NO20040101L - Hemming av apoptoseprosessen og forbedring av cellenes yteevne - Google Patents
Hemming av apoptoseprosessen og forbedring av cellenes yteevneInfo
- Publication number
- NO20040101L NO20040101L NO20040101A NO20040101A NO20040101L NO 20040101 L NO20040101 L NO 20040101L NO 20040101 A NO20040101 A NO 20040101A NO 20040101 A NO20040101 A NO 20040101A NO 20040101 L NO20040101 L NO 20040101L
- Authority
- NO
- Norway
- Prior art keywords
- cell
- enhancement
- inhibition
- cell performance
- production
- Prior art date
Links
- 230000006654 negative regulation of apoptotic process Effects 0.000 title 1
- 230000002424 anti-apoptotic effect Effects 0.000 abstract 2
- 238000003782 apoptosis assay Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000005522 programmed cell death Effects 0.000 abstract 2
- 238000002659 cell therapy Methods 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Foreliggende oppfinnelse vedrører forhindring eller forsinkelse av programmert celledød gjennom å uttrykke en eller flere anti-apoptotiske polypeptider i en celle slik at programmert celledød i cellen blir forhindret eller forsinket. Foreliggende oppfinnelse vedrører også økning av produksjon av et cellerelatert produkt gjennom å uttrykke en eller flere anti-apoptotiske polypeptider i en celle slik at produksjonen av det cellerelaterte produktet av cellen blir økt. Rekombinante celler nyttige for fremstilling av cellerelaterte produkter eller celleterapi er også tilveiebrakt.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30381301P | 2001-07-10 | 2001-07-10 | |
PCT/US2002/021606 WO2003006607A2 (en) | 2001-07-10 | 2002-07-10 | Inhibition of apoptosis process and improvement of cell performance |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20040101L true NO20040101L (no) | 2004-03-09 |
Family
ID=23173824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20040101A NO20040101L (no) | 2001-07-10 | 2004-01-09 | Hemming av apoptoseprosessen og forbedring av cellenes yteevne |
Country Status (13)
Country | Link |
---|---|
US (1) | US7604989B2 (no) |
EP (1) | EP1414948B1 (no) |
JP (2) | JP4435563B2 (no) |
KR (1) | KR20040044433A (no) |
CN (1) | CN1526011A (no) |
AT (1) | ATE443131T1 (no) |
AU (1) | AU2002315534B2 (no) |
CA (1) | CA2452005C (no) |
DE (1) | DE60233738D1 (no) |
MX (1) | MXPA04000281A (no) |
NO (1) | NO20040101L (no) |
WO (1) | WO2003006607A2 (no) |
ZA (2) | ZA200508985B (no) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7812148B2 (en) | 2001-04-05 | 2010-10-12 | Millipore Corporation | Vectors comprising CpG islands without position effect varigation and having increased expression |
KR100454016B1 (ko) * | 2002-01-05 | 2004-10-26 | 한국과학기술원 | 항예정사 유전자로 형질전환되고 dhfr 유전자가결핍된 신규한 cho 세포주, 그의 제조 방법 및 상기형질전환된 cho 숙주 세포를 이용한 목적단백질의 생산방법 |
US9057079B2 (en) | 2003-02-01 | 2015-06-16 | Emd Millipore Corporation | Expression elements |
ATE465245T1 (de) * | 2003-10-24 | 2010-05-15 | Chemo Sero Therapeut Res Inst | Neue rekombinante tierzellen mit hoher proteinproduktion, verfahren zur konstruktion davon sowie verfahren zur massenproduktion von protein unter verwendung davon |
WO2005065348A2 (en) | 2003-12-31 | 2005-07-21 | Kalobios, Inc. | Transactivation system for mammalian cells |
US7537930B2 (en) | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
US7531327B2 (en) * | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
AU2005333513B2 (en) * | 2004-07-23 | 2011-06-02 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
US7608425B2 (en) * | 2004-07-23 | 2009-10-27 | Immunomedics, Inc. | Methods for protein expression in mammalian cells in serum-free medium |
WO2007015691A2 (en) * | 2004-07-23 | 2007-02-08 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
GB0509965D0 (en) | 2005-05-17 | 2005-06-22 | Ml Lab Plc | Improved expression elements |
JP4977691B2 (ja) * | 2006-04-13 | 2012-07-18 | 中外製薬株式会社 | タウリントランスポーター遺伝子 |
US20100167396A1 (en) * | 2006-04-21 | 2010-07-01 | Bayer Healthcare Llc | Application of Anti-Apoptotic Gene Expression in Mammalian Cells for Perfusion Culture |
EP2118270A2 (en) * | 2007-01-08 | 2009-11-18 | Millipore Corporation | Cell culture methods for producing recombinant proteins in the presence of reduced levels of one or more contaminants |
EP2300600B1 (en) | 2008-06-13 | 2015-09-30 | Janssen Biotech, Inc. | Methods for improving viability and productivity in cell culture |
US20130065312A1 (en) * | 2009-11-03 | 2013-03-14 | The Johns Hopkins University | Method and composition for generating programmed cell death resistant algal cells |
HUP1000243A2 (en) | 2010-05-06 | 2012-01-30 | Avidin Kft | 8-hidroxy-quinoline derivatives |
KR20200002050A (ko) | 2018-06-28 | 2020-01-08 | 삼성디스플레이 주식회사 | 유기 발광 표시 장치 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136310A (en) | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
DE669986T1 (de) | 1992-11-13 | 1996-10-10 | Idec Pharma Corp | Völlig unfunktionelle konsensus-kozak-sequenzen zur säugetier-exprimierung. |
US5565491A (en) * | 1994-01-31 | 1996-10-15 | Bristol-Myers Squibb Company | Use of phosphotyrosine phospatase inhibitors for controlling cellular proliferation |
US5550050A (en) | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
US5811524A (en) | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
US6001358A (en) | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
US6087129A (en) | 1996-01-19 | 2000-07-11 | Betagene, Inc. | Recombinant expression of proteins from secretory cell lines |
US5897992A (en) | 1996-09-27 | 1999-04-27 | Cold Spring Harbor Laboratory | Cell-free assay using oncogene-induced apoptosis in drug-resistant cells |
US6011138A (en) | 1997-02-20 | 2000-01-04 | Idec Pharmaceuticals Corporation | Gamma-1 anti-human CD23 monoclonal antibodies |
US5969102A (en) * | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
US5830698A (en) | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
WO2000008057A2 (en) | 1998-08-07 | 2000-02-17 | Immunex Corporation | Molecules designated b7l-1 |
AU760466B2 (en) | 1999-02-26 | 2003-05-15 | Johns Hopkins University, The | A novel inhibitor of programmed cell death |
US6140118A (en) | 1999-08-11 | 2000-10-31 | Wisconsin Alumni Research Foundation | Avian blastodermal cell lines |
WO2001023592A2 (en) | 1999-09-27 | 2001-04-05 | Genentech, Inc. | Methods for making recombinant proteins using apoptosis inhibitors |
WO2001034149A1 (en) * | 1999-11-12 | 2001-05-17 | Merck & Co., Inc. | Diaryl piperidyl pyrrole derivatives as antiprotozoal agents |
KR100454016B1 (ko) | 2002-01-05 | 2004-10-26 | 한국과학기술원 | 항예정사 유전자로 형질전환되고 dhfr 유전자가결핍된 신규한 cho 세포주, 그의 제조 방법 및 상기형질전환된 cho 숙주 세포를 이용한 목적단백질의 생산방법 |
EP1348758A1 (en) | 2002-03-28 | 2003-10-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Host cells having improved cell survival properties and methods to generate such cells |
-
2002
- 2002-07-10 KR KR10-2004-7000349A patent/KR20040044433A/ko not_active Application Discontinuation
- 2002-07-10 CN CNA028138511A patent/CN1526011A/zh active Pending
- 2002-07-10 ZA ZA200508985A patent/ZA200508985B/xx unknown
- 2002-07-10 US US10/191,052 patent/US7604989B2/en not_active Expired - Fee Related
- 2002-07-10 DE DE60233738T patent/DE60233738D1/de not_active Expired - Lifetime
- 2002-07-10 JP JP2003512366A patent/JP4435563B2/ja not_active Expired - Fee Related
- 2002-07-10 AU AU2002315534A patent/AU2002315534B2/en not_active Ceased
- 2002-07-10 WO PCT/US2002/021606 patent/WO2003006607A2/en active Application Filing
- 2002-07-10 CA CA2452005A patent/CA2452005C/en not_active Expired - Fee Related
- 2002-07-10 MX MXPA04000281A patent/MXPA04000281A/es not_active Application Discontinuation
- 2002-07-10 AT AT02742400T patent/ATE443131T1/de not_active IP Right Cessation
- 2002-07-10 EP EP02742400A patent/EP1414948B1/en not_active Expired - Lifetime
-
2004
- 2004-01-08 ZA ZA200400137A patent/ZA200400137B/xx unknown
- 2004-01-09 NO NO20040101A patent/NO20040101L/no not_active Application Discontinuation
-
2009
- 2009-02-04 JP JP2009024345A patent/JP2009118851A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1526011A (zh) | 2004-09-01 |
WO2003006607A9 (en) | 2003-04-10 |
EP1414948A4 (en) | 2006-06-21 |
KR20040044433A (ko) | 2004-05-28 |
JP2009118851A (ja) | 2009-06-04 |
JP4435563B2 (ja) | 2010-03-17 |
ZA200508985B (en) | 2006-07-26 |
JP2005525782A (ja) | 2005-09-02 |
EP1414948A2 (en) | 2004-05-06 |
US20030064510A1 (en) | 2003-04-03 |
US7604989B2 (en) | 2009-10-20 |
ZA200400137B (en) | 2006-06-28 |
MXPA04000281A (es) | 2004-07-23 |
WO2003006607A2 (en) | 2003-01-23 |
CA2452005C (en) | 2011-03-15 |
CA2452005A1 (en) | 2003-01-23 |
DE60233738D1 (de) | 2009-10-29 |
AU2002315534B2 (en) | 2008-05-22 |
EP1414948B1 (en) | 2009-09-16 |
WO2003006607A3 (en) | 2003-07-31 |
ATE443131T1 (de) | 2009-10-15 |
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