NO20051932L - Derivater omfattende steroler og/eller stanoler og spesifikke klasser av antiinflammatoriske midler og anvendelse derav ved behandling eller forebyggelse av kardiovaskulaer sykdom. - Google Patents
Derivater omfattende steroler og/eller stanoler og spesifikke klasser av antiinflammatoriske midler og anvendelse derav ved behandling eller forebyggelse av kardiovaskulaer sykdom.Info
- Publication number
- NO20051932L NO20051932L NO20051932A NO20051932A NO20051932L NO 20051932 L NO20051932 L NO 20051932L NO 20051932 A NO20051932 A NO 20051932A NO 20051932 A NO20051932 A NO 20051932A NO 20051932 L NO20051932 L NO 20051932L
- Authority
- NO
- Norway
- Prior art keywords
- inflammation
- treatment
- derivatives
- stanols
- sterols
- Prior art date
Links
- 229930182558 Sterol Natural products 0.000 title abstract 3
- 150000003432 sterols Chemical class 0.000 title abstract 3
- 235000003702 sterols Nutrition 0.000 title abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 abstract 5
- 230000004054 inflammatory process Effects 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VGSSUFQMXBFFTM-UHFFFAOYSA-N (24R)-24-ethyl-5alpha-cholestane-3beta,5,6beta-triol Natural products C1C(O)C2(O)CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 VGSSUFQMXBFFTM-UHFFFAOYSA-N 0.000 abstract 1
- ARYTXMNEANMLMU-UHFFFAOYSA-N 24alpha-methylcholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(C)C(C)C)C1(C)CC2 ARYTXMNEANMLMU-UHFFFAOYSA-N 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- LGJMUZUPVCAVPU-JFBKYFIKSA-N Sitostanol Natural products O[C@@H]1C[C@H]2[C@@](C)([C@@H]3[C@@H]([C@H]4[C@@](C)([C@@H]([C@@H](CC[C@H](C(C)C)CC)C)CC4)CC3)CC2)CC1 LGJMUZUPVCAVPU-JFBKYFIKSA-N 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
- 150000003870 salicylic acids Chemical class 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/255,558 US20040236125A1 (en) | 2002-09-25 | 2002-09-25 | Novel structures and compositions comprising sterols and/or stanols and specific classes of anti-inflammatory agents and use thereof in treating or preventing cardiovascular disease, its underlying conditions including hyperlipidemia and other disorders having inflammation as part of their aetiology or presentation |
| US66484303A | 2003-09-16 | 2003-09-16 | |
| PCT/CA2003/001412 WO2004029068A1 (en) | 2002-09-25 | 2003-09-25 | Derivatives comprising sterols and/or stanols and specific classes of anti-inflammatory agents and use thereof in treating or preventing cardiovascular disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20051932L true NO20051932L (no) | 2005-04-20 |
Family
ID=32044971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20051932A NO20051932L (no) | 2002-09-25 | 2005-04-20 | Derivater omfattende steroler og/eller stanoler og spesifikke klasser av antiinflammatoriske midler og anvendelse derav ved behandling eller forebyggelse av kardiovaskulaer sykdom. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1556406A1 (de) |
| JP (1) | JP2006503840A (de) |
| KR (1) | KR20050084572A (de) |
| CN (1) | CN1684971A (de) |
| AU (1) | AU2003266885A1 (de) |
| BR (1) | BR0314700A (de) |
| CA (1) | CA2499817A1 (de) |
| NO (1) | NO20051932L (de) |
| RU (1) | RU2005112247A (de) |
| WO (1) | WO2004029068A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080182801A1 (en) | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
| GB0513881D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
| GB0329667D0 (en) | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
| DE102004008035A1 (de) * | 2004-02-19 | 2005-09-08 | Symrise Gmbh & Co. Kg | Verwendung von (2-Hydroxyphenyl)-alkoholen sowie diese Verbindungen enthaltende kosmetische oder therapeutische Formulierungen |
| GB0513888D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| GB0513883D0 (en) | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Diagnosis of Atherosclerosis |
| DK2662382T3 (en) * | 2012-05-10 | 2016-06-27 | Beta Innov | Sterol, MANUFACTURING METHOD THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USE THEREOF FOR THE TREATMENT OF MULTIPLE glioblastoma |
| CN104434927A (zh) * | 2014-12-16 | 2015-03-25 | 吉林农业大学 | 丙二酸双环戊烷并多氢菲酯b在制备降血压药物中的应用 |
| CN104530167B (zh) * | 2014-12-16 | 2016-02-24 | 吉林农业大学 | 水杨酸环戊烷并多氢菲酯a及其提取方法和药物用途 |
| CN111053741B (zh) * | 2019-12-31 | 2021-09-28 | 江苏省中医院 | 一种用于治疗炎症性肠病的基于β-谷甾醇与5-ASA的口服多敏感胶束前药 |
| CN114014905B (zh) * | 2021-12-03 | 2023-07-21 | 浙江科技学院 | 靶向PPARγ的甘草次酸类衍生物及其制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19518221A1 (de) * | 1995-05-10 | 1996-11-14 | Schering Ag | Verwendung nichtsteroidaler Entzündungshemmer zur Verbesserung der physiologischen Verträglichkeit partikulärer pharmazeutischer Zubereitungen |
| AU4891699A (en) * | 1998-07-20 | 2000-02-14 | Forbes Medi-Tech Inc. | Compositions comprising phytosterol, phytostanol or mixtures of both and omega-3fatty acids or derivatives thereof and use of the composition in treating or preventing cardiovascular disease and other disorders |
| CN1370179A (zh) * | 1999-06-21 | 2002-09-18 | 福布斯医药技术股份有限公司 | 用于治疗或预防心血管疾病的植物甾醇和/或植物甾烷醇的芳族和杂环衍生物 |
| DE60013130T2 (de) * | 1999-06-23 | 2005-01-05 | Forbes Medi-Tech Inc., Vancouver | Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten |
| AU2001242130A1 (en) * | 2000-03-07 | 2001-09-17 | Forbes Medi-Tech Inc. | Novel derivatives comprising phytosterols and/or phytostanols and alpha-lipoic and use thereof in treating or preventing cardiovascular disease, its underlying conditions and other disorders |
| CA2426895A1 (en) * | 2000-10-25 | 2002-05-02 | Forbes Medi-Tech Inc. | Compounds comprising a phytosterol and/or phytostanol moiety and ascorbis acid and use thereof as weight regulating agents |
| WO2003063908A1 (en) * | 2002-01-30 | 2003-08-07 | Pharmacia Corporation | Aldosterone antagonist and non-steroidal anti-inflammatory agent combination therapy to prevent or treat cardiovascular disorders |
-
2003
- 2003-09-25 EP EP03747766A patent/EP1556406A1/de not_active Withdrawn
- 2003-09-25 RU RU2005112247/04A patent/RU2005112247A/ru not_active Application Discontinuation
- 2003-09-25 CA CA002499817A patent/CA2499817A1/en not_active Abandoned
- 2003-09-25 JP JP2004538597A patent/JP2006503840A/ja not_active Withdrawn
- 2003-09-25 CN CNA038230283A patent/CN1684971A/zh active Pending
- 2003-09-25 WO PCT/CA2003/001412 patent/WO2004029068A1/en not_active Ceased
- 2003-09-25 AU AU2003266885A patent/AU2003266885A1/en not_active Abandoned
- 2003-09-25 BR BR0314700-2A patent/BR0314700A/pt not_active IP Right Cessation
- 2003-09-25 KR KR1020057004898A patent/KR20050084572A/ko not_active Withdrawn
-
2005
- 2005-04-20 NO NO20051932A patent/NO20051932L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0314700A (pt) | 2005-07-26 |
| CN1684971A (zh) | 2005-10-19 |
| EP1556406A1 (de) | 2005-07-27 |
| AU2003266885A1 (en) | 2004-04-19 |
| KR20050084572A (ko) | 2005-08-26 |
| WO2004029068A1 (en) | 2004-04-08 |
| CA2499817A1 (en) | 2004-04-08 |
| JP2006503840A (ja) | 2006-02-02 |
| RU2005112247A (ru) | 2006-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69325178T2 (de) | Durch peptidylketon aktivierte inhibitoren, die natürliche und nicht-natürliche peptidsequenzen enthalten | |
| US5925772A (en) | Cysteine protease inhibitors containing heterocyclic leaving groups | |
| NO950774L (no) | Fremgangsmåte for inhibering av bentap og nedsettelse av serumkolesterol | |
| ATE202346T1 (de) | Benzofuran derivate und ihre verwendung als inhibitoren der knochenresorption | |
| JPH02233610A (ja) | 血管新生阻害剤 | |
| NO20071577L (no) | Bifenyloksyiddiksyrederivater for behandling av luftveissykdommer | |
| NO20013367L (no) | Colchinolderivater som vaskulorskadende midler | |
| ATE208397T1 (de) | Arylsubstituierte 5,5 verknüpfte aromatische nitroverbindungen als entzündungshemmende wirkstoffe | |
| BRPI0412439A (pt) | compostos e composições compreendendo esteróis e/ou estanóis e inibidores de biossìntese de colesterol e uso dos mesmos no tratamento ou prevenção de uma variedade de doenças e condições | |
| WO2001015593A3 (en) | Compositions for reducing vascular plaque formation and methods of using same | |
| NO20003514L (no) | Hypolipidemiske benzothiazepin-forbindelser | |
| NO331512B1 (no) | Preparat omfattende sterolabsorpsjonsinhibitor, oral doseringsform omfattende preparatet og anvendelse av preparatet for fremstilling av et medikament for samadministrering med aktivator(er) for peroksisom-proliferator¬aktivert reseptor(PPAR) for behandling og/eller forebygging av vaskulaere indikasjoner | |
| CZ292712B6 (cs) | Farmaceutická kompozice pro léčbu hyperplaze prostaty | |
| ATE308327T1 (de) | Verwendung von 2-hydroxy-5-phenylazobenzoesäure- derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs | |
| ATE273992T1 (de) | Konjugate von ascorbinsäure und phytosterolen oder phytostanolen und ihre verwendung zur behandlung von gefässkrankheiten | |
| ATE212837T1 (de) | Pharmazeutische zubereitung zur behandlung akuter rhinitiden, enthaltend sympthomimeticum und pantothenol und/oder pantothensäure | |
| BRPI0418973A (pt) | composições de risedronato e seus métodos de uso | |
| JP5490409B2 (ja) | スタチンおよびメチルニコチンアミド誘導体を含んでなるリポ蛋白質異常の処置用調剤 | |
| BR0312584A (pt) | Novas substâncias anti-inflamatórias não-esteróides, compostos e métodos para o uso das mesmas | |
| WO2005105066A2 (en) | Histone deacetylases inhibitors against hyperlipidaemias, atherosclerosis, cardiovascular diseases | |
| BR0314700A (pt) | Derivados que compreendem esteróis e/ou estanóis e classes especìficas de agentes antiinflamatórios e seu uso no tratamento ou prevenção de doença cardiovascular | |
| BRPI0410490A (pt) | composto de macrolìdeo, composição farmacêutica e método de tratamento compreendendo o mesmo | |
| HUP0202692A2 (hu) | Interleukin-5 inhibitor hatású 6-azauracil-származékok, ezeket tartalmazó gyógyszerkészítmények és intermedierjeik | |
| MA27157A1 (fr) | Methode de traitement d'affections osseuses. | |
| Kleinert et al. | Renin inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |