NO307337B1 - Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike - Google Patents

Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike

Info

Publication number
NO307337B1
NO307337B1 NO965607A NO965607A NO307337B1 NO 307337 B1 NO307337 B1 NO 307337B1 NO 965607 A NO965607 A NO 965607A NO 965607 A NO965607 A NO 965607A NO 307337 B1 NO307337 B1 NO 307337B1
Authority
NO
Norway
Prior art keywords
alkyl
cycloalkyl
het
cor
opt
Prior art date
Application number
NO965607A
Other languages
English (en)
Norwegian (no)
Other versions
NO965607L (no
NO965607D0 (no
Inventor
William Edward Bondinell
William H Miller
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PT96923553T priority Critical patent/PT910563E/pt
Priority to DE69627899T priority patent/DE69627899T2/de
Priority to ES96923553T priority patent/ES2197950T3/es
Priority to EP96923553A priority patent/EP0910563B1/de
Priority to JP50460197A priority patent/JP3960482B2/ja
Priority to PCT/US1996/011108 priority patent/WO1997001540A1/en
Priority to DK96923553T priority patent/DK0910563T3/da
Priority to SI9630616T priority patent/SI0910563T1/xx
Priority to HK99104723.8A priority patent/HK1019594B/en
Priority to AT96923553T priority patent/ATE238996T1/de
Priority to NZ299914A priority patent/NZ299914A/en
Priority to CA002192764A priority patent/CA2192764C/en
Priority to HU9603432A priority patent/HU226056B1/hu
Priority to CZ19963679A priority patent/CZ292925B6/cs
Priority to AU75461/96A priority patent/AU736487B2/en
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Priority to NO965607A priority patent/NO307337B1/no
Priority to BR9606200A priority patent/BR9606200A/pt
Publication of NO965607D0 publication Critical patent/NO965607D0/no
Publication of NO965607L publication Critical patent/NO965607L/no
Publication of NO307337B1 publication Critical patent/NO307337B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
NO965607A 1995-06-29 1996-12-27 Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike NO307337B1 (no)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE69627899T DE69627899T2 (de) 1995-06-29 1996-06-28 Integrin-rezeptor-antagonisten
ES96923553T ES2197950T3 (es) 1995-06-29 1996-06-28 Antagonistas del receptor de la integrina.
EP96923553A EP0910563B1 (de) 1995-06-29 1996-06-28 Integrin-rezeptor-antagonisten
JP50460197A JP3960482B2 (ja) 1995-06-29 1996-06-28 インテグリン受容体アンタゴニスト
PCT/US1996/011108 WO1997001540A1 (en) 1995-06-29 1996-06-28 Integrin receptor antagonists
DK96923553T DK0910563T3 (da) 1995-06-29 1996-06-28 Integrinreceptorantagonister
SI9630616T SI0910563T1 (en) 1995-06-29 1996-06-28 Integrin receptor antagonists
HK99104723.8A HK1019594B (en) 1995-06-29 1996-06-28 Integrin receptor antagonists
AT96923553T ATE238996T1 (de) 1995-06-29 1996-06-28 Integrin-rezeptor-antagonisten
PT96923553T PT910563E (pt) 1995-06-29 1996-06-28 Antagonistas de receptores de integrina
NZ299914A NZ299914A (en) 1995-06-29 1996-12-10 Tricyclic integrin receptor antagonists, preparation and pharmaceutical compositions thereof
CA002192764A CA2192764C (en) 1995-06-29 1996-12-12 Integrin receptor antagonists
HU9603432A HU226056B1 (en) 1995-06-29 1996-12-12 Acetic acid derivatives with dibenzo[a,d]cycloheptene and dibenz[b,e]azepine skeleton, process for their preparation and pharmaceutical compositions containing them
CZ19963679A CZ292925B6 (cs) 1995-06-29 1996-12-13 Antagonisté receptorů integrinu, způsob jejich přípravy, farmaceutický prostředek obsahující tyto látky a použití
AU75461/96A AU736487B2 (en) 1995-06-29 1996-12-19 Integrin receptor antagonists
NO965607A NO307337B1 (no) 1995-06-29 1996-12-27 Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike
BR9606200A BR9606200A (pt) 1995-06-29 1996-12-27 Antagonistas de receptor de integrina

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US66595P 1995-06-29 1995-06-29
US278895P 1995-08-25 1995-08-25
NZ299914A NZ299914A (en) 1995-06-29 1996-12-10 Tricyclic integrin receptor antagonists, preparation and pharmaceutical compositions thereof
HU9603432A HU226056B1 (en) 1995-06-29 1996-12-12 Acetic acid derivatives with dibenzo[a,d]cycloheptene and dibenz[b,e]azepine skeleton, process for their preparation and pharmaceutical compositions containing them
CA002192764A CA2192764C (en) 1995-06-29 1996-12-12 Integrin receptor antagonists
AU75461/96A AU736487B2 (en) 1995-06-29 1996-12-19 Integrin receptor antagonists
NO965607A NO307337B1 (no) 1995-06-29 1996-12-27 Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike
BR9606200A BR9606200A (pt) 1995-06-29 1996-12-27 Antagonistas de receptor de integrina

Publications (3)

Publication Number Publication Date
NO965607D0 NO965607D0 (no) 1996-12-27
NO965607L NO965607L (no) 1998-06-29
NO307337B1 true NO307337B1 (no) 2000-03-20

Family

ID=89994543

Family Applications (1)

Application Number Title Priority Date Filing Date
NO965607A NO307337B1 (no) 1995-06-29 1996-12-27 Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike

Country Status (16)

Country Link
EP (1) EP0910563B1 (de)
JP (1) JP3960482B2 (de)
AT (1) ATE238996T1 (de)
AU (1) AU736487B2 (de)
BR (1) BR9606200A (de)
CA (1) CA2192764C (de)
CZ (1) CZ292925B6 (de)
DE (1) DE69627899T2 (de)
DK (1) DK0910563T3 (de)
ES (1) ES2197950T3 (de)
HU (1) HU226056B1 (de)
NO (1) NO307337B1 (de)
NZ (1) NZ299914A (de)
PT (1) PT910563E (de)
SI (1) SI0910563T1 (de)
WO (1) WO1997001540A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030125317A1 (en) 1996-10-02 2003-07-03 Smithkline Beecham Corporation Vitronectin receptor antagonists
DE19653647A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
US6482821B2 (en) 1996-12-20 2002-11-19 Hoechst Aktiengellschaft Vitronectin receptor antagonists, their preparation and their use
US6218387B1 (en) 1996-12-20 2001-04-17 Hoechst Aktiengesellschaft Vitronectin receptor anatagonists, their preparation and their use
DE19653645A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
CO4920232A1 (es) * 1997-01-08 2000-05-29 Smithkline Beecham Corp Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin
AU8689798A (en) * 1997-08-04 1999-02-22 Smithkline Beecham Corporation Integrin receptor antagonists
EP1027337A4 (de) * 1997-09-04 2002-04-03 Smithkline Beecham Corp Integrin-rezeptor-antagonisten
PE122699A1 (es) * 1997-09-19 2000-02-12 Smithkline Beecham Corp Antagonistas de receptores de vitronectina
US6576643B2 (en) 1997-09-19 2003-06-10 Smithkline Beecham Corporation Vitronectin receptor antagonists
WO1999031061A1 (en) * 1997-12-17 1999-06-24 Merck & Co., Inc. Integrin receptor antagonists
KR20010042587A (ko) 1998-04-09 2001-05-25 기따자또 이찌로 인테그린 알파브이베타3 길항제로서 아미노피페리딘 유도체
UA71586C2 (en) 1998-12-04 2004-12-15 Smithkline Beecham Corp A vitronectin receptor antagonist
US6339083B1 (en) 1998-12-14 2002-01-15 Bayer Aktiengesellschaft Multiheterocyclic pharmAceuticals
EP1150965A4 (de) 1999-02-03 2002-05-15 Merck & Co Inc Benzazepin derivate als alpha-v intgrin rezeptor antagonisten
JP2002537260A (ja) * 1999-02-17 2002-11-05 メルク エンド カムパニー インコーポレーテッド αVインテグリン受容体拮抗薬としてのジベンゾ−アゼピン誘導体
DE19916837A1 (de) * 1999-04-14 2000-10-19 Merck Patent Gmbh Dibenzoazulenderivate
EP1198231A1 (de) 1999-07-21 2002-04-24 American Home Products Corporation Bicyklischer antagonist selektiv für (alpha)v (beta)3 integrin
EP1209152A4 (de) 1999-08-05 2003-03-12 Meiji Seika Kaisha Omega-amino-alpha-hydroxy-carbonsäure-derivate mit einem integrin alpha v beta antagonismus
EP1208101A4 (de) * 1999-08-06 2003-03-19 Smithkline Beecham Corp Zur behandlung von schlaganfällen nützliche vitronektin-rezeptor-antagonisten
DE19936780A1 (de) * 1999-08-09 2001-02-15 Basf Ag Neue Antagonisten von Integrinrezeptoren
US6514964B1 (en) * 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
DE10039998A1 (de) * 2000-08-11 2002-02-21 Basf Ag Neue substituierte Diareno-azepin-Derivate als Integrin Liganden
US20020035104A1 (en) 2000-08-18 2002-03-21 Genentech, Inc. Integrin receptor inhibitors
ES2366775T3 (es) 2001-04-24 2011-10-25 Merck Patent Gmbh POLITERAPIA UTILIZANDO AGENTES ANTIANGIOGÉNICOS Y TNF(alfa).
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
AU2007207465B2 (en) 2006-01-18 2012-12-06 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
BRPI0806596A2 (pt) 2007-01-18 2013-07-23 Merck Patent Ges Mit Berchraenkter Haftung medicamento e terapia especÍfica usando-se ligantes de integrina para o tratamento de cÂncer
EP2445534A2 (de) 2009-05-25 2012-05-02 Merck Patent GmbH Kontinuierliche verabreichung von cilengitid in der krebstherapie
ES2864079T3 (es) 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794424A (fr) * 1972-01-24 1973-07-23 Science Union & Cie Nouveaux dibenzocycloheptenes, leur procede d'obtention et leur application comme medicament
US3972936A (en) * 1974-02-01 1976-08-03 Merck & Co., Inc. 10,11-Dihydro-5-(3-amino-propyl-or-propylidene)-10,10,11,11-tetra-fluoro-5H-dibenzo[a,d]cycloheptenes and-5-ols
AU612437B2 (en) * 1987-12-14 1991-07-11 Kyowa Hakko Kogyo Co. Ltd. Tricyclic compounds

Also Published As

Publication number Publication date
EP0910563B1 (de) 2003-05-02
JP3960482B2 (ja) 2007-08-15
NO965607L (no) 1998-06-29
HUP9603432A3 (en) 1999-05-28
JPH11508887A (ja) 1999-08-03
NO965607D0 (no) 1996-12-27
DE69627899T2 (de) 2004-05-19
EP0910563A4 (de) 1999-04-28
CZ292925B6 (cs) 2004-01-14
HUP9603432A2 (hu) 1998-09-28
ATE238996T1 (de) 2003-05-15
EP0910563A1 (de) 1999-04-28
CA2192764C (en) 2008-03-11
CA2192764A1 (en) 1998-06-12
DK0910563T3 (da) 2003-09-01
PT910563E (pt) 2003-09-30
HK1019594A1 (en) 2000-02-18
AU736487B2 (en) 2001-07-26
CZ367996A3 (cs) 1998-08-12
BR9606200A (pt) 1998-11-03
ES2197950T3 (es) 2004-01-16
HU226056B1 (en) 2008-04-28
AU7546196A (en) 1998-06-25
WO1997001540A1 (en) 1997-01-16
SI0910563T1 (en) 2003-10-31
HU9603432D0 (en) 1997-01-28
NZ299914A (en) 1998-04-27
DE69627899D1 (de) 2003-06-05

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