FI924579A - Anti-endotoxinfoereningar - Google Patents

Anti-endotoxinfoereningar Download PDF

Info

Publication number
FI924579A
FI924579A FI924579A FI924579A FI924579A FI 924579 A FI924579 A FI 924579A FI 924579 A FI924579 A FI 924579A FI 924579 A FI924579 A FI 924579A FI 924579 A FI924579 A FI 924579A
Authority
FI
Finland
Prior art keywords
endotoxinfoereningar
Prior art date
Application number
FI924579A
Other languages
English (en)
Other versions
FI924579A0 (fi
Inventor
William J Christ
Lynn D Hawkins
Osamu Asano
Tsutomu Kawata
Seiichi Kobayashi
Daniel P Rossignol
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/935,050 external-priority patent/US5530113A/en
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of FI924579A0 publication Critical patent/FI924579A0/fi
Publication of FI924579A publication Critical patent/FI924579A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
FI924579A 1991-10-11 1992-10-09 Anti-endotoxinfoereningar FI924579A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77610091A 1991-10-11 1991-10-11
US07/935,050 US5530113A (en) 1991-10-11 1992-08-25 Anti-endotoxin compounds

Publications (2)

Publication Number Publication Date
FI924579A0 FI924579A0 (fi) 1992-10-09
FI924579A true FI924579A (fi) 1993-04-12

Family

ID=27119147

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924579A FI924579A (fi) 1991-10-11 1992-10-09 Anti-endotoxinfoereningar

Country Status (12)

Country Link
US (3) US5612476A (fi)
EP (1) EP0536969A3 (fi)
JP (1) JP3865411B2 (fi)
CN (1) CN1071668A (fi)
AU (1) AU660325B2 (fi)
CA (1) CA2079971A1 (fi)
FI (1) FI924579A (fi)
HU (1) HUT64538A (fi)
IL (1) IL103298A0 (fi)
NO (1) NO180491C (fi)
NZ (1) NZ244643A (fi)
RU (1) RU2095366C1 (fi)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU660325B2 (en) * 1991-10-11 1995-06-22 Eisai Co. Ltd. Anti-endotoxin compounds and related molecules and methods
US5530113A (en) * 1991-10-11 1996-06-25 Eisai Co., Ltd. Anti-endotoxin compounds
US5648343A (en) * 1994-02-28 1997-07-15 The University Of Georgia Research Foundation Method for treating LPS-mediated disorders
US6417172B1 (en) 1995-06-05 2002-07-09 Eisai Co., Ltd. Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
US5681824A (en) * 1995-06-05 1997-10-28 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
AU7254396A (en) * 1995-09-29 1997-04-17 Eisai Research Institute Method for treating alcoholic liver disease
WO1998001139A1 (en) * 1996-07-03 1998-01-15 Eisai Co., Ltd. Injections containing lipid a analogues and process for the preparation thereof
JP2002501540A (ja) * 1997-05-23 2002-01-15 エーザイ株式会社 製薬製剤を調製するための方法
US6368604B1 (en) 1997-09-26 2002-04-09 University Of Maryland Biotechnology Institute Non-pyrogenic derivatives of lipid A
WO2000013029A1 (fr) 1998-09-01 2000-03-09 Eisai Co., Ltd Procede pour evaluer des injections contenant des analogues de lipide a
WO2000042994A2 (en) * 1999-01-21 2000-07-27 North Shore-Long Island Jewish Research Institute Inhibition of bacterial dissemination
US20040006242A1 (en) 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
AU757507B2 (en) 1999-02-10 2003-02-20 Sankyo Company Limited Ether type lipid A1-carboxylic acid analogues
WO2001036433A2 (en) 1999-11-15 2001-05-25 Biomira, Inc. Synthetic lipid-a analogs and uses thereof
US6861512B2 (en) 2000-03-01 2005-03-01 Eisai Co., Ltd. Separation of olefinic isomers
WO2001077133A1 (fr) * 2000-04-06 2001-10-18 Sankyo Company, Limited Analogues 1-carboxymethyl du lipide a
CN1606446A (zh) * 2000-05-19 2005-04-13 科里克萨有限公司 用单糖和二糖类化合物预防和治疗传染病和其他疾病的方法
US20030105033A1 (en) 2000-06-09 2003-06-05 Rossignol Daniel P. Administration of an anti-endotoxin drug by bolus or intermittent intravenous infusion
JP2004503472A (ja) * 2000-06-09 2004-02-05 エーザイ株式会社 ボーラスまたは間欠的な静脈内注入による、抗内毒素薬の投与
WO2002085117A1 (en) * 2001-04-24 2002-10-31 Eisai Co., Ltd. Methods and compositions for preventing and treating septic shock and endotoxemia
WO2002088156A1 (fr) * 2001-04-26 2002-11-07 Sankyo Company, Limited Derivé d'acide 1-carboxylique de lipide a
US20040254128A1 (en) 2001-08-10 2004-12-16 Seiichi Kobayashi Treatment and prevention of heat shock protein-associated diseases and conditions
AU2003289493A1 (en) * 2002-12-24 2004-07-22 Mochizuki, Takashi Lipid a analogues having glucose as the right sugar
WO2004074303A2 (en) * 2003-02-20 2004-09-02 Eisai Co, Ltd. Reagents and methods for preparing lps antagonist b1287 and stereoisomers thereof
WO2007092632A2 (en) * 2006-02-09 2007-08-16 Elevance Renawable Sciences, Inc. Surface coating compositions and methods
RU2008132757A (ru) * 2006-02-09 2010-03-20 Елевансе Реневал Сайенсез, Инк. (US) Антибактериальные составы, способы и системы
US20090181078A1 (en) * 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
LT2484375T (lt) 2006-09-26 2018-07-10 Infectious Disease Research Institute Vakcinos kompozicija, turinti sintetinio adjuvanto
US8518903B2 (en) 2007-04-19 2013-08-27 University of Pittsburgh—of the Commonwealth System of Higher Education Use of toll-like receptor-9 agonists
BRPI1011072B1 (pt) 2009-06-05 2021-09-28 Infectious Disease Research Institute Composto de gla, composições de vacina e farmacêutica compreendendo dito composto, bem como uso dos mesmos para estimular, induzir ou acentuar uma resposta imune em um indivíduo
US9072760B2 (en) 2010-09-24 2015-07-07 University of Pittsburgh—of the Commonwealth System of Higher Education TLR4 inhibitors for the treatment of human infectious and inflammatory disorders
US10668092B2 (en) 2010-09-24 2020-06-02 The John Hopkins University Compositions and methods for treatment of inflammatory disorders
WO2012088425A2 (en) 2010-12-22 2012-06-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Gap junction-enhancing agents for treatment of necrotizing enterocolitis and inflammatory bowel disease
MX350795B (es) 2011-04-08 2017-09-19 Inmune Design Corp Composiciones inmunogenicas y metodos para utilizar las composiciones para inducir respuestas inmunes humorales y celulares.
PL2850431T3 (pl) 2012-05-16 2018-09-28 Immune Design Corp. Szczepionki przeciwko HSV-2
US9562066B2 (en) 2012-09-25 2017-02-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Oral therapy of necrotizing enterocolitis
BR112015025709A2 (pt) 2013-04-18 2017-07-18 Immune Design Corp monoterapia com gla para uso em tratamento de câncer
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
RU2564918C1 (ru) * 2014-05-07 2015-10-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Оренбургская государственная медицинская академия" Министерства здравоохранения Российской Федерации /ГБОУ ВПО ОрГМА Минздрава России/ Средство для снижения системной патологической эндотоксинемии
US11633411B2 (en) 2016-10-04 2023-04-25 University Of Maryland, Baltimore Methods of treating sepsis using anti-sepsis lipid A (ASLA) based therapeutics
CN114315893B (zh) * 2021-12-22 2023-08-25 科之杰新材料集团有限公司 一种季铵盐功能单体及其制备方法、高适应性聚羧酸保坍剂及其制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495346A (en) * 1981-03-30 1985-01-22 Wisconsin Alumni Research Foundation Method of preparing a disaccharide
US5057598A (en) * 1983-05-06 1991-10-15 Centocor, Inc. Monoclonal antibodies reactive with endotoxin core
US4844894A (en) * 1984-07-12 1989-07-04 Ribi Immunochem Research Inc. Method of inhibiting the onset of septicemia and endotoxemia
US4629722A (en) * 1984-07-12 1986-12-16 Ribi Immunochem Research, Inc. Method of inhibiting the onset of acute radiation syndrome
US5066794A (en) * 1984-08-24 1991-11-19 Daiichi Pharmaceutical Co., Ltd. Process for preparing a disaccharide derivative
JPS6153295A (ja) * 1984-08-24 1986-03-17 Dai Ichi Seiyaku Co Ltd ジサツカライド誘導体
HU199494B (en) * 1985-06-28 1990-02-28 Sandoz Ag Process for producing new saccharides and pharmaceutical compositions comprising same
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
US4877611A (en) * 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4929604A (en) * 1986-05-28 1990-05-29 Board Of Regents, The University Of Texas System Lipopolysaccharides of reduced toxicity and the production thereof
JP2535048B2 (ja) * 1988-02-29 1996-09-18 第一製薬株式会社 新規ジサッカライド誘導体及びその塩
ZA881430B (fi) * 1988-03-02 1988-10-28
US5134230A (en) * 1988-03-02 1992-07-28 Daiichi Pharmaceutical Co., Ltd. 2-Deoxy-2-aminoglucopyranoside derivatives
JPH0219319A (ja) * 1988-05-26 1990-01-23 Duphar Internatl Res Bv ラクツロースシロップから単離したフラクション及びこれを有効成分とする抗内毒素作用を有する医薬組成物
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5158939A (en) 1989-07-21 1992-10-27 Wisconsin Alumni Research Foundation Method of stimulating the immune systems of animals and compositions useful therefor
US5041427A (en) * 1989-07-21 1991-08-20 Wisconsin Alumni Research Foundation Lipid A derivatives
JPH0655749B2 (ja) * 1989-09-20 1994-07-27 日本たばこ産業株式会社 リピッドａ単糖類縁体
JP2839916B2 (ja) * 1989-10-20 1998-12-24 三共株式会社 リピドａ３位エーテル類縁体
US5158941A (en) * 1990-06-08 1992-10-27 E. I. Du Pont De Nemours And Company Lipid A analog as stimulant for production of interleukin-1 in human monocytes and tumor cell growth inhibitor
AU660325B2 (en) * 1991-10-11 1995-06-22 Eisai Co. Ltd. Anti-endotoxin compounds and related molecules and methods
IL105131A (en) * 1992-03-27 2000-06-01 Igen Inc Compounds and compositions containing such compounds comprising lipid-A analogs for eliciting therapeutic antibodies

Also Published As

Publication number Publication date
FI924579A0 (fi) 1992-10-09
NO180491B (no) 1997-01-20
US5612476A (en) 1997-03-18
RU2095366C1 (ru) 1997-11-10
NZ244643A (en) 1995-07-26
CN1071668A (zh) 1993-05-05
HU9203204D0 (en) 1992-12-28
CA2079971A1 (en) 1993-04-12
EP0536969A3 (en) 1994-05-18
NO923939L (no) 1993-04-13
US5843918A (en) 1998-12-01
EP0536969A2 (en) 1993-04-14
IL103298A0 (en) 1993-02-21
JP3865411B2 (ja) 2007-01-10
JPH05194470A (ja) 1993-08-03
NO923939D0 (no) 1992-10-09
AU2526692A (en) 1993-04-22
NO180491C (no) 1997-04-30
HUT64538A (en) 1994-01-28
US5756718A (en) 1998-05-26
AU660325B2 (en) 1995-06-22

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Legal Events

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FD Application lapsed
FD Application lapsed