NO20063574L - C1-symmetriske bisfosfin-ligander og deres anvendelse i assymetrisk syntese av pre-gabalin - Google Patents

C1-symmetriske bisfosfin-ligander og deres anvendelse i assymetrisk syntese av pre-gabalin

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Publication number
NO20063574L
NO20063574L NO20063574A NO20063574A NO20063574L NO 20063574 L NO20063574 L NO 20063574L NO 20063574 A NO20063574 A NO 20063574A NO 20063574 A NO20063574 A NO 20063574A NO 20063574 L NO20063574 L NO 20063574L
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NO
Norway
Prior art keywords
gabaline
asymmetric synthesis
bisphosphine ligands
symmetric bisphosphine
symmetric
Prior art date
Application number
NO20063574A
Other languages
English (en)
Inventor
Vladimir Genukh Beylin
Jian Bao
Derek Joseph Greene
Garrett Hoge
William Kissel
Mark Eugene Marlatt
Derek Andrew Pflum
He Ping Wu
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34961258&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20063574(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO20063574L publication Critical patent/NO20063574L/no

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22Organic complexes
    • B01J31/2282Unsaturated compounds used as ligands
    • B01J31/2295Cyclic compounds, e.g. cyclopentadienyls
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00Asymmetric syntheses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30Preparation of optical isomers
    • C07C227/32Preparation of optical isomers by stereospecific synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/16Preparation of optical isomers
    • C07C231/18Preparation of optical isomers by stereospecific synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/50Organo-phosphines
    • C07F9/5027Polyphosphines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/50Organo-phosphines
    • C07F9/5045Complexes or chelates of phosphines with metallic compounds or metals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/50Organo-phosphines
    • C07F9/53Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5329Polyphosphine oxides or thioxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5463Compounds of the type "quasi-phosphonium", e.g. (C)a-P-(Y)b wherein a+b=4, b>=1 and Y=heteroatom, generally N or O
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60Reduction reactions, e.g. hydrogenation
    • B01J2231/64Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82Metals of the platinum group
    • B01J2531/822Rhodium
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Det beskrives materiale og fremgangsmåter for å fremstille (S)-(+)-3-(aminometyl)-5-metyl-heksanoisk syre og strukturelt beslektede forbindelser via enantioselektiv hydrogenering av prokirale olefiner. Fremgangsmåtene benytter nye kirale katalysatorer, som inkluderer C1-symmetriske bifosfinligander bundet til transisjonsmetaller.
NO20063574A 2004-03-12 2006-08-07 C1-symmetriske bisfosfin-ligander og deres anvendelse i assymetrisk syntese av pre-gabalin NO20063574L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55258604P 2004-03-12 2004-03-12
US58651204P 2004-07-09 2004-07-09
PCT/IB2005/000642 WO2005087370A1 (en) 2004-03-12 2005-03-09 C1-symmetric bisphosphine ligands and their use in the asymmetric synthesis of pregabalin

Publications (1)

Publication Number Publication Date
NO20063574L true NO20063574L (no) 2006-09-05

Family

ID=34961258

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063574A NO20063574L (no) 2004-03-12 2006-08-07 C1-symmetriske bisfosfin-ligander og deres anvendelse i assymetrisk syntese av pre-gabalin

Country Status (21)

Country Link
US (2) US20050228190A1 (no)
EP (1) EP1727620B1 (no)
JP (1) JP2007528893A (no)
KR (2) KR100847922B1 (no)
AR (1) AR051533A1 (no)
AT (1) ATE371496T1 (no)
AU (1) AU2005221401A1 (no)
BR (1) BRPI0508615A (no)
CA (1) CA2559086A1 (no)
CY (1) CY1106877T1 (no)
DE (1) DE602005002253T2 (no)
DK (1) DK1727620T3 (no)
ES (1) ES2292107T3 (no)
IL (1) IL177482A0 (no)
NO (1) NO20063574L (no)
NZ (1) NZ549004A (no)
PL (1) PL1727620T3 (no)
PT (1) PT1727620E (no)
RU (1) RU2335342C2 (no)
TW (1) TWI299990B (no)
WO (1) WO2005087370A1 (no)

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KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
CN101160281A (zh) 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
WO2006110783A2 (en) * 2005-04-11 2006-10-19 Teva Pharmaceutical Industries Ltd. Process for making (s)-pregabalin
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
JP2008505980A (ja) 2005-05-10 2008-02-28 テバ ファーマシューティカル インダストリーズ リミティド イソブチルグルタル酸を有さないプレガバリン及びその調製方法
ATE486841T1 (de) * 2005-05-10 2010-11-15 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
CA2604624A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
EP1841726B1 (en) * 2005-09-19 2012-10-31 Teva Pharmaceutical Industries Ltd An asymmetric synthesis of (s)-(+)-3-(aminomethyl)-5-methylhexanoic acid
WO2007127309A2 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
TW200815323A (en) * 2006-05-24 2008-04-01 Teva Pharma Processes for the preparation of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof
BRPI0702897A2 (pt) * 2006-05-31 2011-03-15 Teva Pharmaceutical Ind Ltda processo para preparar um intermediário de pregabalina
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
GB0700622D0 (en) * 2007-01-12 2007-02-21 Johnson Matthey Plc Process for preparing cationic rhodium complexes
BRPI0803092A2 (pt) * 2007-03-22 2011-08-30 Teva Pharma sìntese de (s)-(+)-3-(aminometil)-5-metil ácido hexanóico, (s)-pregabalina
US20090137842A1 (en) * 2007-10-03 2009-05-28 Vollerner Yuri Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
WO2009141362A2 (en) 2008-05-21 2009-11-26 Sandoz Ag Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
GB0812290D0 (en) * 2008-07-04 2008-08-13 Johnson Matthey Plc Process for preparing cationic rhodium complexes
JP5750449B2 (ja) 2009-11-05 2015-07-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規キラルリンリガンド
US20120309997A1 (en) 2010-02-12 2012-12-06 Enantia, S.L. Enantiomerically Enriched Aminodiphosphines as Ligands for the Preparation of Catalysts for Asymmetric Synthesis
GB201103092D0 (en) * 2011-02-23 2011-04-06 Univ Dublin Process
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2018106746A2 (en) 2016-12-06 2018-06-14 Boehringer Ingelheim International Gmbh Novel chiral dihydrobenzooxaphosphole ligands and synthesis thereof
US10196413B2 (en) 2016-12-06 2019-02-05 Boehringer Ingelheim International Gmbh Chiral dihydrobenzoazaphosphole ligands and synthesis thereof
JP6949903B2 (ja) 2019-06-24 2021-10-13 日本化学工業株式会社 光学活性ビスホスフィノメタン及びその製造方法、並びに遷移金属錯体及び不斉触媒
CN111647020A (zh) * 2020-04-09 2020-09-11 宁波赜军医药科技有限公司 一种膦氧双齿配体的合成方法

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Also Published As

Publication number Publication date
NZ549004A (en) 2009-04-30
KR20060118603A (ko) 2006-11-23
KR100823758B1 (ko) 2008-04-21
RU2006132505A (ru) 2008-03-27
BRPI0508615A (pt) 2007-07-31
ES2292107T3 (es) 2008-03-01
EP1727620B1 (en) 2007-08-29
AR051533A1 (es) 2007-01-24
DE602005002253D1 (de) 2007-10-11
KR100847922B1 (ko) 2008-07-22
IL177482A0 (en) 2006-12-10
EP1727620A1 (en) 2006-12-06
CA2559086A1 (en) 2005-09-22
TWI299990B (en) 2008-08-21
DK1727620T3 (da) 2007-12-03
US20090124820A1 (en) 2009-05-14
US20050228190A1 (en) 2005-10-13
KR20070074671A (ko) 2007-07-12
PT1727620E (pt) 2007-11-05
WO2005087370A1 (en) 2005-09-22
RU2335342C2 (ru) 2008-10-10
ATE371496T1 (de) 2007-09-15
AU2005221401A1 (en) 2005-09-22
DE602005002253T2 (de) 2008-05-29
PL1727620T3 (pl) 2007-12-31
TW200600090A (en) 2006-01-01
CY1106877T1 (el) 2012-09-26
JP2007528893A (ja) 2007-10-18

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