NO20081789L - Substituert sykloalkenderivat - Google Patents

Substituert sykloalkenderivat

Info

Publication number
NO20081789L
NO20081789L NO20081789A NO20081789A NO20081789L NO 20081789 L NO20081789 L NO 20081789L NO 20081789 A NO20081789 A NO 20081789A NO 20081789 A NO20081789 A NO 20081789A NO 20081789 L NO20081789 L NO 20081789L
Authority
NO
Norway
Prior art keywords
substituted
group
integer
ring
hydrogen atom
Prior art date
Application number
NO20081789A
Other languages
English (en)
Inventor
Nobuyuki Ohkawa
Takayoshi Nagasaki
Tomio Kimura
Atsuhiro Sugidachi
Osamu Ando
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of NO20081789L publication Critical patent/NO20081789L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/50—Spiro compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)

Abstract

som har en virkning ved å undertrykke intracellulær signaloverføring eller celleaktivering forårsaket av endotoksin og en cellerespons, slik som overproduksjon av en inflammatorisk mediator forårsaket av dem, et farmakologisk akseptabelt salt derav, en fremgangsmåte for fremstilling av de samme, og et farmasøytisk preparat som inneholder sykloalkenderivatet som en aktiv bestanddel, som er utmerket ved forebyggelse og/eller behandling av en slik sykdom som blodforgiftning (septisk sjokk, disseminert intravaskulær koagulasjon, multippel organsvikt eller lignende). Generell formel (I): I formelen er X og Y en gruppe som danner ringen A sammen med karbonatomet i ringen B som X og Y er bundet til, eller lignende; 1 og m er uavhengig av hverandre et helt tall på 0-3; 1 + m er 1-3; R1 er en alifatisk hydrokarbongruppe som kan være substituert, eller lignende; n er et helt tall på 0-3; R er et hydrogenatom, en alkylgruppe som kan være substituert, eller lignende; R3 er en fenylgruppe som kan være substituert, eller lignende; og R5 er et hydrogenatom, en alkylgruppe som kan være substituert, eller lignende.
NO20081789A 2005-09-14 2008-04-11 Substituert sykloalkenderivat NO20081789L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005267504 2005-09-14
PCT/JP2006/318103 WO2007032362A1 (ja) 2005-09-14 2006-09-13 置換シクロアルケン誘導体

Publications (1)

Publication Number Publication Date
NO20081789L true NO20081789L (no) 2008-06-12

Family

ID=37864954

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081789A NO20081789L (no) 2005-09-14 2008-04-11 Substituert sykloalkenderivat

Country Status (17)

Country Link
US (2) US7935835B2 (no)
EP (1) EP1935879B1 (no)
JP (1) JP4195074B2 (no)
KR (1) KR101327610B1 (no)
CN (1) CN101309900B (no)
AU (1) AU2006289921B2 (no)
BR (1) BRPI0615932A2 (no)
CA (1) CA2622694C (no)
IL (1) IL190063A (no)
MX (1) MX2008003759A (no)
MY (1) MY146284A (no)
NO (1) NO20081789L (no)
NZ (1) NZ567269A (no)
RU (1) RU2386613C2 (no)
TW (1) TWI387453B (no)
WO (1) WO2007032362A1 (no)
ZA (1) ZA200802382B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5778161B2 (ja) * 2010-09-24 2015-09-16 第一三共株式会社 置換シクロアルケン誘導体の結晶
EP3296296A4 (en) * 2015-05-08 2019-01-09 Takeda Pharmaceutical Company Limited CYCLIC CONNECTION
CA2985325C (en) * 2015-05-08 2023-09-26 Takeda Pharmaceutical Company Limited Cyclic compounds for inhibition of toll-like receptor 4
BR112019004520A2 (pt) 2016-09-09 2019-05-28 Takeda Pharmaceuticals Co composto, medicamento, métodos para inibição de um receptor toll-like 4 e para prevenção ou tratamento de uma doença, e, uso do composto.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4497954A (en) * 1983-11-15 1985-02-05 Riker Laboratories, Inc. Cyclopentanone derivatives
US5001144A (en) * 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
HRP940124A2 (en) * 1994-02-21 1997-10-31 Pliva Pharm & Chem Works Novel sulfonamidodioxepanes, methods of preparation, intermediates, salts and the use thereof
CA2320467C (en) * 1998-03-09 2010-05-04 Takeda Chemical Industries, Ltd. Cycloalkene derivatives, their production and use
EP2298311B1 (en) 1999-01-13 2012-05-09 Bayer HealthCare LLC w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
JP4108260B2 (ja) 1999-08-06 2008-06-25 武田薬品工業株式会社 置換芳香環化合物、その製造法および用途
AU1553001A (en) 1999-11-29 2001-06-12 Takeda Chemical Industries Ltd. Process for the production of optically active cyclohexene derivatives and intermediates therefor
WO2002013816A1 (fr) * 2000-08-10 2002-02-21 Takeda Chemical Industries, Ltd. Composition pharmaceutique
JP2004002370A (ja) 2002-04-08 2004-01-08 Takeda Chem Ind Ltd 重症セプシス予防治療剤
EP2039681A4 (en) 2006-07-07 2009-10-28 Takeda Pharmaceutical CYCLOALKENE DERIVATIVES, PROCESS FOR PRODUCTION OF DERIVATIVES, AND USE THEREOF

Also Published As

Publication number Publication date
USRE43858E1 (en) 2012-12-11
TW200745002A (en) 2007-12-16
BRPI0615932A2 (pt) 2011-05-31
KR20080043846A (ko) 2008-05-19
EP1935879A4 (en) 2011-07-06
CN101309900B (zh) 2015-04-22
NZ567269A (en) 2010-06-25
MY146284A (en) 2012-07-31
CN101309900A (zh) 2008-11-19
JP4195074B2 (ja) 2008-12-10
RU2386613C2 (ru) 2010-04-20
AU2006289921B2 (en) 2010-11-18
AU2006289921A1 (en) 2007-03-22
WO2007032362A1 (ja) 2007-03-22
IL190063A0 (en) 2008-08-07
US7935835B2 (en) 2011-05-03
EP1935879A1 (en) 2008-06-25
US20090233952A1 (en) 2009-09-17
CA2622694C (en) 2011-02-08
ZA200802382B (en) 2009-06-24
EP1935879B1 (en) 2016-05-11
IL190063A (en) 2015-10-29
RU2008114340A (ru) 2009-10-20
TWI387453B (zh) 2013-03-01
CA2622694A1 (en) 2007-03-22
JPWO2007032362A1 (ja) 2009-03-19
KR101327610B1 (ko) 2013-11-12
MX2008003759A (es) 2008-09-12

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