NO308216B1 - FremgangsmÕte for utvinning av proinsulin med korrekt forbundede cystinbroer - Google Patents

FremgangsmÕte for utvinning av proinsulin med korrekt forbundede cystinbroer

Info

Publication number
NO308216B1
NO308216B1 NO934357A NO934357A NO308216B1 NO 308216 B1 NO308216 B1 NO 308216B1 NO 934357 A NO934357 A NO 934357A NO 934357 A NO934357 A NO 934357A NO 308216 B1 NO308216 B1 NO 308216B1
Authority
NO
Norway
Prior art keywords
proinsulin
recovery
procedure
properly connected
cystine bridges
Prior art date
Application number
NO934357A
Other languages
English (en)
Norwegian (no)
Other versions
NO934357L (no
NO934357D0 (no
Inventor
Rainer Obermeier
Martin Gerl
Juergen Ludwig
Walter Sabel
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO934357D0 publication Critical patent/NO934357D0/no
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO934357L publication Critical patent/NO934357L/no
Publication of NO308216B1 publication Critical patent/NO308216B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
NO934357A 1992-12-02 1993-12-01 FremgangsmÕte for utvinning av proinsulin med korrekt forbundede cystinbroer NO308216B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4240420 1992-12-02

Publications (3)

Publication Number Publication Date
NO934357D0 NO934357D0 (no) 1993-11-30
NO934357L NO934357L (no) 1994-06-03
NO308216B1 true NO308216B1 (no) 2000-08-14

Family

ID=6474135

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934357A NO308216B1 (no) 1992-12-02 1993-12-01 FremgangsmÕte for utvinning av proinsulin med korrekt forbundede cystinbroer

Country Status (13)

Country Link
US (1) US5473049A (fi)
EP (1) EP0600372B1 (fi)
JP (1) JP2798351B2 (fi)
AT (1) ATE148710T1 (fi)
AU (1) AU662083B2 (fi)
CA (1) CA2110442C (fi)
DE (1) DE59305396D1 (fi)
DK (1) DK0600372T3 (fi)
ES (1) ES2097426T3 (fi)
FI (1) FI108727B (fi)
HK (1) HK1006170A1 (fi)
NO (1) NO308216B1 (fi)
SG (1) SG46612A1 (fi)

Families Citing this family (34)

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Publication number Priority date Publication date Assignee Title
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
JP3778936B2 (ja) * 1995-02-20 2006-05-24 アムラド・オペレイションズ・プロプライエタリー・リミテッド インシュリン依存性糖尿病（ｉｄｄｍ）患者に作用する免疫反応および免疫治療分子
SE9504019D0 (sv) * 1995-11-13 1995-11-13 Pharmacia Ab Method for production of proteins
ATE264871T1 (de) 1996-07-26 2004-05-15 Aventis Pharma Gmbh Insulinderivate mit erhöhter zinkbindung
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
DE19735711C2 (de) 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
KR100253916B1 (ko) * 1997-12-29 2000-05-01 김충환 사람 인슐린 전구체의 제조방법
CA2324513C (en) 1998-03-31 2013-05-28 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence and its application to insulin production
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
DE19838097A1 (de) 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
JP3971108B2 (ja) * 1999-01-06 2007-09-05 ジェネンテック・インコーポレーテッド インシュリン様成長因子（ｉｇｆ）ｉ突然変異体
AU762047B2 (en) * 1999-01-06 2003-06-19 Genentech Inc. Insulin-like growth factor (IGF) I mutant variants
JP3406244B2 (ja) * 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法
EP1242610A1 (en) 1999-12-22 2002-09-25 Novo Nordisk A/S Method for extractive refolding of scrambledsingle-chain polypeptides
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
US7193035B2 (en) * 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
WO2009101672A1 (ja) * 2008-02-12 2009-08-20 Itoham Foods Inc. 高発現分泌インスリン前駆体を含む融合タンパク質、それをコードするｄｎａおよびインスリンの製造方法
US9296806B2 (en) * 2008-04-30 2016-03-29 Wockhardt Limited Processes for refolding of insulin
HUE037449T2 (hu) 2008-10-17 2018-08-28 Sanofi Aventis Deutschland Egy inzulin és egy GLP-1 agonista kombinációja
EP3831402A1 (de) 2009-11-13 2021-06-09 Sanofi-Aventis Deutschland GmbH Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten, ein insulin und methionin
ES2965209T3 (es) 2009-11-13 2024-04-11 Sanofi Aventis Deutschland Composición farmacéutica que comprende desPro36exendina-4(1-39)-Lys6-NH2 y metionina
PT2611458T (pt) 2010-08-30 2016-12-16 Sanofi Aventis Deutschland Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
EP2931301B2 (en) 2012-12-17 2021-09-15 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
WO2015138548A1 (en) 2014-03-14 2015-09-17 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
DK3229828T5 (da) 2014-12-12 2024-10-14 Sanofi Aventis Deutschland Formulering med fast forhold mellem insulin glargin og lixisenatid
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
WO2017040363A1 (en) 2015-09-02 2017-03-09 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO81951B (ro) 1980-03-27 1984-02-28 Eli Lilly And Company Procedeu de preparare a unui precursor de insulina
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
NZ199391A (en) 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
DE3537708A1 (de) 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
DE4012818A1 (de) 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3726655A1 (de) 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
ATE101620T1 (de) 1988-06-23 1994-03-15 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung.
GB8819826D0 (en) * 1988-08-20 1988-09-21 Kabivitrum Ab Glycosylated igf-1
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
US5227293A (en) * 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
GR1005153B (el) * 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.

Also Published As

Publication number Publication date
US5473049A (en) 1995-12-05
EP0600372B1 (de) 1997-02-05
AU662083B2 (en) 1995-08-17
SG46612A1 (en) 1998-02-20
JP2798351B2 (ja) 1998-09-17
AU5203993A (en) 1994-06-16
FI935358A0 (fi) 1993-11-30
CA2110442C (en) 2004-05-04
EP0600372A1 (de) 1994-06-08
DK0600372T3 (da) 1997-08-11
NO934357L (no) 1994-06-03
FI935358A (fi) 1994-06-03
JPH06228191A (ja) 1994-08-16
FI108727B (fi) 2002-03-15
ES2097426T3 (es) 1997-04-01
CA2110442A1 (en) 1994-06-03
DE59305396D1 (de) 1997-03-20
NO934357D0 (no) 1993-11-30
HK1006170A1 (en) 1999-02-12
ATE148710T1 (de) 1997-02-15

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