NO307337B1 - Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike - Google Patents
Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slikeInfo
- Publication number
- NO307337B1 NO307337B1 NO965607A NO965607A NO307337B1 NO 307337 B1 NO307337 B1 NO 307337B1 NO 965607 A NO965607 A NO 965607A NO 965607 A NO965607 A NO 965607A NO 307337 B1 NO307337 B1 NO 307337B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- cycloalkyl
- het
- cor
- opt
- Prior art date
Links
- 229940127449 Integrin Receptor Antagonists Drugs 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 27
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 abstract 3
- 101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 abstract 3
- 101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 abstract 3
- 101150111293 cor-1 gene Proteins 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- BGFHMYJZJZLMHW-UHFFFAOYSA-N 4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol Chemical compound N1=C(C=2C3=CC=CC=C3SC=2)N=C2N(C(C)C)C=NC2=C1NCCC1=CC=C(O)C=C1 BGFHMYJZJZLMHW-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- GRHZLQBPAJAHDM-SPRQWYLLSA-N [(3as,4r,6ar)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] n-[(2s,4s,5s)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]carbamate Chemical compound CC1=CC=CC(C)=C1OCC(=O)N[C@H]([C@@H](O)C[C@H](CC=1C=CC=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)CC1=CC=CC=C1 GRHZLQBPAJAHDM-SPRQWYLLSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 101100212791 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) YBL068W-A gene Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000005188 oxoalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE69627899T DE69627899T2 (de) | 1995-06-29 | 1996-06-28 | Integrin-rezeptor-antagonisten |
| ES96923553T ES2197950T3 (es) | 1995-06-29 | 1996-06-28 | Antagonistas del receptor de la integrina. |
| EP96923553A EP0910563B1 (de) | 1995-06-29 | 1996-06-28 | Integrin-rezeptor-antagonisten |
| JP50460197A JP3960482B2 (ja) | 1995-06-29 | 1996-06-28 | インテグリン受容体アンタゴニスト |
| PCT/US1996/011108 WO1997001540A1 (en) | 1995-06-29 | 1996-06-28 | Integrin receptor antagonists |
| DK96923553T DK0910563T3 (da) | 1995-06-29 | 1996-06-28 | Integrinreceptorantagonister |
| SI9630616T SI0910563T1 (en) | 1995-06-29 | 1996-06-28 | Integrin receptor antagonists |
| HK99104723.8A HK1019594B (en) | 1995-06-29 | 1996-06-28 | Integrin receptor antagonists |
| AT96923553T ATE238996T1 (de) | 1995-06-29 | 1996-06-28 | Integrin-rezeptor-antagonisten |
| PT96923553T PT910563E (pt) | 1995-06-29 | 1996-06-28 | Antagonistas de receptores de integrina |
| NZ299914A NZ299914A (en) | 1995-06-29 | 1996-12-10 | Tricyclic integrin receptor antagonists, preparation and pharmaceutical compositions thereof |
| CA002192764A CA2192764C (en) | 1995-06-29 | 1996-12-12 | Integrin receptor antagonists |
| HU9603432A HU226056B1 (en) | 1995-06-29 | 1996-12-12 | Acetic acid derivatives with dibenzo[a,d]cycloheptene and dibenz[b,e]azepine skeleton, process for their preparation and pharmaceutical compositions containing them |
| CZ19963679A CZ292925B6 (cs) | 1995-06-29 | 1996-12-13 | Antagonisté receptorů integrinu, způsob jejich přípravy, farmaceutický prostředek obsahující tyto látky a použití |
| AU75461/96A AU736487B2 (en) | 1995-06-29 | 1996-12-19 | Integrin receptor antagonists |
| NO965607A NO307337B1 (no) | 1995-06-29 | 1996-12-27 | Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike |
| BR9606200A BR9606200A (pt) | 1995-06-29 | 1996-12-27 | Antagonistas de receptor de integrina |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66595P | 1995-06-29 | 1995-06-29 | |
| US278895P | 1995-08-25 | 1995-08-25 | |
| NZ299914A NZ299914A (en) | 1995-06-29 | 1996-12-10 | Tricyclic integrin receptor antagonists, preparation and pharmaceutical compositions thereof |
| HU9603432A HU226056B1 (en) | 1995-06-29 | 1996-12-12 | Acetic acid derivatives with dibenzo[a,d]cycloheptene and dibenz[b,e]azepine skeleton, process for their preparation and pharmaceutical compositions containing them |
| CA002192764A CA2192764C (en) | 1995-06-29 | 1996-12-12 | Integrin receptor antagonists |
| AU75461/96A AU736487B2 (en) | 1995-06-29 | 1996-12-19 | Integrin receptor antagonists |
| NO965607A NO307337B1 (no) | 1995-06-29 | 1996-12-27 | Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike |
| BR9606200A BR9606200A (pt) | 1995-06-29 | 1996-12-27 | Antagonistas de receptor de integrina |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO965607D0 NO965607D0 (no) | 1996-12-27 |
| NO965607L NO965607L (no) | 1998-06-29 |
| NO307337B1 true NO307337B1 (no) | 2000-03-20 |
Family
ID=89994543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO965607A NO307337B1 (no) | 1995-06-29 | 1996-12-27 | Integrin-reseptor-antagonister, anvendelse derav og farmasøytiske preparater inneholdende slike |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0910563B1 (de) |
| JP (1) | JP3960482B2 (de) |
| AT (1) | ATE238996T1 (de) |
| AU (1) | AU736487B2 (de) |
| BR (1) | BR9606200A (de) |
| CA (1) | CA2192764C (de) |
| CZ (1) | CZ292925B6 (de) |
| DE (1) | DE69627899T2 (de) |
| DK (1) | DK0910563T3 (de) |
| ES (1) | ES2197950T3 (de) |
| HU (1) | HU226056B1 (de) |
| NO (1) | NO307337B1 (de) |
| NZ (1) | NZ299914A (de) |
| PT (1) | PT910563E (de) |
| SI (1) | SI0910563T1 (de) |
| WO (1) | WO1997001540A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030125317A1 (en) | 1996-10-02 | 2003-07-03 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| DE19653647A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
| US6482821B2 (en) | 1996-12-20 | 2002-11-19 | Hoechst Aktiengellschaft | Vitronectin receptor antagonists, their preparation and their use |
| US6218387B1 (en) | 1996-12-20 | 2001-04-17 | Hoechst Aktiengesellschaft | Vitronectin receptor anatagonists, their preparation and their use |
| DE19653645A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
| CO4920232A1 (es) * | 1997-01-08 | 2000-05-29 | Smithkline Beecham Corp | Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin |
| AU8689798A (en) * | 1997-08-04 | 1999-02-22 | Smithkline Beecham Corporation | Integrin receptor antagonists |
| EP1027337A4 (de) * | 1997-09-04 | 2002-04-03 | Smithkline Beecham Corp | Integrin-rezeptor-antagonisten |
| PE122699A1 (es) * | 1997-09-19 | 2000-02-12 | Smithkline Beecham Corp | Antagonistas de receptores de vitronectina |
| US6576643B2 (en) | 1997-09-19 | 2003-06-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| WO1999031061A1 (en) * | 1997-12-17 | 1999-06-24 | Merck & Co., Inc. | Integrin receptor antagonists |
| KR20010042587A (ko) | 1998-04-09 | 2001-05-25 | 기따자또 이찌로 | 인테그린 알파브이베타3 길항제로서 아미노피페리딘 유도체 |
| UA71586C2 (en) | 1998-12-04 | 2004-12-15 | Smithkline Beecham Corp | A vitronectin receptor antagonist |
| US6339083B1 (en) | 1998-12-14 | 2002-01-15 | Bayer Aktiengesellschaft | Multiheterocyclic pharmAceuticals |
| EP1150965A4 (de) | 1999-02-03 | 2002-05-15 | Merck & Co Inc | Benzazepin derivate als alpha-v intgrin rezeptor antagonisten |
| JP2002537260A (ja) * | 1999-02-17 | 2002-11-05 | メルク エンド カムパニー インコーポレーテッド | αVインテグリン受容体拮抗薬としてのジベンゾ−アゼピン誘導体 |
| DE19916837A1 (de) * | 1999-04-14 | 2000-10-19 | Merck Patent Gmbh | Dibenzoazulenderivate |
| EP1198231A1 (de) | 1999-07-21 | 2002-04-24 | American Home Products Corporation | Bicyklischer antagonist selektiv für (alpha)v (beta)3 integrin |
| EP1209152A4 (de) | 1999-08-05 | 2003-03-12 | Meiji Seika Kaisha | Omega-amino-alpha-hydroxy-carbonsäure-derivate mit einem integrin alpha v beta antagonismus |
| EP1208101A4 (de) * | 1999-08-06 | 2003-03-19 | Smithkline Beecham Corp | Zur behandlung von schlaganfällen nützliche vitronektin-rezeptor-antagonisten |
| DE19936780A1 (de) * | 1999-08-09 | 2001-02-15 | Basf Ag | Neue Antagonisten von Integrinrezeptoren |
| US6514964B1 (en) * | 1999-09-27 | 2003-02-04 | Amgen Inc. | Fused cycloheptane and fused azacycloheptane compounds and their methods of use |
| DE10039998A1 (de) * | 2000-08-11 | 2002-02-21 | Basf Ag | Neue substituierte Diareno-azepin-Derivate als Integrin Liganden |
| US20020035104A1 (en) | 2000-08-18 | 2002-03-21 | Genentech, Inc. | Integrin receptor inhibitors |
| ES2366775T3 (es) | 2001-04-24 | 2011-10-25 | Merck Patent Gmbh | POLITERAPIA UTILIZANDO AGENTES ANTIANGIOGÉNICOS Y TNF(alfa). |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| AU2007207465B2 (en) | 2006-01-18 | 2012-12-06 | Merck Patent Gmbh | Specific therapy using integrin ligands for treating cancer |
| BRPI0806596A2 (pt) | 2007-01-18 | 2013-07-23 | Merck Patent Ges Mit Berchraenkter Haftung | medicamento e terapia especÍfica usando-se ligantes de integrina para o tratamento de cÂncer |
| EP2445534A2 (de) | 2009-05-25 | 2012-05-02 | Merck Patent GmbH | Kontinuierliche verabreichung von cilengitid in der krebstherapie |
| ES2864079T3 (es) | 2014-05-30 | 2021-10-13 | Pfizer | Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794424A (fr) * | 1972-01-24 | 1973-07-23 | Science Union & Cie | Nouveaux dibenzocycloheptenes, leur procede d'obtention et leur application comme medicament |
| US3972936A (en) * | 1974-02-01 | 1976-08-03 | Merck & Co., Inc. | 10,11-Dihydro-5-(3-amino-propyl-or-propylidene)-10,10,11,11-tetra-fluoro-5H-dibenzo[a,d]cycloheptenes and-5-ols |
| AU612437B2 (en) * | 1987-12-14 | 1991-07-11 | Kyowa Hakko Kogyo Co. Ltd. | Tricyclic compounds |
-
1996
- 1996-06-28 ES ES96923553T patent/ES2197950T3/es not_active Expired - Lifetime
- 1996-06-28 JP JP50460197A patent/JP3960482B2/ja not_active Expired - Fee Related
- 1996-06-28 AT AT96923553T patent/ATE238996T1/de not_active IP Right Cessation
- 1996-06-28 EP EP96923553A patent/EP0910563B1/de not_active Expired - Lifetime
- 1996-06-28 WO PCT/US1996/011108 patent/WO1997001540A1/en not_active Ceased
- 1996-06-28 DK DK96923553T patent/DK0910563T3/da active
- 1996-06-28 PT PT96923553T patent/PT910563E/pt unknown
- 1996-06-28 SI SI9630616T patent/SI0910563T1/xx unknown
- 1996-06-28 DE DE69627899T patent/DE69627899T2/de not_active Expired - Fee Related
- 1996-12-10 NZ NZ299914A patent/NZ299914A/en unknown
- 1996-12-12 CA CA002192764A patent/CA2192764C/en not_active Expired - Fee Related
- 1996-12-12 HU HU9603432A patent/HU226056B1/hu not_active IP Right Cessation
- 1996-12-13 CZ CZ19963679A patent/CZ292925B6/cs not_active IP Right Cessation
- 1996-12-19 AU AU75461/96A patent/AU736487B2/en not_active Ceased
- 1996-12-27 NO NO965607A patent/NO307337B1/no not_active IP Right Cessation
- 1996-12-27 BR BR9606200A patent/BR9606200A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0910563B1 (de) | 2003-05-02 |
| JP3960482B2 (ja) | 2007-08-15 |
| NO965607L (no) | 1998-06-29 |
| HUP9603432A3 (en) | 1999-05-28 |
| JPH11508887A (ja) | 1999-08-03 |
| NO965607D0 (no) | 1996-12-27 |
| DE69627899T2 (de) | 2004-05-19 |
| EP0910563A4 (de) | 1999-04-28 |
| CZ292925B6 (cs) | 2004-01-14 |
| HUP9603432A2 (hu) | 1998-09-28 |
| ATE238996T1 (de) | 2003-05-15 |
| EP0910563A1 (de) | 1999-04-28 |
| CA2192764C (en) | 2008-03-11 |
| CA2192764A1 (en) | 1998-06-12 |
| DK0910563T3 (da) | 2003-09-01 |
| PT910563E (pt) | 2003-09-30 |
| HK1019594A1 (en) | 2000-02-18 |
| AU736487B2 (en) | 2001-07-26 |
| CZ367996A3 (cs) | 1998-08-12 |
| BR9606200A (pt) | 1998-11-03 |
| ES2197950T3 (es) | 2004-01-16 |
| HU226056B1 (en) | 2008-04-28 |
| AU7546196A (en) | 1998-06-25 |
| WO1997001540A1 (en) | 1997-01-16 |
| SI0910563T1 (en) | 2003-10-31 |
| HU9603432D0 (en) | 1997-01-28 |
| NZ299914A (en) | 1998-04-27 |
| DE69627899D1 (de) | 2003-06-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE238996T1 (de) | Integrin-rezeptor-antagonisten | |
| HUP9903769A2 (hu) | Vitronektin receptor antagonisták | |
| EE04282B1 (et) | Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon | |
| DK1371645T3 (da) | Anvendelse af (3S,2'R)-glycopyrronium som lægemiddel | |
| GR3036924T3 (en) | Benzodiazepine derivatives. | |
| EE200200202A (et) | Uudsed tritsüklilised ühendid, nende saamine ja kasutamine ravimi valmistamiseks, mis on ette nähtud HIV-nakkuse raviks, ning neid sisaldav farmatseutiline kompositsioon | |
| EE9700227A (et) | Arüülglütsiinamiidi derivaadid, meetod nende valmistamiseks ja neid ühendeid sisaldavad farmatseutilised preparaadid | |
| ATE231488T1 (de) | Harnstoffderivate und ihre anwendung als integrin-inhibitoren | |
| HU229443B1 (en) | Betha-carboline particulate form, pharmaceutical compositions containing it, their preparations and their use | |
| EP0689541A1 (de) | Pterinderivate und seine anwendung zur herstellung von immunotestverfahren | |
| ATE171374T1 (de) | Verwendung von 1-(aminoalkyl)-3-quinoxalin-2-on derivaten zur herstellung von neuroprotektiven mitteln | |
| ATE166648T1 (de) | Benzoxazinderivate, deren herstellung und deren verwendung in therapie | |
| DK0636367T3 (da) | Anvendelse af phenylalkylaminer til fremstilling af cholesterolsænkende lægemidler | |
| IL116526A0 (en) | Piperazinediones their preparation and use | |
| CA2101952A1 (en) | Sulfonylurea derivatives, their preparation and their use | |
| FI970434A0 (fi) | Uudet 3-substituoidut 3H-2,3-bentsodiatsepiinijohdannaiset, niiden valmistus ja käyttö lääkkeenä | |
| ATE166339T1 (de) | Pharmakologisch aktive alpha-(tertiär-aminoethyl)-phenylmethanol-deriv te | |
| DK0625982T3 (da) | 4-Oxo- og 4H-imidazo(5,1-c)(1,4)benzoxaziner anvendelige som benzodiazepinreceptor-bindemidler | |
| ES2070500T3 (es) | Inhibidores de la enzima convertidora de la angiotensina. | |
| PL312329A1 (en) | Derivatives of arylothioalkyl thiopyridine | |
| SI0946264T1 (de) | ||
| DE60116517D1 (de) | Aminoalkylpyrrolidine als serotoninrezeptorliganden sowie diese enthaltende zusammensetzungen, pharmazeutische verwendungen und methoden zu deren synthese | |
| NO305439B1 (no) | Pyrido(1,2,3-de)kinoksalinderivater og legemidler inneholdende disse | |
| IT1282950B1 (it) | Derivati eterociclo-condensati di morfinoidi | |
| Whitaker et al. | TENNET IV: Theoretical and Experimental Neuropsychology-Neuropsychologie Expbrimentale et Thborique |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |