NO176569C - Analogifremgangsmåte for fremstilling av nye, terapeutisk aktive, aromatisk substituerte alkylaminoalkandifosfonsyrer - Google Patents
Analogifremgangsmåte for fremstilling av nye, terapeutisk aktive, aromatisk substituerte alkylaminoalkandifosfonsyrerInfo
- Publication number
- NO176569C NO176569C NO894727A NO894727A NO176569C NO 176569 C NO176569 C NO 176569C NO 894727 A NO894727 A NO 894727A NO 894727 A NO894727 A NO 894727A NO 176569 C NO176569 C NO 176569C
- Authority
- NO
- Norway
- Prior art keywords
- acids
- alkandiphosphonic
- aromatically
- preparation
- new
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 125000003282 alkyl amino group Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 230000003913 calcium metabolism Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000000865 phosphorylative effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH440488 | 1988-11-28 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO894727D0 NO894727D0 (no) | 1989-11-27 |
| NO894727L NO894727L (no) | 1990-05-29 |
| NO176569B NO176569B (no) | 1995-01-16 |
| NO176569C true NO176569C (no) | 1995-04-26 |
Family
ID=4275504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO894727A NO176569C (no) | 1988-11-28 | 1989-11-27 | Analogifremgangsmåte for fremstilling av nye, terapeutisk aktive, aromatisk substituerte alkylaminoalkandifosfonsyrer |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5162310A (sv) |
| EP (1) | EP0371921B1 (sv) |
| JP (1) | JPH02184694A (sv) |
| KR (1) | KR900007858A (sv) |
| AT (1) | ATE106889T1 (sv) |
| AU (1) | AU624449B2 (sv) |
| CA (1) | CA2003766A1 (sv) |
| DD (1) | DD289276A5 (sv) |
| DE (1) | DE58907831D1 (sv) |
| DK (1) | DK170303B1 (sv) |
| ES (1) | ES2055157T3 (sv) |
| FI (1) | FI92705C (sv) |
| HU (1) | HU206119B (sv) |
| IE (1) | IE64074B1 (sv) |
| IL (1) | IL92380A0 (sv) |
| MX (1) | MX18478A (sv) |
| NO (1) | NO176569C (sv) |
| NZ (1) | NZ231521A (sv) |
| PT (1) | PT92399B (sv) |
| TW (1) | TW198039B (sv) |
| ZA (1) | ZA899024B (sv) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
| SK144694A3 (en) * | 1992-05-29 | 1995-06-07 | Procter & Gamble Pharma | Thio-substituted nitrogen containing heterocyclic phosphate compounds for treating calcium and phosphate metabolism |
| US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
| KR950701929A (ko) * | 1992-05-29 | 1995-05-17 | 제이코버스 코넬리스 레이서 | 비정상적인 칼슘 및 인산염 대사를 치료하기 위한 황-함유 포스포네이트 화합물(sulfur-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism) |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| CA2136825C (en) * | 1992-05-29 | 1997-10-28 | Frank H. Ebetino | Quaternary nitrogen-containing phosphonate compounds, for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque |
| US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
| RU2119794C1 (ru) * | 1992-06-30 | 1998-10-10 | Проктер энд Гэмбл Фармасьютикалз, Инк. | Использование фосфонатов и нестероидных противовоспалительных лекарственных средств для лечения артрита, способ лечения |
| US5591730A (en) * | 1993-10-12 | 1997-01-07 | The Regents Of The University Of California | Inhibition of urinary calculi growth |
| US6143919A (en) * | 1999-05-18 | 2000-11-07 | 3M Innovative Properties Company | Polymerizable acidic compounds and methods of preparation |
| US6315566B1 (en) | 1999-05-18 | 2001-11-13 | 3M Innovative Properties Company | Dental materials |
| TR200101250A2 (tr) * | 2001-05-10 | 2003-04-21 | E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. | 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses |
| EP1848727B1 (en) * | 2005-02-01 | 2015-06-17 | F.Hoffmann-La Roche Ag | Ibandronate polymorph b |
| AU2006210009B2 (en) * | 2005-02-01 | 2009-08-13 | F. Hoffmann-La Roche Ag | Ibandronate polymorph A |
| CN111542471A (zh) | 2017-08-21 | 2020-08-14 | 劲锋铁马股份有限公司 | 具有夹紧连接的自行车塔轮 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3683080A (en) * | 1970-08-28 | 1972-08-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| DE3540150A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| ES2054868T3 (es) * | 1987-12-11 | 1994-08-16 | Ciba Geigy Ag | Acidos aralifatilaminoalcanodifosfonicos. |
-
1989
- 1989-10-30 TW TW078108341A patent/TW198039B/zh active
- 1989-11-15 US US07/437,484 patent/US5162310A/en not_active Expired - Fee Related
- 1989-11-20 DE DE58907831T patent/DE58907831D1/de not_active Expired - Fee Related
- 1989-11-20 ES ES89810884T patent/ES2055157T3/es not_active Expired - Lifetime
- 1989-11-20 AT AT89810884T patent/ATE106889T1/de active
- 1989-11-20 EP EP89810884A patent/EP0371921B1/de not_active Expired - Lifetime
- 1989-11-21 IL IL92380A patent/IL92380A0/xx unknown
- 1989-11-22 AU AU45467/89A patent/AU624449B2/en not_active Ceased
- 1989-11-24 PT PT92399A patent/PT92399B/pt not_active IP Right Cessation
- 1989-11-24 CA CA002003766A patent/CA2003766A1/en not_active Abandoned
- 1989-11-24 NZ NZ231521A patent/NZ231521A/en unknown
- 1989-11-24 FI FI895634A patent/FI92705C/sv not_active IP Right Cessation
- 1989-11-24 MX MX1847889A patent/MX18478A/es unknown
- 1989-11-27 DK DK596489A patent/DK170303B1/da not_active IP Right Cessation
- 1989-11-27 NO NO894727A patent/NO176569C/no unknown
- 1989-11-27 IE IE377289A patent/IE64074B1/en not_active IP Right Cessation
- 1989-11-27 ZA ZA899024A patent/ZA899024B/xx unknown
- 1989-11-27 HU HU896195A patent/HU206119B/hu unknown
- 1989-11-27 JP JP1304939A patent/JPH02184694A/ja active Pending
- 1989-11-27 DD DD89334893A patent/DD289276A5/de not_active IP Right Cessation
- 1989-11-28 KR KR1019890017282A patent/KR900007858A/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| FI92705C (sv) | 1994-12-27 |
| NO176569B (no) | 1995-01-16 |
| EP0371921A3 (en) | 1990-08-22 |
| FI92705B (sv) | 1994-09-15 |
| US5162310A (en) | 1992-11-10 |
| FI895634A0 (sv) | 1989-11-24 |
| JPH02184694A (ja) | 1990-07-19 |
| DD289276A5 (de) | 1991-04-25 |
| AU4546789A (en) | 1990-05-31 |
| DK170303B1 (da) | 1995-07-31 |
| CA2003766A1 (en) | 1990-05-28 |
| PT92399A (pt) | 1990-05-31 |
| NO894727D0 (no) | 1989-11-27 |
| HUT52515A (en) | 1990-07-28 |
| DK596489D0 (da) | 1989-11-27 |
| IE893772L (en) | 1990-05-28 |
| DK596489A (da) | 1990-05-29 |
| HU206119B (en) | 1992-08-28 |
| EP0371921B1 (de) | 1994-06-08 |
| NZ231521A (en) | 1990-12-21 |
| MX18478A (es) | 1994-01-31 |
| KR900007858A (ko) | 1990-06-02 |
| DE58907831D1 (de) | 1994-07-14 |
| PT92399B (pt) | 1995-08-09 |
| IL92380A0 (en) | 1990-07-26 |
| NO894727L (no) | 1990-05-29 |
| TW198039B (sv) | 1993-01-11 |
| AU624449B2 (en) | 1992-06-11 |
| ATE106889T1 (de) | 1994-06-15 |
| IE64074B1 (en) | 1995-07-12 |
| ZA899024B (en) | 1990-08-29 |
| ES2055157T3 (es) | 1994-08-16 |
| EP0371921A2 (de) | 1990-06-06 |
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