|
US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
|
US4366241A
(en)
|
1980-08-07 |
1982-12-28 |
Syva Company |
Concentrating zone method in heterogeneous immunoassays
|
|
US4517288A
(en)
|
1981-01-23 |
1985-05-14 |
American Hospital Supply Corp. |
Solid phase system for ligand assay
|
|
US4702909A
(en)
|
1982-05-05 |
1987-10-27 |
Louisiana State University A & M |
Non-A, non-B hepatitis antigen, antigen compositions, vaccine and diagnostic reagent
|
|
CA1291031C
(en)
|
1985-12-23 |
1991-10-22 |
Nikolaas C.J. De Jaeger |
Method for the detection of specific binding agents and their correspondingbindable substances
|
|
US5231000A
(en)
|
1987-10-08 |
1993-07-27 |
The Mclean Hospital |
Antibodies to A4 amyloid peptide
|
|
US5118606A
(en)
|
1988-09-02 |
1992-06-02 |
The Regents Of The University Of California |
Methods for detecting cellular pathology by assaying spectrin and spectrin breakdown products
|
|
US5234814A
(en)
|
1989-06-01 |
1993-08-10 |
Du Pont Merck Pharmaceutical Company |
Diagnostic assay for alzheimer's disease
|
|
US5118937A
(en)
|
1989-08-22 |
1992-06-02 |
Finnigan Mat Gmbh |
Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules
|
|
US5045694A
(en)
|
1989-09-27 |
1991-09-03 |
The Rockefeller University |
Instrument and method for the laser desorption of ions in mass spectrometry
|
|
WO1991013904A1
(en)
|
1990-03-05 |
1991-09-19 |
Cephalon, Inc. |
Chymotrypsin-like proteases and their inhibitors
|
|
US5586226A
(en)
|
1990-05-16 |
1996-12-17 |
Canon Kabushiki Kaisha |
Control method and device for a unicolor printer
|
|
US5660985A
(en)
*
|
1990-06-11 |
1997-08-26 |
Nexstar Pharmaceuticals, Inc. |
High affinity nucleic acid ligands containing modified nucleotides
|
|
US5637459A
(en)
*
|
1990-06-11 |
1997-06-10 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: chimeric selex
|
|
US5683867A
(en)
|
1990-06-11 |
1997-11-04 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: blended SELEX
|
|
US5496938A
(en)
|
1990-06-11 |
1996-03-05 |
Nexstar Pharmaceuticals, Inc. |
Nucleic acid ligands to HIV-RT and HIV-1 rev
|
|
US5707796A
(en)
|
1990-06-11 |
1998-01-13 |
Nexstar Pharmaceuticals, Inc. |
Method for selecting nucleic acids on the basis of structure
|
|
EP0533838B1
(en)
*
|
1990-06-11 |
1997-12-03 |
NeXstar Pharmaceuticals, Inc. |
Nucleic acid ligands
|
|
US5270163A
(en)
|
1990-06-11 |
1993-12-14 |
University Research Corporation |
Methods for identifying nucleic acid ligands
|
|
US5567588A
(en)
|
1990-06-11 |
1996-10-22 |
University Research Corporation |
Systematic evolution of ligands by exponential enrichment: Solution SELEX
|
|
US6011020A
(en)
*
|
1990-06-11 |
2000-01-04 |
Nexstar Pharmaceuticals, Inc. |
Nucleic acid ligand complexes
|
|
US5252463A
(en)
|
1990-06-22 |
1993-10-12 |
The Du Pont Merck Pharmaceutical Company |
Clipsin, a chymotrypsin-like protease and method of using same
|
|
AU2414092A
(en)
|
1991-08-01 |
1993-03-02 |
Paul H. Voorheis |
Diagnostic method for alzheimer's disease
|
|
EP0664884A4
(en)
|
1992-05-29 |
1997-05-02 |
Univ Rockefeller |
METHOD AND PRODUCT FOR DETERMINING THE SEQUENCE OF PEPTIDES USING A MASS SPECTROMETER.
|
|
US5792664A
(en)
|
1992-05-29 |
1998-08-11 |
The Rockefeller University |
Methods for producing and analyzing biopolymer ladders
|
|
EP1347493A3
(en)
|
1993-05-28 |
2005-11-23 |
Baylor College Of Medicine |
Method and apparatus for desorption and ionization of analytes
|
|
DE4337654C2
(de)
|
1993-11-04 |
1996-08-08 |
Biotest Pharma Gmbh |
Verwendung boviner Kolostralmilch von nicht mit Viren hyperimmunisierten Tieren als Leberschutzpräparat
|
|
US5536639A
(en)
|
1994-03-25 |
1996-07-16 |
Cephalon, Inc. |
Methods for detecting calpain activation by detection of calpain activated spectrin breakdown products
|
|
EP0773991B1
(en)
|
1994-07-15 |
2004-06-09 |
Cephalon, Inc. |
Active calpain expressed by baculovirus
|
|
US5614649A
(en)
|
1994-11-14 |
1997-03-25 |
Cephalon, Inc. |
Multicatalytic protease inhibitors
|
|
US5777194A
(en)
*
|
1995-04-26 |
1998-07-07 |
Cephalon, Inc. |
Gene-targeted mice with humanized Aβ sequence and Swedish FAD mutation
|
|
CZ287488B6
(en)
|
1996-02-02 |
2000-12-13 |
Biotrin Intellectual Pty Ltd |
Method of determining state of liver functions of individual including liver implant recipient
|
|
US6048703A
(en)
*
|
1996-11-15 |
2000-04-11 |
Cephalon, Inc. |
Methods for detecting cell apoptosis
|
|
NZ516848A
(en)
|
1997-06-20 |
2004-03-26 |
Ciphergen Biosystems Inc |
Retentate chromatography apparatus with applications in biology and medicine
|
|
EP1037626A1
(en)
|
1997-12-16 |
2000-09-27 |
Cephalon, Inc. |
Multicatalytic protease inhibitors for use as anti-tumor agents
|
|
US6537749B2
(en)
|
1998-04-03 |
2003-03-25 |
Phylos, Inc. |
Addressable protein arrays
|
|
US6406921B1
(en)
|
1998-07-14 |
2002-06-18 |
Zyomyx, Incorporated |
Protein arrays for high-throughput screening
|
|
EP1112500B1
(en)
|
1998-09-08 |
2004-09-22 |
Innogenetics N.V. |
Tau as a marker for early cns damage
|
|
AU4025300A
(en)
|
1999-03-24 |
2000-10-09 |
Packard Bioscience Company |
Continuous porous matrix arrays
|
|
US6218005B1
(en)
*
|
1999-04-01 |
2001-04-17 |
3M Innovative Properties Company |
Tapes for heat sealing substrates
|
|
US20020002270A1
(en)
|
1999-06-16 |
2002-01-03 |
Raymond P. Zinkowski |
Purified antigen for alzheimer's disease, and methods of obtaining and using same
|
|
US6589746B1
(en)
|
1999-10-21 |
2003-07-08 |
University Of Cincinnati |
Method of detecting axonally-derived protein tau in patients with traumatic CNS injury
|
|
AU2001253020A1
(en)
*
|
2000-03-30 |
2001-10-15 |
Elan Pharmaceuticals, Inc. |
Screening markers and methods for neurodegenerative disorders
|
|
US20050063942A1
(en)
|
2001-02-02 |
2005-03-24 |
Clark Mike A. |
Methods for predicting sensitivity of tumors to arginine deprivation
|
|
US6949377B2
(en)
|
2001-03-05 |
2005-09-27 |
Ho Winston Z |
Chemiluminescence-based microfluidic biochip
|
|
US20030199000A1
(en)
|
2001-08-20 |
2003-10-23 |
Valkirs Gunars E. |
Diagnostic markers of stroke and cerebral injury and methods of use thereof
|
|
US20040203083A1
(en)
|
2001-04-13 |
2004-10-14 |
Biosite, Inc. |
Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
|
|
US20040253637A1
(en)
|
2001-04-13 |
2004-12-16 |
Biosite Incorporated |
Markers for differential diagnosis and methods of use thereof
|
|
WO2003016910A1
(en)
|
2001-08-20 |
2003-02-27 |
Biosite, Inc. |
Diagnostic markers of stroke and cerebral injury and methods of use thereof
|
|
US7713705B2
(en)
|
2002-12-24 |
2010-05-11 |
Biosite, Inc. |
Markers for differential diagnosis and methods of use thereof
|
|
US20020172676A1
(en)
|
2001-05-16 |
2002-11-21 |
George Jackowski |
Method of treatment of alzheimer's disease and device therefor
|
|
US7144708B2
(en)
|
2001-06-25 |
2006-12-05 |
The Cleveland Clinic Foundation |
Markers of blood barrier disruption and methods of using same
|
|
JP2003070498A
(ja)
|
2001-07-19 |
2003-03-11 |
Pharma Design Inc |
ユビキチンカルボキシルターミナルヒドロラーゼl1遺伝子異常の検出方法
|
|
US20030040660A1
(en)
|
2001-08-27 |
2003-02-27 |
George Jackowski |
Method for diagnosing and distinguishing traumatic brain injury and diagnostic devices for use therein
|
|
WO2003032894A2
(en)
|
2001-10-12 |
2003-04-24 |
Pfizer Products Inc. |
Method of monitoring neuroprotective treatment
|
|
WO2003062824A1
(en)
|
2002-01-23 |
2003-07-31 |
Boditech Inc. |
Lateral flow quantitative assay method and strip and laser-induced fluoerescence detection device therefor
|
|
CA2471661A1
(en)
|
2002-01-31 |
2003-08-07 |
Gene Logic, Inc. |
Molecular hepatotoxicology modeling
|
|
EP1495419A2
(en)
|
2002-04-01 |
2005-01-12 |
Phase-1 Molecular Toxicology Inc. |
Liver necrosis predictive genes
|
|
AU2003243563A1
(en)
|
2002-06-12 |
2004-09-28 |
The Cleveland Clinic Foundation |
Markers of blood barrier permeability and methods of using same
|
|
AU2003270509B2
(en)
*
|
2002-09-11 |
2009-03-26 |
University Of Florida |
Analyzing nerve cell damage
|
|
CA2511501A1
(en)
|
2002-12-24 |
2004-07-15 |
Biosite Incorporated |
Markers for differential diagnosis and methods of use thereof
|
|
JP4716517B2
(ja)
|
2003-06-09 |
2011-07-06 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
神経変性疾患を治療する方法
|
|
GB0322063D0
(en)
*
|
2003-09-20 |
2003-10-22 |
Univ Geneve |
Diagnostic method for brain damage-related disorders
|
|
EP2341350B1
(en)
|
2003-09-20 |
2017-11-08 |
Electrophoretics Limited |
Diagnostic method for brain damage-related disorders based on detection of dj-1
|
|
EP1519194A1
(en)
|
2003-09-24 |
2005-03-30 |
Roche Diagnostics GmbH |
Use of gfap for identification of intracerebral hemorrhage
|
|
US20050130226A1
(en)
|
2003-09-26 |
2005-06-16 |
The University Of Cincinnati |
Fully integrated protein lab-on-a-chip with smart microfluidics for spot array generation
|
|
US7794948B2
(en)
|
2003-11-07 |
2010-09-14 |
Vermilllion, Inc. |
Biomarkers for alzheimer's disease
|
|
US20060094064A1
(en)
|
2003-11-19 |
2006-05-04 |
Sandip Ray |
Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids
|
|
US20050112585A1
(en)
|
2003-11-21 |
2005-05-26 |
Dominic Zichi |
Method for adjusting the quantification range of individual analytes in a multiplexed assay
|
|
TWI281473B
(en)
|
2003-12-19 |
2007-05-21 |
Ind Tech Res Inst |
Biomarkers for liver diseases and method for using same
|
|
CA2564609C
(en)
|
2003-12-31 |
2014-02-11 |
President And Fellows Of Harvard College |
Assay device and method
|
|
US8492107B2
(en)
|
2004-04-15 |
2013-07-23 |
University Of Florida Research Foundation, Inc. |
Neural proteins as biomarkers for nervous system injury and other neural disorders
|
|
CA2578680C
(en)
*
|
2004-04-15 |
2011-06-14 |
University Of Florida Research Foundation, Inc. |
Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining
|
|
US20140303041A1
(en)
|
2004-04-15 |
2014-10-09 |
University Of Florida Research Foundation Inc. |
In vitro diagnostic devices for nervous system injury and other neural disorders
|
|
JP4659025B2
(ja)
*
|
2004-04-15 |
2011-03-30 |
ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド |
神経系傷害および他の神経障害についての生物マーカーとしての神経タンパク質
|
|
US20060292558A1
(en)
|
2004-07-19 |
2006-12-28 |
Cell Biosciences Inc. |
Methods and apparatus for protein assay diagnostics
|
|
EP1807208B1
(de)
|
2004-10-15 |
2013-03-20 |
Siemens Aktiengesellschaft |
Anordnung zur integrierten und automatisierten dna- oder protein-analyse in einer einmal verwendbaren cartridge, herstellungsverfahren für eine solche cartridge und betriebsverfahren der dna- oder protein-analyse unter verwendung einer solchen cartridge
|
|
US8048638B2
(en)
|
2005-04-01 |
2011-11-01 |
University Of Florida Research Foundation, Inc. |
Biomarkers of liver injury
|
|
ES2732071T3
(es)
|
2005-04-01 |
2019-11-20 |
Univ Florida |
Biomarcadores de lesiones hepáticas
|
|
GB2428240A
(en)
|
2005-07-14 |
2007-01-24 |
Univ Gen Ve |
Diagnostic method for brain damage-related disorders
|
|
US20070074972A1
(en)
|
2005-09-13 |
2007-04-05 |
Fluidigm Corporation |
Microfluidic assay devices and methods
|
|
WO2007046811A2
(en)
|
2005-10-20 |
2007-04-26 |
Biosite, Inc. |
Diagnostic markers of stroke and cerebral injury and methods of use thereof
|
|
JP5507085B2
(ja)
|
2006-01-12 |
2014-05-28 |
マイクロラボ ピーティーワイ エルティーディー |
新しい計装システム及び方法
|
|
JP5266459B2
(ja)
|
2006-02-15 |
2013-08-21 |
国立大学法人三重大学 |
診断用組換えプロテオリポソームの作製法
|
|
US20070255113A1
(en)
|
2006-05-01 |
2007-11-01 |
Grimes F R |
Methods and apparatus for identifying disease status using biomarkers
|
|
WO2007136617A2
(en)
|
2006-05-18 |
2007-11-29 |
Walter Reed Army Institute Of Research (Wrair) |
Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury
|
|
EP2024395A4
(en)
|
2006-05-26 |
2009-07-01 |
Biosite Inc |
USE OF NATRIURETIC PEPTIDES AS DIAGNOSTIC AND PROGNOSTIC INDICATORS IN VASCULAR DISEASES
|
|
WO2008008819A2
(en)
|
2006-07-11 |
2008-01-17 |
University Of Florida Research Foundation, Inc. |
Diagnosis and treatment of neurological inflammation
|
|
AU2007322252A1
(en)
|
2006-11-01 |
2008-05-29 |
George Mason Intellectual Properties, Inc. |
Biomarkers for neurological conditions
|
|
US8293489B2
(en)
|
2007-01-31 |
2012-10-23 |
Henkin Robert I |
Methods for detection of biological substances
|
|
US20120196307A1
(en)
|
2007-02-06 |
2012-08-02 |
Banyan Biomarkers, Inc. |
Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury
|
|
WO2008097618A1
(en)
|
2007-02-06 |
2008-08-14 |
University Of Florida Research Foundation, Inc. |
Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury
|
|
EP3115785A3
(en)
|
2008-02-04 |
2017-02-22 |
Banyan Biomarkers, Inc. |
Process to diagnose or treat brain injury
|
|
WO2009129476A2
(en)
|
2008-04-17 |
2009-10-22 |
Banyan Biomarkers, Inc. |
An antibody bound synthetic vesicle containing active agent molecules
|
|
EP2143735A1
(en)
|
2008-07-10 |
2010-01-13 |
Institut Pasteur |
Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
|
|
US20140342381A1
(en)
|
2008-08-11 |
2014-11-20 |
Banyan Biomarkers, Inc. |
Devices and methods for biomarker detection process and assay of neurological condition
|
|
NO2324360T3
(enExample)
*
|
2008-08-11 |
2018-06-30 |
|
|
|
AU2009292959B2
(en)
|
2008-09-19 |
2016-02-25 |
Henry Ford Health System |
Methods, systems, and compositions for calpain inhibition
|
|
US20120094295A1
(en)
|
2008-11-21 |
2012-04-19 |
The Johns Hopkins University |
Neurodegenerative disease diagnostic compositions and methods of use
|
|
US20170315136A9
(en)
|
2009-06-19 |
2017-11-02 |
Banyan Biomarkers, Inc. |
Biomarker assay of neurological condition
|
|
CA2766057A1
(en)
|
2009-06-19 |
2010-12-23 |
Banyan Biomarkers, Inc. |
Biomarker assay of neurological condition
|
|
WO2011011334A2
(en)
|
2009-07-18 |
2011-01-27 |
Banyan Biomarkers, Inc. |
SYNERGISTIC BIOMARKER ASSAY OF NEUROLGICAL CONDITION USING S-100β
|
|
ES2687469T3
(es)
|
2009-09-14 |
2018-10-25 |
Banyan Biomarkers, Inc. |
Marcadores autoanticuerpos para el diagnóstico de traumatismo craneoencefálico
|
|
US9682132B2
(en)
|
2010-01-26 |
2017-06-20 |
Banyan Biomarkers, Inc |
Compositions and methods relating to argininosucccinate synthetase
|
|
EP2553466A4
(en)
|
2010-04-01 |
2013-10-16 |
Banyan Biomarkers Inc |
MARKERS AND ASSAYS FOR DETECTING NEUROTOXICITY
|
|
WO2011160096A2
(en)
|
2010-06-17 |
2011-12-22 |
Banyan Biomarkers, Inc. |
Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as biomarkers of neural injury or neurological disorder or condition
|
|
EP2628013B1
(en)
|
2010-10-14 |
2019-06-12 |
The Johns Hopkins University |
Biomarkers of brain injury
|
|
AU2012308305B2
(en)
|
2011-09-14 |
2017-11-23 |
Banyan Biomarkers, Inc. |
Processes and kits to detect and monitor for diagnostic biomarkers for post traumatic stress disorder (PTSD) and to differentiate between suicidal and non-suicidal form of the disorder
|
|
US20140018299A1
(en)
|
2012-07-10 |
2014-01-16 |
Banyan Biomarkers, Inc. |
Method and device to detect, monitor and promote neural regeneration and improvement of cognitive function in a subject suffering from neural injury
|
|
US20140024053A1
(en)
|
2012-07-20 |
2014-01-23 |
Banyan Biomarkers, Inc. |
Methods, kits and devices for detecting bii-spectrin, and breakdown products thereof, as biomarkers for the diagnosis of neural injury
|
|
US20140275294A1
(en)
|
2013-03-15 |
2014-09-18 |
Banyan Biomarkers, Inc. |
Devices and methods for biomarker detection process and assay of liver injury
|
|
US20150141528A1
(en)
|
2013-05-31 |
2015-05-21 |
Banyan Biomarkers, Inc. |
Neural specific s100b for biomarker assays and devices for detection of a neurological condition
|
|
CA2943396A1
(en)
|
2014-04-07 |
2015-10-15 |
Iron Horse Diagnostics, Inc. |
Traumatic brain injury and neurodegenerative biomarkers, methods, and systems
|
|
CN106605146B
(zh)
|
2014-04-08 |
2020-07-28 |
佛罗里达大学研究基金会有限公司 |
用于中枢神经系统的急性、亚急性和慢性创伤性损伤的蛋白质标志物
|
|
WO2018081649A1
(en)
|
2016-10-28 |
2018-05-03 |
Banyan Biomarkers, Inc. |
Antibodies to ubiquitin c-terminal hydrolase l1 (uch-l1) and glial fibrillary acidic protein (gfap) and related methods
|
|
CN110546513A
(zh)
*
|
2017-04-15 |
2019-12-06 |
雅培实验室 |
使用早期生物标记物帮助超急性诊断和确定人类受试者中的创伤性脑损伤的方法
|
|
CN110603449A
(zh)
*
|
2017-04-28 |
2019-12-20 |
雅培实验室 |
用同一人受试者的至少两种样品的早期生物标记物帮助超急性诊断确定创伤性脑损伤的方法
|
|
US10849548B2
(en)
*
|
2017-05-30 |
2020-12-01 |
Abbott Laboratories |
Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin I and early biomarkers
|
|
US11022617B2
(en)
*
|
2017-12-09 |
2021-06-01 |
Abbott Laboratories |
Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (TBI), using glial fibrillary acidic protein (GFAP) and/or ubiquitin carboxy-terminal hydrolase L1 (UCH-L1)
|
|
CA3067055A1
(en)
*
|
2017-12-09 |
2019-06-13 |
Abbott Laboratories |
Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1
|