NO20060466L - Variable antibodies - Google Patents
Variable antibodiesInfo
- Publication number
- NO20060466L NO20060466L NO20060466A NO20060466A NO20060466L NO 20060466 L NO20060466 L NO 20060466L NO 20060466 A NO20060466 A NO 20060466A NO 20060466 A NO20060466 A NO 20060466A NO 20060466 L NO20060466 L NO 20060466L
- Authority
- NO
- Norway
- Prior art keywords
- antibodies
- factor viii
- modified glycosylation
- inhibitory
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0319118A GB0319118D0 (en) | 2003-08-14 | 2003-08-14 | Variable antibodies |
GB0319345A GB0319345D0 (en) | 2003-08-18 | 2003-08-18 | Variable antibodies |
PCT/BE2004/000118 WO2005016455A2 (en) | 2003-08-14 | 2004-08-16 | Antibodies against factor viii with modified glycosylation in the variable region |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20060466L true NO20060466L (no) | 2006-04-24 |
Family
ID=34196257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20060466A NO20060466L (no) | 2003-08-14 | 2006-01-30 | Variable antibodies |
Country Status (9)
Country | Link |
---|---|
US (4) | US7785594B2 (ja) |
EP (1) | EP1706079B1 (ja) |
JP (1) | JP4934796B2 (ja) |
AU (1) | AU2004264265C1 (ja) |
CA (1) | CA2535489C (ja) |
ES (1) | ES2412489T3 (ja) |
IL (1) | IL173557A (ja) |
NO (1) | NO20060466L (ja) |
WO (1) | WO2005016455A2 (ja) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7829085B2 (en) * | 1999-07-14 | 2010-11-09 | Life Sciences Research Partners Vzw | Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII |
SG177008A1 (en) | 2003-03-05 | 2012-01-30 | Halozyme Inc | Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
EP1706079B1 (en) * | 2003-08-14 | 2013-02-20 | ThromboGenics N.V. | Antibodies against factor viii with modified glycosylation in the variable region |
FR2897868B1 (fr) * | 2006-02-24 | 2012-08-31 | Lab Francais Du Fractionnement | Anticorps anti-idiotypiques neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii. |
RU2466189C2 (ru) * | 2006-12-28 | 2012-11-10 | Сентокор Орто Байотек Инк. | ВЕКТОР ДЛЯ ЭКСПРЕССИИ ПОЛИПЕПТИДОВ С СИАЛИДАЗНОЙ АКТИВНОСТЬЮ, СПОСОБ ОБЕСПЕЧЕНИЯ СИАЛИДАЗНОЙ АКТИВНОСТИ В КУЛЬТУРЕ КЛЕТОК И СПОСОБ РЕГУЛИРОВАНИЯ СВОЙСТВ Fc-СОДЕРЖАЩИХ МОЛЕКУЛ, ЭКСПРЕССИРУЕМЫХ В ЛИНИИ КЛЕТОК |
CA2734549A1 (en) * | 2007-08-23 | 2009-02-26 | Lfb Biotechnologies | Anti-idiotypic antibodies which neutralise the inhibitory activity of an inhibitory antibody directed against the c1 domain of factor viii |
BRPI0821599A2 (pt) * | 2007-12-28 | 2015-06-16 | Baxter Int | Método de filtração de uma mistura líquida de proteína |
CN102007146A (zh) * | 2008-04-23 | 2011-04-06 | 西福根有限公司 | 用于制备多克隆蛋白质的方法 |
EP2297207B1 (en) * | 2008-06-19 | 2018-10-03 | Prothix BV | Use of anti-factor xi antibodies for prevention or treatment of thrombus formation |
EP2233499A1 (en) * | 2009-03-26 | 2010-09-29 | CSL Behring AG | Antibody composition with altered Fab sialylation |
KR20120050442A (ko) | 2009-07-10 | 2012-05-18 | 쓰롬보제닉스 엔.브이. | 플라스미노겐 및 플라스민의 변이체 |
US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
ES2534911T3 (es) | 2009-08-28 | 2015-04-30 | Thrombogenics N.V. | Uso de plasmina para el tratamiento de fallo de filtración después de trabeculectomía |
JP6334166B2 (ja) * | 2010-08-10 | 2018-05-30 | グリコトープ ゲーエムベーハー | Fabグリコシル化抗体 |
CA2823491A1 (en) | 2011-01-05 | 2012-07-12 | Thrombogenics Nv | Plasminogen and plasmin variants |
CN102172359A (zh) * | 2011-03-02 | 2011-09-07 | 张始状 | 腺苷与核苷组合在制备治疗肿瘤药物中的应用 |
US9644196B2 (en) | 2011-08-12 | 2017-05-09 | Thrombogenics Nv | Plasminogen and plasmin variants |
ES2628321T3 (es) | 2011-12-01 | 2017-08-02 | Thrombogenics N.V. | Mejora del resultado de una trabeculectomía |
SG11201404885RA (en) | 2012-02-15 | 2014-09-26 | Amunix Operating Inc | Factor viii compositions and methods of making and using same |
US10370430B2 (en) | 2012-02-15 | 2019-08-06 | Bioverativ Therapeutics Inc. | Recombinant factor VIII proteins |
EP2855529A4 (en) * | 2012-05-24 | 2015-12-09 | Alexion Pharma Inc | HUMANIZED ANTI-FACTOR B ANTIBODIES |
US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
AU2016301303B2 (en) | 2015-08-03 | 2021-10-07 | Bioverativ Therapeutics Inc. | Factor IX fusion proteins and methods of making and using same |
US20190031762A1 (en) | 2016-03-10 | 2019-01-31 | Thrombogenics Nv | Posterior ocular fibrosis inhibition by antagonizing placental growth factor |
CA3062238A1 (en) * | 2017-05-11 | 2018-11-15 | Vib Vzw | Glycosylation of variable immunoglobulin domains |
US20210187118A1 (en) | 2018-05-18 | 2021-06-24 | Daiichi Sankyo Co., Ltd. | Anti-muc1 antibody-drug conjugate |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4451454A (en) | 1981-06-16 | 1984-05-29 | Wong Dennis W | Prophylaxis and treatment of thromboembolic disorders in man and in warm-blooded animals with bicarbonate salts of alkali metals |
IL82935A0 (en) | 1986-08-12 | 1987-12-20 | Phillips Petroleum Co | Secretion of heterologous proteins from yeast |
US5135854A (en) | 1987-10-29 | 1992-08-04 | Zymogenetics, Inc. | Methods of regulating protein glycosylation |
US5602015A (en) | 1989-04-25 | 1997-02-11 | Igen, Inc. | Autoantibodies which enhance the rate of a chemical reaction |
NO905438L (no) | 1989-12-18 | 1991-06-19 | Wellcome Found | Virusmiddel. |
GB9022543D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
US5714350A (en) * | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
US5744446A (en) | 1992-04-07 | 1998-04-28 | Emory University | Hybrid human/animal factor VIII |
ES2153433T3 (es) | 1993-10-25 | 2001-03-01 | Ca Nat Research Council | Inhibidores de trombina bivalentes. |
IT1277827B1 (it) | 1995-03-01 | 1997-11-12 | Ministero Uni Ricerca Scient E | Anticorpo monoclonale chimerico murino/umano o un suo frammento specifico per il recettore egf (egf-r) |
MA24512A1 (fr) | 1996-01-17 | 1998-12-31 | Univ Vermont And State Agrienl | Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose |
JP2002514422A (ja) | 1998-05-08 | 2002-05-21 | ステイヒテイング・サンキン・ブロードボールジーニング | インヒビターを有する血友病a患者の診断および治療方法 |
WO2000007626A1 (en) | 1998-08-07 | 2000-02-17 | Smithkline Beecham Corporation | Use of anti-coagulation factor antibodies as long-lasting protective agents |
DE19913707A1 (de) | 1999-03-26 | 2000-10-05 | Privates Inst Bioserv Gmbh | Immunadsorber zur Sepsistherapie |
US7067313B1 (en) | 1999-07-14 | 2006-06-27 | D. Collen Research Foundation | Ligands for use in therapeutic compositions for the treatment of hemostasis disorders |
ES2283308T3 (es) * | 1999-07-14 | 2007-11-01 | D. Collen Research Foundation Vzw | Anticuerpo monoclonal para el factor viii, que incluso cuando esta presente en exceso molar inactiva el factor viii solo en parte y metodo para producir dicho anticuerpo. |
US7829085B2 (en) * | 1999-07-14 | 2010-11-09 | Life Sciences Research Partners Vzw | Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII |
MXPA02011868A (es) | 2000-05-30 | 2003-04-10 | Smithkline Beecham Corp | Antagonistas de receptor de interleucina 8. |
CA2415954A1 (en) | 2000-07-19 | 2003-01-17 | Kazuhiro Maeda | Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products |
JP4272338B2 (ja) | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
DE60236386D1 (de) | 2001-01-11 | 2010-07-01 | D Collen Res Foundation Vzw | Verfahren und pharmazeutische Zusammensetzung zur Vorbeugung und/oder Behandlung des Syndroms der systemischen entzündlichen Reaktion |
WO2002101040A1 (en) | 2001-06-12 | 2002-12-19 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Human-type anti-blood coagulation factor viii antibody |
EP1461082A4 (en) | 2001-12-03 | 2006-06-28 | Abgenix Inc | ANTIBODIES AGAINST THE TUMOR ANTIGEN OF CARBON IX ANHYDRASE (CA IX) |
US20030175268A1 (en) | 2002-01-11 | 2003-09-18 | Saint-Remy Jean-Marie R. | Method and pharmaceutical composition for preventing and/or treating systemic inflammatory response syndrome |
EP1706079B1 (en) * | 2003-08-14 | 2013-02-20 | ThromboGenics N.V. | Antibodies against factor viii with modified glycosylation in the variable region |
WO2005046583A2 (en) | 2003-10-30 | 2005-05-26 | Emory University | Modified fviii having reduced immunogenicity through mutagenesis of a2 and c2 epitopes |
WO2007017154A2 (en) | 2005-07-29 | 2007-02-15 | Life Sciences Research Partners Vzw | Human inhibitory anti-factor viii antibodies binding to the a2 domain |
-
2004
- 2004-08-16 EP EP04761479A patent/EP1706079B1/en active Active
- 2004-08-16 CA CA2535489A patent/CA2535489C/en not_active Expired - Fee Related
- 2004-08-16 AU AU2004264265A patent/AU2004264265C1/en not_active Ceased
- 2004-08-16 JP JP2006522852A patent/JP4934796B2/ja not_active Expired - Fee Related
- 2004-08-16 US US10/566,851 patent/US7785594B2/en not_active Expired - Fee Related
- 2004-08-16 ES ES04761479T patent/ES2412489T3/es active Active
- 2004-08-16 WO PCT/BE2004/000118 patent/WO2005016455A2/en active Application Filing
-
2006
- 2006-01-30 NO NO20060466A patent/NO20060466L/no not_active Application Discontinuation
- 2006-02-06 IL IL173557A patent/IL173557A/en not_active IP Right Cessation
-
2010
- 2010-03-26 US US12/732,556 patent/US8277805B2/en not_active Expired - Fee Related
- 2010-03-29 US US12/748,478 patent/US8293234B2/en not_active Expired - Fee Related
- 2010-03-29 US US12/748,486 patent/US8282923B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2412489T3 (es) | 2013-07-11 |
AU2004264265A1 (en) | 2005-02-24 |
AU2004264265B2 (en) | 2009-09-17 |
US20110070226A1 (en) | 2011-03-24 |
US20100272715A1 (en) | 2010-10-28 |
CA2535489A1 (en) | 2005-02-24 |
CA2535489C (en) | 2014-09-30 |
US8293234B2 (en) | 2012-10-23 |
US8277805B2 (en) | 2012-10-02 |
US8282923B2 (en) | 2012-10-09 |
EP1706079A2 (en) | 2006-10-04 |
EP1706079B1 (en) | 2013-02-20 |
US20060292149A1 (en) | 2006-12-28 |
AU2004264265C1 (en) | 2012-06-28 |
US20100266586A1 (en) | 2010-10-21 |
WO2005016455A3 (en) | 2005-03-17 |
JP2007502250A (ja) | 2007-02-08 |
IL173557A (en) | 2012-09-24 |
US7785594B2 (en) | 2010-08-31 |
JP4934796B2 (ja) | 2012-05-16 |
IL173557A0 (en) | 2006-07-05 |
WO2005016455A2 (en) | 2005-02-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20060466L (no) | Variable antibodies | |
WO2002089738A3 (en) | Proteomimetic compounds and methods | |
ATE259215T1 (de) | Zusammensetzung zur regulierung des hauterscheinungsbildes | |
GEP20084520B (en) | Use of retinyl derivatives and compositions thereof for treating ophthalmic diseases | |
GB0117326D0 (en) | Napthoquinone-type inhibitors of protein aggregation | |
WO2005012242A3 (en) | Substituted benzimidazole-, benztriazole-, and benzimidazolone-o-glucosides | |
WO2006091459A3 (en) | Compositions and methods for treating vascular permeability | |
HK1092467A1 (en) | N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n- | |
WO2006012621A3 (en) | Compositions and methods for regulating the alternative pathway of complement | |
WO2007027559A3 (en) | Neuroprotective and neurorestorative methods and compositions | |
ATE407698T1 (de) | Zusammensetzungen und verfahren zur behandlung von entzündlicher darmerkrankung | |
ATE525480T1 (de) | Verwendung von a33-antigenen und jam-it | |
WO2002079474A3 (en) | Human b7 polypeptides | |
WO2007067737A3 (en) | Methods and compositions for inhibiting hiv infection | |
HK1063601A1 (en) | Compositions and methods for treating hyperimmune response in the eye | |
WO2005070042A8 (en) | Novel chemical compounds | |
ATE432275T1 (de) | Pyrrol- bzw. imidazolamide zur behandlung von obesitas | |
DK1196442T3 (da) | VGF-polypeptider og fremgangsmåder til behandling af VGF-relaterede lidelser | |
ATE230414T1 (de) | Mimetika von beta-faltblatt und verfahren zur verwendung davon | |
UA107177C2 (uk) | Імуногенна композиція цвс2 та спосіб приготування такої композиції | |
ATE550345T1 (de) | Sfrp, mit sfrp-interagierende peptidmotive sowie verwendungsverfahren | |
WO2003038130A8 (en) | Therapeutics and diagnostics for disorders of erythropoiesis | |
WO2005087806A3 (en) | Cd38 splice variant and uses thereof | |
WO2004089302A3 (en) | Posh polypeptides, complexes and related methods | |
ATE165594T1 (de) | Triarylethylenderivate zur therapeutischen verwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |