NO20050290L - Nye tetrahydropyridin-derivater som renin-inhibitorer - Google Patents

Nye tetrahydropyridin-derivater som renin-inhibitorer

Info

Publication number
NO20050290L
NO20050290L NO20050290A NO20050290A NO20050290L NO 20050290 L NO20050290 L NO 20050290L NO 20050290 A NO20050290 A NO 20050290A NO 20050290 A NO20050290 A NO 20050290A NO 20050290 L NO20050290 L NO 20050290L
Authority
NO
Norway
Prior art keywords
renin inhibitors
tetrahydropyridine derivatives
novel
novel tetrahydropyridine
compounds
Prior art date
Application number
NO20050290A
Other languages
English (en)
Norwegian (no)
Inventor
Thomas Weller
Sylvia Richard-Bildstein
Walter Fischli
Olivier Bezencon
Daniel Bur
Lubos Remen
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of NO20050290L publication Critical patent/NO20050290L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20050290A 2002-06-27 2005-01-19 Nye tetrahydropyridin-derivater som renin-inhibitorer NO20050290L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0207102 2002-06-27
PCT/EP2003/004445 WO2004002957A1 (en) 2002-06-27 2003-04-29 Novel tetrahydropyridine derivatives as renin inhibitors

Publications (1)

Publication Number Publication Date
NO20050290L true NO20050290L (no) 2005-01-19

Family

ID=29797098

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050290A NO20050290L (no) 2002-06-27 2005-01-19 Nye tetrahydropyridin-derivater som renin-inhibitorer

Country Status (16)

Country Link
US (1) US20060009497A1 (enExample)
EP (1) EP1519920A1 (enExample)
JP (1) JP2005532371A (enExample)
CN (1) CN1662498A (enExample)
AU (1) AU2003229746A1 (enExample)
BR (1) BR0312000A (enExample)
CA (1) CA2490138A1 (enExample)
CL (1) CL2003002043A1 (enExample)
IL (1) IL165887A0 (enExample)
MX (1) MXPA04012136A (enExample)
NO (1) NO20050290L (enExample)
PL (1) PL375214A1 (enExample)
RU (1) RU2005102002A (enExample)
TW (1) TW200514772A (enExample)
WO (1) WO2004002957A1 (enExample)
ZA (1) ZA200408423B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060217371A1 (en) * 2003-04-28 2006-09-28 Olivier Bezencon Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors
CN1972912A (zh) * 2003-04-29 2007-05-30 埃科特莱茵药品有限公司 新型3,4－二取代的1,2,3,6－四氢吡啶衍生物
CN1780663A (zh) * 2003-04-30 2006-05-31 埃科特莱茵药品有限公司 作为肾素抑制剂的新型3－位具有杂原子的9－氮杂双环壬烯衍生物
MXPA05011711A (es) * 2003-05-02 2006-01-23 Actelion Pharmaceuticals Ltd Derivados de diazabiciclononeno.
WO2004105738A2 (en) * 2003-05-30 2004-12-09 Actelion Pharmaceuticals Ltd Use of tetrahydropyridine derivatives
CN1863773A (zh) * 2003-10-09 2006-11-15 埃科特莱茵药品有限公司 四氢吡啶衍生物
WO2005040165A1 (en) * 2003-10-13 2005-05-06 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors
CA2547547A1 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors
CA2552965A1 (en) * 2004-01-14 2005-07-28 Takeda Pharmaceutical Company Limited Carboxamide derivative and use thereof
NZ549535A (en) * 2004-03-17 2010-11-26 Novartis Ag Use of aliskiren for treating renal and other disorders
AU2005276624B2 (en) 2004-08-25 2011-09-29 Actelion Pharmaceuticals Ltd. Bicyclononene derivatives as renin inhibitors
GB0428526D0 (en) * 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0504850D0 (en) * 2005-03-09 2005-04-13 Novartis Ag Organic compounds
GB0510810D0 (en) * 2005-05-26 2005-06-29 Novartis Ag Organic compounds
US7799805B2 (en) * 2005-05-27 2010-09-21 Actelion Pharmaceuticals Ltd. Piperidine carboxylic acid amide derivatives
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
WO2007049224A1 (en) * 2005-10-25 2007-05-03 Actelion Pharmaceuticals Ltd Novel hexahydro- or octahydro-cyclopenta[c]pyrrole derivatives
KR20080091273A (ko) * 2006-02-02 2008-10-09 액테리온 파마슈티칼 리미티드 레닌 저해제로서의 2차 아민
BRPI0708487A2 (pt) * 2006-03-03 2011-05-31 Actelion Pharmaceuticals Ltd composto, composição farmacêutica que o compreende e seu uso
CL2007000595A1 (es) * 2006-03-08 2008-01-04 Actelion Pharmaceuticals Ltd Compuestos derivados de piperidina; composicion farmaceutica y uso para el tratamiento y/o profilaxis de enfermedades seleccionadas entre hipertension, insuficiencia cardiaca congestiva e insuficiencia renal entre otras.
EP1908471A1 (en) * 2006-10-04 2008-04-09 Speedel Experimenta AG Tetrahydropyridines as renin inhibitors
CA2688057A1 (en) 2007-05-24 2008-11-27 Merck Frosst Canada Ltd. Novel case of renin inhibitors
EP2190811B1 (en) 2007-08-20 2013-08-07 Merck Canada Inc. Renin inhibitors
NZ589019A (en) 2008-05-05 2012-10-26 Merck Frosst Canada Ltd 3, 4 - substituted piperidine derivatives as renin inhibitors
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
CN117865941B (zh) * 2024-03-13 2024-06-28 上海方予健康医药科技有限公司 取代哌啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376666A (en) * 1992-11-30 1994-12-27 The Du Pont Merck Pharmaceutical Company Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl
PL193686B1 (pl) * 1995-09-07 2007-03-30 Hoffmann La Roche Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych
US6376672B1 (en) * 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors

Also Published As

Publication number Publication date
CN1662498A (zh) 2005-08-31
CA2490138A1 (en) 2004-01-08
BR0312000A (pt) 2005-03-22
AU2003229746A1 (en) 2004-01-19
IL165887A0 (en) 2006-01-15
WO2004002957A1 (en) 2004-01-08
US20060009497A1 (en) 2006-01-12
PL375214A1 (en) 2005-11-28
MXPA04012136A (es) 2005-04-19
CL2003002043A1 (es) 2005-01-28
TW200514772A (en) 2005-05-01
JP2005532371A (ja) 2005-10-27
EP1519920A1 (en) 2005-04-06
RU2005102002A (ru) 2005-09-20
ZA200408423B (en) 2005-10-11

Similar Documents

Publication Publication Date Title
NO20050932L (no) 1-pyridin-4-yl-ureaderivater
TW200514772A (en) Novel tetrahydropyridine derivatives
NO20064347L (no) Substituerte 1,2,3,4-tetrahydroisokinolinderivater
NO20064584L (no) Tetrahydropyridoindolderivater
NO20050525L (no) Benzimidazol-1-yl-tiofenforbindelser for behandling av cancer
NO20051102L (no) Sulfonylamino-eddiksyre-derivater
ECSP045378A (es) Derivados novedosos de diazabiciclononeno
DK1320531T3 (da) Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse
NO20031331L (no) Substituerte amino-aza-cykloalkaner anvendelige mot malaria
NO20050668L (no) 7,8,9,10-tetrahydro-6H-azepino6,7,8,9-tetrahydro-pyrido og 2,3-dihydro-2H-pyrrolo [2,1-B]-kinazolinon-derivater
NO20055623L (no) Azabicyklononenderivater
NO20054974L (no) 9-azabicyklo(3.3.1)non-6-en derivater med et heteroatom i 3-posisjonen som renin inhibitorer
DE602005021770D1 (de) Indol-1-yl-essigsäurederivate
NO20084186L (no) Nye aminer
DK1246809T3 (da) 5-aryl-1H-1,2,4-triazolforbindelser som inhibitor for cyclooxygenase-2 og farmaceutiske sammensætninger som indeholder dem
NO20083738L (no) Sekundaere aminer som renininhibitorer
NO20076448L (no) Novel piperidine carboxylic acid amide derivatives
NO20061395L (no) Nye pyridinderivater
NO20080801L (no) Aerosolformulering for inhalering av beta-agonister
NO20055624L (no) Tropanderivater og deres anvendelse som Ace-inhibitorer
NO20084055L (no) Nye primaere aminer
NO20030417D0 (no) Benzofuranderivater og deres anvendelse som antibakterielle midler
NO20040821L (no) 3-substituerte 6,7-dihydroksytetrahydroisokinolinderivater for andvendelse som antibakterielle midler.
TW200621773A (en) Bicyclononene derivatives
TW200628468A (en) Bicyclononene derivatives

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application