NO20053903L - Nukleotidlipidesterderivater. - Google Patents

Nukleotidlipidesterderivater.

Info

Publication number
NO20053903L
NO20053903L NO20053903A NO20053903A NO20053903L NO 20053903 L NO20053903 L NO 20053903L NO 20053903 A NO20053903 A NO 20053903A NO 20053903 A NO20053903 A NO 20053903A NO 20053903 L NO20053903 L NO 20053903L
Authority
NO
Norway
Prior art keywords
nukleotidlipidesterderivater
lipid esters
tumors
treatment
adenine nucleotides
Prior art date
Application number
NO20053903A
Other languages
English (en)
Norwegian (no)
Other versions
NO20053903D0 (no
Inventor
Dieter Herrmann
Brigitte Heckl-Ostreicher
Christoph Mueller
Christian Lutz
Robert Voigt
Original Assignee
Heidelberg Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Gmbh filed Critical Heidelberg Pharma Gmbh
Publication of NO20053903D0 publication Critical patent/NO20053903D0/no
Publication of NO20053903L publication Critical patent/NO20053903L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fats And Perfumes (AREA)
  • Medicines Containing Plant Substances (AREA)
NO20053903A 2003-03-19 2005-08-22 Nukleotidlipidesterderivater. NO20053903L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45600303P 2003-03-19 2003-03-19
EP03006059A EP1460082A1 (en) 2003-03-19 2003-03-19 Phospholipid esters of clofarabine derivatives
PCT/EP2004/002810 WO2004083155A2 (en) 2003-03-19 2004-03-18 Nucleotide lipid ester derivatives

Publications (2)

Publication Number Publication Date
NO20053903D0 NO20053903D0 (no) 2005-08-22
NO20053903L true NO20053903L (no) 2005-12-19

Family

ID=33031244

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053903A NO20053903L (no) 2003-03-19 2005-08-22 Nukleotidlipidesterderivater.

Country Status (21)

Country Link
US (1) US7419965B2 (el)
EP (2) EP1460082A1 (el)
JP (1) JP2006520359A (el)
KR (1) KR20050109939A (el)
CN (1) CN100369926C (el)
AT (1) ATE328000T1 (el)
AU (1) AU2004222163A1 (el)
CA (1) CA2519434A1 (el)
CY (1) CY1105572T1 (el)
DE (1) DE602004001047T2 (el)
DK (1) DK1606233T3 (el)
ES (1) ES2265636T3 (el)
MX (1) MXPA05008817A (el)
NO (1) NO20053903L (el)
NZ (1) NZ542011A (el)
PL (1) PL1606233T3 (el)
PT (1) PT1606233E (el)
RU (1) RU2347786C2 (el)
SI (1) SI1606233T1 (el)
WO (1) WO2004083155A2 (el)
ZA (1) ZA200507541B (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2070938A1 (en) * 2007-12-13 2009-06-17 Heidelberg Pharma AG Clofarabine dietherphospholipid derivatives
CN102079766A (zh) * 2009-11-29 2011-06-01 海南中化联合制药工业股份有限公司 一种单磷酸阿糖腺苷的制备方法
CN101709073B (zh) * 2009-12-01 2013-01-23 北京大学 核苷酸磷脂分子及脂质体及其制备方法和应用
CN103232510B (zh) * 2012-11-23 2015-12-23 北京大学 5’-氨基-2’,5’-双脱氧核苷酸磷脂分子及其制备方法和应用
US9771385B2 (en) * 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
KR102371969B1 (ko) 2016-12-23 2022-03-08 주식회사 엘지에너지솔루션 배터리 모듈
CA3105038A1 (en) * 2018-06-26 2020-01-02 Tsrl, Inc. Metabolically stable prodrugs
WO2024059754A1 (en) * 2022-09-14 2024-03-21 Quantapore, Inc. Polythiolated linkers for stable nanoparticle suspensions and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
US4751221A (en) 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
JPS6383094A (ja) * 1986-09-27 1988-04-13 Toyo Jozo Co Ltd エ−テル型ヌクレオシド−リン脂質複合体
DE4026265A1 (de) 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
US5512671A (en) * 1993-02-16 1996-04-30 Wake Forest University Ether lipid-nucleoside covalent conjugates
DE4321978A1 (de) * 1993-07-01 1995-01-12 Boehringer Mannheim Gmbh Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
DK0791056T3 (da) * 1994-11-12 2005-07-04 Heidelberg Pharma Gmbh Lipidopspaltende enzymkompleks
US7517858B1 (en) * 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
US6670341B1 (en) * 1999-10-28 2003-12-30 Wake Forest University Health Sciences Compositions and methods for double-targeting virus infections and targeting cancer cells

Also Published As

Publication number Publication date
ATE328000T1 (de) 2006-06-15
DE602004001047D1 (de) 2006-07-06
RU2005130992A (ru) 2006-04-10
PL1606233T3 (pl) 2006-10-31
NZ542011A (en) 2008-02-29
AU2004222163A1 (en) 2004-09-30
US7419965B2 (en) 2008-09-02
JP2006520359A (ja) 2006-09-07
CY1105572T1 (el) 2010-07-28
EP1460082A1 (en) 2004-09-22
ES2265636T3 (es) 2007-02-16
CN1771253A (zh) 2006-05-10
EP1606233A2 (en) 2005-12-21
RU2347786C2 (ru) 2009-02-27
PT1606233E (pt) 2006-09-29
CA2519434A1 (en) 2004-09-30
SI1606233T1 (sl) 2006-10-31
CN100369926C (zh) 2008-02-20
DK1606233T3 (da) 2006-09-18
ZA200507541B (en) 2006-05-31
WO2004083155A3 (en) 2005-03-31
MXPA05008817A (es) 2005-10-18
DE602004001047T2 (de) 2007-04-19
WO2004083155A2 (en) 2004-09-30
KR20050109939A (ko) 2005-11-22
US20060293514A1 (en) 2006-12-28
NO20053903D0 (no) 2005-08-22
EP1606233B1 (en) 2006-05-31

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application