NO301577B1 - Fremgangsmåte for fremstilling av en stabil vaksineblanding og fremgangsmåte for stabilisering av interleukin i en vaksineblanding - Google Patents
Fremgangsmåte for fremstilling av en stabil vaksineblanding og fremgangsmåte for stabilisering av interleukin i en vaksineblanding Download PDFInfo
- Publication number
- NO301577B1 NO301577B1 NO920161A NO920161A NO301577B1 NO 301577 B1 NO301577 B1 NO 301577B1 NO 920161 A NO920161 A NO 920161A NO 920161 A NO920161 A NO 920161A NO 301577 B1 NO301577 B1 NO 301577B1
- Authority
- NO
- Norway
- Prior art keywords
- interleukin
- antigen
- bacterial
- rhil
- alum
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 40
- 102000015696 Interleukins Human genes 0.000 title claims abstract description 38
- 108010063738 Interleukins Proteins 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title claims description 17
- 230000000087 stabilizing effect Effects 0.000 title claims description 4
- 239000000427 antigen Substances 0.000 claims abstract description 59
- 102000036639 antigens Human genes 0.000 claims abstract description 59
- 108091007433 antigens Proteins 0.000 claims abstract description 59
- 229940037003 alum Drugs 0.000 claims abstract description 38
- 239000000203 mixture Substances 0.000 claims abstract description 33
- 239000002671 adjuvant Substances 0.000 claims abstract description 18
- 239000003755 preservative agent Substances 0.000 claims abstract description 6
- 230000002335 preservative effect Effects 0.000 claims abstract description 6
- 230000001580 bacterial effect Effects 0.000 claims description 12
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 10
- 102000003886 Glycoproteins Human genes 0.000 claims description 7
- 108090000288 Glycoproteins Proteins 0.000 claims description 7
- 108010002350 Interleukin-2 Proteins 0.000 claims description 7
- 102000000588 Interleukin-2 Human genes 0.000 claims description 7
- 102000000646 Interleukin-3 Human genes 0.000 claims description 7
- 108010002386 Interleukin-3 Proteins 0.000 claims description 7
- 241000700605 Viruses Species 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 6
- 241000606768 Haemophilus influenzae Species 0.000 claims description 6
- 241000588650 Neisseria meningitidis Species 0.000 claims description 6
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 6
- 229940047650 haemophilus influenzae Drugs 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 102000000589 Interleukin-1 Human genes 0.000 claims description 5
- 108010002352 Interleukin-1 Proteins 0.000 claims description 5
- 102000004388 Interleukin-4 Human genes 0.000 claims description 5
- 108090000978 Interleukin-4 Proteins 0.000 claims description 5
- 102000000743 Interleukin-5 Human genes 0.000 claims description 5
- 108010002616 Interleukin-5 Proteins 0.000 claims description 5
- 102000004889 Interleukin-6 Human genes 0.000 claims description 5
- 108090001005 Interleukin-6 Proteins 0.000 claims description 5
- 102000000704 Interleukin-7 Human genes 0.000 claims description 5
- 108010002586 Interleukin-7 Proteins 0.000 claims description 5
- 108010052285 Membrane Proteins Proteins 0.000 claims description 5
- 241000702670 Rotavirus Species 0.000 claims description 5
- 241000193996 Streptococcus pyogenes Species 0.000 claims description 5
- 229940076264 interleukin-3 Drugs 0.000 claims description 5
- 229940028885 interleukin-4 Drugs 0.000 claims description 5
- 229940100602 interleukin-5 Drugs 0.000 claims description 5
- 229940100601 interleukin-6 Drugs 0.000 claims description 5
- 229940100994 interleukin-7 Drugs 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 241000588747 Klebsiella pneumoniae Species 0.000 claims description 4
- 241000588655 Moraxella catarrhalis Species 0.000 claims description 4
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims description 4
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 4
- 241000191967 Staphylococcus aureus Species 0.000 claims description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- 239000007900 aqueous suspension Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 4
- 235000014633 carbohydrates Nutrition 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 230000003612 virological effect Effects 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 3
- 241000233866 Fungi Species 0.000 claims description 3
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 101710116435 Outer membrane protein Proteins 0.000 claims description 3
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 241000193998 Streptococcus pneumoniae Species 0.000 claims description 3
- 244000052616 bacterial pathogen Species 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 208000002672 hepatitis B Diseases 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 244000045947 parasite Species 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims description 3
- 231100000699 Bacterial toxin Toxicity 0.000 claims description 2
- 241000588832 Bordetella pertussis Species 0.000 claims description 2
- 241000193449 Clostridium tetani Species 0.000 claims description 2
- 102000016607 Diphtheria Toxin Human genes 0.000 claims description 2
- 108010053187 Diphtheria Toxin Proteins 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 108091006027 G proteins Proteins 0.000 claims description 2
- 102000030782 GTP binding Human genes 0.000 claims description 2
- 108091000058 GTP-Binding Proteins 0.000 claims description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 2
- 101710085938 Matrix protein Proteins 0.000 claims description 2
- 102000018697 Membrane Proteins Human genes 0.000 claims description 2
- 101710127721 Membrane protein Proteins 0.000 claims description 2
- 201000005702 Pertussis Diseases 0.000 claims description 2
- 206010043376 Tetanus Diseases 0.000 claims description 2
- 241000607626 Vibrio cholerae Species 0.000 claims description 2
- 239000000688 bacterial toxin Substances 0.000 claims description 2
- 206010013023 diphtheria Diseases 0.000 claims description 2
- 231100000590 oncogenic Toxicity 0.000 claims description 2
- 230000002246 oncogenic effect Effects 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 229940118696 vibrio cholerae Drugs 0.000 claims description 2
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102000000585 Interleukin-9 Human genes 0.000 claims 1
- 108010002335 Interleukin-9 Proteins 0.000 claims 1
- 101710141454 Nucleoprotein Proteins 0.000 claims 1
- 230000028993 immune response Effects 0.000 abstract description 15
- 229940047122 interleukins Drugs 0.000 abstract description 12
- 230000001681 protective effect Effects 0.000 abstract description 8
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 7
- 239000011707 mineral Substances 0.000 abstract description 7
- 239000000725 suspension Substances 0.000 abstract description 4
- 230000004071 biological effect Effects 0.000 abstract description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 11
- 239000000546 pharmaceutical excipient Substances 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 238000002255 vaccination Methods 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 230000005875 antibody response Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 230000000240 adjuvant effect Effects 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 230000004936 stimulating effect Effects 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 3
- -1 ethanol polyols Chemical class 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 230000005867 T cell response Effects 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002519 immonomodulatory effect Effects 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 238000005462 in vivo assay Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229940023143 protein vaccine Drugs 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- ITFICYZHWXDVMU-IPTZIORSSA-N (2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-oxopentanoyl]amino]pentanedioic acid Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CS)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(=O)O)N ITFICYZHWXDVMU-IPTZIORSSA-N 0.000 description 1
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- FJLUATLTXUNBOT-UHFFFAOYSA-N 1-Hexadecylamine Chemical compound CCCCCCCCCCCCCCCCN FJLUATLTXUNBOT-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 description 1
- LYFYWXLKKQIOKO-UHFFFAOYSA-N 3,3-diaminopentan-1-ol Chemical compound CCC(N)(N)CCO LYFYWXLKKQIOKO-UHFFFAOYSA-N 0.000 description 1
- AWIGZBIWTRYADH-UHFFFAOYSA-N 3-methoxynonadecane-1,2,3-triol Chemical compound CCCCCCCCCCCCCCCCC(O)(OC)C(O)CO AWIGZBIWTRYADH-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 201000007336 Cryptococcosis Diseases 0.000 description 1
- 241000221204 Cryptococcus neoformans Species 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 238000011765 DBA/2 mouse Methods 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000606790 Haemophilus Species 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 description 1
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
- 102100029251 Phagocytosis-stimulating peptide Human genes 0.000 description 1
- 239000012979 RPMI medium Substances 0.000 description 1
- 241000710799 Rubella virus Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 108010008038 Synthetic Vaccines Proteins 0.000 description 1
- 208000000389 T-cell leukemia Diseases 0.000 description 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
- 108010084754 Tuftsin Proteins 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 241000710772 Yellow fever virus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001687 destabilization Effects 0.000 description 1
- 229960000633 dextran sulfate Drugs 0.000 description 1
- PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 description 1
- 108700003601 dimethylglycine Proteins 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 229940035670 tuftsin Drugs 0.000 description 1
- IESDGNYHXIOKRW-LEOABGAYSA-N tuftsin Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(O)=O IESDGNYHXIOKRW-LEOABGAYSA-N 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 229940051021 yellow-fever virus Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37974289A | 1989-07-14 | 1989-07-14 | |
| PCT/US1990/003982 WO1991001143A1 (en) | 1989-07-14 | 1990-07-16 | Stable vaccine compositions containing interleukins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO920161D0 NO920161D0 (no) | 1992-01-13 |
| NO920161L NO920161L (no) | 1992-03-05 |
| NO301577B1 true NO301577B1 (no) | 1997-11-17 |
Family
ID=23498494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO920161A NO301577B1 (no) | 1989-07-14 | 1992-01-13 | Fremgangsmåte for fremstilling av en stabil vaksineblanding og fremgangsmåte for stabilisering av interleukin i en vaksineblanding |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0482076B1 (fi) |
| JP (2) | JP3485184B2 (fi) |
| KR (1) | KR0177179B1 (fi) |
| AT (1) | ATE121629T1 (fi) |
| AU (1) | AU648509B2 (fi) |
| CA (1) | CA2063587C (fi) |
| DE (1) | DE69018990T2 (fi) |
| DK (1) | DK0482076T3 (fi) |
| ES (1) | ES2075900T3 (fi) |
| FI (1) | FI104233B1 (fi) |
| NO (1) | NO301577B1 (fi) |
| WO (1) | WO1991001143A1 (fi) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406696B1 (en) | 1989-10-27 | 2002-06-18 | Tolerance Therapeutics, Inc. | Methods of stimulating the immune system with anti-CD3 antibodies |
| CA2071478A1 (en) * | 1989-10-27 | 1991-04-28 | Jeffery A. Bluestone | Methods and compositions for promoting immunopotentiation |
| GR1000881B (el) * | 1990-08-06 | 1993-03-16 | Praxis Biolog Inc | Σταθερες συνθεσεις εμβολιου που περιεχουν ιντερλευκινες. |
| ATE129900T1 (de) * | 1990-12-19 | 1995-11-15 | Schering Corp | Anwendung von il-4 zur steigerung der immunantwort auf immunogene in impfstoffen. |
| WO1992020370A1 (en) * | 1991-05-13 | 1992-11-26 | Regents Of The University Of California | Liposomal polysaccharide vaccines |
| DE4126983A1 (de) * | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke |
| DE69310182T2 (de) * | 1992-08-10 | 1997-12-04 | Us Health | Interleukin-4 stimulierter t-lymphozyten-zelltod |
| ZA936095B (en) * | 1992-08-21 | 1994-03-14 | Univ Melbourne | Cytokine applications. |
| US6491916B1 (en) | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| WO1996007102A1 (en) * | 1994-09-01 | 1996-03-07 | Wisconsin Alumni Research Foundation | Therapeutic remodeling in aids |
| US6509313B1 (en) * | 1996-02-28 | 2003-01-21 | Cornell Research Foundation, Inc. | Stimulation of immune response with low doses of cytokines |
| ES2262181T3 (es) * | 1996-05-31 | 2006-11-16 | National University Of Ireland, Maynooth | Il-12 como adyuvante en la vacuna contra la especie bordetella pertussis. |
| TW586934B (en) * | 1997-05-19 | 2004-05-11 | Sumitomo Pharma | Immunopotentiating composition |
| US6270758B1 (en) | 1998-10-08 | 2001-08-07 | Duke University | Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects |
| US6027731A (en) * | 1998-11-17 | 2000-02-22 | Wisconsin Alumni Research Foundation | Pertussis toxin induced lymphocytosis |
| IT1302534B1 (it) | 1998-12-21 | 2000-09-05 | Fidia Advanced Biopolymers Srl | Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per |
| SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| WO2001039803A2 (en) | 1999-12-03 | 2001-06-07 | Celltech Chiroscience Ltd. | Interleukin-1 muteins useful as vaccine adjuvants |
| CA2614640A1 (en) | 2005-07-11 | 2007-01-18 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| WO2007039584A1 (en) * | 2005-09-30 | 2007-04-12 | Lipoxen Technologies Limited | Multivalent liposomal vaccine compositions comprising polysaccharide antigens and a protein adjuvant |
| SG177907A1 (en) | 2006-06-14 | 2012-02-28 | Macrogenics Inc | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| EP2129394B1 (en) * | 2007-03-09 | 2012-06-20 | Merck Sharp & Dohme Corp. | Papillomavirus vaccine compositions |
| EP2925297B1 (en) * | 2012-11-02 | 2017-06-21 | CyTuVax | Composition comprising cytokine macro-aggregates |
| JOP20190242A1 (ar) * | 2018-10-12 | 2020-04-12 | Serum Institute Of India Pvt Ltd | تركيبة لقاح توليفي تشمل فيروس شلل الأطفال ذو جرعة مخفّضة خاملة التنشيط وطريقة لتحضيرها |
| WO2020102728A1 (en) | 2018-11-16 | 2020-05-22 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and an immune checkpoint inhibitor |
| JP2023512456A (ja) | 2020-01-13 | 2023-03-27 | ネオイミューンテック， インコーポレイテッド | Ｉｌ－７タンパク質と二重特異性抗体の組み合わせで腫瘍を治療する方法 |
| US20230210952A1 (en) | 2020-02-05 | 2023-07-06 | Washington University | Method of treating a solid tumor with a combination of an il-7 protein and car-bearing immune cells |
| EP4232070A1 (en) | 2020-10-26 | 2023-08-30 | NeoImmuneTech, Inc. | Methods of inducing stem cell mobilization |
| EP4236989A1 (en) | 2020-11-02 | 2023-09-06 | NeoImmuneTech, Inc. | Use of interleukin-7 for the treatment of coronavirus |
| EP4240408A1 (en) | 2020-11-05 | 2023-09-13 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of an il-7 protein and a nucleotide vaccine |
| WO2023130081A1 (en) | 2021-12-30 | 2023-07-06 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and vegf antagonist |
| WO2024102722A1 (en) | 2022-11-07 | 2024-05-16 | Neoimmunetech, Inc. | Methods of treating a tumor with an unmethylated mgmt promoter |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2849632B2 (ja) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | ワクチン製剤 |
| DE3818054C2 (de) * | 1988-05-27 | 1994-02-17 | Biotest Pharma Gmbh | Verwendung einer Kombination aus einem Antigen bzw. einer Vakzine und humanem Interleukin zur Behandlung der Non-Responsiveness gegenüber immunologischen Defektzuständen |
| JPH0236129A (ja) * | 1988-07-22 | 1990-02-06 | Ajinomoto Co Inc | ワクチン効果増強剤 |
-
1990
- 1990-07-16 AU AU60500/90A patent/AU648509B2/en not_active Ceased
- 1990-07-16 JP JP51060090A patent/JP3485184B2/ja not_active Expired - Fee Related
- 1990-07-16 DK DK90911344.1T patent/DK0482076T3/da active
- 1990-07-16 KR KR1019920700086A patent/KR0177179B1/ko not_active IP Right Cessation
- 1990-07-16 EP EP90911344A patent/EP0482076B1/en not_active Expired - Lifetime
- 1990-07-16 ES ES90911344T patent/ES2075900T3/es not_active Expired - Lifetime
- 1990-07-16 DE DE69018990T patent/DE69018990T2/de not_active Expired - Fee Related
- 1990-07-16 WO PCT/US1990/003982 patent/WO1991001143A1/en active IP Right Grant
- 1990-07-16 CA CA002063587A patent/CA2063587C/en not_active Expired - Fee Related
- 1990-07-16 AT AT90911344T patent/ATE121629T1/de not_active IP Right Cessation
-
1992
- 1992-01-13 NO NO920161A patent/NO301577B1/no unknown
- 1992-01-13 FI FI920132A patent/FI104233B1/fi not_active IP Right Cessation
-
2003
- 2003-07-31 JP JP2003284148A patent/JP2004002463A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR0177179B1 (ko) | 1999-03-20 |
| NO920161L (no) | 1992-03-05 |
| FI920132A0 (fi) | 1992-01-13 |
| DK0482076T3 (da) | 1995-07-17 |
| FI104233B (fi) | 1999-12-15 |
| CA2063587C (en) | 2005-08-30 |
| NO920161D0 (no) | 1992-01-13 |
| DE69018990T2 (de) | 1995-12-14 |
| JP3485184B2 (ja) | 2004-01-13 |
| JP2004002463A (ja) | 2004-01-08 |
| KR920703103A (ko) | 1992-12-17 |
| DE69018990D1 (de) | 1995-06-01 |
| JPH04506663A (ja) | 1992-11-19 |
| AU6050090A (en) | 1991-02-22 |
| WO1991001143A1 (en) | 1991-02-07 |
| EP0482076A1 (en) | 1992-04-29 |
| CA2063587A1 (en) | 1991-01-15 |
| EP0482076B1 (en) | 1995-04-26 |
| ATE121629T1 (de) | 1995-05-15 |
| AU648509B2 (en) | 1994-04-28 |
| ES2075900T3 (es) | 1995-10-16 |
| FI104233B1 (fi) | 1999-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO301577B1 (no) | Fremgangsmåte for fremstilling av en stabil vaksineblanding og fremgangsmåte for stabilisering av interleukin i en vaksineblanding | |
| US7169391B2 (en) | Vaccines | |
| Nunberg et al. | Interleukin 2 acts as an adjuvant to increase the potency of inactivated rabies virus vaccine. | |
| Lin et al. | Present status of the use of cytokines as adjuvants with vaccines to protect against infectious diseases | |
| US7374751B1 (en) | QS-21 and IL-12 as an adjuvant combination | |
| AU2001270031A1 (en) | QS-21 and IL-12 as an adjuvant combination | |
| IE914436A1 (en) | Use of IL-4 to enhance immune response to immunogens in vaccines | |
| AU2002225972B2 (en) | Adjuvant combination formulations | |
| NZ250555A (en) | Vaccine with enhanced immunogenicity by inclusion of a cytokine | |
| EP1490100B1 (en) | Combined dna/protein vaccine compositions | |
| WO1999040937A2 (en) | Vaccines comprising interleukin-12 and respiratory syncytial viral antigens | |
| MXPA00007881A (en) | Vaccines comprising interleukin-12 and respiratory syncytial viral antigens |