DK0512661T3 - Makrocykliske polymer-kompleksdannere, deres komplekser, fremgangsmåde til deres fremstilling og farmaceutisk middel indeho - Google Patents

Makrocykliske polymer-kompleksdannere, deres komplekser, fremgangsmåde til deres fremstilling og farmaceutisk middel indeho

Info

Publication number
DK0512661T3
DK0512661T3 DK92250110T DK92250110T DK0512661T3 DK 0512661 T3 DK0512661 T3 DK 0512661T3 DK 92250110 T DK92250110 T DK 92250110T DK 92250110 T DK92250110 T DK 92250110T DK 0512661 T3 DK0512661 T3 DK 0512661T3
Authority
DK
Denmark
Prior art keywords
complexes
preparation
pharmaceutical agent
macrocyclic polymer
macrocyclic
Prior art date
Application number
DK92250110T
Other languages
Danish (da)
English (en)
Inventor
Johannes Dr Platzek
Heribert Dr Schmitt-Willich
Heinz Dr Gries
Gabriele D Schuhmann-Giampieri
Thomas Dr Frenzel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0512661T3 publication Critical patent/DK0512661T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK92250110T 1991-05-10 1992-05-07 Makrocykliske polymer-kompleksdannere, deres komplekser, fremgangsmåde til deres fremstilling og farmaceutisk middel indeho DK0512661T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4115789A DE4115789A1 (de) 1991-05-10 1991-05-10 Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (1)

Publication Number Publication Date
DK0512661T3 true DK0512661T3 (da) 1998-09-14

Family

ID=6431673

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92250110T DK0512661T3 (da) 1991-05-10 1992-05-07 Makrocykliske polymer-kompleksdannere, deres komplekser, fremgangsmåde til deres fremstilling og farmaceutisk middel indeho

Country Status (15)

Country Link
US (1) US5876698A (fr)
EP (1) EP0512661B1 (fr)
JP (1) JPH05214096A (fr)
AT (1) ATE162082T1 (fr)
AU (1) AU661305B2 (fr)
CA (1) CA2068266A1 (fr)
DE (2) DE4115789A1 (fr)
DK (1) DK0512661T3 (fr)
ES (1) ES2113918T3 (fr)
GR (1) GR3026249T3 (fr)
IE (1) IE921504A1 (fr)
IL (1) IL101817A (fr)
NO (1) NO302951B1 (fr)
NZ (1) NZ242683A (fr)
ZA (1) ZA923394B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
AU5360994A (en) * 1992-10-13 1994-05-09 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
WO1994027498A1 (fr) * 1993-05-20 1994-12-08 The Regents Of The University Of California Agent de contraste macromoleculaire s'utilisant en imagerie par resonance magnetique
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
US5605672A (en) * 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
GB9404208D0 (en) * 1994-03-04 1994-04-20 Nycomed Salutar Inc Chelants
US5756066A (en) * 1995-06-07 1998-05-26 Schering Aktiengesellschaft Iodine-containing peptides
US5801228A (en) * 1995-06-07 1998-09-01 Nycomed Imaging As Polymeric contrast agents for medical imaging
AU735018B2 (en) 1997-03-18 2001-06-28 Toshihiro Akaike MRI contrast media recognizing microenvironmental changes
FR2772025B1 (fr) * 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
US6342598B1 (en) 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
US20030050452A1 (en) * 2000-12-26 2003-03-13 Yuji Hashiguchi Process for producing metal complex of aminooligosaccharide derivative
US6549798B2 (en) 2001-02-07 2003-04-15 Epix Medical, Inc. Magnetic resonance angiography data
DE10135355C1 (de) * 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
TWI221406B (en) * 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
US7648678B2 (en) * 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
AR047692A1 (es) * 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
JP5237821B2 (ja) 2005-12-05 2013-07-17 日東電工株式会社 ポリグルタミン酸−アミノ酸結合体および方法
DE102007002726A1 (de) 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
CN104800856A (zh) * 2007-04-10 2015-07-29 日东电工株式会社 多功能聚谷氨酸盐药物载体
EP2155255B1 (fr) 2007-05-09 2013-08-14 Nitto Denko Corporation Compositions comprenant un composé hydrophobe et un conjugué polyamino acide
WO2009111271A1 (fr) * 2008-03-06 2009-09-11 Nitto Denko Corporation Conjugués polymère paclitaxel et procédé de traitement du cancer
EP2988756B2 (fr) 2013-04-26 2022-05-18 Guerbet Formulation de produit de contraste et son procede de preparation associe
US10781188B2 (en) 2015-12-10 2020-09-22 Bracco Imaging S.P.A. Contrast agents
ES2932302T3 (es) 2015-12-10 2023-01-17 Bracco Imaging Spa Agentes de contraste diméricos
US11007283B2 (en) 2016-04-13 2021-05-18 Bracco Imaging S.P.A. Contrast agents
ES2899033T3 (es) 2016-12-12 2022-03-09 Bracco Imaging Spa Agentes de contraste diméricos
EP3655373A1 (fr) 2017-07-17 2020-05-27 Ecolab USA, Inc. Agents de modification de rhéologie pour bouillies
CN114805800B (zh) * 2022-06-09 2023-03-07 大连理工大学 一种n-磺酰脒聚合物的制备方法及应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4385046A (en) * 1980-12-15 1983-05-24 Minnesota Mining And Manufacturing Company Diagnostic radio-labeled polysaccharide derivatives
US4423158A (en) * 1983-01-27 1983-12-27 Gelinnovation Handelsaktiebolag Ion adsorbent for metals having a coordination number greater than two
DE3577185D1 (de) * 1984-11-01 1990-05-23 Nycomed As Paramagnetische kontrastmittel fuer die anwendung in "in vivo" nmr-diagnostischen methoden und die herstellung davon.
SE465907B (sv) * 1984-11-01 1991-11-18 Nyegaard & Co As Diagnosticeringsmedel innehaallande en paramagnetisk metall
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DK172629B1 (da) * 1986-02-14 1999-03-22 Nihon Mediphysics Co Ltd Reaktive højmolekylære forbindelser med mindst én fri aminogruppe, højmolekylære forbindelser kombineret med et fysiologisk
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US5198208A (en) * 1987-07-16 1993-03-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
GB9008724D0 (en) * 1990-04-18 1990-06-13 Celltech Ltd Chemical compounds
CA2039399C (fr) * 1990-04-25 2000-09-05 C. Allen Chang Excipient a double fonction pour les agents de contraste a base de chelate metallique
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JP2894879B2 (ja) * 1991-10-04 1999-05-24 日本メジフィジックス株式会社 診断用造影剤

Also Published As

Publication number Publication date
DE4115789A1 (de) 1992-11-12
IL101817A0 (en) 1992-12-30
NO302951B1 (no) 1998-05-11
IE921504A1 (en) 1992-11-18
NZ242683A (en) 1995-04-27
JPH05214096A (ja) 1993-08-24
NO921832D0 (no) 1992-05-08
AU661305B2 (en) 1995-07-20
CA2068266A1 (fr) 1992-11-11
ZA923394B (en) 1993-01-27
IL101817A (en) 1998-03-10
ATE162082T1 (de) 1998-01-15
EP0512661A1 (fr) 1992-11-11
ES2113918T3 (es) 1998-05-16
DE59209127D1 (de) 1998-02-19
NO921832L (no) 1992-11-11
GR3026249T3 (en) 1998-05-29
US5876698A (en) 1999-03-02
AU1613992A (en) 1992-11-12
EP0512661B1 (fr) 1998-01-14

Similar Documents

Publication Publication Date Title
DK0512661T3 (da) Makrocykliske polymer-kompleksdannere, deres komplekser, fremgangsmåde til deres fremstilling og farmaceutisk middel indeho
DE10075007I2 (de) 1,4,7,10-Tetraazacyclododecan-butyltriole Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE59400751D1 (de) Glycosidreste aufweisende Organosiliciumverbindungen und Verfahren zu deren Herstellung
ZA926276B (en) 2,4-thiazolidinedione compounds, process for preparing them and pharmaceutical compositions containing them.
IL99775A0 (en) Antimicrobial agents containing substituted 2-cyclohexan-1-yl-amino derivatives,certain such novel compounds and their preparation
ZA926328B (en) Naphthylethylureas and naphthylethylthioureas process for the preparation thereof and pharmaceutical compositions containing them.
DE69415373T2 (de) Pyridothiadiazine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
AU642053B2 (en) Novel compounds of N-benzoylproline, process for their preparation and pharmaceutical compositions containing them
DE69310391T2 (de) Neue Naphthalin-Amide und Sulfonamide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
DE69406853T2 (de) Alpha Aminosäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE69321861D1 (de) 3-Aminochroman-Spiroderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE69412980T2 (de) Eburnan-Derivate, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
CZ228195A3 (en) Derivatives of hydroxymethylfurazancarboxylic acid, process of their preparation, their use for treating cardiovascular diseases and a pharmaceutical composition containing thereof
DE69211637T2 (de) Neue dna-gyrase inhibitoren, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
DK0437144T3 (da) Ikke-ionisk iodholdige sammensætninger, fremgangsmåde til deres fremstilling og kontrastmidler indeholdende dem
NO903291D0 (no) Renin-hemmende aminooligohydroksy-derivater.
ZA941196B (en) Angiopeptin cyclopeptide compounds process for the preparation thereof and pharmaceutical compositions containing them
DK0552631T3 (da) Alfa-Aryl-alfa-hydroxy-beta-imidazolinyl-propionsyreamider
IL103855A0 (en) 5,6-dihydro-dibenz(b,e)azepin-6,11-dione-11-oximes,their preparation and pharmaceutical compositions containing them
ATE80161T1 (de) Ketendithioacetal-derivate und verfahren zu deren herstellung und diese enthaltende zusammenstellung.
DK0635491T3 (da) (Thia)cycloalkylab indoler, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse forbindelser.