NO20080629L - Tiazolderivater som AMPK-aktiverere - Google Patents
Tiazolderivater som AMPK-aktiverereInfo
- Publication number
- NO20080629L NO20080629L NO20080629A NO20080629A NO20080629L NO 20080629 L NO20080629 L NO 20080629L NO 20080629 A NO20080629 A NO 20080629A NO 20080629 A NO20080629 A NO 20080629A NO 20080629 L NO20080629 L NO 20080629L
- Authority
- NO
- Norway
- Prior art keywords
- thiazole derivatives
- ampk activators
- activators
- ampk
- monophosphate
- Prior art date
Links
- 239000012190 activator Substances 0.000 title abstract 2
- 150000007979 thiazole derivatives Chemical class 0.000 title abstract 2
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 title 1
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 title 1
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 abstract 1
- 229950006790 adenosine phosphate Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN870CH2005 | 2005-07-04 | ||
| PCT/US2006/025898 WO2007005785A1 (en) | 2005-07-04 | 2006-06-30 | Thiazoles derivatives as ampk activator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20080629L true NO20080629L (no) | 2008-02-19 |
Family
ID=37604805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080629A NO20080629L (no) | 2005-07-04 | 2008-02-04 | Tiazolderivater som AMPK-aktiverere |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8080668B2 (ja) |
| EP (1) | EP1907369A4 (ja) |
| JP (1) | JP2009500351A (ja) |
| CN (1) | CN101273022A (ja) |
| AU (1) | AU2006265675A1 (ja) |
| BR (1) | BRPI0613555A2 (ja) |
| CA (1) | CA2614098A1 (ja) |
| EA (1) | EA200800240A1 (ja) |
| IL (1) | IL188398A0 (ja) |
| NO (1) | NO20080629L (ja) |
| WO (1) | WO2007005785A1 (ja) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007002461A1 (en) * | 2005-06-23 | 2007-01-04 | Dr. Reddy's Laboratories Ltd. | 3,4-substituted thiazoles as ampk activators |
| JP2009501775A (ja) * | 2005-07-21 | 2009-01-22 | ベタゲノン・エイビー | 癌治療におけるチアゾール誘導体およびアナログの使用 |
| US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
| WO2010036613A1 (en) * | 2008-09-26 | 2010-04-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| CA2741125A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| CN102271509A (zh) * | 2008-10-31 | 2011-12-07 | 默沙东公司 | 用于抗糖尿病药的新型环苯并咪唑衍生物 |
| JP2013047189A (ja) * | 2009-12-25 | 2013-03-07 | Kyorin Pharmaceutical Co Ltd | 新規パラバン酸誘導体及びそれらを有効成分とする医薬 |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| EP2552435A1 (en) | 2010-04-02 | 2013-02-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1) |
| JP2013230986A (ja) * | 2010-08-25 | 2013-11-14 | Kyorin Pharmaceutical Co Ltd | 新規ヒダントイン誘導体及びそれらを有効成分とする医薬 |
| US9005909B2 (en) | 2011-01-06 | 2015-04-14 | Rigel Pharmaceuticals, Inc. | Whole blood assay for measuring AMPK activation |
| EP2677869B1 (en) | 2011-02-25 | 2017-11-08 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| EP2683690A1 (en) * | 2011-03-07 | 2014-01-15 | GlaxoSmithKline LLC | Quinolinone derivatives |
| CN104159697B (zh) | 2011-07-05 | 2017-02-15 | 伊雷克托科学工业股份有限公司 | 在使用过程中为声光射束偏转器和声光调制器提供温度稳定性的系统和方法 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| EP2882726A4 (en) * | 2012-08-09 | 2016-04-06 | Neuropore Therapies Inc | ARYL AND HETEROARYL-SUBSTITUTED BENZENE DERIVATIVES AS MODULATORS OF PI-3 KINASE SIGNALING PATHWAYS |
| EP2888008B1 (en) | 2012-08-22 | 2018-12-26 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole tetrahydrofuran derivatives |
| BR112015003109A2 (pt) | 2012-08-22 | 2017-08-15 | Merck Sharp & Dohme | Composto, composição, uso de um composto, e, métodos para tratar ou prevenir um distúrbio, condição ou doença e para tratar diabetes mellitus tipo 2. |
| EP2906040B1 (en) | 2012-08-22 | 2021-02-17 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydropyran derivatives |
| EP2887807B1 (en) | 2012-08-22 | 2019-09-18 | Merck Sharp & Dohme Corp. | Benzimidazole hexahydrofuro[3,2-b]furan derivatives useful as amp-activated protein kinase activators |
| US9382243B2 (en) | 2012-08-22 | 2016-07-05 | Merck Sharp & Dohme Corp. | Azabenzimidazole tetrahydropyran derivatives |
| WO2014031441A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydrofuran derivatives |
| EP2970119B1 (en) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2922703A1 (en) * | 2013-08-29 | 2015-03-05 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic and body weight related disorders |
| WO2017055925A2 (en) | 2015-09-30 | 2017-04-06 | Instituto De Medicina Molecular | Methods for attenuating parasite virulence |
| EP3478297A1 (en) | 2016-06-30 | 2019-05-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cardiomyopathies |
| CN111372579B (zh) | 2017-10-30 | 2023-08-22 | 神经孔疗法股份有限公司 | 取代的苯基磺酰基苯基三唑硫酮和其用途 |
| WO2020201263A1 (en) | 2019-04-01 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling |
| JP7493835B2 (ja) * | 2019-11-06 | 2024-06-03 | アルベルト・アインシュタイン・カレッジ・オブ・メディシン | 小分子プロスタグラジン輸送阻害剤 |
| JP2023544026A (ja) | 2020-09-30 | 2023-10-19 | バイオベラティブ セラピューティクス インコーポレイテッド | Ａｍｐｋ活性化因子及びその使用方法 |
| WO2022106892A1 (en) | 2020-11-17 | 2022-05-27 | Instituto De Medicina Molecular | Anti-malarial compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025528A (en) * | 1973-10-24 | 1977-05-24 | Shionogi & Co., Ltd. | Thiazole derivatives of benzoic and phenylalkanoic acids |
| FR2581063B1 (fr) * | 1985-04-30 | 1987-07-17 | Chauvin Blache Lab | Amino-2 thiazoles n-substitues, leur procede de preparation et leur application en therapeutique |
| CA2272285C (en) * | 1997-01-23 | 2006-11-21 | Yamanouchi Pharmaceutical Co., Ltd. | Amide derivatives and medicinal compositions thereof |
| US7119205B2 (en) * | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
| BRPI0417376A (pt) | 2003-12-08 | 2007-04-10 | Hoffmann La Roche | compostos, processo para a manufatura dos mesmos, composições farmacêuticas que os compreendem, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com a modulação de receptores de cb1 e sua utilização |
| AU2005311251A1 (en) | 2004-12-01 | 2006-06-08 | Devgen Nv | 5-carboxamido substituted thiazole derivatives that interact with ion channels, in particular with ion channels from the Kv family |
| MX2007008434A (es) * | 2005-01-19 | 2007-07-25 | Squibb Bristol Myers Co | Derivados de 2-fenoxi-n-(1,3,4-tiadizol-2il)piridin-3-amina y compuestos relacionados como inhibidores del receptor p2y1 para el tratamiento de trastornos tromboembolicos. |
-
2006
- 2006-06-30 CA CA002614098A patent/CA2614098A1/en not_active Abandoned
- 2006-06-30 CN CNA2006800314604A patent/CN101273022A/zh active Pending
- 2006-06-30 US US11/480,032 patent/US8080668B2/en not_active Expired - Fee Related
- 2006-06-30 EP EP06774435A patent/EP1907369A4/en not_active Withdrawn
- 2006-06-30 JP JP2008519672A patent/JP2009500351A/ja active Pending
- 2006-06-30 EA EA200800240A patent/EA200800240A1/ru unknown
- 2006-06-30 WO PCT/US2006/025898 patent/WO2007005785A1/en active Application Filing
- 2006-06-30 AU AU2006265675A patent/AU2006265675A1/en not_active Abandoned
- 2006-06-30 BR BRPI0613555-2A patent/BRPI0613555A2/pt not_active Application Discontinuation
-
2007
- 2007-12-25 IL IL188398A patent/IL188398A0/en unknown
-
2008
- 2008-02-04 NO NO20080629A patent/NO20080629L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007005785B1 (en) | 2007-03-22 |
| CA2614098A1 (en) | 2007-01-11 |
| EP1907369A4 (en) | 2009-07-22 |
| EA200800240A1 (ru) | 2008-06-30 |
| WO2007005785A1 (en) | 2007-01-11 |
| JP2009500351A (ja) | 2009-01-08 |
| IL188398A0 (en) | 2008-08-07 |
| EP1907369A1 (en) | 2008-04-09 |
| AU2006265675A1 (en) | 2007-01-11 |
| US8080668B2 (en) | 2011-12-20 |
| US20070015665A1 (en) | 2007-01-18 |
| CN101273022A (zh) | 2008-09-24 |
| BRPI0613555A2 (pt) | 2011-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |