NO180584C - Bisnaftalimider som inneholder aminosyreavledete linkere, for anvendelse som antikreftmidler, samt farmasöytiske preparater - Google Patents

Bisnaftalimider som inneholder aminosyreavledete linkere, for anvendelse som antikreftmidler, samt farmasöytiske preparater

Info

Publication number
NO180584C
NO180584C NO933455A NO933455A NO180584C NO 180584 C NO180584 C NO 180584C NO 933455 A NO933455 A NO 933455A NO 933455 A NO933455 A NO 933455A NO 180584 C NO180584 C NO 180584C
Authority
NO
Norway
Prior art keywords
bisnaphthalimides
amino acid
well
pharmaceutical preparations
containing amino
Prior art date
Application number
NO933455A
Other languages
English (en)
Norwegian (no)
Other versions
NO180584B (no
NO933455L (no
NO933455D0 (no
Inventor
Jung-Hui Sun
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of NO933455D0 publication Critical patent/NO933455D0/no
Publication of NO933455L publication Critical patent/NO933455L/no
Publication of NO180584B publication Critical patent/NO180584B/no
Publication of NO180584C publication Critical patent/NO180584C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
NO933455A 1991-03-27 1993-09-27 Bisnaftalimider som inneholder aminosyreavledete linkere, for anvendelse som antikreftmidler, samt farmasöytiske preparater NO180584C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67606191A 1991-03-27 1991-03-27
US07/805,044 US5206249A (en) 1991-03-27 1991-12-11 Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
PCT/US1992/002134 WO1992017453A1 (en) 1991-03-27 1992-03-25 Bis-naphthalimides containing amino-acid derived linkers as anticancer agents

Publications (4)

Publication Number Publication Date
NO933455D0 NO933455D0 (no) 1993-09-27
NO933455L NO933455L (no) 1993-11-26
NO180584B NO180584B (no) 1997-02-03
NO180584C true NO180584C (no) 1997-05-14

Family

ID=27101469

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933455A NO180584C (no) 1991-03-27 1993-09-27 Bisnaftalimider som inneholder aminosyreavledete linkere, for anvendelse som antikreftmidler, samt farmasöytiske preparater

Country Status (17)

Country Link
US (1) US5206249A (fi)
EP (2) EP0577753A1 (fi)
JP (1) JPH06506229A (fi)
CZ (1) CZ281868B6 (fi)
FI (1) FI934225A (fi)
HU (1) HUT68969A (fi)
IE (1) IE920958A1 (fi)
IL (1) IL101380A (fi)
MA (1) MA22476A1 (fi)
MX (1) MX9201355A (fi)
MY (1) MY108433A (fi)
NO (1) NO180584C (fi)
NZ (1) NZ242126A (fi)
SK (1) SK107193A3 (fi)
TW (1) TW205547B (fi)
WO (1) WO1992017453A1 (fi)
YU (1) YU30092A (fi)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5461176A (en) * 1991-03-27 1995-10-24 The Du Pont Merck Pharmaceutical Company Processes for preparing bis-naphthalimides containing amino-acid derived linkers
US5329048A (en) * 1991-03-27 1994-07-12 The Dupont Merck Pharmaceutical Company Process of preparing tetraamino intermediates
ES2088661T3 (es) * 1991-12-11 1996-08-16 Du Pont Merck Pharma Bis-naftalimidas fuertemente solubles en agua utiles como agentes anti-cancerigenos.
US5235045A (en) * 1992-03-19 1993-08-10 Microbiomed Corporation Non-azo naphthalimide dyes
US5376664A (en) * 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
US5364867A (en) * 1992-11-30 1994-11-15 Sterling Winthrop Inc. 4-phenylpiperdine agents for treating cns disorders
US5359070A (en) * 1993-02-11 1994-10-25 The Du Pont Merck Pharmaceutical Company Unsymmetrical bis-imides as anticancer agents
US5416089A (en) * 1993-06-24 1995-05-16 The Du Pont Merck Pharmaceutical Company Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
US5766600A (en) * 1993-08-09 1998-06-16 Microbiomed Corporation Non-azo naphtalimide dyes and uses for same
IL110460A (en) * 1993-08-18 2001-01-11 Basf Ag Bite-naphthalimides, their preparation and pharmaceutical preparations containing them
US6204243B1 (en) 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
AU7831694A (en) * 1993-09-24 1995-04-10 Du Pont Merck Pharmaceutical Company, The Improved methods for preparing bis-imide compounds
US5561042A (en) * 1994-07-22 1996-10-01 Cancer Therapy And Research Center Diamine platinum naphthalimide complexes as antitumor agents
US5604095A (en) * 1994-07-22 1997-02-18 Cancer Therapy & Research Center Unsymmetrically linked bisnaphthalimides as antitumor agents
US5641782A (en) * 1995-02-16 1997-06-24 The Dupont Merck Pharmaceutical Company 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
FR2751655B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9723407D0 (en) 1997-11-05 1998-01-07 Ciba Geigy Ag Organic compounds
CA2300069C (en) 1998-07-03 2006-01-17 Taiho Pharmaceutical Co., Ltd. Naphthalimidobenzamide derivatives
WO2000051998A1 (en) * 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
WO2000055166A1 (en) 1999-03-16 2000-09-21 Regents Of The University Of California Glycosylated polyamines
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
GB0003111D0 (en) 2000-02-10 2000-03-29 Novartis Ag Organic compounds
EP1539150A4 (en) * 2002-07-08 2006-10-11 Chemgenex Pharmaceuticals Inc SYNTHESIS OF NAPHTHALIMIDES, INCLUDING AMONAFIDS, AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME
EP1711634A4 (en) * 2004-01-30 2008-04-02 Chemgenex Pharmaceuticals Inc NAPHTHALIMIDE ASSAY BY GENOTYPING N-ACETYL TRANSFERASE
CA2569279A1 (en) * 2004-06-04 2005-12-15 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors
US7947839B2 (en) * 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
WO2009089537A2 (en) 2008-01-11 2009-07-16 Northwestern University Anti-cancer compounds
JP5523573B2 (ja) * 2009-10-08 2014-06-18 アンガス ケミカル カンパニー 低ｖｏｃポリアミン
CN109490291B (zh) * 2018-11-20 2021-05-11 上海应用技术大学 基于吸电子基取代的1,8-萘酰亚胺类化合物作为氟离子的显色试剂的用途
US20220289680A1 (en) * 2018-12-27 2022-09-15 Alucent Biomedical, Inc. Methods for making dimeric naphthalimides and solid state forms of the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146720A (en) * 1976-10-27 1979-03-27 Laboratorios Made, S.A. N-aminoethyl-substituted-3-nitronaphthalimides
DE3481120D1 (de) * 1983-04-01 1990-03-01 Warner Lambert Co 3,6-disubstituierte-1,8-naphthalimide, verfahren zu ihrer herstellung und ihre verwendung.
US4665071A (en) * 1984-02-21 1987-05-12 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
DE3535496A1 (de) * 1985-10-04 1987-04-16 Bayer Ag Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents

Also Published As

Publication number Publication date
AU1767692A (en) 1992-11-02
JPH06506229A (ja) 1994-07-14
NZ242126A (en) 1996-09-25
WO1992017453A1 (en) 1992-10-15
AU666847B2 (en) 1996-02-29
EP0506008A1 (en) 1992-09-30
FI934225A (fi) 1993-10-15
TW205547B (fi) 1993-05-11
IL101380A0 (en) 1992-11-15
CZ206093A3 (en) 1994-03-16
MX9201355A (es) 1992-10-01
NO180584B (no) 1997-02-03
EP0577753A1 (en) 1994-01-12
SK107193A3 (en) 1994-08-10
CZ281868B6 (cs) 1997-03-12
US5206249A (en) 1993-04-27
NO933455L (no) 1993-11-26
IE920958A1 (en) 1992-10-07
MA22476A1 (fr) 1992-10-01
NO933455D0 (no) 1993-09-27
FI934225A0 (fi) 1993-09-27
MY108433A (en) 1996-09-30
IL101380A (en) 1996-10-31
YU30092A (sr) 1996-01-09
HUT68969A (en) 1995-08-28
HU9302719D0 (en) 1993-12-28

Similar Documents

Publication Publication Date Title
NO180584C (no) Bisnaftalimider som inneholder aminosyreavledete linkere, for anvendelse som antikreftmidler, samt farmasöytiske preparater
NO179911C (no) Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet
NO965377D0 (no) Indolinonforbindelser samt farmasöytiske preparater inneholdende forbindelsene
NO307459B1 (no) Piperazinderivater, samt farmasøytiske preparater inneholdende slike
DE69814091D1 (de) Voriconazol-enthaltende pharmazeutische zubereitungen
SE9704545D0 (sv) Novel compounds
SE9704544D0 (sv) Novel compounds
NL194828B (nl) Somatostatinepeptiden, alsmede dergelijke somatostatinepeptiden bevattende farmaceutische preparaten.
DE58901934D1 (de) Verschlussanordnung fuer pharmazeutische flaschen.
ATE98480T1 (de) Arzneimittelformulierungen.
ITMI913324A0 (it) Agenti farmaceutici
ZA926019B (en) Pharmaceutical spheroid formulation.
DE3882157D1 (de) Nichtsteroide antientzuendungswirkstoffe enthaltende pharmazeutische zubereitungen.
IT1231012B (it) Composizione farmaceutica per uso orale contenente nac.
IT8820386A0 (it) Composizioni farmaceutiche orosolubili contenti acetilcisteina.
FI891227A (fi) Katekolderivat och farmaceutiska preparat som innehaoller dessa.
FR2680686B1 (fr) Lotion tri-phases destinee a un usage corporel, pharmaceutique ou cosmetique.
DK276189D0 (da) Polypeptidforbindelser, fremgangsmaader til fremstilling heraf farmaceutiske midler indeholdende disse
FI941447A0 (fi) Suun kautta annettavat, kapseleina olevat ubidekarenonivalmisteet
DK13089A (da) Substituerede 5,6,7,8-tetrahydro-4h-thieno-(2,3-d)azepin-forbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
EE9800275A (et) Misolastiini sisaldavad prolongeeritud toimega farmatseutilised preparaadid
FI895463A0 (fi) Farmaceutiska kompositioner, som innehaoller labdanditerpenoidderivat och pyrimido (6,1-a) isokinolin -4-onderivat, samt anvaendning daerav.
NO985171D0 (no) Sulfonamidsubstituerte kondenserte 5-ringforbindelser, deres anvendelse som medikament samt farmas°ytiske preparater inneholdende forbindelsene
DK256689D0 (da) 1,2-dithiol-3-thion-s-oxid-forbindelser til anven delse som laegemidler
NO940533D0 (no) Rensede streptograminer, deres fremstilling samt farmasöytiske preparater inneholdende forbindelsene