NO20035761L - T1R heterooligomere smaksreseptorer og cellelinjer som uttrykker nevnte reseptorer og anvendelse derav for identifisering av smaksforbindelser - Google Patents
T1R heterooligomere smaksreseptorer og cellelinjer som uttrykker nevnte reseptorer og anvendelse derav for identifisering av smaksforbindelserInfo
- Publication number
- NO20035761L NO20035761L NO20035761A NO20035761A NO20035761L NO 20035761 L NO20035761 L NO 20035761L NO 20035761 A NO20035761 A NO 20035761A NO 20035761 A NO20035761 A NO 20035761A NO 20035761 L NO20035761 L NO 20035761L
- Authority
- NO
- Norway
- Prior art keywords
- receptors
- taste
- sweet
- umami
- discovered
- Prior art date
Links
- 108091005708 gustatory receptors Proteins 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 108020003175 receptors Proteins 0.000 title abstract 4
- 239000000796 flavoring agent Substances 0.000 title 1
- 235000019634 flavors Nutrition 0.000 title 1
- 102100035942 Taste receptor type 1 member 3 Human genes 0.000 abstract 5
- 235000019583 umami taste Nutrition 0.000 abstract 5
- 101000659774 Homo sapiens Taste receptor type 1 member 3 Proteins 0.000 abstract 4
- 235000019605 sweet taste sensations Nutrition 0.000 abstract 4
- 235000019607 umami taste sensations Nutrition 0.000 abstract 4
- 102000005962 receptors Human genes 0.000 abstract 3
- 101000659767 Homo sapiens Taste receptor type 1 member 1 Proteins 0.000 abstract 2
- 101000659765 Homo sapiens Taste receptor type 1 member 2 Proteins 0.000 abstract 2
- 102100035941 Taste receptor type 1 member 1 Human genes 0.000 abstract 2
- 102100035948 Taste receptor type 1 member 2 Human genes 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- MIEKOFWWHVOKQX-UHFFFAOYSA-N (S)-2-(4-Methoxyphenoxy)propanoic acid Chemical compound COC1=CC=C(OC(C)C(O)=O)C=C1 MIEKOFWWHVOKQX-UHFFFAOYSA-N 0.000 abstract 1
- 101100315276 Homo sapiens TAS1R2 gene Proteins 0.000 abstract 1
- 101100315287 Homo sapiens TAS1R3 gene Proteins 0.000 abstract 1
- 108091052352 Tir receptor family Proteins 0.000 abstract 1
- 102000008229 Toll-like receptor 1 Human genes 0.000 abstract 1
- 108010060889 Toll-like receptor 1 Proteins 0.000 abstract 1
- 102000008230 Toll-like receptor 3 Human genes 0.000 abstract 1
- 108010060885 Toll-like receptor 3 Proteins 0.000 abstract 1
- 239000008122 artificial sweetener Substances 0.000 abstract 1
- 235000021311 artificial sweeteners Nutrition 0.000 abstract 1
- 238000000423 cell based assay Methods 0.000 abstract 1
- 235000009508 confectionery Nutrition 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- -1 lactisol Chemical class 0.000 abstract 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 abstract 1
- 235000013923 monosodium glutamate Nutrition 0.000 abstract 1
- 239000004223 monosodium glutamate Substances 0.000 abstract 1
- 238000007423 screening assay Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30043401P | 2001-06-26 | 2001-06-26 | |
US09/897,427 US6955887B2 (en) | 2001-03-30 | 2001-07-03 | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
US30474901P | 2001-07-13 | 2001-07-13 | |
US31049301P | 2001-08-08 | 2001-08-08 | |
US33177101P | 2001-11-21 | 2001-11-21 | |
US33947201P | 2001-12-14 | 2001-12-14 | |
US10/035,045 US7241880B2 (en) | 2001-01-03 | 2002-01-03 | T1R taste receptors and genes encoding same |
US37209002P | 2002-04-15 | 2002-04-15 | |
US37414302P | 2002-04-22 | 2002-04-22 | |
US37452202P | 2002-04-23 | 2002-04-23 | |
PCT/US2002/019970 WO2003001876A2 (en) | 2001-06-26 | 2002-06-26 | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20035761L true NO20035761L (no) | 2004-02-20 |
Family
ID=29588022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20035761A NO20035761L (no) | 2001-06-26 | 2003-12-22 | T1R heterooligomere smaksreseptorer og cellelinjer som uttrykker nevnte reseptorer og anvendelse derav for identifisering av smaksforbindelser |
Country Status (6)
Country | Link |
---|---|
EP (4) | EP2003451B1 (zh) |
CN (1) | CN100489102C (zh) |
AU (1) | AU2002326315B2 (zh) |
CA (1) | CA2451317C (zh) |
NO (1) | NO20035761L (zh) |
WO (1) | WO2003001876A2 (zh) |
Families Citing this family (43)
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US7402400B2 (en) | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
TW201006846A (en) | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
TW201022287A (en) | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
US20080244761A1 (en) | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
US7368285B2 (en) | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
US7309577B2 (en) | 2001-03-07 | 2007-12-18 | Senomyx, Inc. | Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste |
US7301009B2 (en) | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
DK2327985T3 (en) | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
WO2003004992A2 (en) | 2001-07-03 | 2003-01-16 | The Regents Of The University Of California | Mammalian sweet and amino acid heterodimeric taste receptors |
WO2003025137A2 (en) | 2001-09-18 | 2003-03-27 | Irm, Llc | Sweet taste receptors |
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US20050106571A1 (en) | 2003-10-02 | 2005-05-19 | The Regents Of The University Of California | Mammalian T1R3 sweet taste receptors |
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US8796441B2 (en) | 2005-04-13 | 2014-08-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human sweet and umami taste receptor variants |
WO2006127936A2 (en) | 2005-05-23 | 2006-11-30 | Cadbury Adams Usa Llc | Taste potentiator compositions and edible confectionery and chewing gum products containing same |
CN101179943B (zh) | 2005-05-23 | 2013-06-26 | 卡夫食品环球品牌有限责任公司 | 填充液体的咀嚼型胶基糖组合物 |
TW200715993A (en) | 2005-06-15 | 2007-05-01 | Senomyx Inc | Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers |
CA2952660C (en) * | 2005-10-20 | 2018-09-11 | Senomyx, Inc. | Chimeric human sweet-umami and umami-sweet taste receptors |
WO2007124152A2 (en) | 2006-04-21 | 2007-11-01 | Senomyx, Inc. | Comestible compositions comprising high potency savory flavorants, and processes for producing them |
CN101294970B (zh) * | 2007-04-25 | 2012-12-05 | 中国医学科学院基础医学研究所 | 蛋白质三维结构的预测方法 |
US8633186B2 (en) | 2007-06-08 | 2014-01-21 | Senomyx Inc. | Modulation of chemosensory receptors and ligands associated therewith |
US9603848B2 (en) | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
US7928111B2 (en) | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
GB0713297D0 (en) | 2007-07-10 | 2007-08-15 | Cadbury Schweppes Plc | Chocolate compositions having improved flavour characteristics |
WO2009045617A1 (en) * | 2007-10-03 | 2009-04-09 | The Regents Of The University Of California | Porcine umami taste receptors and uses therefor |
EP2093234A1 (en) | 2008-02-08 | 2009-08-26 | Nutrinova Nutrition Specialties & Food Ingredients GmbH | Oligopeptides for use as taste modulators |
TWI429404B (zh) | 2008-03-03 | 2014-03-11 | Senomyx Inc | 異山梨醇衍生物及彼等作為風味改良劑、促味劑及促味增強劑之用途 |
MY153622A (en) | 2008-07-31 | 2015-02-27 | Senomyx Inc | Processes and intermediates for making sweet taste enhancers |
ES2525551T3 (es) | 2008-07-31 | 2014-12-26 | Senomyx, Inc. | Composiciones que comprenden potenciadores de dulzor y métodos de producirlas |
CN103153096B (zh) | 2010-08-12 | 2016-08-03 | 赛诺米克斯公司 | 提高甜味增强剂的稳定性的方法和包含稳定的甜味增强剂的组合物 |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
EP2529632B1 (de) | 2011-05-31 | 2013-08-28 | Symrise AG | Zimtsäureamide als würzige Geschmacksstoffe |
CN104603132B (zh) | 2012-08-06 | 2020-02-21 | 弗门尼舍公司 | 甜味调节剂 |
JO3155B1 (ar) | 2013-02-19 | 2017-09-20 | Senomyx Inc | معدِّل نكهة حلوة |
US9804157B1 (en) | 2013-03-15 | 2017-10-31 | Senomyx, Inc. | Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives |
EP2918270A1 (de) | 2014-03-12 | 2015-09-16 | Symrise AG | Aromatische Alkensäurederivate zur Appetithemmung und Stimmungsaufhellung |
EP3482214A1 (en) * | 2016-07-11 | 2019-05-15 | Ranvier Health Limited | Method of diagnostic relevance based on taste recognition |
EP3777563A4 (en) * | 2018-03-30 | 2022-01-26 | Suntory Holdings Limited | SWEET COMPOSITION THAT PRODUCES A SWEET TASTE RESPONSE MEDIATED BY SWEET RECEPTORS OTHER THAN SWEET RECEPTORS (T1R2 AND T1R3). |
JP7453210B2 (ja) | 2018-08-07 | 2024-03-19 | フィルメニッヒ インコーポレイテッド | 5-置換4-アミノ-1H-ベンゾ[c][1,2,6]チアジアジン2,2-ジオキシド並びにその配合物及び使用 |
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-
2002
- 2002-06-26 AU AU2002326315A patent/AU2002326315B2/en not_active Ceased
- 2002-06-26 WO PCT/US2002/019970 patent/WO2003001876A2/en active IP Right Grant
- 2002-06-26 CN CNB028128303A patent/CN100489102C/zh not_active Expired - Lifetime
- 2002-06-26 EP EP08075748A patent/EP2003451B1/en not_active Expired - Lifetime
- 2002-06-26 EP EP10180331.0A patent/EP2327985B2/en not_active Expired - Lifetime
- 2002-06-26 EP EP10180335.1A patent/EP2293067B1/en not_active Expired - Lifetime
- 2002-06-26 EP EP02761016A patent/EP1412750B1/en not_active Expired - Lifetime
- 2002-06-26 CA CA2451317A patent/CA2451317C/en not_active Expired - Fee Related
-
2003
- 2003-12-22 NO NO20035761A patent/NO20035761L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP2003451A2 (en) | 2008-12-17 |
CA2451317C (en) | 2016-03-29 |
EP2293067A2 (en) | 2011-03-09 |
EP2293067A3 (en) | 2012-01-18 |
EP2327985B1 (en) | 2016-05-25 |
EP2003451A3 (en) | 2008-12-24 |
EP2003451B1 (en) | 2012-05-30 |
AU2002326315B2 (en) | 2007-07-05 |
EP1412750B1 (en) | 2012-05-23 |
CN1520516A (zh) | 2004-08-11 |
WO2003001876A2 (en) | 2003-01-09 |
WO2003001876A8 (en) | 2004-08-19 |
EP1412750A4 (en) | 2005-02-09 |
EP2327985B2 (en) | 2019-08-21 |
WO2003001876A3 (en) | 2003-12-04 |
EP2293067B1 (en) | 2016-04-20 |
CA2451317A1 (en) | 2003-01-09 |
EP2327985A2 (en) | 2011-06-01 |
CN100489102C (zh) | 2009-05-20 |
EP1412750A2 (en) | 2004-04-28 |
EP2327985A3 (en) | 2012-01-18 |
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