GB1309714A - Propionic acid derivatives and therapeutic compositions containing them - Google Patents
Propionic acid derivatives and therapeutic compositions containing themInfo
- Publication number
- GB1309714A GB1309714A GB2219571A GB2219571A GB1309714A GB 1309714 A GB1309714 A GB 1309714A GB 2219571 A GB2219571 A GB 2219571A GB 2219571 A GB2219571 A GB 2219571A GB 1309714 A GB1309714 A GB 1309714A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chlorophenoxy
- formula
- derivatives
- isobutyramide
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1309714 Isobutyramide derivatives SYNTHELABO SA 19 April 1971 [19 Feb 1970 27 March 1970] 22195/71 Heading C2C Novel isobutyramide derivatives of the formula wherein Z is 2-(4-chlorophenoxy)-2-methylpropionyl; R is a group of the formula C m H 2m-1 OZ or C m B 2m-1 (OZ) 2 , the two hydroxy or acyloxy groups, where both present, not being attached to the same carbon atom; and R 1 is H or C n H 2n OH or C m H 2m OZ; or R is C(CH 2 OH) 3 or -C(CH 2 OZ) 2 -CH 2 OH and R 1 is H; or R and R 1 , together with the nitrogen atom to which they are attached, form a saturated heterocyclic ring which is substituted by at least one C 1-3 hydroxyalkyl in which the OH group may be esterified by 2; m is 1 to 6 and n is 1, 3, 4, 5 or 6 are prepared by reacting 2-(4- chlorophenoxy)-2-methylpropionic acid or functional derivatives thereof with the appropriate amino alcohols of the formula HN(R<SP>1</SP>)R<SP>1</SP> 1 , wherein R<SP>1</SP> and R<SP>1</SP> 1 are any of the unesterified groups represented by R and R<SP>1</SP>, followed by if desired esterification, of one or more of the OH groups present. 2 - (4 - Chlorophenoxy) - 2 - methylpropionyl chloride is obtained by reacting the acid with thionyl chloride. Pharmaceutical compositions, suitable for oral administration, contain the above novel compounds together with excipients. The compounds possess antilipemic and anticholestrolemic activities.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7005949A FR2077862A1 (en) | 1970-02-19 | 1970-02-19 | Derivs, antilipemic antichesterolemic - derivs, antilipemic anticholesteralemic |
FR7011180A FR2081590A1 (en) | 1970-03-27 | 1970-03-27 | Derivs, antilipemic antichesterolemic - derivs, antilipemic anticholesteralemic |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1309714A true GB1309714A (en) | 1973-03-14 |
Family
ID=26215564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2219571A Expired GB1309714A (en) | 1970-02-19 | 1971-04-19 | Propionic acid derivatives and therapeutic compositions containing them |
Country Status (6)
Country | Link |
---|---|
AU (1) | AU2552771A (en) |
BE (1) | BE762978A (en) |
DE (1) | DE2107630A1 (en) |
ES (1) | ES388441A1 (en) |
GB (1) | GB1309714A (en) |
NL (1) | NL7102047A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2622977A1 (en) * | 1976-05-21 | 1977-12-22 | Kotobuki Seiyaku Co Ltd | (p)-Chlorophenoxy-isobutyryl-glycinamide - for use as lipid metaboliser |
-
1971
- 1971-02-15 BE BE762978A patent/BE762978A/en unknown
- 1971-02-16 AU AU25527/71A patent/AU2552771A/en not_active Expired
- 1971-02-16 NL NL7102047A patent/NL7102047A/xx unknown
- 1971-02-17 DE DE19712107630 patent/DE2107630A1/en active Pending
- 1971-02-19 ES ES388441A patent/ES388441A1/en not_active Expired
- 1971-04-19 GB GB2219571A patent/GB1309714A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2622977A1 (en) * | 1976-05-21 | 1977-12-22 | Kotobuki Seiyaku Co Ltd | (p)-Chlorophenoxy-isobutyryl-glycinamide - for use as lipid metaboliser |
Also Published As
Publication number | Publication date |
---|---|
ES388441A1 (en) | 1974-02-16 |
AU2552771A (en) | 1972-08-17 |
BE762978A (en) | 1971-07-16 |
DE2107630A1 (en) | 1971-09-23 |
NL7102047A (en) | 1971-08-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |