
| AT (1) | ATE234095T1 (fr) |
| AU (1) | AU700653B2 (fr) |
| BR (1) | BR9605895A (fr) |
| CA (1) | CA2192298A1 (fr) |
| CZ (2) | CZ6498A3 (fr) |
| DE (1) | DE69626610T2 (fr) |
| DK (1) | DK0778023T3 (fr) |
| ES (1) | ES2188730T3 (fr) |
| HU (1) | HUP9603370A3 (fr) |
| IL (1) | IL119778A (fr) |
| MX (1) | MX9606131A (fr) |
| NO (1) | NO309966B1 (fr) |
| NZ (1) | NZ299888A (fr) |
| PT (1) | PT778023E (fr) |
| SI (1) | SI0778023T1 (fr) |
| SK (1) | SK154796A3 (fr) |
| TW (1) | TW427904B (fr) |
| ZA (1) | ZA9610245B (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1002535A1 (fr) * | 1998-10-28 | 2000-05-24 | Hrissanthi Ikonomidou | Nouvelle utilisation des antagonistes du glutamate pour le traitement du cancer |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| US6417189B1 (en) * | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
| FR2806626B1 (fr) * | 2000-03-22 | 2003-11-28 | Centre Nat Rech Scient | Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues |
| WO2001079177A1 (fr) * | 2000-04-17 | 2001-10-25 | Gpi Nil Holdings, Inc. | Composes diaza cycliques pour le traitement de troubles neurodegeneratifs |
| GB0117645D0 (en) * | 2001-07-19 | 2001-09-12 | Isis Innovation | Therapeutic stratergies for prevention and treatment of alzheimers disease |
| UA78529C2 (en) * | 2001-10-10 | 2007-04-10 | Wyeth Corp | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
| US20030176455A1 (en) * | 2002-03-13 | 2003-09-18 | Wyeth | Method of inhibiting cell death |
| JP2006522834A (ja) * | 2003-04-09 | 2006-10-05 | ワイス | ［２−（８，９−ジオキソ−２，６−ジアザビシクロ［５．２．０］ノナ−１（７）−エン−２−イル）アルキル］ホスホン酸および誘導体の鼻腔内投与用医薬組成物およびその使用法 |
| CA2521313A1 (fr) | 2003-04-09 | 2004-10-28 | Wyeth | Derives d'acide phosphonique 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non- 1(7)-en-2-yl)-alkyl et leurs methodes d'utilisation |
| US20070155771A1 (en) * | 2003-04-11 | 2007-07-05 | David Rubinsztein | Methods and means for treating protein conformational disorders |
| US7485706B2 (en) * | 2003-07-30 | 2009-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Neurodegenerative protein aggregation inhibition methods and compounds |
| TW200514775A (en) | 2003-10-22 | 2005-05-01 | Wyeth Corp | Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof |
| JP2008524232A (ja) | 2004-12-20 | 2008-07-10 | ワイス | ラパマイシン誘導体及び神経障害の治療におけるその使用 |
| DK1828202T3 (da) | 2004-12-20 | 2012-05-07 | Wyeth Llc | Rapamycinanaloge samt deres anvendelse ved behandling af neurologiske, proliferative og inflammatoriske lidelser |
| JP4857071B2 (ja) * | 2006-10-12 | 2012-01-18 | 潤平 笹部 | 筋萎縮性側策硬化症（ａｌｓ）の検出方法 |
| EP2065038A1 (fr) | 2007-11-30 | 2009-06-03 | Pharnext | Nouvelles approches thérapeutiques pour traiter la maladie de Charcot-Marie-Tooth |
| EP2135607A1 (fr) | 2008-06-18 | 2009-12-23 | Pharnext | Combinaison de pilocarpine et methimazol pour le traitement de la maladie de Charcot-MarieTooth et des troubles associés |
| KR20120061081A (ko) * | 2009-04-10 | 2012-06-12 | 하이얀 치 | 새로운 노화 방지 물질 및 그 확인 방법 |
| EP2263665A1 (fr) * | 2009-06-02 | 2010-12-22 | Pharnext | Nouvelles compositions pour traiter le CMT et troubles associés |
| US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
| EP2456437A4 (fr) * | 2009-07-24 | 2013-01-09 | Inst Nat Rech Scient | Thérapie de combinaison pour des tauopathies |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| US9121859B2 (en) | 2012-12-04 | 2015-09-01 | Siemens Healthcare Diagnostics Inc. | Compounds and methods for determination of FKBP-binding immunosuppressant drugs |
| EA029478B1 (ru) | 2013-06-05 | 2018-03-30 | Фарнекст | Стабильные растворы объединенных активных фармацевтических ингредиентов для перорального применения |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| US10383870B2 (en) | 2016-06-10 | 2019-08-20 | Pharnext | Early treatment of CMT disease |
| MX2020005029A (es) * | 2017-11-15 | 2020-08-13 | Univ Vanderbilt | Metodos y composiciones para el mejoramiento de la funcion lisosomal y tratamiento de enfermedad neurodegenerativa. |
| CN114366738A (zh) * | 2021-12-20 | 2022-04-19 | 中国人民解放军军事科学院军事医学研究院 | 雷帕霉素在促进神经干细胞扩增中的用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206018A (en) * | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
| JPH04230389A (ja) * | 1990-07-16 | 1992-08-19 | American Home Prod Corp | ラパマイシン誘導体 |
| US5078999A (en) * | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
| IL101353A0 (en) * | 1991-04-03 | 1992-11-15 | American Home Prod | Pharmaceutical compositions for treating diabetes |
| DE4118740A1 (de) * | 1991-06-05 | 1992-12-10 | Schering Ag | Neue kombinationspraeparate zur behandlung des morbus parkinson |
| ZA924953B (en) * | 1991-07-25 | 1993-04-28 | Univ Louisville Res Found | Method of treating ocular inflammation |
| US5260299A (en) * | 1992-03-05 | 1993-11-09 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-Carboalkoxy)Sulfamates Useful as Immunosuppressive Agents |
| IL111003A0 (en) * | 1993-09-30 | 1994-11-28 | American Home Prod | Multi-component oral rapamycin formulation |
-
1996
- 1996-11-28 TW TW085114700A patent/TW427904B/zh not_active IP Right Cessation
- 1996-12-04 CZ CZ9864A patent/CZ6498A3/cs unknown
- 1996-12-04 SK SK1547-96A patent/SK154796A3/sk unknown
- 1996-12-04 SI SI9630586T patent/SI0778023T1/xx unknown
- 1996-12-04 ES ES96308786T patent/ES2188730T3/es not_active Expired - Lifetime
- 1996-12-04 DE DE69626610T patent/DE69626610T2/de not_active Expired - Fee Related
- 1996-12-04 AT AT96308786T patent/ATE234095T1/de not_active IP Right Cessation
- 1996-12-04 EP EP96308786A patent/EP0778023B1/fr not_active Expired - Lifetime
- 1996-12-04 CZ CZ963544A patent/CZ354496A3/cs unknown
- 1996-12-04 DK DK96308786T patent/DK0778023T3/da active
- 1996-12-04 PT PT96308786T patent/PT778023E/pt unknown
- 1996-12-05 NZ NZ299888A patent/NZ299888A/en unknown
- 1996-12-05 AU AU74178/96A patent/AU700653B2/en not_active Ceased
- 1996-12-05 ZA ZA9610245A patent/ZA9610245B/xx unknown
- 1996-12-05 MX MX9606131A patent/MX9606131A/es unknown
- 1996-12-05 KR KR1019960062011A patent/KR970032856A/ko not_active Application Discontinuation
- 1996-12-06 NO NO965238A patent/NO309966B1/no not_active IP Right Cessation
- 1996-12-06 BR BR9605895A patent/BR9605895A/pt not_active Application Discontinuation
- 1996-12-06 AR ARP960105543A patent/AR008747A1/es not_active Application Discontinuation
- 1996-12-06 IL IL11977896A patent/IL119778A/xx not_active IP Right Cessation
- 1996-12-06 CN CN96123098A patent/CN1112925C/zh not_active Expired - Fee Related
- 1996-12-06 HU HU9603370A patent/HUP9603370A3/hu unknown
- 1996-12-06 JP JP8326582A patent/JPH09183727A/ja active Pending
- 1996-12-06 CA CA002192298A patent/CA2192298A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2188730T3 (es) | 2003-07-01 |
| CZ354496A3 (cs) | 1998-03-18 |
| EP0778023B1 (fr) | 2003-03-12 |
| CN1159915A (zh) | 1997-09-24 |
| DE69626610T2 (de) | 2003-10-02 |
| JPH09183727A (ja) | 1997-07-15 |
| PT778023E (pt) | 2003-06-30 |
| CN1112925C (zh) | 2003-07-02 |
| ATE234095T1 (de) | 2003-03-15 |
| HUP9603370A2 (en) | 1997-05-28 |
| SI0778023T1 (en) | 2003-08-31 |
| AU700653B2 (en) | 1999-01-14 |
| NO965238D0 (no) | 1996-12-06 |
| IL119778A (en) | 1999-07-14 |
| HUP9603370A3 (en) | 1998-12-28 |
| CA2192298A1 (fr) | 1997-06-08 |
| AR008747A1 (es) | 2000-02-23 |
| ZA9610245B (en) | 1998-06-05 |
| DE69626610D1 (de) | 2003-04-17 |
| CZ6498A3 (cs) | 1998-06-17 |
| DK0778023T3 (da) | 2003-06-30 |
| SK154796A3 (en) | 1997-09-10 |
| IL119778A0 (en) | 1997-03-18 |
| AU7417896A (en) | 1997-06-12 |
| NZ299888A (en) | 2001-02-23 |
| NO965238L (no) | 1997-06-09 |
| TW427904B (en) | 2001-04-01 |
| MX9606131A (es) | 1997-08-30 |
| EP0778023A1 (fr) | 1997-06-11 |
| KR970032856A (ko) | 1997-07-22 |
| BR9605895A (pt) | 1998-08-18 |
| HU9603370D0 (en) | 1997-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |