NO20054442L - Pyrrolidinderivater som oksytocinantagonister - Google Patents
Pyrrolidinderivater som oksytocinantagonisterInfo
- Publication number
- NO20054442L NO20054442L NO20054442A NO20054442A NO20054442L NO 20054442 L NO20054442 L NO 20054442L NO 20054442 A NO20054442 A NO 20054442A NO 20054442 A NO20054442 A NO 20054442A NO 20054442 L NO20054442 L NO 20054442L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- heteroaryl
- alkynyl
- alkenyl
- aryl
- Prior art date
Links
- 150000003235 pyrrolidines Chemical class 0.000 title abstract 2
- 239000003336 oxytocin antagonist Substances 0.000 title 1
- 229940121361 oxytocin antagonists Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 3
- -1 sulfonyloxy Chemical group 0.000 abstract 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005157 alkyl carboxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03100477 | 2003-02-27 | ||
| PCT/EP2004/050142 WO2004076407A2 (en) | 2003-02-27 | 2004-02-16 | Pyrrolidine derivatives as oxytocin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20054442L true NO20054442L (no) | 2005-09-26 |
Family
ID=32921609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054442A NO20054442L (no) | 2003-02-27 | 2005-09-26 | Pyrrolidinderivater som oksytocinantagonister |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7557136B2 (de) |
| EP (1) | EP1597229B1 (de) |
| JP (1) | JP4773335B2 (de) |
| AT (1) | ATE449067T1 (de) |
| AU (1) | AU2004215661B2 (de) |
| CA (1) | CA2515546C (de) |
| DE (1) | DE602004024170D1 (de) |
| ES (1) | ES2333719T3 (de) |
| NO (1) | NO20054442L (de) |
| WO (1) | WO2004076407A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2845850A1 (de) | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidinderivate als Oxytocin/Vasopressin-V1a-Rezeptorantagonisten |
| EP2886107A1 (de) * | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Orale Formulierungen von Pyrrolydinderivaten |
| EP3753921A1 (de) | 2014-07-02 | 2020-12-23 | ObsEva S.A. | Kristallines (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-on-o-methyloxim und verfahren zur verwendung davon |
| CN115073344B (zh) * | 2022-06-24 | 2024-03-26 | 苏州富士莱医药股份有限公司 | 一种r-(1-叔丁氧羰基吡咯烷-2-基)丙烯酸的制备方法及其应用 |
| TW202435864A (zh) | 2023-02-09 | 2024-09-16 | 大陸商上海葆正醫藥科技有限公司 | 亞胺化合物及其製備方法和應用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1268419T3 (da) * | 2000-03-27 | 2006-10-02 | Applied Research Systems | Farmaceutisk aktive pyrrolidinderivater som BAX-inhibitorer |
| EP1829861A3 (de) | 2001-03-20 | 2009-01-21 | Laboratoires Serono SA | Als Oxytocinantagonisten wirksame Pyrrolidinesterderivate |
| KR20040030678A (ko) | 2001-06-18 | 2004-04-09 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 피롤리딘 옥사디아졸 및 티아디아졸 유도체 |
-
2004
- 2004-02-16 DE DE602004024170T patent/DE602004024170D1/de not_active Expired - Lifetime
- 2004-02-16 WO PCT/EP2004/050142 patent/WO2004076407A2/en not_active Ceased
- 2004-02-16 ES ES04711384T patent/ES2333719T3/es not_active Expired - Lifetime
- 2004-02-16 JP JP2006502031A patent/JP4773335B2/ja not_active Expired - Fee Related
- 2004-02-16 US US10/547,032 patent/US7557136B2/en not_active Expired - Fee Related
- 2004-02-16 AT AT04711384T patent/ATE449067T1/de not_active IP Right Cessation
- 2004-02-16 AU AU2004215661A patent/AU2004215661B2/en not_active Ceased
- 2004-02-16 CA CA2515546A patent/CA2515546C/en not_active Expired - Fee Related
- 2004-02-16 EP EP04711384A patent/EP1597229B1/de not_active Expired - Lifetime
-
2005
- 2005-09-26 NO NO20054442A patent/NO20054442L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2515546A1 (en) | 2004-09-10 |
| AU2004215661B2 (en) | 2009-12-03 |
| US7557136B2 (en) | 2009-07-07 |
| JP2006519212A (ja) | 2006-08-24 |
| EP1597229B1 (de) | 2009-11-18 |
| DE602004024170D1 (de) | 2009-12-31 |
| JP4773335B2 (ja) | 2011-09-14 |
| WO2004076407A2 (en) | 2004-09-10 |
| CA2515546C (en) | 2011-11-22 |
| ATE449067T1 (de) | 2009-12-15 |
| EP1597229A2 (de) | 2005-11-23 |
| ES2333719T3 (es) | 2010-02-26 |
| AU2004215661A1 (en) | 2004-09-10 |
| WO2004076407A3 (en) | 2004-10-21 |
| US20070037806A1 (en) | 2007-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CREP | Change of representative |
Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS |
|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |