NO302824B1 - Isolert DNA-sekvens som koder for interleukin-7, ekspresjonsvektor inneholdende sekvensen, fremgangsmåte for fremstilling av interleukin-7, samt antistoff mot proteinet - Google Patents
Isolert DNA-sekvens som koder for interleukin-7, ekspresjonsvektor inneholdende sekvensen, fremgangsmåte for fremstilling av interleukin-7, samt antistoff mot proteinet Download PDFInfo
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- NO302824B1 NO302824B1 NO892630A NO892630A NO302824B1 NO 302824 B1 NO302824 B1 NO 302824B1 NO 892630 A NO892630 A NO 892630A NO 892630 A NO892630 A NO 892630A NO 302824 B1 NO302824 B1 NO 302824B1
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US11356687A | 1987-10-26 | 1987-10-26 | |
PCT/US1988/003747 WO1989003884A1 (en) | 1987-10-26 | 1988-10-19 | Interleukin-7 |
Publications (3)
Publication Number | Publication Date |
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NO892630L NO892630L (no) | 1989-06-23 |
NO892630D0 NO892630D0 (no) | 1989-06-23 |
NO302824B1 true NO302824B1 (no) | 1998-04-27 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO892630A NO302824B1 (no) | 1987-10-26 | 1989-06-23 | Isolert DNA-sekvens som koder for interleukin-7, ekspresjonsvektor inneholdende sekvensen, fremgangsmåte for fremstilling av interleukin-7, samt antistoff mot proteinet |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0314415B1 (fi) |
JP (1) | JP2749838B2 (fi) |
AT (1) | ATE109829T1 (fi) |
AU (1) | AU616456B2 (fi) |
CA (1) | CA1340491C (fi) |
DE (1) | DE3851035T2 (fi) |
DK (1) | DK175865B1 (fi) |
FI (1) | FI103987B1 (fi) |
IE (1) | IE64159B1 (fi) |
IL (1) | IL88151A (fi) |
NO (1) | NO302824B1 (fi) |
NZ (1) | NZ226679A (fi) |
WO (1) | WO1989003884A1 (fi) |
ZA (1) | ZA887773B (fi) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2687995B2 (ja) | 1980-04-03 | 1997-12-08 | バイオゲン インコーポレイテッド | Dna配列、組替えdna分子およびヒト繊維芽細胞インターフェロン様ポリペプチドの製造方法 |
US5032396A (en) * | 1989-02-17 | 1991-07-16 | Immunex Corporation | IL-7 to stimulate platelet production |
ZA943348B (en) | 1993-05-21 | 1995-11-16 | Hirano Toshio | A gene encoding a polypeptide having pre-B cell growth-supporting ability |
ZA948016B (en) * | 1993-10-15 | 1995-05-31 | Toshio Hirano | A membrane protein polypeptide having pre-B cell crowth-supporting ability and a gene thereof |
US5795569A (en) * | 1994-03-31 | 1998-08-18 | Amgen Inc. | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
HU218893B (hu) * | 1994-03-31 | 2000-12-28 | Amgen Inc. | A megakariocita szaporodás és differenciálódás stimulálására szolgáló módszerek és vízoldható készítmények |
EP1115867A1 (en) * | 1998-09-21 | 2001-07-18 | Schering Corporation | Human interleukin-b50. therapeutic uses |
US20030099947A1 (en) | 1998-09-21 | 2003-05-29 | Bazan J. Fernando | Mammalian cytokines; related reagents and methods |
NZ514095A (en) | 1999-02-10 | 2001-09-28 | Welfide Corp | Amide compounds and medicinal use thereof |
DE10137792A1 (de) * | 2001-08-06 | 2003-02-27 | Erdmann Volker | Verfahren zur Genexpression |
EP1391513A1 (en) * | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
ES2342964T3 (es) * | 2004-12-09 | 2010-07-20 | Merck Patent Gmbh | Variantes de la interleucina-7 con inmunogenicidad reducida. |
EP1746161A1 (en) | 2005-07-20 | 2007-01-24 | Cytheris | Glycosylated IL-7, preparation and uses |
KR101525631B1 (ko) | 2006-12-14 | 2015-06-04 | 엠에스디 인터내셔널 홀딩즈 게엠베하 | 개 흉선 간질 림포포이에틴 단백질 및 이의 용도 |
JP2014521679A (ja) | 2011-08-03 | 2014-08-28 | シテリ | Hcv免疫療法 |
US8962913B2 (en) * | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
RU2708160C2 (ru) | 2015-06-11 | 2019-12-04 | Дженексин, Инк. | Модифицированный белок интерлейкина-7 и способы его применения |
KR102386735B1 (ko) | 2015-11-06 | 2022-04-14 | 주식회사 제넥신 | 변형된 인터루킨-7 융합 단백질의 제형 |
KR102604595B1 (ko) | 2015-12-04 | 2023-11-21 | 주식회사 제넥신 | 면역글로불린 Fc가 융합된 인터루킨-7 융합 단백질을 포함하는 인플루엔자 바이러스 감염의 예방 또는 치료용 약학적 조성물 |
KR20170066265A (ko) | 2015-12-04 | 2017-06-14 | 주식회사 제넥신 | 면역글로불린 Fc가 융합된 인터루킨-7 융합 단백질을 포함하는 사람 파필로마바이러스 유래 질환의 예방 또는 치료용 약학적 조성물 |
EP3898677A1 (en) | 2018-12-21 | 2021-10-27 | OSE Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
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US4411993A (en) | 1981-04-29 | 1983-10-25 | Steven Gillis | Hybridoma antibody which inhibits interleukin 2 activity |
US4579821A (en) | 1981-11-23 | 1986-04-01 | University Patents, Inc. | Control of DNA sequence transcription |
US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
US4720482A (en) * | 1982-10-20 | 1988-01-19 | Dana Farber Cancer Institute | Pharmaceutical compositions containing one or more lymphocyte growth factors |
US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
US4730036A (en) * | 1984-01-03 | 1988-03-08 | Sloan-Kettering Institute For Cancer Research | Purifications of B-cell inducing factor (BIF) and B-cell growth factor (BGF) |
US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
US4675285A (en) | 1984-09-19 | 1987-06-23 | Genetics Institute, Inc. | Method for identification and isolation of DNA encoding a desired protein |
JPS6490199A (en) * | 1987-09-30 | 1989-04-06 | Hiromi Fujiwara | T cell growth factor derived from thymic interstitial cell and production thereof |
-
1988
- 1988-10-18 ZA ZA887773A patent/ZA887773B/xx unknown
- 1988-10-19 WO PCT/US1988/003747 patent/WO1989003884A1/en active IP Right Grant
- 1988-10-19 AU AU28272/89A patent/AU616456B2/en not_active Expired
- 1988-10-21 NZ NZ226679A patent/NZ226679A/en unknown
- 1988-10-24 DE DE3851035T patent/DE3851035T2/de not_active Expired - Lifetime
- 1988-10-24 EP EP88309977A patent/EP0314415B1/en not_active Expired - Lifetime
- 1988-10-24 AT AT88309977T patent/ATE109829T1/de not_active IP Right Cessation
- 1988-10-25 CA CA000581198A patent/CA1340491C/en not_active Expired - Lifetime
- 1988-10-25 IE IE322188A patent/IE64159B1/en not_active IP Right Cessation
- 1988-10-25 IL IL88151A patent/IL88151A/xx not_active IP Right Cessation
- 1988-10-26 JP JP63270627A patent/JP2749838B2/ja not_active Expired - Lifetime
-
1989
- 1989-06-19 DK DK198903020A patent/DK175865B1/da not_active IP Right Cessation
- 1989-06-23 NO NO892630A patent/NO302824B1/no not_active IP Right Cessation
-
1990
- 1990-04-25 FI FI902077A patent/FI103987B1/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ226679A (en) | 1991-06-25 |
IE64159B1 (en) | 1995-07-12 |
ATE109829T1 (de) | 1994-08-15 |
DK302089D0 (da) | 1989-06-19 |
CA1340491C (en) | 1999-04-13 |
DE3851035D1 (de) | 1994-09-15 |
FI103987B (fi) | 1999-10-29 |
EP0314415B1 (en) | 1994-08-10 |
ZA887773B (en) | 1989-07-26 |
IL88151A (en) | 1993-01-31 |
AU616456B2 (en) | 1991-10-31 |
AU2827289A (en) | 1989-05-23 |
WO1989003884A1 (en) | 1989-05-05 |
NO892630L (no) | 1989-06-23 |
FI902077A0 (fi) | 1990-04-25 |
JPH05268971A (ja) | 1993-10-19 |
JP2749838B2 (ja) | 1998-05-13 |
IL88151A0 (en) | 1989-06-30 |
IE883221L (en) | 1989-04-26 |
DK302089A (da) | 1989-06-19 |
EP0314415A3 (en) | 1990-05-30 |
NO892630D0 (no) | 1989-06-23 |
DE3851035T2 (de) | 1994-12-01 |
DK175865B1 (da) | 2005-04-18 |
FI103987B1 (fi) | 1999-10-29 |
EP0314415A2 (en) | 1989-05-03 |
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Legal Events
Date | Code | Title | Description |
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MK1K | Patent expired |