NO300595B1 - Fremgangsmåte for fremstilling av et hybridprotein som omfatter et PE40-domene, samt plasmid for anvendelse ved ekspresjon av hybridproteinet - Google Patents
Fremgangsmåte for fremstilling av et hybridprotein som omfatter et PE40-domene, samt plasmid for anvendelse ved ekspresjon av hybridproteinet Download PDFInfo
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- NO300595B1 NO300595B1 NO900758A NO900758A NO300595B1 NO 300595 B1 NO300595 B1 NO 300595B1 NO 900758 A NO900758 A NO 900758A NO 900758 A NO900758 A NO 900758A NO 300595 B1 NO300595 B1 NO 300595B1
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- tgf
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- hybrid protein
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- 229960000723 ampicillin Drugs 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
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- 238000002512 chemotherapy Methods 0.000 description 1
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- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
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- 239000002095 exotoxin Substances 0.000 description 1
- 239000013613 expression plasmid Substances 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
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- 238000011534 incubation Methods 0.000 description 1
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- 238000010369 molecular cloning Methods 0.000 description 1
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- 238000011580 nude mouse model Methods 0.000 description 1
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- 230000000607 poisoning effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31254089A | 1989-02-17 | 1989-02-17 | |
| US38909289A | 1989-08-03 | 1989-08-03 | |
| US44918789A | 1989-12-21 | 1989-12-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO900758D0 NO900758D0 (no) | 1990-02-16 |
| NO900758L NO900758L (no) | 1990-08-20 |
| NO300595B1 true NO300595B1 (no) | 1997-06-23 |
Family
ID=27405603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO900758A NO300595B1 (no) | 1989-02-17 | 1990-02-16 | Fremgangsmåte for fremstilling av et hybridprotein som omfatter et PE40-domene, samt plasmid for anvendelse ved ekspresjon av hybridproteinet |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0383599B1 (fi) |
| JP (2) | JPH07106159B2 (fi) |
| KR (1) | KR0169729B1 (fi) |
| AT (1) | ATE133993T1 (fi) |
| AU (1) | AU617039B2 (fi) |
| CA (1) | CA2010256C (fi) |
| CY (1) | CY1987A (fi) |
| DE (1) | DE69025211T2 (fi) |
| DK (1) | DK0383599T3 (fi) |
| ES (1) | ES2085329T3 (fi) |
| FI (1) | FI102383B (fi) |
| GR (1) | GR3019836T3 (fi) |
| HK (1) | HK15597A (fi) |
| IE (1) | IE71934B1 (fi) |
| IL (1) | IL93425A (fi) |
| NO (1) | NO300595B1 (fi) |
| NZ (1) | NZ232564A (fi) |
| PT (1) | PT93178B (fi) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU631200B2 (en) * | 1989-02-17 | 1992-11-19 | Merck & Co., Inc. | Production of modified pe40 |
| WO1990012592A1 (en) * | 1989-04-21 | 1990-11-01 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Recombinant antibody-toxin fusion protein |
| IL98528A0 (en) * | 1990-06-21 | 1992-07-15 | Merck & Co Inc | Pharmaceutical compositions containing hybrid for killing bladder cancer cells |
| GB2246779B (en) * | 1990-08-03 | 1994-08-17 | Delta Biotechnology Ltd | Tumour-associated protease inhibitors targeted to tumour cells |
| AUPM959894A0 (en) * | 1994-11-22 | 1994-12-15 | Crc For Biopharmaceutical Research Pty Ltd | Fusion proteins with cytotoxic activity against cells overexpressing erbb2-4 |
| WO1998029453A1 (fr) * | 1996-12-27 | 1998-07-09 | Mochida Pharmaceutical Co., Ltd. | Medicaments diriges vers la membrane cellulaire |
| EP0981606A2 (en) * | 1997-05-12 | 2000-03-01 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Method and construct for inhibition of cell migration |
| GB0008802D0 (en) * | 2000-04-10 | 2000-05-31 | Univ London | Molecule |
| JP4940136B2 (ja) | 2004-06-28 | 2012-05-30 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | キメラタンパク質およびその使用 |
| CN105766069B (zh) | 2013-11-20 | 2019-04-16 | 株式会社村田制作所 | 多层布线基板及具备该多层布线基板的探针卡 |
| JP6795813B2 (ja) * | 2015-10-05 | 2020-12-02 | 国立研究開発法人産業技術総合研究所 | がん細胞の検出方法、がん細胞内に物質を導入するための試薬、及びがん治療用組成物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL90047A (en) * | 1982-10-19 | 1992-12-01 | Cetus Oncology Corp | Cysteine-depleted biologically active muteins other than interferon - ' |
| FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
| US4545985A (en) * | 1984-01-26 | 1985-10-08 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services | Pseudomonas exotoxin conjugate immunotoxins |
| US4892827A (en) * | 1986-09-24 | 1990-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects |
| WO1990012592A1 (en) * | 1989-04-21 | 1990-11-01 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Recombinant antibody-toxin fusion protein |
-
1990
- 1990-02-15 DE DE69025211T patent/DE69025211T2/de not_active Expired - Fee Related
- 1990-02-15 EP EP90301639A patent/EP0383599B1/en not_active Expired - Lifetime
- 1990-02-15 AT AT90301639T patent/ATE133993T1/de not_active IP Right Cessation
- 1990-02-15 DK DK90301639.2T patent/DK0383599T3/da active
- 1990-02-15 ES ES90301639T patent/ES2085329T3/es not_active Expired - Lifetime
- 1990-02-16 IL IL9342590A patent/IL93425A/en not_active IP Right Cessation
- 1990-02-16 CA CA002010256A patent/CA2010256C/en not_active Expired - Fee Related
- 1990-02-16 NO NO900758A patent/NO300595B1/no not_active IP Right Cessation
- 1990-02-16 IE IE58790A patent/IE71934B1/en not_active IP Right Cessation
- 1990-02-16 FI FI900783A patent/FI102383B/fi not_active IP Right Cessation
- 1990-02-16 NZ NZ232564A patent/NZ232564A/xx unknown
- 1990-02-16 PT PT93178A patent/PT93178B/pt not_active IP Right Cessation
- 1990-02-17 JP JP2037126A patent/JPH07106159B2/ja not_active Expired - Fee Related
- 1990-02-17 KR KR1019900002018A patent/KR0169729B1/ko not_active IP Right Cessation
- 1990-02-19 AU AU49946/90A patent/AU617039B2/en not_active Ceased
-
1995
- 1995-02-02 JP JP7050281A patent/JP2510846B2/ja not_active Expired - Fee Related
-
1996
- 1996-05-06 GR GR960401211T patent/GR3019836T3/el unknown
-
1997
- 1997-02-05 HK HK15597A patent/HK15597A/xx not_active IP Right Cessation
- 1997-09-05 CY CY198797A patent/CY1987A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT93178B (pt) | 1996-04-30 |
| FI102383B1 (fi) | 1998-11-30 |
| EP0383599A2 (en) | 1990-08-22 |
| KR900012626A (ko) | 1990-09-01 |
| HK15597A (en) | 1997-02-14 |
| ES2085329T3 (es) | 1996-06-01 |
| GR3019836T3 (en) | 1996-08-31 |
| IL93425A0 (en) | 1990-11-29 |
| JPH02276590A (ja) | 1990-11-13 |
| KR0169729B1 (ko) | 1999-01-15 |
| CA2010256A1 (en) | 1990-08-17 |
| JPH07278200A (ja) | 1995-10-24 |
| CA2010256C (en) | 2000-07-25 |
| NO900758D0 (no) | 1990-02-16 |
| DE69025211T2 (de) | 1996-09-19 |
| EP0383599A3 (en) | 1991-03-27 |
| IE71934B1 (en) | 1997-03-12 |
| AU4994690A (en) | 1990-08-23 |
| IL93425A (en) | 1999-08-17 |
| DK0383599T3 (da) | 1996-08-05 |
| IE900587L (en) | 1990-08-17 |
| NO900758L (no) | 1990-08-20 |
| DE69025211D1 (de) | 1996-03-21 |
| CY1987A (en) | 1997-09-05 |
| ATE133993T1 (de) | 1996-02-15 |
| FI102383B (fi) | 1998-11-30 |
| NZ232564A (en) | 1992-08-26 |
| AU617039B2 (en) | 1991-11-14 |
| EP0383599B1 (en) | 1996-02-07 |
| FI900783A0 (fi) | 1990-02-16 |
| JP2510846B2 (ja) | 1996-06-26 |
| JPH07106159B2 (ja) | 1995-11-15 |
| PT93178A (pt) | 1990-08-31 |
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