NO20050861L - Anvendelse av 1-fenyl-3-dimetylamino-propanforbindelser til terapi av depressive symtpomer - Google Patents

Anvendelse av 1-fenyl-3-dimetylamino-propanforbindelser til terapi av depressive symtpomer

Info

Publication number
NO20050861L
NO20050861L NO20050861A NO20050861A NO20050861L NO 20050861 L NO20050861 L NO 20050861L NO 20050861 A NO20050861 A NO 20050861A NO 20050861 A NO20050861 A NO 20050861A NO 20050861 L NO20050861 L NO 20050861L
Authority
NO
Norway
Prior art keywords
dimethylamino
therapy
phenyl
depressive symptoms
propane compounds
Prior art date
Application number
NO20050861A
Other languages
English (en)
Other versions
NO333812B1 (no
Inventor
Derek John Saunders
Wolfgang Werner A Strassburger
Werner Guenter Englberger
Hagen-Heinrich Hennies
Oswald Karl Zimmer
Helmut Heinrich Buschmann
Jorg Holenz
Elmar Josef Friderichs
Ulrich Jahnel
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of NO20050861L publication Critical patent/NO20050861L/no
Publication of NO333812B1 publication Critical patent/NO333812B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
    • C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives metabolitter av [2-(3-metoksyfenyl)-cykloheksylmetyl]-dimetylamin som frie baser og/eller i form av fysiologisk akseptable salter, de tilsvarende medikamenter, anvendelsen av [2-(3-metoksyfenyl)-cykloheksylmetyl]-dimetylamin og metabolittene derav for fremstilling av et medikament for anvendelse av depresjoner, samt metoder for behandling av depresjoner.
NO20050861A 2002-07-19 2005-02-17 Anvendelse av 1-fenyl-3-dimetylamino-propanforbindelser til terapi av depressive symptomer,samt metabolitter og legemidler NO333812B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10233048A DE10233048A1 (de) 2002-07-19 2002-07-19 Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken
PCT/EP2003/007720 WO2004009067A1 (de) 2002-07-19 2003-07-16 1-phenyl-2-dimethylaminomethylcyclohexanverbindungen zur therapie von depressiven symptomatiken, schmerz und inkontinenz

Publications (2)

Publication Number Publication Date
NO20050861L true NO20050861L (no) 2005-02-17
NO333812B1 NO333812B1 (no) 2013-09-23

Family

ID=29796483

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050861A NO333812B1 (no) 2002-07-19 2005-02-17 Anvendelse av 1-fenyl-3-dimetylamino-propanforbindelser til terapi av depressive symptomer,samt metabolitter og legemidler

Country Status (26)

Country Link
EP (1) EP1530462B1 (no)
JP (1) JP4616644B2 (no)
KR (1) KR101056343B1 (no)
CN (1) CN1697651B (no)
AR (1) AR040574A1 (no)
AT (1) ATE491442T1 (no)
AU (1) AU2003263179B2 (no)
BR (1) BR0312854A (no)
CA (1) CA2492876C (no)
CO (1) CO5680411A2 (no)
CY (1) CY1111607T1 (no)
DE (2) DE10233048A1 (no)
DK (1) DK1530462T3 (no)
EC (1) ECSP055583A (no)
ES (1) ES2357947T3 (no)
HK (1) HK1075843A1 (no)
IL (2) IL166363A (no)
MX (1) MXPA05000791A (no)
NO (1) NO333812B1 (no)
PE (1) PE20050126A1 (no)
PL (1) PL214703B1 (no)
PT (1) PT1530462E (no)
RU (1) RU2387446C2 (no)
SI (1) SI1530462T1 (no)
WO (1) WO2004009067A1 (no)
ZA (1) ZA200501428B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3241550T3 (da) * 2002-11-22 2020-08-24 Gruenenthal Gmbh Anvendelse af (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol til behandling af inflammatoriske smerter
DE10356362A1 (de) 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen
WO2006038084A1 (en) * 2004-10-01 2006-04-13 Neurocure Ltd Use of pharmaceutical compositions of lofepramine for the treatment of adhd, cfs, fm and depression
EP2336103A3 (de) * 2005-07-22 2011-07-20 Grünenthal GmbH HCL-Polymorphe von 3-[2-(Dimethylamino)methyl-(cyclohex-1-yl)]phenol
DE102005034973A1 (de) * 2005-07-22 2007-02-15 Grünenthal GmbH Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen
EP3296289A3 (en) 2007-05-31 2018-06-20 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
EP2085081A1 (de) * 2008-02-04 2009-08-05 Grünenthal GmbH 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz
US20110295038A1 (en) * 2010-05-28 2011-12-01 Gruenenthal Gmbh Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds
WO2012100423A1 (en) * 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
US8853393B2 (en) 2011-07-29 2014-10-07 Anhui New Star Pharmaceutical Development Co., Ltd. Intermediate for preparing tapentadol or analogues thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
JP2001233762A (ja) * 2000-02-21 2001-08-28 Gruenenthal Gmbh Ｏ−デスメチル−ｎ−モノ−デスメチル−トラマドールの使用方法
DE10059411A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz

Also Published As

Publication number Publication date
DE50313329D1 (de) 2011-01-27
CN1697651B (zh) 2011-09-21
ES2357947T3 (es) 2011-05-04
ZA200501428B (en) 2006-09-27
EP1530462A1 (de) 2005-05-18
RU2005104821A (ru) 2006-01-20
SI1530462T1 (sl) 2011-03-31
CA2492876C (en) 2011-06-14
DE10233048A1 (de) 2004-01-29
CA2492876A1 (en) 2004-01-29
WO2004009067A1 (de) 2004-01-29
PL375629A1 (en) 2005-12-12
EP1530462B1 (de) 2010-12-15
KR20050019909A (ko) 2005-03-03
PT1530462E (pt) 2011-02-22
CO5680411A2 (es) 2006-09-29
MXPA05000791A (es) 2005-10-19
RU2387446C2 (ru) 2010-04-27
ATE491442T1 (de) 2011-01-15
JP2006511453A (ja) 2006-04-06
AU2003263179B2 (en) 2009-10-22
JP4616644B2 (ja) 2011-01-19
DK1530462T3 (da) 2011-02-14
IL166363A0 (en) 2006-01-16
KR101056343B1 (ko) 2011-08-12
AU2003263179A1 (en) 2004-02-09
HK1075843A1 (en) 2005-12-30
CN1697651A (zh) 2005-11-16
IL209789A0 (en) 2011-02-28
PE20050126A1 (es) 2005-04-19
ECSP055583A (es) 2005-04-18
BR0312854A (pt) 2005-04-19
PL214703B1 (pl) 2013-09-30
AR040574A1 (es) 2005-04-13
NO333812B1 (no) 2013-09-23
CY1111607T1 (el) 2015-10-07
IL166363A (en) 2012-05-31

Similar Documents

Publication Publication Date Title
NO20050861L (no) Anvendelse av 1-fenyl-3-dimetylamino-propanforbindelser til terapi av depressive symtpomer
NO20065878L (no) Terapeutiske forbindelser
NO20065904L (no) Terapeutiske forbindelser
NO20065535L (no) Behandling av respiratorisk sykdom
NO20050060L (no) Medikament for behandling av overaktiv blaere
NO20052761L (no) Spirocykliske cykloheksanderivater.
NO20080936L (no) Transdermale medikamentleveringsinnretninger inneholdende O-desmetylvenlafaksin (ODV) eller salter derav
NO20052420L (no) Farmakologisk behandling av sovnapn±.
NO20044436L (no) Substituerte fenyleddiksyrer
NO20060847L (no) Substituert 2-aminotetralin til behandling av depresjon
NO20070067L (no) Pyrrolopyridinderivater
NO20100250L (no) Farmasoytisk preparat som innbefatter en S1P reseptoragonist og en sukkeralkohol, og framgangsmate til fremstilling derav
UY27186A1 (es) Formulación farmacéutica
NO20082753L (no) Transdermalt terapeutisk system
NO20074295L (no) Substituerte gamma lactamer som terapeutiske midler
DK1636236T3 (da) Pyrazolo-quinazolin-derivater, en fremgangsmåde til fremstilling deraf, og deres anvendelse som kinase-inhibitorer
NO20064041L (no) Substituerte pyrazolin sammensetninger, deres fremstilling og anvendelse som medikamenter
DE602004019053D1 (de) Titrationsdosierschema für kontrolliert freigesetztes tramadol
NO20065880L (no) 3-Amino-l-arylpropylindoler som monoamin-gjenopptagelsesinhibitor
DK1771155T3 (da) Fremgangsmåde og sammensætning til behandling af rhinitis
NO20044322L (no) Benzoksanon-avledede forbindelser, deres fremstilling og anvendelse som medikament
GB0222514D0 (en) Organic compounds
NO20080950L (no) Topiske formuleringer inneholdende O-desmetylvenlafaksin (ODV) eller salter derav
CY1109666T1 (el) Μεθοδος θεραπειας διαταραχων ξηροφθαλμιας και ραγοειδιτιδας
ATE390128T1 (de) Tramadol-formulierungen mit verzögerter freisetzung und 24-stunden-wirksamkeit

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees