NO302951B1 - Polymerforbindelser omfattende 1,4,7,10-tetraazasyklododekaner bundet via en <beta>-hydroksy-bindingsgruppe til en polylysinryggrad, fremgangsmåte for fremstilling av disse samt anvendelse av slike for fremst. av midler for NMR- og röntgendiagno - Google Patents
Polymerforbindelser omfattende 1,4,7,10-tetraazasyklododekaner bundet via en <beta>-hydroksy-bindingsgruppe til en polylysinryggrad, fremgangsmåte for fremstilling av disse samt anvendelse av slike for fremst. av midler for NMR- og röntgendiagno Download PDFInfo
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- NO302951B1 NO302951B1 NO921832A NO921832A NO302951B1 NO 302951 B1 NO302951 B1 NO 302951B1 NO 921832 A NO921832 A NO 921832A NO 921832 A NO921832 A NO 921832A NO 302951 B1 NO302951 B1 NO 302951B1
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- 229910052747 lanthanoid Inorganic materials 0.000 description 1
- 150000002602 lanthanoids Chemical class 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 230000005291 magnetic effect Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- MIKKOBKEXMRYFQ-WZTVWXICSA-N meglumine amidotrizoate Chemical compound C[NH2+]C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I MIKKOBKEXMRYFQ-WZTVWXICSA-N 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- NKHAVTQWNUWKEO-IHWYPQMZSA-N methyl hydrogen fumarate Chemical compound COC(=O)\C=C/C(O)=O NKHAVTQWNUWKEO-IHWYPQMZSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- GBCAVSYHPPARHX-UHFFFAOYSA-M n'-cyclohexyl-n-[2-(4-methylmorpholin-4-ium-4-yl)ethyl]methanediimine;4-methylbenzenesulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.C1CCCCC1N=C=NCC[N+]1(C)CCOCC1 GBCAVSYHPPARHX-UHFFFAOYSA-M 0.000 description 1
- NJVDPMFWASDKDP-UHFFFAOYSA-N n,n-dibenzyl-1-(oxiran-2-yl)methanamine Chemical compound C=1C=CC=CC=1CN(CC=1C=CC=CC=1)CC1CO1 NJVDPMFWASDKDP-UHFFFAOYSA-N 0.000 description 1
- YTPHPLPECVRZAI-UHFFFAOYSA-N n,n-dibenzyl-2-(oxiran-2-ylmethoxy)ethanamine Chemical compound C1OC1COCCN(CC=1C=CC=CC=1)CC1=CC=CC=C1 YTPHPLPECVRZAI-UHFFFAOYSA-N 0.000 description 1
- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229960003330 pentetic acid Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 108010011110 polyarginine Proteins 0.000 description 1
- 229920002714 polyornithine Polymers 0.000 description 1
- 108010055896 polyornithine Proteins 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- WCWKKSOQLQEJTE-UHFFFAOYSA-N praseodymium(3+) Chemical compound [Pr+3] WCWKKSOQLQEJTE-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000006894 reductive elimination reaction Methods 0.000 description 1
- 239000012465 retentate Substances 0.000 description 1
- DOSGOCSVHPUUIA-UHFFFAOYSA-N samarium(3+) Chemical compound [Sm+3] DOSGOCSVHPUUIA-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000003579 shift reagent Substances 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 description 1
- 150000003556 thioamides Chemical class 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 125000005490 tosylate group Chemical group 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 150000003673 urethanes Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- AWSFICBXMUKWSK-UHFFFAOYSA-N ytterbium(3+) Chemical compound [Yb+3] AWSFICBXMUKWSK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
- A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4115789A DE4115789A1 (de) | 1991-05-10 | 1991-05-10 | Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
Publications (3)
Publication Number | Publication Date |
---|---|
NO921832D0 NO921832D0 (no) | 1992-05-08 |
NO921832L NO921832L (no) | 1992-11-11 |
NO302951B1 true NO302951B1 (no) | 1998-05-11 |
Family
ID=6431673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO921832A NO302951B1 (no) | 1991-05-10 | 1992-05-08 | Polymerforbindelser omfattende 1,4,7,10-tetraazasyklododekaner bundet via en <beta>-hydroksy-bindingsgruppe til en polylysinryggrad, fremgangsmåte for fremstilling av disse samt anvendelse av slike for fremst. av midler for NMR- og röntgendiagno |
Country Status (15)
Country | Link |
---|---|
US (1) | US5876698A (fr) |
EP (1) | EP0512661B1 (fr) |
JP (1) | JPH05214096A (fr) |
AT (1) | ATE162082T1 (fr) |
AU (1) | AU661305B2 (fr) |
CA (1) | CA2068266A1 (fr) |
DE (2) | DE4115789A1 (fr) |
DK (1) | DK0512661T3 (fr) |
ES (1) | ES2113918T3 (fr) |
GR (1) | GR3026249T3 (fr) |
IE (1) | IE921504A1 (fr) |
IL (1) | IL101817A (fr) |
NO (1) | NO302951B1 (fr) |
NZ (1) | NZ242683A (fr) |
ZA (1) | ZA923394B (fr) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
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US5914095A (en) * | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
DE4237943C2 (de) * | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
AU5360994A (en) * | 1992-10-13 | 1994-05-09 | Mallinckrodt Medical, Inc. | Novel compositions for magnetic resonance imaging |
WO1994027498A1 (fr) * | 1993-05-20 | 1994-12-08 | The Regents Of The University Of California | Agent de contraste macromoleculaire s'utilisant en imagerie par resonance magnetique |
DE4317588C2 (de) * | 1993-05-24 | 1998-04-16 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung |
DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
US5605672A (en) * | 1993-06-09 | 1997-02-25 | The General Hospital Corporation | Blood pool imaging composition and method of its use |
GB9404208D0 (en) * | 1994-03-04 | 1994-04-20 | Nycomed Salutar Inc | Chelants |
US5756066A (en) * | 1995-06-07 | 1998-05-26 | Schering Aktiengesellschaft | Iodine-containing peptides |
US5801228A (en) * | 1995-06-07 | 1998-09-01 | Nycomed Imaging As | Polymeric contrast agents for medical imaging |
AU735018B2 (en) | 1997-03-18 | 2001-06-28 | Toshihiro Akaike | MRI contrast media recognizing microenvironmental changes |
FR2772025B1 (fr) * | 1997-12-10 | 2000-03-03 | Guerbet Sa | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique |
US6342598B1 (en) | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
US20030050452A1 (en) * | 2000-12-26 | 2003-03-13 | Yuji Hashiguchi | Process for producing metal complex of aminooligosaccharide derivative |
US6549798B2 (en) | 2001-02-07 | 2003-04-15 | Epix Medical, Inc. | Magnetic resonance angiography data |
DE10135355C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie |
TWI221406B (en) * | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
US7648678B2 (en) * | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
AR047692A1 (es) * | 2003-07-10 | 2006-02-08 | Epix Medical Inc | Imagenes de blancos estacionarios |
JP5237821B2 (ja) | 2005-12-05 | 2013-07-17 | 日東電工株式会社 | ポリグルタミン酸−アミノ酸結合体および方法 |
DE102007002726A1 (de) | 2007-01-18 | 2008-07-31 | Bayer Schering Pharma Aktiengesellschaft | Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
CN104800856A (zh) * | 2007-04-10 | 2015-07-29 | 日东电工株式会社 | 多功能聚谷氨酸盐药物载体 |
EP2155255B1 (fr) | 2007-05-09 | 2013-08-14 | Nitto Denko Corporation | Compositions comprenant un composé hydrophobe et un conjugué polyamino acide |
WO2009111271A1 (fr) * | 2008-03-06 | 2009-09-11 | Nitto Denko Corporation | Conjugués polymère paclitaxel et procédé de traitement du cancer |
EP2988756B2 (fr) | 2013-04-26 | 2022-05-18 | Guerbet | Formulation de produit de contraste et son procede de preparation associe |
US10781188B2 (en) | 2015-12-10 | 2020-09-22 | Bracco Imaging S.P.A. | Contrast agents |
ES2932302T3 (es) | 2015-12-10 | 2023-01-17 | Bracco Imaging Spa | Agentes de contraste diméricos |
US11007283B2 (en) | 2016-04-13 | 2021-05-18 | Bracco Imaging S.P.A. | Contrast agents |
ES2899033T3 (es) | 2016-12-12 | 2022-03-09 | Bracco Imaging Spa | Agentes de contraste diméricos |
EP3655373A1 (fr) | 2017-07-17 | 2020-05-27 | Ecolab USA, Inc. | Agents de modification de rhéologie pour bouillies |
CN114805800B (zh) * | 2022-06-09 | 2023-03-07 | 大连理工大学 | 一种n-磺酰脒聚合物的制备方法及应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4385046A (en) * | 1980-12-15 | 1983-05-24 | Minnesota Mining And Manufacturing Company | Diagnostic radio-labeled polysaccharide derivatives |
US4423158A (en) * | 1983-01-27 | 1983-12-27 | Gelinnovation Handelsaktiebolag | Ion adsorbent for metals having a coordination number greater than two |
DE3577185D1 (de) * | 1984-11-01 | 1990-05-23 | Nycomed As | Paramagnetische kontrastmittel fuer die anwendung in "in vivo" nmr-diagnostischen methoden und die herstellung davon. |
SE465907B (sv) * | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
DK172629B1 (da) * | 1986-02-14 | 1999-03-22 | Nihon Mediphysics Co Ltd | Reaktive højmolekylære forbindelser med mindst én fri aminogruppe, højmolekylære forbindelser kombineret med et fysiologisk |
DE3625417C2 (de) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
US5198208A (en) * | 1987-07-16 | 1993-03-30 | Nycomed Imaging As | Aminopolycarboxylic acids and derivatives thereof |
US5364613A (en) * | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
GB8916781D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5190744A (en) * | 1990-03-09 | 1993-03-02 | Salutar | Methods for detecting blood perfusion variations by magnetic resonance imaging |
GB9008724D0 (en) * | 1990-04-18 | 1990-06-13 | Celltech Ltd | Chemical compounds |
CA2039399C (fr) * | 1990-04-25 | 2000-09-05 | C. Allen Chang | Excipient a double fonction pour les agents de contraste a base de chelate metallique |
DE4035760A1 (de) * | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
JP2894879B2 (ja) * | 1991-10-04 | 1999-05-24 | 日本メジフィジックス株式会社 | 診断用造影剤 |
-
1991
- 1991-05-10 DE DE4115789A patent/DE4115789A1/de not_active Withdrawn
-
1992
- 1992-05-07 AT AT92250110T patent/ATE162082T1/de active
- 1992-05-07 JP JP4114636A patent/JPH05214096A/ja active Pending
- 1992-05-07 DE DE59209127T patent/DE59209127D1/de not_active Expired - Lifetime
- 1992-05-07 EP EP92250110A patent/EP0512661B1/fr not_active Expired - Lifetime
- 1992-05-07 ES ES92250110T patent/ES2113918T3/es not_active Expired - Lifetime
- 1992-05-07 DK DK92250110T patent/DK0512661T3/da active
- 1992-05-08 AU AU16139/92A patent/AU661305B2/en not_active Ceased
- 1992-05-08 NO NO921832A patent/NO302951B1/no unknown
- 1992-05-08 CA CA002068266A patent/CA2068266A1/fr not_active Abandoned
- 1992-05-10 IL IL101817A patent/IL101817A/en not_active IP Right Cessation
- 1992-05-11 US US07/881,269 patent/US5876698A/en not_active Expired - Fee Related
- 1992-05-11 NZ NZ242683A patent/NZ242683A/en unknown
- 1992-05-11 ZA ZA923394A patent/ZA923394B/xx unknown
- 1992-07-01 IE IE150492A patent/IE921504A1/en not_active Application Discontinuation
-
1998
- 1998-02-27 GR GR980400425T patent/GR3026249T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE4115789A1 (de) | 1992-11-12 |
IL101817A0 (en) | 1992-12-30 |
IE921504A1 (en) | 1992-11-18 |
NZ242683A (en) | 1995-04-27 |
JPH05214096A (ja) | 1993-08-24 |
NO921832D0 (no) | 1992-05-08 |
AU661305B2 (en) | 1995-07-20 |
CA2068266A1 (fr) | 1992-11-11 |
ZA923394B (en) | 1993-01-27 |
IL101817A (en) | 1998-03-10 |
DK0512661T3 (da) | 1998-09-14 |
ATE162082T1 (de) | 1998-01-15 |
EP0512661A1 (fr) | 1992-11-11 |
ES2113918T3 (es) | 1998-05-16 |
DE59209127D1 (de) | 1998-02-19 |
NO921832L (no) | 1992-11-11 |
GR3026249T3 (en) | 1998-05-29 |
US5876698A (en) | 1999-03-02 |
AU1613992A (en) | 1992-11-12 |
EP0512661B1 (fr) | 1998-01-14 |
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