NO20063381L - CB1 modulatorforbindelser - Google Patents

CB1 modulatorforbindelser

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Publication number
NO20063381L
NO20063381L NO20063381A NO20063381A NO20063381L NO 20063381 L NO20063381 L NO 20063381L NO 20063381 A NO20063381 A NO 20063381A NO 20063381 A NO20063381 A NO 20063381A NO 20063381 L NO20063381 L NO 20063381L
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NO
Norway
Prior art keywords
compounds
treatment
useful
disorders
suppression
Prior art date
Application number
NO20063381A
Other languages
English (en)
Inventor
Jr Winton Dennis Jones
Jennifer Rebecca Allen
Albert Kudzovi Amegadzie
Kevin Matthew Gardinier
George Stuart Gregory
Steven Andrew Hitchcock
Paul J Hoogestraat
Daryl Lynn Smith
Original Assignee
Lilly Co Eli
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Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20063381L publication Critical patent/NO20063381L/no

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

Nye forbindelser med strukturformel (I). er beskrevet. Sommodulatoreravcannabinoid-1 (CB1) reseptoren er disse forbindelsene anvendelige ved behandling, hindring eller undertrykking av sykdommer mediert av CB1 reseptoren. Som sådan er forbindelsene i følge oppfinnelsen anvendelige ved behandling, hindring eller undertrykking av psykose, hukommelsessvikt, kognitiv forstyrrelse, migrene, neuropati, neuroinflammasjon forstyrrelser (for eksempel multipell sklerose, Guillain-Barre syndrom og inflammasjons følgeskader av viral encefalititt), cerebrale vaskulære ulykker, hodetraume, angstforstyrrelse, stress, epilepsi, Parkinsons sykdom og schizofreni. Forbindelsene er også anvendelige ved behandling av substansmisbmk forstyrrelser, særlig av opiater, alkohol og nikotin. Forbindelsene er også anvendelige for behandling av fedme eller spiseforstyrrelser assosiert med for stort matinntak og komplikasjoner assosiert dermed.
NO20063381A 2003-12-23 2006-07-21 CB1 modulatorforbindelser NO20063381L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53224703P 2003-12-23 2003-12-23
PCT/US2004/039763 WO2005066126A1 (en) 2003-12-23 2004-12-13 Cb1 modulator compounds

Publications (1)

Publication Number Publication Date
NO20063381L true NO20063381L (no) 2006-09-20

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Family Applications (1)

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NO20063381A NO20063381L (no) 2003-12-23 2006-07-21 CB1 modulatorforbindelser

Country Status (17)

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US (2) US7276516B2 (no)
EP (1) EP1699761B1 (no)
JP (1) JP2007519631A (no)
AR (1) AR047160A1 (no)
AT (1) ATE502009T1 (no)
AU (1) AU2004312311A1 (no)
BR (1) BRPI0418079A (no)
CA (1) CA2549396A1 (no)
DE (1) DE602004031875D1 (no)
ES (1) ES2360112T3 (no)
IL (1) IL176069A0 (no)
NO (1) NO20063381L (no)
PE (1) PE20050598A1 (no)
SV (1) SV2005001984A (no)
TW (1) TW200522944A (no)
WO (1) WO2005066126A1 (no)
ZA (1) ZA200605159B (no)

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AU2004312311A1 (en) 2005-07-21
ATE502009T1 (de) 2011-04-15
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CA2549396A1 (en) 2005-07-21
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US20070088018A1 (en) 2007-04-19
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