US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
US4366241A
(en)
|
1980-08-07 |
1982-12-28 |
Syva Company |
Concentrating zone method in heterogeneous immunoassays
|
US4517288A
(en)
|
1981-01-23 |
1985-05-14 |
American Hospital Supply Corp. |
Solid phase system for ligand assay
|
US4702909A
(en)
|
1982-05-05 |
1987-10-27 |
Louisiana State University A & M |
Non-A, non-B hepatitis antigen, antigen compositions, vaccine and diagnostic reagent
|
CA1291031C
(en)
|
1985-12-23 |
1991-10-22 |
Nikolaas C.J. De Jaeger |
Method for the detection of specific binding agents and their correspondingbindable substances
|
US5231000A
(en)
|
1987-10-08 |
1993-07-27 |
The Mclean Hospital |
Antibodies to A4 amyloid peptide
|
US5118606A
(en)
|
1988-09-02 |
1992-06-02 |
The Regents Of The University Of California |
Methods for detecting cellular pathology by assaying spectrin and spectrin breakdown products
|
US5234814A
(en)
|
1989-06-01 |
1993-08-10 |
Du Pont Merck Pharmaceutical Company |
Diagnostic assay for alzheimer's disease
|
GB2236186B
(en)
|
1989-08-22 |
1994-01-05 |
Finnigan Mat Gmbh |
Process and device for laser desorption of analyte molecular ions, especially of biomolecules
|
US5045694A
(en)
|
1989-09-27 |
1991-09-03 |
The Rockefeller University |
Instrument and method for the laser desorption of ions in mass spectrometry
|
EP0732399A3
(en)
|
1990-03-05 |
1997-03-12 |
Cephalon Inc |
Chymotrypsin-like proteases and their inhibitors
|
US5586226A
(en)
|
1990-05-16 |
1996-12-17 |
Canon Kabushiki Kaisha |
Control method and device for a unicolor printer
|
US5707796A
(en)
*
|
1990-06-11 |
1998-01-13 |
Nexstar Pharmaceuticals, Inc. |
Method for selecting nucleic acids on the basis of structure
|
US5567588A
(en)
*
|
1990-06-11 |
1996-10-22 |
University Research Corporation |
Systematic evolution of ligands by exponential enrichment: Solution SELEX
|
US5683867A
(en)
*
|
1990-06-11 |
1997-11-04 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: blended SELEX
|
US5637459A
(en)
|
1990-06-11 |
1997-06-10 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: chimeric selex
|
US6011020A
(en)
*
|
1990-06-11 |
2000-01-04 |
Nexstar Pharmaceuticals, Inc. |
Nucleic acid ligand complexes
|
US5496938A
(en)
|
1990-06-11 |
1996-03-05 |
Nexstar Pharmaceuticals, Inc. |
Nucleic acid ligands to HIV-RT and HIV-1 rev
|
ATE318832T1
(de)
|
1990-06-11 |
2006-03-15 |
Gilead Sciences Inc |
Verfahren zur vervendung von nukleinsäureliganden
|
US5270163A
(en)
|
1990-06-11 |
1993-12-14 |
University Research Corporation |
Methods for identifying nucleic acid ligands
|
US5660985A
(en)
|
1990-06-11 |
1997-08-26 |
Nexstar Pharmaceuticals, Inc. |
High affinity nucleic acid ligands containing modified nucleotides
|
US5252463A
(en)
|
1990-06-22 |
1993-10-12 |
The Du Pont Merck Pharmaceutical Company |
Clipsin, a chymotrypsin-like protease and method of using same
|
AU2414092A
(en)
|
1991-08-01 |
1993-03-02 |
Paul H. Voorheis |
Diagnostic method for alzheimer's disease
|
EP1130399B1
(en)
|
1992-05-29 |
2009-04-01 |
The Rockefeller University |
Method for the sequence determination of peptides using a mass spectrometer
|
US5792664A
(en)
|
1992-05-29 |
1998-08-11 |
The Rockefeller University |
Methods for producing and analyzing biopolymer ladders
|
AU676582B2
(en)
|
1993-05-28 |
1997-03-13 |
Baylor College Of Medicine |
Method and apparatus for desorption and ionization of analytes
|
DE4337654C2
(de)
|
1993-11-04 |
1996-08-08 |
Biotest Pharma Gmbh |
Verwendung boviner Kolostralmilch von nicht mit Viren hyperimmunisierten Tieren als Leberschutzpräparat
|
US5536639A
(en)
|
1994-03-25 |
1996-07-16 |
Cephalon, Inc. |
Methods for detecting calpain activation by detection of calpain activated spectrin breakdown products
|
JP4429385B2
(ja)
|
1994-07-15 |
2010-03-10 |
セフアロン・インコーポレーテツド |
バキュロウイルスにより発現される活性カルパイン
|
US5614649A
(en)
*
|
1994-11-14 |
1997-03-25 |
Cephalon, Inc. |
Multicatalytic protease inhibitors
|
US5777194A
(en)
*
|
1995-04-26 |
1998-07-07 |
Cephalon, Inc. |
Gene-targeted mice with humanized Aβ sequence and Swedish FAD mutation
|
JP2000505544A
(ja)
|
1996-02-02 |
2000-05-09 |
バイオトリン・インテレクチュアル・プロパティーズ・リミテッド |
肝臓移植レシピエントを含めた個体の肝状態の決定法
|
US6048703A
(en)
*
|
1996-11-15 |
2000-04-11 |
Cephalon, Inc. |
Methods for detecting cell apoptosis
|
NZ516848A
(en)
|
1997-06-20 |
2004-03-26 |
Ciphergen Biosystems Inc |
Retentate chromatography apparatus with applications in biology and medicine
|
WO1999030707A1
(en)
|
1997-12-16 |
1999-06-24 |
Cephalon Inc. |
Multicatalytic protease inhibitors for use as anti-tumor agents
|
US6537749B2
(en)
|
1998-04-03 |
2003-03-25 |
Phylos, Inc. |
Addressable protein arrays
|
US6406921B1
(en)
|
1998-07-14 |
2002-06-18 |
Zyomyx, Incorporated |
Protein arrays for high-throughput screening
|
JP4624559B2
(ja)
|
1998-09-08 |
2011-02-02 |
イノジェネティックス・ナムローゼ・フェンノートシャップ |
初期cnsダメージのマーカーとしてのタウ
|
WO2000056934A1
(en)
|
1999-03-24 |
2000-09-28 |
Packard Bioscience Company |
Continuous porous matrix arrays
|
US6218005B1
(en)
*
|
1999-04-01 |
2001-04-17 |
3M Innovative Properties Company |
Tapes for heat sealing substrates
|
US20020002270A1
(en)
|
1999-06-16 |
2002-01-03 |
Raymond P. Zinkowski |
Purified antigen for alzheimer's disease, and methods of obtaining and using same
|
US6589746B1
(en)
|
1999-10-21 |
2003-07-08 |
University Of Cincinnati |
Method of detecting axonally-derived protein tau in patients with traumatic CNS injury
|
WO2001075165A2
(en)
*
|
2000-03-30 |
2001-10-11 |
Elan Pharmaceuticals, Inc. |
Screening markers and methods for neurodegenerative disorders
|
US20050063942A1
(en)
|
2001-02-02 |
2005-03-24 |
Clark Mike A. |
Methods for predicting sensitivity of tumors to arginine deprivation
|
US6949377B2
(en)
|
2001-03-05 |
2005-09-27 |
Ho Winston Z |
Chemiluminescence-based microfluidic biochip
|
US20040253637A1
(en)
|
2001-04-13 |
2004-12-16 |
Biosite Incorporated |
Markers for differential diagnosis and methods of use thereof
|
US20030199000A1
(en)
|
2001-08-20 |
2003-10-23 |
Valkirs Gunars E. |
Diagnostic markers of stroke and cerebral injury and methods of use thereof
|
US7713705B2
(en)
|
2002-12-24 |
2010-05-11 |
Biosite, Inc. |
Markers for differential diagnosis and methods of use thereof
|
US20040203083A1
(en)
|
2001-04-13 |
2004-10-14 |
Biosite, Inc. |
Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
|
US20020172676A1
(en)
|
2001-05-16 |
2002-11-21 |
George Jackowski |
Method of treatment of alzheimer's disease and device therefor
|
US7144708B2
(en)
|
2001-06-25 |
2006-12-05 |
The Cleveland Clinic Foundation |
Markers of blood barrier disruption and methods of using same
|
JP2003070498A
(ja)
|
2001-07-19 |
2003-03-11 |
Pharma Design Inc |
ユビキチンカルボキシルターミナルヒドロラーゼl1遺伝子異常の検出方法
|
CA2457775A1
(en)
*
|
2001-08-20 |
2003-02-27 |
Biosite Incorporated |
Diagnostic markers of stroke and cerebral injury and methods of use thereof
|
US20030040660A1
(en)
|
2001-08-27 |
2003-02-27 |
George Jackowski |
Method for diagnosing and distinguishing traumatic brain injury and diagnostic devices for use therein
|
AU2002329570A1
(en)
*
|
2001-10-12 |
2003-01-30 |
Pfizer Products Inc. |
Method of monitoring neuroprotective treatment
|
WO2003062824A1
(en)
|
2002-01-23 |
2003-07-31 |
Boditech Inc. |
Lateral flow quantitative assay method and strip and laser-induced fluoerescence detection device therefor
|
JP2005535285A
(ja)
|
2002-01-31 |
2005-11-24 |
ジーン ロジック インコーポレイテッド |
分子肝毒性モデリング
|
WO2003085083A2
(en)
|
2002-04-01 |
2003-10-16 |
Phase-1 Molecular Toxicology, Inc. |
Liver necrosis predictive genes
|
AU2003243563A1
(en)
|
2002-06-12 |
2004-09-28 |
The Cleveland Clinic Foundation |
Markers of blood barrier permeability and methods of using same
|
CA2498614C
(en)
|
2002-09-11 |
2013-04-16 |
University Of Florida |
Analyzing nerve cell damage
|
JP2006526140A
(ja)
|
2002-12-24 |
2006-11-16 |
バイオサイト インコーポレイテッド |
鑑別診断のためのマーカーおよびその使用方法
|
EP2508608A1
(en)
|
2003-06-09 |
2012-10-10 |
Alnylam Pharmaceuticals Inc. |
Method of treating neurodegenerative disease
|
GB0322063D0
(en)
*
|
2003-09-20 |
2003-10-22 |
Univ Geneve |
Diagnostic method for brain damage-related disorders
|
JP5019878B2
(ja)
|
2003-09-20 |
2012-09-05 |
エレクトロフォレティックス リミテッド |
脳障害関連疾患の診断のためのマーカーの検出に関する方法
|
EP1519194A1
(en)
*
|
2003-09-24 |
2005-03-30 |
Roche Diagnostics GmbH |
Use of gfap for identification of intracerebral hemorrhage
|
US20050130226A1
(en)
|
2003-09-26 |
2005-06-16 |
The University Of Cincinnati |
Fully integrated protein lab-on-a-chip with smart microfluidics for spot array generation
|
EP2369348A1
(en)
|
2003-11-07 |
2011-09-28 |
Ciphergen Biosystems, Inc. |
Biomarkers for Alzheimer's disease
|
US20060094064A1
(en)
|
2003-11-19 |
2006-05-04 |
Sandip Ray |
Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids
|
US20050112585A1
(en)
|
2003-11-21 |
2005-05-26 |
Dominic Zichi |
Method for adjusting the quantification range of individual analytes in a multiplexed assay
|
TWI281473B
(en)
|
2003-12-19 |
2007-05-21 |
Ind Tech Res Inst |
Biomarkers for liver diseases and method for using same
|
WO2005066613A1
(en)
|
2003-12-31 |
2005-07-21 |
President And Fellows Of Harvard College |
Assay device and method
|
ATE512365T1
(de)
|
2004-04-15 |
2011-06-15 |
Univ Florida |
Map-2 proteolytische produkte als diagnostische biomarker fur neuralen verletzungen
|
US20140303041A1
(en)
|
2004-04-15 |
2014-10-09 |
University Of Florida Research Foundation Inc. |
In vitro diagnostic devices for nervous system injury and other neural disorders
|
US8492107B2
(en)
|
2004-04-15 |
2013-07-23 |
University Of Florida Research Foundation, Inc. |
Neural proteins as biomarkers for nervous system injury and other neural disorders
|
AU2005238446B2
(en)
*
|
2004-04-15 |
2009-07-30 |
Banyan Biomarkers Inc. |
Neural proteins as biomarkers for nervous system injury and other neural disorders
|
US20060292558A1
(en)
|
2004-07-19 |
2006-12-28 |
Cell Biosciences Inc. |
Methods and apparatus for protein assay diagnostics
|
JP4546534B2
(ja)
|
2004-10-15 |
2010-09-15 |
シーメンス アクチエンゲゼルシヤフト |
使い捨てカートリッジ内のdnaまたはタンパク質の総合的かつ自動的な分析装置、このようなカートリッジの製造方法、およびこのようなカートリッジを使用したdnaまたはタンパク質分析のための操作方法
|
WO2006107846A2
(en)
|
2005-04-01 |
2006-10-12 |
University Of Florida Research Foundation, Inc. |
Biomakers of liver injury
|
US8048638B2
(en)
|
2005-04-01 |
2011-11-01 |
University Of Florida Research Foundation, Inc. |
Biomarkers of liver injury
|
GB2428240A
(en)
|
2005-07-14 |
2007-01-24 |
Univ Gen Ve |
Diagnostic method for brain damage-related disorders
|
WO2007033385A2
(en)
|
2005-09-13 |
2007-03-22 |
Fluidigm Corporation |
Microfluidic assay devices and methods
|
WO2007046811A2
(en)
|
2005-10-20 |
2007-04-26 |
Biosite, Inc. |
Diagnostic markers of stroke and cerebral injury and methods of use thereof
|
EP1977223B8
(en)
|
2006-01-12 |
2013-05-15 |
MycroLab Diagnostics Pty Ltd |
Smart card with integrated microfluidic analysis
|
EP1992688B1
(en)
|
2006-02-15 |
2016-06-22 |
Mie University |
Method of constructing recombinant proteoliposome for diagnostic use
|
US20070255113A1
(en)
|
2006-05-01 |
2007-11-01 |
Grimes F R |
Methods and apparatus for identifying disease status using biomarkers
|
WO2007136617A2
(en)
|
2006-05-18 |
2007-11-29 |
Walter Reed Army Institute Of Research (Wrair) |
Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury
|
WO2007140188A2
(en)
|
2006-05-26 |
2007-12-06 |
Biosite Incorporated |
Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
|
WO2008008819A2
(en)
|
2006-07-11 |
2008-01-17 |
University Of Florida Research Foundation, Inc. |
Diagnosis and treatment of neurological inflammation
|
WO2008063369A2
(en)
|
2006-11-01 |
2008-05-29 |
George Mason Intellectual Properties, Inc. |
Biomarkers for neurological conditions
|
US8293489B2
(en)
|
2007-01-31 |
2012-10-23 |
Henkin Robert I |
Methods for detection of biological substances
|
US20120196307A1
(en)
|
2007-02-06 |
2012-08-02 |
Banyan Biomarkers, Inc. |
Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury
|
WO2008097618A1
(en)
|
2007-02-06 |
2008-08-14 |
University Of Florida Research Foundation, Inc. |
Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury
|
US20110082203A1
(en)
|
2008-02-04 |
2011-04-07 |
Kevin Ka-Wang Wang |
Process to diagnose or treat brain injury
|
EP2274011A4
(en)
|
2008-04-17 |
2013-04-24 |
Banyan Biomarkers Inc |
ANTIBODY-TIED SYNTHETIC VESICLE WITH ACTIVE MOLECULES
|
EP2143735A1
(en)
|
2008-07-10 |
2010-01-13 |
Institut Pasteur |
Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
|
US20140342381A1
(en)
|
2008-08-11 |
2014-11-20 |
Banyan Biomarkers, Inc. |
Devices and methods for biomarker detection process and assay of neurological condition
|
NO2324360T3
(no)
|
2008-08-11 |
2018-06-30 |
|
|
WO2010033912A2
(en)
|
2008-09-19 |
2010-03-25 |
Henry Ford Health System |
Methods, systems, and compositions for calpain inhibition
|
US20120094295A1
(en)
|
2008-11-21 |
2012-04-19 |
The Johns Hopkins University |
Neurodegenerative disease diagnostic compositions and methods of use
|
JP5875514B2
(ja)
|
2009-06-19 |
2016-03-02 |
バンヤン・バイオマーカーズ・インコーポレーテッド |
神経学的状態のバイオマーカーアッセイ
|
US20170315136A9
(en)
|
2009-06-19 |
2017-11-02 |
Banyan Biomarkers, Inc. |
Biomarker assay of neurological condition
|
WO2011011334A2
(en)
|
2009-07-18 |
2011-01-27 |
Banyan Biomarkers, Inc. |
SYNERGISTIC BIOMARKER ASSAY OF NEUROLGICAL CONDITION USING S-100β
|
EP2478360B1
(en)
|
2009-09-14 |
2018-06-27 |
Banyan Biomarkers, Inc. |
Autoantibody markers for diagnosis of traumatic brain injury
|
ES2735530T3
(es)
|
2010-01-26 |
2019-12-19 |
Bioregency Inc |
Composiciones y métodos relacionados con la argininosuccinato sintetasa
|
CN102918397A
(zh)
|
2010-04-01 |
2013-02-06 |
班扬生物标记公司 |
用于神经毒性检测的标志物和测定方法
|
WO2011160096A2
(en)
|
2010-06-17 |
2011-12-22 |
Banyan Biomarkers, Inc. |
Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as biomarkers of neural injury or neurological disorder or condition
|
JP6071886B2
(ja)
|
2010-10-14 |
2017-02-01 |
ザ・ジョンズ・ホプキンス・ユニバーシティ |
脳損傷のバイオマーカー
|
CN108593926A
(zh)
|
2011-09-14 |
2018-09-28 |
促进军事医学的亨利·M·杰克逊基金会公司 |
检测和监测用于ptsd的诊断生物标志物以及区分自杀式与非自杀式障碍的方法和试剂盒
|
US20140018299A1
(en)
|
2012-07-10 |
2014-01-16 |
Banyan Biomarkers, Inc. |
Method and device to detect, monitor and promote neural regeneration and improvement of cognitive function in a subject suffering from neural injury
|
US20140024053A1
(en)
|
2012-07-20 |
2014-01-23 |
Banyan Biomarkers, Inc. |
Methods, kits and devices for detecting bii-spectrin, and breakdown products thereof, as biomarkers for the diagnosis of neural injury
|
US20140275294A1
(en)
|
2013-03-15 |
2014-09-18 |
Banyan Biomarkers, Inc. |
Devices and methods for biomarker detection process and assay of liver injury
|
US20150141528A1
(en)
|
2013-05-31 |
2015-05-21 |
Banyan Biomarkers, Inc. |
Neural specific s100b for biomarker assays and devices for detection of a neurological condition
|
CN106461645A
(zh)
|
2014-04-07 |
2017-02-22 |
铁马诊断公司 |
外伤性脑损伤和神经退行性生物标记物、方法和系统
|
AU2015243926A1
(en)
|
2014-04-08 |
2016-11-24 |
The Research Foundation For The State University Of New York |
Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system
|
WO2018081649A1
(en)
|
2016-10-28 |
2018-05-03 |
Banyan Biomarkers, Inc. |
Antibodies to ubiquitin c-terminal hydrolase l1 (uch-l1) and glial fibrillary acidic protein (gfap) and related methods
|
WO2018191531A1
(en)
*
|
2017-04-15 |
2018-10-18 |
Abbott Laboratories |
Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers
|
CN110603449A
(zh)
*
|
2017-04-28 |
2019-12-20 |
雅培实验室 |
用同一人受试者的至少两种样品的早期生物标记物帮助超急性诊断确定创伤性脑损伤的方法
|
EP3631466A1
(en)
*
|
2017-05-30 |
2020-04-08 |
Abbott Laboratories |
Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i and early biomarkers
|
JP7344801B2
(ja)
*
|
2017-12-09 |
2023-09-14 |
アボット・ラボラトリーズ |
グリア原線維性酸性タンパク質(gfap)及び/又はユビキチンカルボキシ末端ヒドロラーゼl1(uch-l1)を使用する、整形外科損傷を負っており、軽度外傷性脳損傷(tbi)などの頭部への損傷を負ったか又は負った可能性がある対象についての診断及び査定の一助となるための方法
|
EP3721234A1
(en)
*
|
2017-12-09 |
2020-10-14 |
Abbott Laboratories |
Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1
|