NO20031771L - Nye derivater av cyanoaryl(eller cyanoheteroaryl)-karbonyl- piperazinylpyrimidiner, deres fremstilling og anvendelse som medikament - Google Patents
Nye derivater av cyanoaryl(eller cyanoheteroaryl)-karbonyl- piperazinylpyrimidiner, deres fremstilling og anvendelse som medikamentInfo
- Publication number
- NO20031771L NO20031771L NO20031771A NO20031771A NO20031771L NO 20031771 L NO20031771 L NO 20031771L NO 20031771 A NO20031771 A NO 20031771A NO 20031771 A NO20031771 A NO 20031771A NO 20031771 L NO20031771 L NO 20031771L
- Authority
- NO
- Norway
- Prior art keywords
- radical
- cyanoheteroaryl
- cyanoaryl
- carbonylpiperazinylpyrimidines
- drug
- Prior art date
Links
- 125000002944 cyanoaryl group Chemical group 0.000 title abstract 2
- RLYTYKUXGBXMRJ-UHFFFAOYSA-N C(=O)=C1N(CCNC1)C1=NC=CC=N1 Chemical class C(=O)=C1N(CCNC1)C1=NC=CC=N1 RLYTYKUXGBXMRJ-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003193 general anesthetic agent Substances 0.000 abstract 1
- 229940005494 general anesthetics Drugs 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200002532A ES2167276B1 (es) | 2000-10-20 | 2000-10-20 | Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
| PCT/ES2001/000378 WO2002032880A1 (es) | 2000-10-20 | 2001-10-10 | Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparación y su aplicación como medicamentos |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20031771D0 NO20031771D0 (no) | 2003-04-16 |
| NO20031771L true NO20031771L (no) | 2003-06-06 |
Family
ID=8495344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20031771A NO20031771L (no) | 2000-10-20 | 2003-04-16 | Nye derivater av cyanoaryl(eller cyanoheteroaryl)-karbonyl- piperazinylpyrimidiner, deres fremstilling og anvendelse som medikament |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7300937B2 (pl) |
| EP (1) | EP1327630B1 (pl) |
| JP (1) | JP2004511550A (pl) |
| KR (1) | KR20030037687A (pl) |
| CN (1) | CN1221536C (pl) |
| AR (1) | AR030885A1 (pl) |
| AT (1) | ATE380795T1 (pl) |
| AU (2) | AU9387701A (pl) |
| BR (1) | BR0114999A (pl) |
| CA (1) | CA2426097A1 (pl) |
| CZ (1) | CZ20031116A3 (pl) |
| DE (1) | DE60131873T2 (pl) |
| ES (2) | ES2167276B1 (pl) |
| HU (1) | HUP0302901A3 (pl) |
| IL (1) | IL155259A0 (pl) |
| MX (1) | MXPA03003348A (pl) |
| NO (1) | NO20031771L (pl) |
| NZ (1) | NZ525246A (pl) |
| PL (1) | PL361033A1 (pl) |
| PT (1) | PT1327630E (pl) |
| RU (1) | RU2259358C2 (pl) |
| TW (1) | TWI220144B (pl) |
| WO (1) | WO2002032880A1 (pl) |
| ZA (1) | ZA200302452B (pl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04008797A (es) * | 2002-03-13 | 2004-11-26 | Janssen Pharmaceutica Nv | Inhibidores de histona desacetilasa. |
| CN103360343B (zh) * | 2012-03-30 | 2017-04-19 | 凯惠药业(上海)有限公司 | 一种哌嗪酰胺类化合物的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2535718A1 (fr) | 1982-11-09 | 1984-05-11 | Sanofi Sa | (piperazinyl-1)-2 pyrimidines, leurs sels, procede pour leur preparation et compositions pharmaceutiques en contenant |
| US4547505A (en) * | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
| US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
| FR2642759B1 (fr) * | 1989-02-09 | 1991-05-17 | Laboratorios Esteve Sa | Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante |
| FR2654621B1 (fr) | 1989-11-22 | 1994-09-23 | Esteve Labor Dr | Inhibition du syndrome d'abstinence. |
| FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
| JPH04202185A (ja) * | 1990-11-30 | 1992-07-22 | Terumo Corp | ピペラジン誘導体及びこれを含有する医薬製剤 |
| FR2701260B1 (fr) * | 1993-02-05 | 1995-05-05 | Esteve Labor Dr | Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments. |
| ES2125206B1 (es) * | 1997-07-21 | 1999-11-16 | Esteve Labor Dr | Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
-
2000
- 2000-10-20 ES ES200002532A patent/ES2167276B1/es not_active Expired - Fee Related
-
2001
- 2001-10-10 MX MXPA03003348A patent/MXPA03003348A/es active IP Right Grant
- 2001-10-10 AU AU9387701A patent/AU9387701A/xx active Pending
- 2001-10-10 PT PT01974344T patent/PT1327630E/pt unknown
- 2001-10-10 RU RU2003114437/04A patent/RU2259358C2/ru not_active IP Right Cessation
- 2001-10-10 CZ CZ20031116A patent/CZ20031116A3/cs unknown
- 2001-10-10 ES ES01974344T patent/ES2296806T3/es not_active Expired - Lifetime
- 2001-10-10 HU HU0302901A patent/HUP0302901A3/hu unknown
- 2001-10-10 JP JP2002536263A patent/JP2004511550A/ja active Pending
- 2001-10-10 CA CA002426097A patent/CA2426097A1/en not_active Abandoned
- 2001-10-10 KR KR10-2003-7005303A patent/KR20030037687A/ko not_active Abandoned
- 2001-10-10 DE DE60131873T patent/DE60131873T2/de not_active Expired - Lifetime
- 2001-10-10 NZ NZ525246A patent/NZ525246A/en unknown
- 2001-10-10 CN CNB018176291A patent/CN1221536C/zh not_active Expired - Fee Related
- 2001-10-10 US US10/312,195 patent/US7300937B2/en not_active Expired - Fee Related
- 2001-10-10 BR BR0114999-7A patent/BR0114999A/pt not_active IP Right Cessation
- 2001-10-10 PL PL01361033A patent/PL361033A1/pl not_active Application Discontinuation
- 2001-10-10 AU AU2001293877A patent/AU2001293877B2/en not_active Ceased
- 2001-10-10 EP EP01974344A patent/EP1327630B1/en not_active Expired - Lifetime
- 2001-10-10 AT AT01974344T patent/ATE380795T1/de not_active IP Right Cessation
- 2001-10-10 WO PCT/ES2001/000378 patent/WO2002032880A1/es not_active Ceased
- 2001-10-10 IL IL15525901A patent/IL155259A0/xx unknown
- 2001-10-12 AR ARP010104819A patent/AR030885A1/es unknown
- 2001-10-17 TW TW090125627A patent/TWI220144B/zh not_active IP Right Cessation
-
2003
- 2003-03-28 ZA ZA200302452A patent/ZA200302452B/en unknown
- 2003-04-16 NO NO20031771A patent/NO20031771L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1327630B1 (en) | 2007-12-12 |
| AR030885A1 (es) | 2003-09-03 |
| PT1327630E (pt) | 2008-03-05 |
| ATE380795T1 (de) | 2007-12-15 |
| JP2004511550A (ja) | 2004-04-15 |
| CA2426097A1 (en) | 2003-04-16 |
| ES2167276B1 (es) | 2003-04-01 |
| ES2296806T3 (es) | 2008-05-01 |
| TWI220144B (en) | 2004-08-11 |
| ES2167276A1 (es) | 2002-05-01 |
| KR20030037687A (ko) | 2003-05-14 |
| IL155259A0 (en) | 2003-11-23 |
| WO2002032880A1 (es) | 2002-04-25 |
| BR0114999A (pt) | 2004-02-03 |
| US7300937B2 (en) | 2007-11-27 |
| NO20031771D0 (no) | 2003-04-16 |
| AU2001293877B2 (en) | 2007-01-04 |
| HK1060358A1 (en) | 2004-08-06 |
| HUP0302901A3 (en) | 2004-04-28 |
| US20040048872A1 (en) | 2004-03-11 |
| RU2259358C2 (ru) | 2005-08-27 |
| PL361033A1 (pl) | 2004-09-20 |
| CZ20031116A3 (cs) | 2003-10-15 |
| EP1327630A1 (en) | 2003-07-16 |
| NZ525246A (en) | 2004-11-26 |
| CN1221536C (zh) | 2005-10-05 |
| DE60131873D1 (de) | 2008-01-24 |
| CN1469866A (zh) | 2004-01-21 |
| ZA200302452B (en) | 2004-03-29 |
| AU9387701A (en) | 2002-04-29 |
| HUP0302901A2 (hu) | 2004-03-01 |
| MXPA03003348A (es) | 2003-06-19 |
| DE60131873T2 (de) | 2008-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |