NO20012100L - Pyrano-, piperidino- og tiopyranoforbindelser og fremgangsmåter ved anvendelse - Google Patents

Pyrano-, piperidino- og tiopyranoforbindelser og fremgangsmåter ved anvendelse

Info

Publication number
NO20012100L
NO20012100L NO20012100A NO20012100A NO20012100L NO 20012100 L NO20012100 L NO 20012100L NO 20012100 A NO20012100 A NO 20012100A NO 20012100 A NO20012100 A NO 20012100A NO 20012100 L NO20012100 L NO 20012100L
Authority
NO
Norway
Prior art keywords
compounds
thiopyrano
pyrano
piperidino
methods
Prior art date
Application number
NO20012100A
Other languages
English (en)
Other versions
NO20012100D0 (no
NO318628B1 (no
Inventor
William A Carroll
Konstantinos A Agrios
Robert J Altenbach
Irene Drizin
Michael E Kort
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of NO20012100D0 publication Critical patent/NO20012100D0/no
Publication of NO20012100L publication Critical patent/NO20012100L/no
Publication of NO318628B1 publication Critical patent/NO318628B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
NO20012100A 1998-10-28 2001-04-27 Pyrano-, piperidino- og tiopyranoforbindelser, farmasoytiske sammensetninger inneholdende det samme og anvendelse av forbindelsene NO318628B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18169098A 1998-10-28 1998-10-28
US09/421,862 US6191140B1 (en) 1998-10-28 1999-10-20 Pyrano, piperidino, and thiopyrano compounds and methods of use
PCT/US1999/025373 WO2000024743A1 (en) 1998-10-28 1999-10-28 Pyrano, piperidino, and thiopyrano compounds and methods of use

Publications (3)

Publication Number Publication Date
NO20012100D0 NO20012100D0 (no) 2001-04-27
NO20012100L true NO20012100L (no) 2001-06-14
NO318628B1 NO318628B1 (no) 2005-04-18

Family

ID=26877422

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012100A NO318628B1 (no) 1998-10-28 2001-04-27 Pyrano-, piperidino- og tiopyranoforbindelser, farmasoytiske sammensetninger inneholdende det samme og anvendelse av forbindelsene

Country Status (21)

Country Link
US (1) US6191140B1 (no)
EP (1) EP1124828B1 (no)
JP (1) JP2002528454A (no)
KR (1) KR20010085975A (no)
CN (1) CN1335846A (no)
AT (1) ATE382620T1 (no)
AU (1) AU764163B2 (no)
BG (1) BG105524A (no)
BR (1) BR9914688A (no)
CA (1) CA2348576A1 (no)
CZ (1) CZ20011480A3 (no)
DE (1) DE69937895T2 (no)
ES (1) ES2299272T3 (no)
HK (1) HK1041877A1 (no)
HU (1) HUP0104146A3 (no)
NO (1) NO318628B1 (no)
NZ (1) NZ511041A (no)
PL (1) PL347552A1 (no)
SK (1) SK5242001A3 (no)
TR (1) TR200101140T2 (no)
WO (1) WO2000024743A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6642222B2 (en) * 1998-10-28 2003-11-04 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
CA2378936A1 (en) * 1999-08-03 2001-02-08 Abbott Laboratories Potassium channel openers
US6538004B2 (en) * 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
JP2004505109A (ja) * 2000-08-02 2004-02-19 アストラゼネカ・アクチエボラーグ 置換された1,4−ジヒドロピリジンの不斉合成法
WO2003011869A1 (en) * 2001-07-30 2003-02-13 Abbott Laboratories Radioligands and their use for identifying potassium channel modulators
US6632418B2 (en) * 2001-07-30 2003-10-14 Abbott Laboratories Radioligands and their use for identifying potassium channel modulators
US20030153773A1 (en) * 2002-02-14 2003-08-14 Wayne Gregory S. Process for the production of dihydropyridines

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321384A (en) 1981-02-27 1982-03-23 American Home Products Corporation Antihypertensive agents
GB2093834B (en) 1981-02-27 1984-08-15 American Home Prod Antihypertensive agents
US4551534A (en) 1984-03-30 1985-11-05 American Home Products Corporation Aralkyl or aryloxyalkyl 1,7-naphthyridine-3-carboxylic acid esters
AU6042686A (en) 1985-07-29 1987-02-05 American Home Products Corporation 1,4,5,6,7,8-hexahydro-(substituted) phenyl-1,7- napthyridine-3-carboxylic acid derivatives
US4596873A (en) 1985-07-29 1986-06-24 American Home Products Corporation 1,4,5,6,7,8-Hexahydro-2-alkyl-4-aryl-5-oxo-1,7-naphthyridine-3-carboxylic acid aromatic esters and pharmaceutically acceptable acid addition salts thereof useful as antihypertensive agents
US4618678A (en) 1985-07-29 1986-10-21 American Home Products Corporation 4-(2,3-dichloro-6-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-1,7-naphthyridine-3-carboxylic acid 2-(2,3-dichlorophenoxy)ethyl ester
GB9220570D0 (en) * 1991-10-21 1992-11-11 Ici Plc Therapeutic agent
CA2080949A1 (en) 1991-10-21 1993-04-22 Cyrus John Ohnmacht Therapeutic agents
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
DE4424678A1 (de) 1994-07-13 1996-01-18 Bayer Ag Dioxo-thiopyrano-pyridin-carbonsäure-derivate
US6593335B1 (en) * 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
HUP0100112A3 (en) * 1997-12-18 2004-05-28 Abbott Lab Fused pyridine derivatives having potassium chanel opening activity and their use
JP2002528452A (ja) * 1998-10-28 2002-09-03 アボット・ラボラトリーズ ジヒドロピリジン化合物および使用方法

Also Published As

Publication number Publication date
DE69937895T2 (de) 2009-01-02
US6191140B1 (en) 2001-02-20
HUP0104146A2 (hu) 2002-04-29
PL347552A1 (en) 2002-04-08
AU764163B2 (en) 2003-08-14
HUP0104146A3 (en) 2002-10-28
NZ511041A (en) 2003-03-28
BR9914688A (pt) 2001-10-02
JP2002528454A (ja) 2002-09-03
TR200101140T2 (tr) 2002-07-22
AU1709500A (en) 2000-05-15
BG105524A (bg) 2001-12-29
CA2348576A1 (en) 2000-05-04
ES2299272T3 (es) 2008-05-16
KR20010085975A (ko) 2001-09-07
CZ20011480A3 (cs) 2001-08-15
NO20012100D0 (no) 2001-04-27
ATE382620T1 (de) 2008-01-15
WO2000024743A1 (en) 2000-05-04
EP1124828B1 (en) 2008-01-02
EP1124828A1 (en) 2001-08-22
HK1041877A1 (zh) 2002-07-26
CN1335846A (zh) 2002-02-13
DE69937895D1 (de) 2008-02-14
SK5242001A3 (en) 2001-12-03
NO318628B1 (no) 2005-04-18

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