NO3055308T3 - - Google Patents

Info

Publication number
NO3055308T3
NO3055308T3 NO14781169A NO14781169A NO3055308T3 NO 3055308 T3 NO3055308 T3 NO 3055308T3 NO 14781169 A NO14781169 A NO 14781169A NO 14781169 A NO14781169 A NO 14781169A NO 3055308 T3 NO3055308 T3 NO 3055308T3
Authority
NO
Norway
Application number
NO14781169A
Other languages
Norwegian (no)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NO3055308T3 publication Critical patent/NO3055308T3/no

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO14781169A 2013-10-08 2014-10-06 NO3055308T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13187764 2013-10-08
PCT/EP2014/071283 WO2015052105A1 (en) 2013-10-08 2014-10-06 Diazacarbazole derivatives as tau-pet-ligands
EP14781169.9A EP3055308B1 (en) 2013-10-08 2014-10-06 Diazacarbazole derivatives as tau-pet-ligands

Publications (1)

Publication Number Publication Date
NO3055308T3 true NO3055308T3 (es) 2018-04-21

Family

ID=49301396

Family Applications (1)

Application Number Title Priority Date Filing Date
NO14781169A NO3055308T3 (es) 2013-10-08 2014-10-06

Country Status (33)

Country Link
US (2) US10004817B2 (es)
EP (1) EP3055308B1 (es)
JP (1) JP6194416B2 (es)
KR (1) KR101770531B1 (es)
CN (1) CN105358558B (es)
AR (1) AR097931A1 (es)
AU (1) AU2014333996B2 (es)
CA (1) CA2917191C (es)
CL (1) CL2016000728A1 (es)
CR (1) CR20150663A (es)
DK (1) DK3055308T3 (es)
EA (1) EA028483B1 (es)
ES (1) ES2657121T3 (es)
HK (1) HK1215574A1 (es)
HR (1) HRP20180049T1 (es)
HU (1) HUE035413T2 (es)
IL (1) IL243249A0 (es)
LT (1) LT3055308T (es)
MA (1) MA38935B1 (es)
MX (1) MX2016002234A (es)
MY (1) MY190196A (es)
NO (1) NO3055308T3 (es)
PE (1) PE20160159A1 (es)
PH (1) PH12016500249B1 (es)
PL (1) PL3055308T3 (es)
PT (1) PT3055308T (es)
RS (1) RS56777B1 (es)
SG (1) SG11201602786UA (es)
SI (1) SI3055308T1 (es)
TW (1) TWI513698B (es)
UA (1) UA116164C2 (es)
WO (1) WO2015052105A1 (es)
ZA (1) ZA201509013B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100135235A (ko) 2008-02-14 2010-12-24 지멘스 메디컬 솔루션즈 유에스에이, 인크. 신경학적 기능이상을 검출하기 위한 조영제
HUE035413T2 (en) 2013-10-08 2018-05-02 Hoffmann La Roche Diazacarbazole derivatives as tau-PET ligand
JP6529986B2 (ja) 2014-05-13 2019-06-12 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 重水素化ヘテロ環式化合物及びイメージング剤としてのその使用
SG11201705727TA (en) * 2015-02-02 2017-08-30 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
EP3118202A1 (en) 2015-07-15 2017-01-18 AC Immune S.A. Dihydropyridopyrrole derivatives as tau-pet-ligands
US20180264146A1 (en) 2015-07-15 2018-09-20 Ac Immune S.A. Novel imaging compounds
WO2018015546A1 (en) 2016-07-22 2018-01-25 Ac Immune S.A. Compounds for imaging tau protein aggregates
WO2018015549A1 (en) * 2016-07-22 2018-01-25 Ac Immune S.A. Compounds for imaging tau protein aggregates
WO2018024642A1 (en) 2016-08-02 2018-02-08 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
WO2018024643A1 (en) 2016-08-02 2018-02-08 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
KR102502701B1 (ko) * 2016-09-09 2023-02-23 에프. 호프만-라 로슈 아게 2-(6-니트로피리딘-3-일)-9H-다이피리도[2,3-b;3',4'-d]피롤의 제조 방법
CA3088219A1 (en) * 2018-01-24 2019-08-01 Ac Immune Sa Novel method of preparing an imaging compound
EP3743426A1 (en) 2018-01-24 2020-12-02 AC Immune SA Azacarboline compounds for the detection of tau aggregates
WO2019145293A1 (en) * 2018-01-24 2019-08-01 Ac Immune Sa Diagnostic compositions for pet imaging, a method for manufacturing the diagnostic composition and its use in diagnostics
US11306089B2 (en) 2018-01-24 2022-04-19 Life Molecular Imaging Limited Gamma-carboline compounds for the detection of Tau aggregates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932557B2 (en) * 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
KR20100135235A (ko) * 2008-02-14 2010-12-24 지멘스 메디컬 솔루션즈 유에스에이, 인크. 신경학적 기능이상을 검출하기 위한 조영제
BRPI0909957A2 (pt) 2008-06-11 2016-04-19 Genentech Inc "composto, composição farmacêutica, método de inibir o crescimento anormal de células ou de tratar um distúrbio hiperproliferativo em um mamífero, método de tratamento do câncer em um mamífero"
US8420052B2 (en) * 2008-07-24 2013-04-16 Siemens Medical Solutions Usa, Inc. Imaging agents useful for identifying AD pathology
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
WO2010111303A2 (en) 2009-03-23 2010-09-30 Siemens Medical Solutions Usa, Inc. Imaging agents for detecting neurological disorders
US20110183938A1 (en) * 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
US20150368244A1 (en) * 2011-01-31 2015-12-24 Genentech, Inc. Diazacarbazoles and methods of use
HUE035413T2 (en) * 2013-10-08 2018-05-02 Hoffmann La Roche Diazacarbazole derivatives as tau-PET ligand

Also Published As

Publication number Publication date
PT3055308T (pt) 2018-01-18
AU2014333996A1 (en) 2015-12-24
EA201690515A1 (ru) 2016-07-29
KR20160047552A (ko) 2016-05-02
TWI513698B (zh) 2015-12-21
MA38935B1 (fr) 2016-12-30
WO2015052105A1 (en) 2015-04-16
LT3055308T (lt) 2018-02-12
KR101770531B1 (ko) 2017-08-22
ES2657121T3 (es) 2018-03-01
HUE035413T2 (en) 2018-05-02
HRP20180049T1 (hr) 2018-02-09
CN105358558B (zh) 2017-09-26
PL3055308T3 (pl) 2018-03-30
MY190196A (en) 2022-04-04
UA116164C2 (uk) 2018-02-12
RS56777B1 (sr) 2018-04-30
AR097931A1 (es) 2016-04-20
SG11201602786UA (en) 2016-05-30
US20160220712A1 (en) 2016-08-04
CR20150663A (es) 2016-01-27
US10004817B2 (en) 2018-06-26
SI3055308T1 (en) 2018-03-30
IL243249A0 (en) 2016-02-29
TW201520212A (zh) 2015-06-01
MX2016002234A (es) 2016-06-06
ZA201509013B (en) 2016-10-26
PH12016500249A1 (en) 2016-05-16
JP6194416B2 (ja) 2017-09-06
PE20160159A1 (es) 2016-03-18
CN105358558A (zh) 2016-02-24
MA38935A1 (fr) 2016-04-29
CA2917191A1 (en) 2015-04-16
PH12016500249B1 (en) 2016-05-16
DK3055308T3 (en) 2018-01-22
HK1215574A1 (zh) 2016-09-02
CA2917191C (en) 2021-08-10
AU2014333996B2 (en) 2018-03-15
US11058781B2 (en) 2021-07-13
EP3055308B1 (en) 2017-11-22
EP3055308A1 (en) 2016-08-17
EA028483B1 (ru) 2017-11-30
JP2016534979A (ja) 2016-11-10
NZ714831A (en) 2021-09-24
US20180326099A1 (en) 2018-11-15
CL2016000728A1 (es) 2016-11-11

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