NO2914282T3 - - Google Patents

Info

Publication number
NO2914282T3
NO2914282T3 NO13811605A NO13811605A NO2914282T3 NO 2914282 T3 NO2914282 T3 NO 2914282T3 NO 13811605 A NO13811605 A NO 13811605A NO 13811605 A NO13811605 A NO 13811605A NO 2914282 T3 NO2914282 T3 NO 2914282T3
Authority
NO
Norway
Application number
NO13811605A
Other languages
Norwegian (no)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NO2914282T3 publication Critical patent/NO2914282T3/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO13811605A 2012-10-31 2013-10-31 NO2914282T3 (Direct)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201219602A GB201219602D0 (en) 2012-10-31 2012-10-31 Recombinant clostridium botulinum neurotoxins
PCT/GB2013/052845 WO2014068317A1 (en) 2012-10-31 2013-10-31 Recombinant clostridium botulinum neurotoxins

Publications (1)

Publication Number Publication Date
NO2914282T3 true NO2914282T3 (Direct) 2018-05-19

Family

ID=47358958

Family Applications (1)

Application Number Title Priority Date Filing Date
NO13811605A NO2914282T3 (Direct) 2012-10-31 2013-10-31

Country Status (26)

Country Link
US (1) US10030238B2 (Direct)
EP (3) EP2914282B1 (Direct)
JP (2) JP2019068823A (Direct)
KR (2) KR102188539B1 (Direct)
CN (2) CN104755098A (Direct)
AR (2) AR093309A1 (Direct)
AU (3) AU2013340610B2 (Direct)
BR (1) BR112015005384A2 (Direct)
CA (1) CA2885519A1 (Direct)
DK (2) DK2914282T3 (Direct)
EA (1) EA201590794A8 (Direct)
ES (2) ES2662402T3 (Direct)
GB (1) GB201219602D0 (Direct)
HU (2) HUE048802T2 (Direct)
IL (1) IL237623B (Direct)
IN (1) IN2015MN00436A (Direct)
MX (2) MX367080B (Direct)
NO (1) NO2914282T3 (Direct)
NZ (1) NZ705575A (Direct)
PL (2) PL2914282T3 (Direct)
PT (2) PT2914282T (Direct)
SG (2) SG10201701140WA (Direct)
TW (3) TWI626307B (Direct)
UA (1) UA118837C2 (Direct)
WO (1) WO2014068317A1 (Direct)
ZA (1) ZA201501449B (Direct)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201219602D0 (en) * 2012-10-31 2012-12-12 Syntaxin Ltd Recombinant clostridium botulinum neurotoxins
CN115925835A (zh) * 2015-03-26 2023-04-07 哈佛大学校长及研究员协会 工程改造的肉毒杆菌神经毒素
WO2017063743A1 (en) 2015-10-14 2017-04-20 Merz Pharma Gmbh & Co. Kgaa Improvements to ultrasound-based therapy of photoaged tissue
EP3423084B1 (en) 2016-03-02 2021-09-01 Merz Pharma GmbH & Co. KGaA Composition comprising botulinum toxin
EP3263710A1 (en) * 2016-07-01 2018-01-03 Ipsen Biopharm Limited Production of activated clostridial neurotoxins
JP7100020B2 (ja) 2016-08-24 2022-07-12 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 操作されたボツリヌス神経毒素
EP3639848A3 (en) 2016-09-13 2020-12-16 Allergan, Inc. Stabilized non-protein clostridial toxin compositions
WO2018233813A1 (en) 2017-06-20 2018-12-27 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum toxin with increased duration of effect
US11155802B2 (en) 2017-07-06 2021-10-26 Merz Pharma Gmbh & Co. Kgaa Recombinant botulinum neurotoxins with increased duration of effect
AU2018347514C1 (en) 2017-10-11 2025-01-02 Illustris Pharmaceuticals, Inc. Methods and compositions for topical delivery
TWI822723B (zh) * 2018-01-29 2023-11-21 英商艾普森生物製藥有限公司 非神經元性 SNARE 裂解的肉毒桿菌神經毒素、裂解 hSNAP-23 之活體外方法、及經修飾 BoNT/A L 鏈蛋白酶之用途
EP3752128B1 (de) * 2018-02-16 2025-01-15 preclinics discovery GmbH Nukleinsäure-basiertes botulinum neurotoxin zur therapeutischen anwendung
GB201815844D0 (en) 2018-09-28 2018-11-14 Ipsen Biopharm Ltd Therapeutic & comestic uses of botulinum neurotoxin serotype e
GB202011055D0 (en) 2020-07-17 2020-09-02 Ipsen Bioinnovation Ltd Treatment of post-operative pain
GB202015618D0 (en) 2020-10-01 2020-11-18 Ipsen Biopharm Ltd Method for producing beta-trypsin
CN115819526A (zh) * 2022-12-02 2023-03-21 海雅美生物技术(珠海)有限公司 一种重组肉毒杆菌神经毒素及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6967088B1 (en) * 1995-03-16 2005-11-22 Allergan, Inc. Soluble recombinant botulinum toxin proteins
NZ308772A (en) * 1995-05-17 1999-04-29 Du Pont Recombinant baculovirus insecticides
EP1119626B1 (en) 1998-07-10 2008-01-02 U.S. Army Medical Research Institute of Infectious Diseases Botulinum neurotoxin vaccine
ATE348178T1 (de) * 1999-08-25 2007-01-15 Allergan Inc Aktivierbare rekombinante neurotoxine
US7374896B2 (en) 2001-08-28 2008-05-20 Allergan, Inc. GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
US7514088B2 (en) * 2005-03-15 2009-04-07 Allergan, Inc. Multivalent Clostridial toxin derivatives and methods of their use
US20110111483A1 (en) 2004-06-30 2011-05-12 Allergan, Inc. Optimizing Expression of Active Botulinum Toxin Type E
WO2006011966A1 (en) * 2004-06-30 2006-02-02 Allergan, Inc. Optimizing expression of active botulinum toxin type e
GB2416122A (en) * 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
DE102004043009A1 (de) * 2004-09-06 2006-03-23 Toxogen Gmbh Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen
DE102005002978B4 (de) * 2005-01-21 2013-04-25 Merz Pharma Gmbh & Co. Kgaa Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form
BRPI0508299A (pt) * 2005-03-03 2007-07-31 Allergan Inc sistema livre de produto animal e processo para purificação de uma toxina botulina
DK1926744T4 (en) * 2005-09-19 2019-01-28 Allergan Inc CLOSTRIDIUM TOXIN-ACTIVABLE CLOSTRIDIAL TOXINES
US20070218084A1 (en) * 2005-12-30 2007-09-20 Fondazione Pierfranco E Luisa Mariani- Onlus Method for the Mapping of the Epileptogenic Focus in the Pre-Surgical Evaluation of Patients with Intractable Epilepsy
JP2009543558A (ja) * 2006-07-11 2009-12-10 アラーガン、インコーポレイテッド 増強した転位置能力および増強したターゲティング活性を有する改変クロストリジウム毒素
US8486422B2 (en) 2007-07-26 2013-07-16 Allergan, Inc. Methods of activating clostridial toxins
RU2535003C2 (ru) 2008-12-10 2014-12-10 Аллерган, Инк. Фармацевтические композиции токсина клостридий
GB0903006D0 (en) * 2009-02-23 2009-04-08 Syntaxin Ltd Modified non-cytotoxic proteases
EP2419128B1 (en) * 2009-04-14 2018-06-06 Medical College of Wisconsin, Inc. Engineered botulinum neurotoxin
JP2013514091A (ja) * 2009-12-16 2013-04-25 アラーガン、インコーポレイテッド 組込型プロテアーゼ切断部位結合ドメインを含む改変クロストリジウム毒素
WO2012112434A1 (en) 2011-02-14 2012-08-23 Allergan, Inc. Inhibiting aberrant blood vessel formation using retargeted endopeptidases
GB201219602D0 (en) * 2012-10-31 2012-12-12 Syntaxin Ltd Recombinant clostridium botulinum neurotoxins
GB201407525D0 (en) * 2014-04-29 2014-06-11 Syntaxin Ltd Manufacture of recombinant clostridium botulinum neurotoxins
JP7100020B2 (ja) * 2016-08-24 2022-07-12 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 操作されたボツリヌス神経毒素

Also Published As

Publication number Publication date
EP3673914B1 (en) 2021-10-27
EP3326644B1 (en) 2020-03-04
AR093309A1 (es) 2015-05-27
TW201435084A (zh) 2014-09-16
EP2914282A1 (en) 2015-09-09
AU2013340610B2 (en) 2018-02-22
SG11201502372SA (en) 2015-05-28
AU2020244481A1 (en) 2020-10-29
TW201825680A (zh) 2018-07-16
MX2019009222A (es) 2019-11-21
JP2019068823A (ja) 2019-05-09
CA2885519A1 (en) 2014-05-08
JP2020078321A (ja) 2020-05-28
GB201219602D0 (en) 2012-12-12
EA201590794A8 (ru) 2016-01-29
WO2014068317A1 (en) 2014-05-08
BR112015005384A2 (pt) 2017-08-08
EA201590794A1 (ru) 2015-08-31
EP2914282B1 (en) 2017-12-20
NZ705575A (en) 2019-08-30
ES2788199T3 (es) 2020-10-20
DK2914282T3 (en) 2018-02-26
CN104755098A (zh) 2015-07-01
EP3673914A1 (en) 2020-07-01
US10030238B2 (en) 2018-07-24
KR20150094590A (ko) 2015-08-19
KR102188539B1 (ko) 2020-12-09
AU2013340610A1 (en) 2015-03-19
PL2914282T3 (pl) 2018-07-31
AU2018203556A1 (en) 2018-06-07
SG10201701140WA (en) 2017-04-27
DK3326644T3 (da) 2020-05-11
KR102264478B1 (ko) 2021-06-15
AU2018203556B2 (en) 2020-08-20
TWI626307B (zh) 2018-06-11
CN110499321A (zh) 2019-11-26
MX367080B (es) 2019-08-05
UA118837C2 (uk) 2019-03-25
EP3326644A1 (en) 2018-05-30
TWI673361B (zh) 2019-10-01
MX2015005156A (es) 2015-09-23
ZA201501449B (en) 2016-08-31
HK1208359A1 (en) 2016-03-04
US20150247139A1 (en) 2015-09-03
PT3326644T (pt) 2020-05-29
IL237623B (en) 2019-05-30
KR20200110470A (ko) 2020-09-23
PL3326644T3 (pl) 2020-08-24
TW202012622A (zh) 2020-04-01
IL237623A0 (en) 2015-04-30
PT2914282T (pt) 2018-03-13
AR117738A2 (es) 2021-08-25
ES2662402T3 (es) 2018-04-06
HUE036764T2 (hu) 2018-07-30
IN2015MN00436A (Direct) 2015-09-04
HUE048802T2 (hu) 2020-08-28

Similar Documents

Publication Publication Date Title
BR112014017635A2 (Direct)
BR112014017614A2 (Direct)
BR112014017708A2 (Direct)
BR112014021401A2 (Direct)
BR112014017625A2 (Direct)
BR112014017659A2 (Direct)
BR112014017592A2 (Direct)
BR112014019235A2 (Direct)
BR112014017646A2 (Direct)
BR112014019610A2 (Direct)
BR112014017607A2 (Direct)
BR112014017638A2 (Direct)
BR112014017609A2 (Direct)
BR112014017634A2 (Direct)
BR112014017644A2 (Direct)
NO2914282T3 (Direct)
BR112014017618A2 (Direct)
BR112014017647A2 (Direct)
BR112014017623A2 (Direct)
BR112014017652A2 (Direct)
BR112014025069A2 (Direct)
BR112014017630A2 (Direct)
BR112014017627A2 (Direct)
BR112014024269A2 (Direct)
BR112014017621A2 (Direct)