NO20043038L - Polymorfe former av klopidogrel-hydrogensulfat - Google Patents
Polymorfe former av klopidogrel-hydrogensulfatInfo
- Publication number
- NO20043038L NO20043038L NO20043038A NO20043038A NO20043038L NO 20043038 L NO20043038 L NO 20043038L NO 20043038 A NO20043038 A NO 20043038A NO 20043038 A NO20043038 A NO 20043038A NO 20043038 L NO20043038 L NO 20043038L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen sulfate
- polymorphic forms
- clopidogrel hydrogen
- clopidogrel hydrogensulfate
- clopidogrel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Liquid Crystal Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34244001P | 2001-12-18 | 2001-12-18 | |
US34235101P | 2001-12-21 | 2001-12-21 | |
US34818202P | 2002-01-11 | 2002-01-11 | |
US10/074,409 US6767913B2 (en) | 2001-12-18 | 2002-02-12 | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
US35915702P | 2002-02-21 | 2002-02-21 | |
PCT/US2002/040679 WO2003051362A2 (fr) | 2001-12-18 | 2002-12-18 | Polymorphes d'hydrogenosulfate de clopidogrel |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20043038L true NO20043038L (no) | 2004-09-09 |
Family
ID=27536010
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20043038A NO20043038L (no) | 2001-12-18 | 2004-07-16 | Polymorfe former av klopidogrel-hydrogensulfat |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1467735B1 (fr) |
JP (2) | JP2005514387A (fr) |
KR (1) | KR100839136B1 (fr) |
CN (1) | CN1620293A (fr) |
AT (1) | ATE417051T1 (fr) |
AU (1) | AU2002366383B2 (fr) |
CA (1) | CA2470479A1 (fr) |
DE (1) | DE60230327D1 (fr) |
ES (1) | ES2316650T3 (fr) |
HR (1) | HRP20040647A2 (fr) |
HU (1) | HUP0402485A3 (fr) |
IL (1) | IL162461A0 (fr) |
IS (1) | IS7319A (fr) |
MX (1) | MXPA04006088A (fr) |
NO (1) | NO20043038L (fr) |
PL (1) | PL370802A1 (fr) |
PT (1) | PT1467735E (fr) |
WO (1) | WO2003051362A2 (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ297472B6 (cs) * | 2002-08-27 | 2006-12-13 | Zentiva, A.S. | Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I |
GB2393181A (en) * | 2002-09-19 | 2004-03-24 | Cipla Ltd | Amorphous clopidogrel |
ITMI20022228A1 (it) * | 2002-10-21 | 2004-04-22 | Dinamite Dipharma S P A | Sali di clopidogrel con acidi alchil-solforici. |
WO2004048385A2 (fr) * | 2002-11-28 | 2004-06-10 | Instytut Farmaceutyczny | Procede de preparation de la forme cristalline 1 du clopidogrel hydrogene sulfate |
WO2004081015A1 (fr) * | 2003-03-10 | 2004-09-23 | Hetero Drugs Limited | Hydrogene sulfate de clopidogrel amorphe |
AU2003238664A1 (en) | 2003-03-12 | 2004-09-30 | Cadila Healthcare Limited | Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate |
HU0302029D0 (en) * | 2003-07-02 | 2003-09-29 | Egyt Gyogyszervegyeszeti Gyar | Amorphous form of an anticoagulant agent |
DE602004026059D1 (de) * | 2003-07-02 | 2010-04-29 | Egis Gyogyszergyar Nyilvanosan | Prozess zur herstellung eines kristallinen polymorphs eines die plättchen aggregation hemmenden arzneistoffs |
EP1648903A2 (fr) * | 2003-07-02 | 2006-04-26 | Egis Gyogyszergyar Rt. | Procede de fabrication d'une forme amorphe d'un medicament inhibant l'agregation plaquettaire |
DE10337773A1 (de) * | 2003-08-13 | 2005-03-24 | Krka Tovarna Zdravil, D.D. | Kristallisation von festen Formen von Clopidogrel-Additionssalzen |
ATE455778T1 (de) | 2003-11-03 | 2010-02-15 | Cadila Healthcare Ltd | Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat |
AU2004318214B2 (en) * | 2004-04-09 | 2007-12-06 | Hanmi Holdings Co., Ltd. | Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutical composition containing same |
EP1740593B1 (fr) | 2004-04-19 | 2016-04-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Procedes pour la preparation de clopidogrel hydrogenosulfate de forme polymorphe i |
ZA200608569B (en) * | 2004-04-20 | 2007-12-27 | Sanofi Aventis | Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide |
JP2007533746A (ja) * | 2004-04-20 | 2007-11-22 | サノフイ−アベンテイス | クロピドグレル塩及びその多形型 |
WO2005117866A1 (fr) * | 2004-06-01 | 2005-12-15 | Ivax Pharmaceuticals S.R.O. | Hydrochlorure de clopidogrel amorphe et son utilisation en tant qu'antithrombotique |
EP1693375A1 (fr) * | 2005-02-21 | 2006-08-23 | KRKA, tovarna zdravil, d.d., Novo mesto | Procédé pour la préparation de Clopidrogel hydrogène sulfate forme I |
KR20070009851A (ko) * | 2005-07-14 | 2007-01-19 | 씨제이 주식회사 | 클로피도그렐 황산수소염 함유 약학 조성물 |
US20090093635A1 (en) * | 2006-03-09 | 2009-04-09 | Sandor Garadnay | PROCESS FOR MAKING POLYMORPH FROM I OF (S) - (+) -METHYL-ALPHA- (2-CHLOROPHENYL) -6, 7-DYHIDRO-THIENO- [3, 2-c] PYRIDINE-5 (4H) -ACETATE HYDROGEN SULFATE |
SI22383A (sl) * | 2006-09-22 | 2008-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli |
HUP0600839A3 (en) * | 2006-11-14 | 2008-09-29 | Egis Gyogyszergyar Nyrt | Solid pharmaceutical composition containing polymorph i of clopidogrel hydrogensulfate and process for the preparation thereof |
KR101464482B1 (ko) * | 2007-05-08 | 2014-11-26 | 경동제약 주식회사 | 클로피도그렐 황산수소염을 함유하는 약학적 조성물 및 그제조방법 |
EP2107061A1 (fr) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Procédé de préparation de clopidogrel enrichi optiquement |
KR101130445B1 (ko) * | 2009-10-29 | 2012-03-27 | 동아제약주식회사 | 클로피도그랠 황산수소염 ⅰ형 제조방법 |
CN101962387B (zh) * | 2010-09-13 | 2013-01-30 | 成都雅途生物技术有限公司 | 一种新结晶形态的氯吡格雷硫酸氢盐及其制备方法 |
CN102358743A (zh) * | 2011-11-05 | 2012-02-22 | 江南大学 | 一种制备无定形氯吡格雷硫酸氢盐的简便方法 |
CN103006599A (zh) * | 2012-12-31 | 2013-04-03 | 广州白云山天心制药股份有限公司 | 含氯化钠药物载体的抗凝血片剂及其制备方法 |
CN103408567B (zh) * | 2013-07-18 | 2016-12-28 | 浙江普洛医药科技有限公司 | 一种制备硫酸氢氯吡格雷晶型ⅰ的方法 |
CN104610274B (zh) * | 2013-11-05 | 2017-04-19 | 亚宝药业集团股份有限公司 | 一种i型氯吡格雷硫酸氢盐的制备方法 |
AR099354A1 (es) | 2013-11-15 | 2016-07-20 | Akebia Therapeutics Inc | Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos |
CN104045653A (zh) * | 2014-07-15 | 2014-09-17 | 苏州天马精细化学品股份有限公司 | 一种硫酸氢氯吡格雷的纯化方法 |
KR101710922B1 (ko) | 2015-06-03 | 2017-02-28 | 경동제약 주식회사 | 클로피도그렐 황산염 결정형 i형의 제조방법 |
CN107163060B (zh) * | 2017-05-24 | 2021-03-02 | 常州制药厂有限公司 | 一种硫酸氢氯吡格雷晶型ii制备方法 |
CN107337683B (zh) * | 2017-08-16 | 2019-08-16 | 中荣凯特(北京)生物科技有限公司 | 一种噻吩并吡啶类衍生物硫酸氢盐的晶型ⅱ及其制备方法和应用 |
WO2020013305A1 (fr) * | 2018-07-12 | 2020-01-16 | 有機合成薬品工業株式会社 | Procédé de production de cristaux de forme i de sulfate de clopidogrel |
KR102220480B1 (ko) * | 2019-02-13 | 2021-02-25 | 한국바이오켐제약 주식회사 | 클로피도그렐황산염의 제조방법 및 이를 포함하는 약학제제 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2664276B1 (fr) * | 1990-07-04 | 1992-10-23 | Sanofi Sa | Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese. |
US5576328A (en) * | 1994-01-31 | 1996-11-19 | Elf Sanofi | Method for the secondary prevention of ischemic events |
FR2751540B1 (fr) * | 1996-07-26 | 1998-10-16 | Sanofi Sa | Composition pharmaceutique antithrombotique |
FR2769313B1 (fr) * | 1997-10-06 | 2000-04-21 | Sanofi Sa | Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese |
FR2779726B1 (fr) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
AU2002356430A1 (en) * | 2002-12-09 | 2004-06-30 | Hetero Drugs Limited | A novel polymorph of clopidogrel hydrogen sulfate |
-
2002
- 2002-12-18 IL IL16246102A patent/IL162461A0/xx unknown
- 2002-12-18 KR KR1020047009420A patent/KR100839136B1/ko not_active IP Right Cessation
- 2002-12-18 PT PT02805215T patent/PT1467735E/pt unknown
- 2002-12-18 AU AU2002366383A patent/AU2002366383B2/en not_active Expired - Fee Related
- 2002-12-18 EP EP02805215A patent/EP1467735B1/fr not_active Expired - Lifetime
- 2002-12-18 AT AT02805215T patent/ATE417051T1/de not_active IP Right Cessation
- 2002-12-18 ES ES02805215T patent/ES2316650T3/es not_active Expired - Lifetime
- 2002-12-18 CA CA002470479A patent/CA2470479A1/fr not_active Abandoned
- 2002-12-18 JP JP2003552295A patent/JP2005514387A/ja active Pending
- 2002-12-18 PL PL02370802A patent/PL370802A1/xx unknown
- 2002-12-18 CN CNA028282043A patent/CN1620293A/zh active Pending
- 2002-12-18 MX MXPA04006088A patent/MXPA04006088A/es not_active Application Discontinuation
- 2002-12-18 WO PCT/US2002/040679 patent/WO2003051362A2/fr active Application Filing
- 2002-12-18 DE DE60230327T patent/DE60230327D1/de not_active Expired - Lifetime
- 2002-12-18 HU HU0402485A patent/HUP0402485A3/hu unknown
-
2004
- 2004-06-16 IS IS7319A patent/IS7319A/is unknown
- 2004-07-15 HR HR20040647A patent/HRP20040647A2/hr not_active Application Discontinuation
- 2004-07-16 NO NO20043038A patent/NO20043038L/no not_active Application Discontinuation
-
2009
- 2009-02-19 JP JP2009036569A patent/JP2009108107A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1620293A (zh) | 2005-05-25 |
HRP20040647A2 (en) | 2005-04-30 |
IS7319A (is) | 2004-06-16 |
AU2002366383A1 (en) | 2003-06-30 |
KR20040066917A (ko) | 2004-07-27 |
AU2002366383B2 (en) | 2007-06-14 |
DE60230327D1 (de) | 2009-01-22 |
WO2003051362A3 (fr) | 2003-08-07 |
EP1467735B1 (fr) | 2008-12-10 |
EP1467735A2 (fr) | 2004-10-20 |
CA2470479A1 (fr) | 2003-06-26 |
HUP0402485A2 (hu) | 2005-04-28 |
WO2003051362A2 (fr) | 2003-06-26 |
ATE417051T1 (de) | 2008-12-15 |
JP2009108107A (ja) | 2009-05-21 |
MXPA04006088A (es) | 2004-09-27 |
JP2005514387A (ja) | 2005-05-19 |
IL162461A0 (en) | 2005-11-20 |
KR100839136B1 (ko) | 2008-06-20 |
ES2316650T3 (es) | 2009-04-16 |
HUP0402485A3 (en) | 2008-10-28 |
EP1467735A4 (fr) | 2005-11-23 |
PT1467735E (pt) | 2009-03-10 |
PL370802A1 (en) | 2005-05-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |