NO305790B1 - Polyaminderivater som radiobeskyttende midler - Google Patents
Polyaminderivater som radiobeskyttende midlerInfo
- Publication number
- NO305790B1 NO305790B1 NO953293A NO953293A NO305790B1 NO 305790 B1 NO305790 B1 NO 305790B1 NO 953293 A NO953293 A NO 953293A NO 953293 A NO953293 A NO 953293A NO 305790 B1 NO305790 B1 NO 305790B1
- Authority
- NO
- Norway
- Prior art keywords
- integer
- radioprotective agents
- polyamine derivatives
- nhr
- naphthyl
- Prior art date
Links
- 229920000768 polyamine Polymers 0.000 title abstract 3
- 239000000718 radiation-protective agent Substances 0.000 title abstract 3
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
- C07C211/58—Naphthylamines; N-substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/45—Monoamines
- C07C211/48—N-alkylated amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyurethanes Or Polyureas (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Polyamides (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2136393A | 1993-02-23 | 1993-02-23 | |
| PCT/US1994/001128 WO1994019311A1 (fr) | 1993-02-23 | 1994-01-31 | Derives de polyamine utilises comme agents radioprotecteurs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO953293D0 NO953293D0 (no) | 1995-08-22 |
| NO953293L NO953293L (no) | 1995-10-19 |
| NO305790B1 true NO305790B1 (no) | 1999-07-26 |
Family
ID=21803772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO953293A NO305790B1 (no) | 1993-02-23 | 1995-08-22 | Polyaminderivater som radiobeskyttende midler |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6114394A (fr) |
| EP (1) | EP0686142B1 (fr) |
| JP (1) | JPH08509699A (fr) |
| KR (1) | KR100311851B1 (fr) |
| CN (1) | CN1118160A (fr) |
| AT (1) | ATE175188T1 (fr) |
| AU (2) | AU679972B2 (fr) |
| CA (2) | CA2219050C (fr) |
| DE (1) | DE69415657T2 (fr) |
| DK (1) | DK0686142T3 (fr) |
| ES (1) | ES2128557T3 (fr) |
| FI (1) | FI953935A (fr) |
| HU (1) | HUT74005A (fr) |
| IL (1) | IL108695A (fr) |
| MX (1) | MXPA94001345A (fr) |
| NO (1) | NO305790B1 (fr) |
| NZ (1) | NZ262986A (fr) |
| WO (1) | WO1994019311A1 (fr) |
| ZA (1) | ZA941098B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1118160A (zh) * | 1993-02-23 | 1996-03-06 | 默里尔多药物公司 | 作为放射保护剂的多胺衍生物 |
| US5994409A (en) * | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| US6489312B1 (en) | 1999-06-15 | 2002-12-03 | Medimmune Oncology, Inc. | Pharmaceutical formulations comprising aminoalkyl phosphorothioates |
| ATE327973T1 (de) | 2000-03-24 | 2006-06-15 | Mediquest Therapeutics Inc | Polyamin-analoge als cytotoxische wirkstoffe |
| US7053072B2 (en) | 2001-05-11 | 2006-05-30 | Medimmune Oncology, Inc. | Methods for the administration of amifostine and related compounds |
| US7045550B2 (en) | 2001-08-07 | 2006-05-16 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
| US20050027016A1 (en) * | 2002-02-07 | 2005-02-03 | Fahl Kathleen L | Polyamine compounds and compositions for use in conjection with cancer therapy |
| US7314959B2 (en) | 2003-08-07 | 2008-01-01 | Wisconsin Alumni Research Foundation | Amino thiol compounds and compositions for use in conjunction with cancer therapy |
| US7754463B2 (en) * | 2006-06-20 | 2010-07-13 | Dana-Farber Cancer Institute | Inhibitors of USP1 Deubiquitinating Enzyme Complex |
| US20100049284A1 (en) * | 2008-05-15 | 2010-02-25 | The Catholic University Of America | Use of heat to treat biological systems exposed to damaging radiation |
| CA2797719C (fr) | 2010-04-30 | 2019-11-26 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de petites molecules de l'activite de l'enzyme de deubiquination usp1 |
| EP2999345B1 (fr) * | 2013-05-22 | 2022-08-10 | Curza Global LLC | Compositions et procédés comprenant une polyamine |
| US8853278B1 (en) | 2013-05-22 | 2014-10-07 | Curza Global, Llc | Compositions comprising a biocidal polyamine |
| US9439433B2 (en) | 2013-05-22 | 2016-09-13 | Curza Global, Llc | Compositions and methods comprising a biocidal polyamine |
| US9725425B1 (en) | 2014-02-25 | 2017-08-08 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
| CN104926695B (zh) * | 2015-06-01 | 2017-05-31 | 上海仁力医药科技有限公司 | 防治辐射损伤的化合物rl‑66301、单晶及其制备方法和应用 |
| EP3606344B1 (fr) | 2017-04-05 | 2022-08-17 | Curza Global, LLC | Compositions et procédés comprenant une triaryl polyamine |
| CN107311891B (zh) * | 2017-06-08 | 2019-08-06 | 山东一航新材料科技有限公司 | 一种亚胺类除水剂的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2653977A (en) * | 1953-09-29 | Chxnx | ||
| US2951092A (en) * | 1956-12-13 | 1960-08-30 | Olin Mathieson | Triamine derivatives |
| US3369905A (en) * | 1963-03-19 | 1968-02-20 | Eastman Kodak Co | Photographic silver halide emulsions containing polyamine sensitizing agents |
| US3892824A (en) * | 1968-12-16 | 1975-07-01 | Southern Res Inst | S-{107 -({107 -aminoalkylamino)alkyl dihydrogen phosphorothioates |
| US4591605A (en) * | 1981-11-10 | 1986-05-27 | Research Foundation Of State University Of New York | Method and ingestible formulation for inhibiting the secretion of stomach acid |
| US5091576A (en) * | 1986-12-02 | 1992-02-25 | University Of Florida | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| US5342945A (en) * | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| US5109024A (en) * | 1987-02-03 | 1992-04-28 | Merrell Dow Pharmaceuticals Inc. | Polyamine derivatives as antineoplastic agents |
| AU602186B2 (en) * | 1987-02-03 | 1990-10-04 | Merrell Dow Pharmaceuticals Inc. | Novel polyamine derivatives |
| US5021567A (en) * | 1987-09-24 | 1991-06-04 | Abbott Laboratories | 8-hydroxyquinoline chelating agents |
| ZA887410B (en) * | 1987-10-08 | 1989-06-28 | Merrell Dow Pharma | Polyamine derivatives as antineoplastic agents |
| DK0378146T3 (da) * | 1989-01-10 | 1995-05-01 | Merrell Pharma Inc | Polyamin-derivater som antineoplastiske midler |
| US5108556A (en) * | 1990-09-14 | 1992-04-28 | Minnesota Mining And Manufacturing Company | Process for preparing tertiary perfluoroamines |
| AU647569B2 (en) * | 1991-01-17 | 1994-03-24 | Merrell Dow Pharmaceuticals Inc. | Polyamine phenols as radioprotective agents |
| US5217964A (en) * | 1991-01-23 | 1993-06-08 | Merrell Dow Pharmaceuticals Inc. | Polyamine thiols as radioprotective agents |
| GB9115375D0 (en) * | 1991-07-17 | 1991-09-04 | Salutar Inc | Compounds |
| US5488042A (en) * | 1992-03-13 | 1996-01-30 | Arch Development Corporation | Method for protection against genotoxic mutagenesis |
| CN1118160A (zh) * | 1993-02-23 | 1996-03-06 | 默里尔多药物公司 | 作为放射保护剂的多胺衍生物 |
-
1994
- 1994-01-31 CN CN94191275A patent/CN1118160A/zh active Pending
- 1994-01-31 CA CA002219050A patent/CA2219050C/fr not_active Expired - Fee Related
- 1994-01-31 EP EP94910666A patent/EP0686142B1/fr not_active Expired - Lifetime
- 1994-01-31 AU AU62971/94A patent/AU679972B2/en not_active Ceased
- 1994-01-31 WO PCT/US1994/001128 patent/WO1994019311A1/fr active IP Right Grant
- 1994-01-31 CA CA002154663A patent/CA2154663C/fr not_active Expired - Fee Related
- 1994-01-31 HU HU9502456A patent/HUT74005A/hu unknown
- 1994-01-31 NZ NZ262986A patent/NZ262986A/en unknown
- 1994-01-31 AT AT94910666T patent/ATE175188T1/de not_active IP Right Cessation
- 1994-01-31 DE DE69415657T patent/DE69415657T2/de not_active Expired - Fee Related
- 1994-01-31 ES ES94910666T patent/ES2128557T3/es not_active Expired - Lifetime
- 1994-01-31 JP JP6518992A patent/JPH08509699A/ja not_active Ceased
- 1994-01-31 DK DK94910666T patent/DK0686142T3/da active
- 1994-01-31 KR KR1019950703616A patent/KR100311851B1/ko not_active IP Right Cessation
- 1994-02-17 IL IL10869594A patent/IL108695A/xx not_active IP Right Cessation
- 1994-02-17 ZA ZA941098A patent/ZA941098B/xx unknown
- 1994-02-22 MX MXPA94001345A patent/MXPA94001345A/es not_active Application Discontinuation
-
1995
- 1995-08-22 NO NO953293A patent/NO305790B1/no unknown
- 1995-08-22 FI FI953935A patent/FI953935A/fi unknown
-
1996
- 1996-07-31 AU AU60815/96A patent/AU683872B2/en not_active Ceased
-
1997
- 1997-10-14 US US08/949,536 patent/US6114394A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1118160A (zh) | 1996-03-06 |
| NZ262986A (en) | 1997-06-24 |
| JPH08509699A (ja) | 1996-10-15 |
| AU6081596A (en) | 1996-10-03 |
| MXPA94001345A (es) | 2010-10-04 |
| KR100311851B1 (ko) | 2002-04-24 |
| US6114394A (en) | 2000-09-05 |
| ATE175188T1 (de) | 1999-01-15 |
| DE69415657D1 (de) | 1999-02-11 |
| CA2219050A1 (fr) | 1994-09-01 |
| NO953293D0 (no) | 1995-08-22 |
| CA2154663A1 (fr) | 1994-09-01 |
| DE69415657T2 (de) | 1999-09-02 |
| FI953935A (fi) | 1995-09-13 |
| AU683872B2 (en) | 1997-11-27 |
| CA2219050C (fr) | 2001-06-19 |
| ZA941098B (en) | 1994-08-30 |
| AU6297194A (en) | 1994-09-14 |
| FI953935A0 (fi) | 1995-08-22 |
| IL108695A0 (en) | 1994-05-30 |
| KR960700996A (ko) | 1996-02-24 |
| AU679972B2 (en) | 1997-07-17 |
| HU9502456D0 (en) | 1995-10-30 |
| EP0686142B1 (fr) | 1998-12-30 |
| WO1994019311A1 (fr) | 1994-09-01 |
| IL108695A (en) | 2000-02-17 |
| EP0686142A1 (fr) | 1995-12-13 |
| ES2128557T3 (es) | 1999-05-16 |
| NO953293L (no) | 1995-10-19 |
| CA2154663C (fr) | 2001-05-15 |
| HUT74005A (en) | 1996-10-28 |
| DK0686142T3 (da) | 1999-08-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0686142T3 (da) | Polyaminderivater som radioprotektive midler | |
| HUP9903762A2 (hu) | Embólia, trombózis és arterioszklerózis megelőzésére vagy kezelésére alkalmas gyűrűs aminszármazékok és alkalmazásuk | |
| ATE269312T1 (de) | N-(amidinophenyl)-n'-(subst.)-3h-2,4- benzodiazepin-3-on derivative als faktor xa inhibitoren | |
| ATE297203T1 (de) | Antithrombotische mitteln | |
| MXPA03011244A (es) | Nuevos derivados de indol con afinidad por el receptor 5-ht6. | |
| EA200201179A1 (ru) | Производные 2-аминокарбонил-9h-пурина | |
| DK0749424T3 (da) | Naphthalenderivater som prostaglandin-I2-agonister | |
| NO20050664L (no) | 2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer | |
| ES2189968T3 (es) | Amidinofenil-pirrolidinas,-pirrolinas,e -isoxazolidinas y derivadOS DE LOS MISMOS. | |
| CA2161869A1 (fr) | Derives de n-alkylthiopolyamines, agents de radioprotection | |
| DE60121461D1 (de) | Kondensierte pyridoindolderivate | |
| DE60230127D1 (de) | Inhibitoren von integrin alpha-v-beta-6 | |
| DK0579833T3 (da) | Ethanolaminderivater med anti-pollakisuria-virkning | |
| NO20034667D0 (no) | Arylsulfonamider som antivirale midler | |
| FI945581A (fi) | Substituoidut (aryylialkoksibentsyyli) aminopropaaniamidijohdannaiset, niiden valmistus ja käyttö antiepileptisinä, neuroprotektiivisina ja antidepressiivisinä aineina | |
| AR044175A1 (es) | Compuestos de cefemo | |
| FR2854157B1 (fr) | Derives de s-triazine possedant 3 groupements para-aminobenzalmalonates particuliers; compositions cosmetiques photoprotectrices contenant ces derives; utilisations desdits derives de s-triazine | |
| DE69330601D1 (de) | Serotoninergische ergolin derivate | |
| DK0648202T3 (da) | Substituerede (arylalkylaminobenzyl)aminopropanamidderivater, fremstilling deraf og anvendelse som anti-epileptiske, neurobeskyttende og antidepressive midler | |
| DK0705263T3 (da) | Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner | |
| SE9603285D0 (sv) | New compounds | |
| TW333533B (en) | Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase | |
| DK0556813T3 (da) | Amfotere tricykliske forbindelser som antihistaminske og antiallergiske midler | |
| ATE248163T1 (de) | Neuartige, pharmazeutisch aktive verbindung | |
| AR038847A1 (es) | Uso del compuesto n-(3,5-dicloro-2-metoxi-fenil) -4-metoxi-3-piperazin-1-il-bencenosulfonamida para la elaboracion de una composicion farmaceutica y dicha composicion farmaceutica |