NO20060977L - Mitokinon-derivater anvendt som mitokondrielle malsokende antioksidanter - Google Patents
Mitokinon-derivater anvendt som mitokondrielle malsokende antioksidanterInfo
- Publication number
- NO20060977L NO20060977L NO20060977A NO20060977A NO20060977L NO 20060977 L NO20060977 L NO 20060977L NO 20060977 A NO20060977 A NO 20060977A NO 20060977 A NO20060977 A NO 20060977A NO 20060977 L NO20060977 L NO 20060977L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- mitokinone
- mitochondrial
- seeking
- antioxidants
- Prior art date
Links
- 239000003963 antioxidant agent Substances 0.000 title abstract 2
- 230000002438 mitochondrial effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002552 dosage form Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 abstract 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical class C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
Abstract
Foreliggende oppfinnelse angår farmasøytisk akseptable amfifile antioksidantforbindelser, sammensetninger og doseringsformer omfattende nevnte forbindelser, og fremgangsmåter og anvendelser basert på nevnte forbindelser. De eksemplifiserte forbindelsene er alle mitokinon-derivater, og er metoksyfenylalkyltrifenylfosfonium- eller metoksydioksocykloheksadienalkyltrifenylfosfonium-derivater. Forbindelsene, sammensetningene, doseringsformene, anvendelsene og fremgangsmåtene er for eksempel anvendelige i behandling av sykdommer eller tilstander assosiert med oksidativt stress.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ52780003 | 2003-08-22 | ||
NZ52915303 | 2003-10-23 | ||
NZ53355604 | 2004-06-14 | ||
PCT/NZ2004/000196 WO2005019232A1 (en) | 2003-08-22 | 2004-08-23 | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20060977L true NO20060977L (no) | 2006-05-19 |
NO337925B1 NO337925B1 (no) | 2016-07-11 |
Family
ID=34222195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20060977A NO337925B1 (no) | 2003-08-22 | 2006-02-28 | Antioksidantforbindelse samt anvendelse og fremstilling derav, farmasøytisk sammensetning, og fremgangsmåte for redusering av oksidativt stress i en celle in vitro |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1664069B8 (no) |
KR (1) | KR100974202B1 (no) |
AU (1) | AU2004266988B2 (no) |
BR (1) | BRPI0413742B8 (no) |
CA (1) | CA2536546C (no) |
NO (1) | NO337925B1 (no) |
RU (1) | RU2487880C2 (no) |
WO (2) | WO2005019233A1 (no) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
SG145715A1 (en) | 2003-08-22 | 2008-09-29 | Antipodean Pharmaceuticals Inc | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
US20070225255A1 (en) * | 2004-07-13 | 2007-09-27 | Eleonore Frohlich | Use of Mitochondrially Targeted Antioxidant in the Treatment of Liver Diseases and Epithelial Cancers |
ES2714900T3 (es) | 2005-06-01 | 2019-05-30 | Bioelectron Tech Corp | Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos |
RU2318500C2 (ru) * | 2005-10-18 | 2008-03-10 | Общество С Ограниченной Ответственностью "Митотехнология" | Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели |
WO2007100652A2 (en) | 2006-02-22 | 2007-09-07 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
JP5616798B2 (ja) * | 2008-03-14 | 2014-10-29 | スティーブン・ジョン・ラルフStephen John RALPH | ミトコンドリア由来の抗ガン化合物 |
CN102046178B (zh) * | 2008-04-01 | 2013-05-08 | 安蒂博汀医药公司 | 用于皮肤护理的组合物和方法 |
LT3827815T (lt) | 2008-09-10 | 2023-10-10 | Ptc Therapeutics, Inc. | Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais |
ES2634423T3 (es) * | 2008-10-06 | 2017-09-27 | Elizabeth Arden International, Sarl | Tratamientos para la piel que contienen derivados de idebenona sustituidos con ácido carboxílico y métodos de preparación y utilización de los mismos |
WO2011108946A1 (en) * | 2010-03-04 | 2011-09-09 | Androgenix Ltd | Methods for improving sperm functionality |
RU2527519C2 (ru) * | 2010-06-24 | 2014-09-10 | Общество С Ограниченной Ответственностью "Митотех" | Мягкие катионные митохондриальные разобщители |
EP2750662A4 (en) | 2011-08-31 | 2015-06-24 | Univ Georgia | NANOPARTICLES TARGETING APOPTOSIS |
US9434753B2 (en) | 2011-09-19 | 2016-09-06 | Gencia Corporation | Modified creatine compounds |
US10806703B2 (en) | 2012-01-20 | 2020-10-20 | Lts Lohmann Therapie-System Ag | Transmucosal administration system for a pharmaceutical drug |
ES2669561T3 (es) | 2012-02-17 | 2018-05-28 | University Of Georgia Research Foundation, Inc. | Nanopartículas para el transporte mitocondrial de agentes |
WO2015138992A1 (en) | 2014-03-14 | 2015-09-17 | University Of Georgia Research Foundation, Inc. | Mitochondrial delivery of 3-bromopyruvate |
US9314457B2 (en) | 2014-06-19 | 2016-04-19 | The University Of Utah Research Foundation | Methods of treating and preventing vascular instability diseases |
CA3008849A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
RU2020120686A (ru) | 2017-11-24 | 2021-12-24 | Лунелла Байотек, Инк. | Соединения производных трифенилфосфония для эрадикации раковых стволовых клеток |
WO2020154724A1 (en) * | 2019-01-25 | 2020-07-30 | Vanderbilt University | Mitochondria-targeted isoketal/isolevuglandin scavengers |
DE102019218241A1 (de) * | 2019-11-26 | 2021-05-27 | Beiersdorf Ag | Wirkstoffkombinationen aus Ubichinol und Carrageenan und kosmetische oder dermatologische Zubereitungen, solche Wirkstoffkombinationen enthaltend |
GB2610815A (en) * | 2021-09-14 | 2023-03-22 | Mitorx Therapeutics Ltd | Compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6331532B1 (en) * | 1998-11-25 | 2001-12-18 | University Of Otago | Mitochondrially targeted antioxidants |
JP4590523B2 (ja) * | 1997-11-25 | 2010-12-01 | アンティポディーン ファーマシューティカルズ インコーポレイテッド | ミトコンドリアを標的とする抗酸化剤 |
NZ513547A (en) * | 2001-08-13 | 2002-09-27 | Antipodean Biotechnology Ltd | Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone) |
-
2004
- 2004-08-23 RU RU2006109020/04A patent/RU2487880C2/ru not_active Application Discontinuation
- 2004-08-23 BR BRPI0413742A patent/BRPI0413742B8/pt active IP Right Grant
- 2004-08-23 WO PCT/NZ2004/000197 patent/WO2005019233A1/en active Application Filing
- 2004-08-23 KR KR1020067003665A patent/KR100974202B1/ko active IP Right Grant
- 2004-08-23 AU AU2004266988A patent/AU2004266988B2/en active Active
- 2004-08-23 CA CA2536546A patent/CA2536546C/en active Active
- 2004-08-23 WO PCT/NZ2004/000196 patent/WO2005019232A1/en active Application Filing
- 2004-08-23 EP EP04775122.7A patent/EP1664069B8/en active Active
-
2006
- 2006-02-28 NO NO20060977A patent/NO337925B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP1664069B8 (en) | 2015-07-01 |
WO2005019232A1 (en) | 2005-03-03 |
KR20070018766A (ko) | 2007-02-14 |
EP1664069A4 (en) | 2009-09-30 |
WO2005019233A1 (en) | 2005-03-03 |
EP1664069A1 (en) | 2006-06-07 |
BRPI0413742B8 (pt) | 2021-05-25 |
BRPI0413742A (pt) | 2006-10-24 |
AU2004266988B2 (en) | 2011-05-26 |
EP1664069B1 (en) | 2015-04-08 |
RU2006109020A (ru) | 2007-09-27 |
KR100974202B1 (ko) | 2010-08-06 |
NO337925B1 (no) | 2016-07-11 |
CA2536546C (en) | 2012-10-02 |
RU2487880C2 (ru) | 2013-07-20 |
AU2004266988A1 (en) | 2005-03-03 |
CA2536546A1 (en) | 2005-03-03 |
BRPI0413742B1 (pt) | 2019-05-21 |
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