NO20021360L - Regioselektiv syntese av rapamycin-derivater - Google Patents

Regioselektiv syntese av rapamycin-derivater

Info

Publication number
NO20021360L
NO20021360L NO20021360A NO20021360A NO20021360L NO 20021360 L NO20021360 L NO 20021360L NO 20021360 A NO20021360 A NO 20021360A NO 20021360 A NO20021360 A NO 20021360A NO 20021360 L NO20021360 L NO 20021360L
Authority
NO
Norway
Prior art keywords
rapamycin derivatives
regioselective synthesis
regioselective
synthesis
rapamycin
Prior art date
Application number
NO20021360A
Other languages
English (en)
Norwegian (no)
Other versions
NO20021360D0 (no
Inventor
Chia-Cheng Shaw
John Hamilton Sellstedt
Razzak Noureldin
Gloria Karen Cheal
Genevieve Fortier
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of NO20021360D0 publication Critical patent/NO20021360D0/no
Publication of NO20021360L publication Critical patent/NO20021360L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20021360A 1999-09-29 2002-03-19 Regioselektiv syntese av rapamycin-derivater NO20021360L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40883099A 1999-09-29 1999-09-29
PCT/US2000/026445 WO2001023395A2 (en) 1999-09-29 2000-09-27 Regioselective synthesis of rapamycin derivatives

Publications (2)

Publication Number Publication Date
NO20021360D0 NO20021360D0 (no) 2002-03-19
NO20021360L true NO20021360L (no) 2002-03-19

Family

ID=23617953

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021360A NO20021360L (no) 1999-09-29 2002-03-19 Regioselektiv syntese av rapamycin-derivater

Country Status (24)

Country Link
EP (1) EP1216251B1 (pl)
JP (1) JP4289813B2 (pl)
KR (1) KR100754236B1 (pl)
CN (1) CN1176925C (pl)
AR (1) AR029181A1 (pl)
AT (1) ATE233269T1 (pl)
AU (1) AU782234B2 (pl)
BR (1) BR0014433A (pl)
CA (1) CA2385461C (pl)
CZ (1) CZ300368B6 (pl)
DE (1) DE60001510T2 (pl)
DK (1) DK1216251T3 (pl)
EA (1) EA004331B1 (pl)
ES (1) ES2189768T3 (pl)
HK (1) HK1044774B (pl)
HU (1) HUP0202609A3 (pl)
IL (2) IL148542A0 (pl)
MX (1) MXPA02003243A (pl)
NO (1) NO20021360L (pl)
NZ (1) NZ517644A (pl)
PL (1) PL200899B1 (pl)
TW (1) TWI256395B (pl)
WO (1) WO2001023395A2 (pl)
ZA (1) ZA200201918B (pl)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
BRPI0414066A (pt) * 2003-09-03 2006-10-24 Wyeth Corp 42-éster de rapamicina amorfo com ácido 3-hidróxi-2-( hidroximetil )-2-metilproipiÈnico e composições farmacêuticas que o contenha
AR046194A1 (es) 2003-11-04 2005-11-30 Mayo Foundation Metodo de tratamiento del linfoma de celulas del manto
US7202256B2 (en) 2004-04-14 2007-04-10 Wyeth Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
JP4224115B2 (ja) 2004-04-14 2009-02-12 ワイス ラパマイシン４２−エステル誘導体の位置特異的合成
BRPI0514206A (pt) 2004-08-10 2008-06-03 Wyeth Corp composto, anticorpo, kit para monitorar a terapia com cci-779, e, métodos para detectar metabólitos de cci-779, e para produzir um metabólito sintético e um derivado de cci-779
ZA200706804B (en) 2005-02-03 2008-10-29 Gen Hospital Corp Method for treating gefitinib resistant cancer
EP1856130A1 (en) 2005-02-09 2007-11-21 Wyeth a Corporation of the State of Delaware Cci-779 polymorph and use thereof
CA2626326C (en) 2005-11-04 2021-02-16 Wyeth Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
DK2310011T3 (da) 2008-06-17 2013-10-14 Wyeth Llc Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin
CN101676291B (zh) 2008-09-18 2012-05-09 上海海和药物研究开发有限公司 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途
WO2011092564A2 (en) * 2010-01-28 2011-08-04 Fresenius Kabi Oncology Ltd Process for the preparation of temsirolimus and its intermediates
CN102020662B (zh) 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔制备方法
KR20140013000A (ko) * 2011-04-01 2014-02-04 산도즈 아게 C-42 위치에서 라파마이신의 위치선택적 아실화
CN103421023B (zh) * 2013-07-30 2015-09-23 福建省微生物研究所 一种替西罗莫司的合成工艺
CN104086564B (zh) * 2014-07-30 2019-02-05 江苏奥赛康药业股份有限公司 一种高纯度坦罗莫司的制备方法
CN106146536B (zh) * 2015-04-25 2019-07-26 山东新时代药业有限公司 一种依维莫司的制备方法
KR102420468B1 (ko) * 2016-03-14 2022-07-13 위스콘신 얼럼나이 리서어치 화운데이션 올리고락트산 컨쥬게이트 및 향상된 항암 효능을 갖는 마이셀
CN107561170B (zh) * 2016-07-02 2021-07-30 山东新时代药业有限公司 一种坦西莫司中间体的分析检测方法
CN108948046B (zh) * 2017-05-20 2020-11-10 鲁南制药集团股份有限公司 一种替西罗莫司的中间体及其制备方法
CN108948045A (zh) * 2017-05-20 2018-12-07 鲁南制药集团股份有限公司 一种替西罗莫司的制备方法
CN109206441B (zh) * 2017-06-30 2022-05-20 正大天晴药业集团股份有限公司 一种依维莫司的纯化方法
CN109776570A (zh) * 2017-11-14 2019-05-21 上海医药工业研究院 一种依维莫司中间体、其制备方法及其应用
EA202092692A1 (ru) 2018-06-15 2021-04-21 Навитор Фармасьютикалз, Инк. Аналоги рапамицина и их применения
CN109369679A (zh) * 2018-12-24 2019-02-22 江苏卓和药业有限公司 一种雷帕霉素的精制方法
CN109851626B (zh) * 2019-01-08 2021-11-02 扬子江药业集团四川海蓉药业有限公司 一种替西罗莫司的分离纯化方法
KR20220128345A (ko) 2019-12-05 2022-09-20 아나쿠리아 테라퓨틱스, 인코포레이티드 라파마이신 유사체 및 이의 용도
CN113372359A (zh) * 2020-03-10 2021-09-10 鲁南制药集团股份有限公司 一种坦西莫司的制备方法
CN114106014B (zh) * 2020-08-27 2024-03-15 鲁南制药集团股份有限公司 一种依维莫司的制备方法
CN115028658A (zh) * 2022-07-06 2022-09-09 国药集团川抗制药有限公司 雷帕霉素硅醇酯及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120842A (en) * 1991-04-01 1992-06-09 American Home Products Corporation Silyl ethers of rapamycin
US5387680A (en) * 1993-08-10 1995-02-07 American Home Products Corporation C-22 ring stabilized rapamycin derivatives
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5563145A (en) * 1994-12-07 1996-10-08 American Home Products Corporation Rapamycin 42-oximes and hydroxylamines

Also Published As

Publication number Publication date
DE60001510D1 (de) 2003-04-03
IL148542A (en) 2006-08-20
CA2385461C (en) 2009-03-17
EP1216251B1 (en) 2003-02-26
JP4289813B2 (ja) 2009-07-01
CN1176925C (zh) 2004-11-24
AU782234B2 (en) 2005-07-14
HK1044774B (en) 2003-05-30
KR100754236B1 (ko) 2007-09-03
AU7718200A (en) 2001-04-30
HUP0202609A3 (en) 2004-11-29
BR0014433A (pt) 2002-06-11
DE60001510T2 (de) 2003-10-02
IL148542A0 (en) 2002-09-12
AR029181A1 (es) 2003-06-18
EA200200412A1 (ru) 2002-10-31
EA004331B1 (ru) 2004-04-29
ATE233269T1 (de) 2003-03-15
NZ517644A (en) 2003-09-26
NO20021360D0 (no) 2002-03-19
CN1402731A (zh) 2003-03-12
MXPA02003243A (es) 2002-09-30
CZ300368B6 (cs) 2009-05-06
KR20020029796A (ko) 2002-04-19
DK1216251T3 (da) 2003-06-16
CA2385461A1 (en) 2001-04-05
EP1216251A2 (en) 2002-06-26
PL200899B1 (pl) 2009-02-27
ES2189768T3 (es) 2003-07-16
CZ20021136A3 (cs) 2002-06-12
PL354461A1 (pl) 2004-01-12
JP2003510329A (ja) 2003-03-18
HUP0202609A2 (hu) 2002-12-28
ZA200201918B (en) 2003-08-27
WO2001023395A2 (en) 2001-04-05
WO2001023395A3 (en) 2001-10-25
TWI256395B (en) 2006-06-11
HK1044774A1 (en) 2002-11-01

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application