NO180491C - Anti-endotoksinforbindelser, mellomprodukter for disse, et farmasöytisk preparat som inneholder dem, fremgangsmåte til kobling av en alkylsidekjede til et azidosakkarid som har en fri hydroksyl, og anvendelse av nevnte forbindelser - Google Patents

Anti-endotoksinforbindelser, mellomprodukter for disse, et farmasöytisk preparat som inneholder dem, fremgangsmåte til kobling av en alkylsidekjede til et azidosakkarid som har en fri hydroksyl, og anvendelse av nevnte forbindelser

Info

Publication number
NO180491C
NO180491C NO923939A NO923939A NO180491C NO 180491 C NO180491 C NO 180491C NO 923939 A NO923939 A NO 923939A NO 923939 A NO923939 A NO 923939A NO 180491 C NO180491 C NO 180491C
Authority
NO
Norway
Prior art keywords
compounds
azidosaccharide
intermediates
coupling
pharmaceutical composition
Prior art date
Application number
NO923939A
Other languages
English (en)
Norwegian (no)
Other versions
NO923939D0 (no
NO180491B (no
NO923939L (no
Inventor
William J Christ
Lynn D Hawkins
Osamu Asano
Tsutomu Kawata
Seiichi Kobayashi
Daniel P Rossignol
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/935,050 external-priority patent/US5530113A/en
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO923939D0 publication Critical patent/NO923939D0/no
Publication of NO923939L publication Critical patent/NO923939L/no
Publication of NO180491B publication Critical patent/NO180491B/no
Publication of NO180491C publication Critical patent/NO180491C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
NO923939A 1991-10-11 1992-10-09 Anti-endotoksinforbindelser, mellomprodukter for disse, et farmasöytisk preparat som inneholder dem, fremgangsmåte til kobling av en alkylsidekjede til et azidosakkarid som har en fri hydroksyl, og anvendelse av nevnte forbindelser NO180491C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77610091A 1991-10-11 1991-10-11
US07/935,050 US5530113A (en) 1991-10-11 1992-08-25 Anti-endotoxin compounds

Publications (4)

Publication Number Publication Date
NO923939D0 NO923939D0 (no) 1992-10-09
NO923939L NO923939L (no) 1993-04-13
NO180491B NO180491B (no) 1997-01-20
NO180491C true NO180491C (no) 1997-04-30

Family

ID=27119147

Family Applications (1)

Application Number Title Priority Date Filing Date
NO923939A NO180491C (no) 1991-10-11 1992-10-09 Anti-endotoksinforbindelser, mellomprodukter for disse, et farmasöytisk preparat som inneholder dem, fremgangsmåte til kobling av en alkylsidekjede til et azidosakkarid som har en fri hydroksyl, og anvendelse av nevnte forbindelser

Country Status (12)

Country Link
US (3) US5843918A (hu)
EP (1) EP0536969A3 (hu)
JP (1) JP3865411B2 (hu)
CN (1) CN1071668A (hu)
AU (1) AU660325B2 (hu)
CA (1) CA2079971A1 (hu)
FI (1) FI924579A (hu)
HU (1) HUT64538A (hu)
IL (1) IL103298A0 (hu)
NO (1) NO180491C (hu)
NZ (1) NZ244643A (hu)
RU (1) RU2095366C1 (hu)

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US5681824A (en) 1995-06-05 1997-10-28 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
US6417172B1 (en) * 1995-06-05 2002-07-09 Eisai Co., Ltd. Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
AU7254396A (en) * 1995-09-29 1997-04-17 Eisai Research Institute Method for treating alcoholic liver disease
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WO1998055106A1 (en) * 1997-05-23 1998-12-10 Eisai Co., Ltd. Method for preparing pharmaceutical formulation
US6368604B1 (en) 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
US6828155B1 (en) 1998-09-01 2004-12-07 Eisai Co., Ltd. Method for evaluating lipid a analog-containing injections
WO2000042994A2 (en) * 1999-01-21 2000-07-27 North Shore-Long Island Jewish Research Institute Inhibition of bacterial dissemination
US20040006242A1 (en) 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
AU757507B2 (en) 1999-02-10 2003-02-20 Sankyo Company Limited Ether type lipid A1-carboxylic acid analogues
AU780577B2 (en) 1999-11-15 2005-04-07 Oncothyreon Inc. Synthetic Lipid-A analogs and uses thereof
US6861512B2 (en) 2000-03-01 2005-03-01 Eisai Co., Ltd. Separation of olefinic isomers
AU2001246858A1 (en) * 2000-04-06 2001-10-23 Sankyo Company Limited 1-carboxymethyl analogues of lipid a
MXPA02011486A (es) * 2000-05-19 2004-01-26 Corixa Corp Tratamiento profilactico y terapeutico de enfermedades infecciosas, autoinmunes y alergicas con compuestos a base de mono y disacarido.
US20020042379A1 (en) * 2000-06-09 2002-04-11 Daniel Rossignol Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion
US20030105033A1 (en) 2000-06-09 2003-06-05 Rossignol Daniel P. Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion
US20040198652A1 (en) * 2001-04-24 2004-10-07 Carter J. Paul Methods and compositions for preventing and treating septic shock and endotoxemia
WO2002088156A1 (fr) * 2001-04-26 2002-11-07 Sankyo Company, Limited Derivé d'acide 1-carboxylique de lipide a
WO2003013440A2 (en) 2001-08-10 2003-02-20 Eisai Co., Ltd. Treatment and prevention of heat shock protein-associated diseases and conditions
WO2004058788A1 (ja) * 2002-12-24 2004-07-15 Sankyo Company, Limited 右糖グルコースリピドa類縁体
JP4773336B2 (ja) * 2003-02-20 2011-09-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｌｐｓアンタゴニストｂ１２８７およびその立体異性体の調製のための試薬および方法
US7951232B2 (en) * 2006-02-09 2011-05-31 Elevance Renewable Sciences, Inc. Surface coating compositions and methods
WO2007092633A2 (en) * 2006-02-09 2007-08-16 Elevance Renewable Sciences, Inc. Antimicrobial compositions, methods and systems
CA2662921C (en) 2006-09-26 2018-11-20 Infectious Disease Research Institute Vaccine and pharmaceutical compositions and kits and uses thereof in stimulating an immune response with a synthetic glucopyranosyl lipid adjuvant
US20090181078A1 (en) * 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US8518903B2 (en) 2007-04-19 2013-08-27 University of Pittsburgh—of the Commonwealth System of Higher Education Use of toll-like receptor-9 agonists
WO2010141861A1 (en) * 2009-06-05 2010-12-09 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
US9072760B2 (en) 2010-09-24 2015-07-07 University of Pittsburgh—of the Commonwealth System of Higher Education TLR4 inhibitors for the treatment of human infectious and inflammatory disorders
US10668092B2 (en) 2010-09-24 2020-06-02 The John Hopkins University Compositions and methods for treatment of inflammatory disorders
WO2012088425A2 (en) 2010-12-22 2012-06-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Gap junction-enhancing agents for treatment of necrotizing enterocolitis and inflammatory bowel disease
SG194083A1 (en) 2011-04-08 2013-11-29 Immune Design Corp Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
WO2013173590A1 (en) 2012-05-16 2013-11-21 Immune Design Corp. Vaccines for hsv-2
US9562066B2 (en) 2012-09-25 2017-02-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Oral therapy of necrotizing enterocolitis
EA032326B1 (ru) 2013-04-18 2019-05-31 Иммьюн Дизайн Корп. Монотерапия gla для применения в лечении рака
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
RU2564918C1 (ru) * 2014-05-07 2015-10-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Оренбургская государственная медицинская академия" Министерства здравоохранения Российской Федерации /ГБОУ ВПО ОрГМА Минздрава России/ Средство для снижения системной патологической эндотоксинемии
WO2018067730A1 (en) * 2016-10-04 2018-04-12 University Of Maryland, Baltimore Methods of treating sepsis using anti-sepsis lipid a (asla) based therapeutics
CN114315893B (zh) * 2021-12-22 2023-08-25 科之杰新材料集团有限公司 一种季铵盐功能单体及其制备方法、高适应性聚羧酸保坍剂及其制备方法

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Also Published As

Publication number Publication date
FI924579A0 (fi) 1992-10-09
AU660325B2 (en) 1995-06-22
NZ244643A (en) 1995-07-26
NO923939D0 (no) 1992-10-09
EP0536969A2 (en) 1993-04-14
CN1071668A (zh) 1993-05-05
IL103298A0 (en) 1993-02-21
AU2526692A (en) 1993-04-22
HU9203204D0 (en) 1992-12-28
US5756718A (en) 1998-05-26
NO180491B (no) 1997-01-20
NO923939L (no) 1993-04-13
FI924579A (fi) 1993-04-12
HUT64538A (en) 1994-01-28
US5612476A (en) 1997-03-18
CA2079971A1 (en) 1993-04-12
EP0536969A3 (en) 1994-05-18
JPH05194470A (ja) 1993-08-03
RU2095366C1 (ru) 1997-11-10
JP3865411B2 (ja) 2007-01-10
US5843918A (en) 1998-12-01

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