NO2849740T3 - - Google Patents
Info
- Publication number
- NO2849740T3 NO2849740T3 NO13723674A NO13723674A NO2849740T3 NO 2849740 T3 NO2849740 T3 NO 2849740T3 NO 13723674 A NO13723674 A NO 13723674A NO 13723674 A NO13723674 A NO 13723674A NO 2849740 T3 NO2849740 T3 NO 2849740T3
- Authority
- NO
- Norway
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003897 | 2012-05-18 | ||
| EP13723674.1A EP2849740B1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano'[3,4,b]indol]-4-amine and paracetamol or propacetamol |
| PCT/EP2013/001468 WO2013170969A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano'[3,4,b]indol]-4-amine and paracetamol or propacetamol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO2849740T3 true NO2849740T3 (cg-RX-API-DMAC10.html) | 2018-02-10 |
Family
ID=48468208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO13723674A NO2849740T3 (cg-RX-API-DMAC10.html) | 2012-05-18 | 2013-05-16 |
Country Status (22)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107427493A (zh) | 2015-01-23 | 2017-12-01 | 格吕伦塔尔有限公司 | 用于治疗肝功能受损和/或肾功能受损的受试者的疼痛的Cebranopadol |
| MX2018010367A (es) | 2016-02-29 | 2018-12-10 | Guenenthal Gmbh | Titulacion de cebranopadol. |
| WO2026161433A1 (en) * | 2025-01-21 | 2026-07-30 | Adneuris Therapeutics, Inc. | Cebranopadol useful for alleviating pain |
| WO2026161842A1 (en) * | 2025-01-27 | 2026-07-30 | Adneuris Therapeutics, Inc. | Cebranopadol useful for treating pain |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068838B1 (en) | 1981-06-26 | 1986-09-17 | The Upjohn Company | Analgesic process and composition |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4404208A (en) | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
| IE55189B1 (en) | 1982-07-08 | 1990-06-20 | Wyeth John & Brother Ltd | Pharmaceutical compositions |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| DE3665538D1 (en) | 1985-01-23 | 1989-10-19 | Asta Pharma Ag | Synergistic combination of flupirtin and non-steroidal anti-phlogistics |
| ES2098264T3 (es) | 1989-05-22 | 1997-05-01 | Biochemical Veterinary Res | Sales metalicas divalentes de indometacina. |
| AU662160B2 (en) | 1991-07-04 | 1995-08-24 | Taisho Pharmaceutical Co., Ltd. | Analgesic |
| JPH05221857A (ja) * | 1992-02-14 | 1993-08-31 | Arakusu:Kk | 配合解熱鎮痛剤 |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| EP0702681A1 (en) | 1993-06-07 | 1996-03-27 | Merck & Co. Inc. | Spiro-substituted azacycles as neurokinin antagonists |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
| RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| EA004032B1 (ru) | 1998-09-10 | 2003-12-25 | Нюкомед Данмарк А/С | Фармацевтические композиции лекарственных веществ с быстрым высвобождением |
| ES2194536T3 (es) | 1998-11-13 | 2003-11-16 | Lilly Co Eli | Combinacion de duloxetina con farmacos antiinflamatorios no esteroideos. |
| EP1219304B1 (de) | 2000-12-28 | 2004-10-20 | Fresenius Kabi Austria GmbH | Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung |
| EP1470126A1 (en) | 2002-01-28 | 2004-10-27 | Pfizer Inc. | N-substituted spiropiperidine compounds as ligands for orl-1 receptor |
| ATE359827T1 (de) | 2002-06-17 | 2007-05-15 | Chiesi Farma Spa | Prozess für die vorbereitung von piroxicam: beta- cyclodextrin einschlusskomplexe |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
| US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| AU2006257274A1 (en) | 2005-06-17 | 2006-12-21 | Pfizer Inc. | Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as ORL1-receptor antagonists |
| CN102675136B (zh) | 2006-04-28 | 2016-01-20 | 格吕伦塔尔有限公司 | 包含3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚和nsaid的药物组合物 |
| CN101431990B (zh) * | 2006-04-28 | 2011-08-03 | 格吕伦塔尔有限公司 | 包含3-（3-二甲基氨基-1-乙基-2-甲基-丙基）-酚和对乙酰氨基酚的药物结合 |
| CN101147735A (zh) * | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| DE102006046745A1 (de) | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| DE102006056458A1 (de) * | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
| US20100279984A1 (en) | 2007-10-09 | 2010-11-04 | Merck Patent Gmbh | Pharmaceutical compositions containing benfotiamine and one or one more pharmaceutically active agents for the treatment of pain conditions of neuropathic origin |
| CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
| EP2331087A1 (en) * | 2008-09-05 | 2011-06-15 | Grünenthal GmbH | Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3 diol and paracetamol |
| WO2010025931A2 (en) | 2008-09-05 | 2010-03-11 | Grünenthal GmbH | Pharmaceutical combination |
| CA2735139A1 (en) | 2008-09-05 | 2010-03-11 | Petra Bloms-Funke | Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol and an nsaid |
| EP3459533A1 (en) * | 2010-08-04 | 2019-03-27 | Grünenthal GmbH | Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for the treatment of nociceptive pain |
| AR082559A1 (es) * | 2010-08-04 | 2012-12-19 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica que comprende 6’-fluoro-(n-metil- o n,n-dimetil)-4’-fenil-4’,9’-dihidro-3’h-espiro[ciclohexan-1,1’-pirano[3,4,b]indol]-4-amina |
| RU2589831C2 (ru) * | 2010-08-04 | 2016-07-10 | Грюненталь Гмбх | ЛЕКАРСТВЕННАЯ ДОЗИРОВАННАЯ ФОРМА, КОТОРАЯ СОДЕРЖИТ 6'-ФТОР-(N-МЕТИЛ- ИЛИ N, N-ДИМЕТИЛ-)-4-ФЕНИЛ-4', 9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1, 1'-ПИРАНО[3, 4, b]ИНДОЛ]-4-АМИН |
| US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
-
2013
- 2013-05-13 US US13/892,969 patent/US20130310435A1/en not_active Abandoned
- 2013-05-16 WO PCT/EP2013/001468 patent/WO2013170969A1/en not_active Ceased
- 2013-05-16 PT PT137236741T patent/PT2849740T/pt unknown
- 2013-05-16 DK DK13723674.1T patent/DK2849740T3/da active
- 2013-05-16 BR BR112014028561A patent/BR112014028561A2/pt not_active IP Right Cessation
- 2013-05-16 MX MX2014012723A patent/MX352596B/es active IP Right Grant
- 2013-05-16 EA EA201401272A patent/EA026949B1/ru not_active IP Right Cessation
- 2013-05-16 HU HUE13723674A patent/HUE034676T2/hu unknown
- 2013-05-16 PL PL13723674T patent/PL2849740T3/pl unknown
- 2013-05-16 EP EP13723674.1A patent/EP2849740B1/en not_active Not-in-force
- 2013-05-16 ES ES13723674.1T patent/ES2650441T3/es active Active
- 2013-05-16 CN CN201810706944.9A patent/CN108524498A/zh active Pending
- 2013-05-16 SI SI201330870T patent/SI2849740T1/en unknown
- 2013-05-16 NO NO13723674A patent/NO2849740T3/no unknown
- 2013-05-16 LT LTEP13723674.1T patent/LT2849740T/lt unknown
- 2013-05-16 HR HRP20171438TT patent/HRP20171438T1/hr unknown
- 2013-05-16 JP JP2015511955A patent/JP6116676B2/ja active Active
- 2013-05-16 RS RS20171229A patent/RS56617B1/sr unknown
- 2013-05-16 AU AU2013262075A patent/AU2013262075B2/en not_active Ceased
- 2013-05-16 CA CA2873644A patent/CA2873644A1/en not_active Abandoned
- 2013-05-16 CN CN201380025683.XA patent/CN104302282A/zh active Pending
-
2014
- 2014-11-12 IL IL235651A patent/IL235651B/en active IP Right Grant
-
2017
- 2017-10-06 US US15/726,761 patent/US20180092867A1/en not_active Abandoned
- 2017-11-20 CY CY20171101212T patent/CY1119610T1/el unknown
-
2019
- 2019-07-03 US US16/502,651 patent/US11311504B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA026949B1 (ru) | 2017-06-30 |
| US20190350884A1 (en) | 2019-11-21 |
| RS56617B1 (sr) | 2018-02-28 |
| HRP20171438T1 (hr) | 2017-11-03 |
| MX352596B (es) | 2017-11-30 |
| JP2015516449A (ja) | 2015-06-11 |
| AU2013262075B2 (en) | 2017-10-26 |
| WO2013170969A1 (en) | 2013-11-21 |
| PT2849740T (pt) | 2017-12-13 |
| EP2849740B1 (en) | 2017-09-13 |
| BR112014028561A2 (pt) | 2017-07-25 |
| CY1119610T1 (el) | 2018-04-04 |
| MX2014012723A (es) | 2015-01-15 |
| ES2650441T3 (es) | 2018-01-18 |
| DK2849740T3 (da) | 2017-11-20 |
| JP6116676B2 (ja) | 2017-04-19 |
| US20180092867A1 (en) | 2018-04-05 |
| HK1204940A1 (en) | 2015-12-11 |
| US11311504B2 (en) | 2022-04-26 |
| HUE034676T2 (hu) | 2018-02-28 |
| CN104302282A (zh) | 2015-01-21 |
| LT2849740T (lt) | 2017-12-27 |
| PL2849740T3 (pl) | 2018-03-30 |
| EA201401272A1 (ru) | 2015-05-29 |
| SI2849740T1 (en) | 2018-01-31 |
| IL235651B (en) | 2018-08-30 |
| AU2013262075A1 (en) | 2015-01-22 |
| IL235651A0 (en) | 2015-01-29 |
| CA2873644A1 (en) | 2013-11-21 |
| EP2849740A1 (en) | 2015-03-25 |
| US20130310435A1 (en) | 2013-11-21 |
| CN108524498A (zh) | 2018-09-14 |