NO20001140L - Fremgangsmõte ved fremstilling av epoksid intermediater - Google Patents
Fremgangsmõte ved fremstilling av epoksid intermediaterInfo
- Publication number
- NO20001140L NO20001140L NO20001140A NO20001140A NO20001140L NO 20001140 L NO20001140 L NO 20001140L NO 20001140 A NO20001140 A NO 20001140A NO 20001140 A NO20001140 A NO 20001140A NO 20001140 L NO20001140 L NO 20001140L
- Authority
- NO
- Norway
- Prior art keywords
- heptanoate
- prostaglandin
- hydroxy
- preparation
- dihydro derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000002118 epoxides Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- BGKHCLZFGPIKKU-UHFFFAOYSA-N (13E,15S)-15-hydroxy-9-oxo-prosta-10,13-dienoic acid Natural products CCCCCC(O)C=CC1C=CC(=O)C1CCCCCCC(O)=O BGKHCLZFGPIKKU-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 238000007142 ring opening reaction Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
Overraskende er det blitt oppdaget at ulempene ved de om- stendelige litteraturprosedyrene for å syntetisere 13,14- dihydroderivater av prostaglandin A, E og F kan overvinnes ved å anvende et nytt metyl-7-(2-hydroksy-5-(2-(2-oksira- ~:nyl)etyl) -4- (1,1,2,2 tetrametyl-1-silapropoksy)cyklo- pentyl)heptanoat-mellomprodukt, som kan syntetiseres fra kommersielt tilgjengelig metyl-7-[3-(R)-hydroksy-5-okso-l- cyklopent-l-yl]-heptanoat. Dette nye mellomprodukt kan kob- les med oksygen-, karbon-, svovel- og nitrogen-nukleofiler, i nærvær av en base eller en Lewis-syre, i en ringåpnings- prosess for å tilveiebringe 13,14-dihydroderivater av prostaglandin A, E og F.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5825497P | 1997-09-09 | 1997-09-09 | |
| PCT/US1998/018593 WO1999012897A1 (en) | 1997-09-09 | 1998-09-04 | A process for making epoxide intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20001140D0 NO20001140D0 (no) | 2000-03-06 |
| NO20001140L true NO20001140L (no) | 2000-05-04 |
Family
ID=22015649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20001140A NO20001140L (no) | 1997-09-09 | 2000-03-06 | Fremgangsmõte ved fremstilling av epoksid intermediater |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6066751A (no) |
| EP (1) | EP1012138A1 (no) |
| JP (1) | JP2001515884A (no) |
| CN (1) | CN1269783A (no) |
| AU (1) | AU9305798A (no) |
| BR (1) | BR9811771A (no) |
| CA (1) | CA2303797A1 (no) |
| HU (1) | HUP0003578A2 (no) |
| ID (1) | ID24840A (no) |
| IL (1) | IL134864A0 (no) |
| NO (1) | NO20001140L (no) |
| PE (1) | PE121499A1 (no) |
| PL (1) | PL339220A1 (no) |
| SK (1) | SK3392000A3 (no) |
| TR (1) | TR200000672T2 (no) |
| WO (1) | WO1999012897A1 (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0200258A2 (hu) | 1999-03-05 | 2002-05-29 | The Procter & Gamble Co. | C16-telítetlen FP-szelektív prosztaglandin analógok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| KR100437873B1 (ko) * | 2001-05-08 | 2004-06-26 | 연성정밀화학(주) | 프로스타글란딘 유도체의 제조방법 및 그의 입체특이적출발물질 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3776938A (en) * | 1958-05-28 | 1973-12-04 | S Bergstrom | Dihydro-pge1 |
| US3505386A (en) * | 1965-12-29 | 1970-04-07 | Upjohn Co | Compounds related to prostaglandins |
| US3435053A (en) * | 1966-06-06 | 1969-03-25 | Upjohn Co | Cyclopenta(b)pyrans |
-
1998
- 1998-09-04 BR BR9811771-8A patent/BR9811771A/pt not_active Application Discontinuation
- 1998-09-04 WO PCT/US1998/018593 patent/WO1999012897A1/en not_active Application Discontinuation
- 1998-09-04 ID IDW20000642A patent/ID24840A/id unknown
- 1998-09-04 AU AU93057/98A patent/AU9305798A/en not_active Abandoned
- 1998-09-04 PL PL98339220A patent/PL339220A1/xx not_active Application Discontinuation
- 1998-09-04 SK SK339-2000A patent/SK3392000A3/sk unknown
- 1998-09-04 CA CA002303797A patent/CA2303797A1/en not_active Abandoned
- 1998-09-04 US US09/148,539 patent/US6066751A/en not_active Expired - Fee Related
- 1998-09-04 EP EP98945917A patent/EP1012138A1/en not_active Ceased
- 1998-09-04 IL IL13486498A patent/IL134864A0/xx unknown
- 1998-09-04 CN CN98808986A patent/CN1269783A/zh active Pending
- 1998-09-04 TR TR2000/00672T patent/TR200000672T2/xx unknown
- 1998-09-04 JP JP2000510709A patent/JP2001515884A/ja not_active Withdrawn
- 1998-09-04 HU HU0003578A patent/HUP0003578A2/hu unknown
- 1998-10-02 PE PE1998000932A patent/PE121499A1/es not_active Application Discontinuation
-
2000
- 2000-03-06 NO NO20001140A patent/NO20001140L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1269783A (zh) | 2000-10-11 |
| AU9305798A (en) | 1999-03-29 |
| JP2001515884A (ja) | 2001-09-25 |
| PE121499A1 (es) | 2000-02-03 |
| CA2303797A1 (en) | 1999-03-18 |
| ID24840A (id) | 2000-08-24 |
| WO1999012897A1 (en) | 1999-03-18 |
| TR200000672T2 (tr) | 2000-07-21 |
| PL339220A1 (en) | 2000-12-04 |
| EP1012138A1 (en) | 2000-06-28 |
| SK3392000A3 (en) | 2000-09-12 |
| IL134864A0 (en) | 2001-05-20 |
| BR9811771A (pt) | 2000-08-29 |
| NO20001140D0 (no) | 2000-03-06 |
| US6066751A (en) | 2000-05-23 |
| HUP0003578A2 (hu) | 2001-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR0131327B1 (en) | Indole derivatives | |
| WO2003048116A3 (en) | Esters and amides as ppar-alpha agonists ____________ | |
| AU3945589A (en) | Substituted 4-piperidinyl-indol-5-yl-alkyl-sulphonamide derivatives | |
| NO20001140L (no) | Fremgangsmõte ved fremstilling av epoksid intermediater | |
| AU567117B2 (en) | Indene derivatives | |
| AU4931590A (en) | Indole derivatives | |
| AU8143487A (en) | New derivatives of 2,2-dimethyl cyclopropane carboxylic acid having a saturated halogenated chain in position 3, the process and the intermediates for their preparation, their use as pesticides and the compositions containing them | |
| ES2139934T3 (es) | Procedimiento mejorado para preparar derivados de cadena lateral de ciclohexapeptidil lipopeptidos. | |
| ES533657A0 (es) | Un procedimiento para la preparacion de nuevos derivados de pirrolo-(2,1-a)isoquilonina. | |
| JO2498B1 (en) | Methods of preparation of derivatives (3-oxy-33,2-2-dihydro-1-isoindol-1-yl) | |
| IL85229A0 (en) | Novel imidazo-and triazolothiadiazines,a process for the preparation thereof,pharmaceutical compositions containing same,and the use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |