NO176274C - Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte pyrolderivater samt mellomprodukter til bruk ved fremgangsmåten - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte pyrolderivater samt mellomprodukter til bruk ved fremgangsmåten

Info

Publication number
NO176274C
NO176274C NO913572A NO913572A NO176274C NO 176274 C NO176274 C NO 176274C NO 913572 A NO913572 A NO 913572A NO 913572 A NO913572 A NO 913572A NO 176274 C NO176274 C NO 176274C
Authority
NO
Norway
Prior art keywords
substituted
derivatives
intermediates
same
therapeutically active
Prior art date
Application number
NO913572A
Other languages
English (en)
Norwegian (no)
Other versions
NO176274B (no
NO913572D0 (no
NO913572L (no
Inventor
Nicola Mongelli
Giovanni Biasoli
Alfredo Paio
Maria Grandi
Marina Ciomei
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of NO913572D0 publication Critical patent/NO913572D0/no
Publication of NO913572L publication Critical patent/NO913572L/no
Publication of NO176274B publication Critical patent/NO176274B/no
Publication of NO176274C publication Critical patent/NO176274C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO913572A 1990-01-11 1991-09-10 Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte pyrolderivater samt mellomprodukter til bruk ved fremgangsmåten NO176274C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909000644A GB9000644D0 (en) 1990-01-11 1990-01-11 New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
PCT/EP1991/000014 WO1991010649A1 (en) 1990-01-11 1991-01-07 New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds

Publications (4)

Publication Number Publication Date
NO913572D0 NO913572D0 (no) 1991-09-10
NO913572L NO913572L (no) 1991-09-10
NO176274B NO176274B (no) 1994-11-28
NO176274C true NO176274C (no) 1995-03-08

Family

ID=10669147

Family Applications (1)

Application Number Title Priority Date Filing Date
NO913572A NO176274C (no) 1990-01-11 1991-09-10 Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte pyrolderivater samt mellomprodukter til bruk ved fremgangsmåten

Country Status (33)

Country Link
US (3) US5260329A (fi)
EP (1) EP0462258B1 (fi)
JP (1) JP3121343B2 (fi)
KR (1) KR0176258B1 (fi)
CN (1) CN1032750C (fi)
AT (1) ATE131810T1 (fi)
AU (1) AU647446B2 (fi)
BG (1) BG60534B2 (fi)
CA (1) CA2050331C (fi)
CZ (1) CZ285251B6 (fi)
DE (1) DE69115570T2 (fi)
DK (1) DK0462258T3 (fi)
ES (1) ES2084153T3 (fi)
FI (1) FI99011C (fi)
GB (1) GB9000644D0 (fi)
GR (1) GR3018767T3 (fi)
HK (1) HK1006455A1 (fi)
HR (1) HRP930311B1 (fi)
HU (2) HUT61280A (fi)
IE (1) IE69462B1 (fi)
IL (1) IL96875A (fi)
MX (1) MX9203119A (fi)
MY (1) MY107890A (fi)
NO (1) NO176274C (fi)
NZ (1) NZ236707A (fi)
PT (1) PT96455B (fi)
RU (1) RU2078079C1 (fi)
SI (1) SI9110025B (fi)
SK (1) SK280190B6 (fi)
UA (1) UA32513A (fi)
WO (1) WO1991010649A1 (fi)
YU (1) YU48548B (fi)
ZA (1) ZA91177B (fi)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
AU1224392A (en) * 1991-02-06 1992-09-07 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
GB2261661A (en) * 1991-11-21 1993-05-26 Erba Carlo Spa Derivatives of poly-4-amino-2-carboxy-1-methyl pyrroles
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9225475D0 (en) * 1992-12-05 1993-01-27 Imp Cancer Res Tech Compounds to combat angiogenesis
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US8143283B1 (en) 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
GB9304589D0 (en) * 1993-03-05 1993-04-21 Erba Carlo Spa Biologically active ureido derivatives useful as antimetastic agents
GB9307948D0 (en) * 1993-04-16 1993-06-02 Erba Carlo Spa Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease
DE4320157A1 (de) * 1993-06-18 1994-12-22 Bayer Ag Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
GB9403909D0 (en) * 1994-03-01 1994-04-20 Erba Carlo Spa Ureido derivatives of naphthalenephosphonic acids and process for their preparation
GB9504065D0 (en) * 1995-03-01 1995-04-19 Pharmacia Spa Poly-pyrrolecarboxamidonaphthalenic acid derivatives
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
GB2310207A (en) * 1996-02-15 1997-08-20 Pharmacia Spa Antiviral ureido derivatives of substituted heterocyclic compounds
JP2002513391A (ja) * 1996-11-05 2002-05-08 ザ チルドレンズ メディカル センター コーポレイション 血管形成の抑制のための方法と組成物
GB9713733D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Poly-branched polycarboxamido compounds
GB9713732D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Substituted triazinic compounds
US6562859B1 (en) 1997-12-04 2003-05-13 The United States Of America As Represented By The Department Of Health And Human Services Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds for inhibition of inflammation
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
US7427606B2 (en) * 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US6232297B1 (en) * 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7378400B2 (en) * 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
DK1353672T3 (da) 2000-11-30 2008-01-21 Childrens Medical Center Syntese af 4-amino-thalidomidenantiomerer
JP2005505508A (ja) * 2001-06-13 2005-02-24 ジーンソフト ファーマシューティカルズ インコーポレイテッド 抗感染活性を有するベンゾチオフェン化合物
ATE428419T1 (de) * 2001-08-06 2009-05-15 Childrens Medical Center Antiangiogenese wirkung von stickstoffsubstituierten thalidomid-analoga
WO2003029264A2 (en) * 2001-10-01 2003-04-10 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
CA2473461C (en) * 2002-01-11 2011-11-01 Sankyo Company, Limited Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these
BRPI0507944A (pt) 2004-02-24 2007-07-24 Sankyo Co composição farmacêutica
WO2006023272A1 (en) * 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
EP1778712B1 (en) * 2004-08-02 2013-01-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
WO2006028618A1 (en) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
US8178509B2 (en) * 2006-02-10 2012-05-15 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
EP3381897A1 (en) 2017-03-27 2018-10-03 Leadiant Biosciences SA Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785182A (en) * 1954-04-19 1957-03-12 American Cyanamid Co Substituted pyrrolecarboxamidopyroles
US2785183A (en) * 1954-04-19 1957-03-12 American Cyanamid Co N [4-aminopyrrolyl-2-carbonyl] amino acids
CA1308516C (en) * 1987-07-06 1992-10-06 J. William Lown Oligopeptide anticancer and antiviral agents
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
GB9028123D0 (en) * 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha

Also Published As

Publication number Publication date
CS9100056A2 (en) 1991-10-15
RU2078079C1 (ru) 1997-04-27
US5593976A (en) 1997-01-14
FI99011C (fi) 1997-09-25
KR920701150A (ko) 1992-08-11
HU211237A9 (en) 1995-11-28
PT96455A (pt) 1991-10-15
UA32513A (uk) 2001-02-15
BG60534B2 (bg) 1995-07-28
CA2050331C (en) 2002-03-19
HRP930311A2 (en) 1994-12-31
ZA91177B (en) 1991-10-30
HRP930311B1 (en) 2000-04-30
US5420296A (en) 1995-05-30
NZ236707A (en) 1992-10-28
DE69115570D1 (de) 1996-02-01
IE910074A1 (en) 1991-07-17
FI99011B (fi) 1997-06-13
CZ285251B6 (cs) 1999-06-16
CN1053230A (zh) 1991-07-24
CN1032750C (zh) 1996-09-11
CA2050331A1 (en) 1991-07-12
DE69115570T2 (de) 1996-05-02
JP3121343B2 (ja) 2000-12-25
NO176274B (no) 1994-11-28
ATE131810T1 (de) 1996-01-15
EP0462258A1 (en) 1991-12-27
FI914251A0 (fi) 1991-09-09
NO913572D0 (no) 1991-09-10
DK0462258T3 (da) 1996-01-29
YU2591A (sh) 1994-05-10
ES2084153T3 (es) 1996-05-01
JPH04504426A (ja) 1992-08-06
KR0176258B1 (ko) 1999-03-20
PT96455B (pt) 1998-06-30
NO913572L (no) 1991-09-10
MY107890A (en) 1996-06-29
IL96875A0 (en) 1992-03-29
WO1991010649A1 (en) 1991-07-25
GR3018767T3 (en) 1996-04-30
HUT61280A (en) 1992-12-28
IL96875A (en) 1995-03-30
US5260329A (en) 1993-11-09
AU647446B2 (en) 1994-03-24
IE69462B1 (en) 1996-09-18
HU912923D0 (en) 1992-01-28
EP0462258B1 (en) 1995-12-20
AU7059991A (en) 1991-08-05
YU48548B (sh) 1998-11-05
MX9203119A (es) 1992-07-01
SI9110025A (en) 1996-10-31
SK280190B6 (sk) 1999-09-10
HK1006455A1 (en) 1999-02-26
GB9000644D0 (en) 1990-03-14
SI9110025B (sl) 1998-06-30

Similar Documents

Publication Publication Date Title
NO176274C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte pyrolderivater samt mellomprodukter til bruk ved fremgangsmåten
LU91362I2 (fr) Palipéridone et ses dérivés pharmaceutiquement acceptables (INVEGA)
NO179868C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive kondenserte heterocykliske forbindelser
NO870199L (no) Analogifremgangsmaate for fremstilling av nye, terapeutisk virksomme dihydrobenzofuran- og chroman-carboxamidderivater.
NO180334C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive difluorstatonanaloger
DK0595111T3 (da) Carbazolonderivater og fremgangsmåde til deres fremstilling
SE8501988L (sv) Iminotiazolidinderivat
MY103368A (en) 1,3-dioxanes
SE8801964D0 (sv) New 5-(omega-ammonio acyloxy methylene) tetrahydrofurans and tetrahydrothiophenes
YU37594A (sh) Postupak za dobivanje oksazolidinkarboksilne kiseline koja se koristi za dobijanje terapetuski aktivnih taksoida
DK243487D0 (da) Heterocyclisk-aromatiske forbindelser, deres fremstilling og farmaceutiske anvendelse
KR960014106A (ko) 신규한 항바이러스성 1-알킬-2,4-피리미딘디온 유도체 및 그의 제조방법
GB1120081A (en) Improvements in or relating to substituted benzofuranols and the manufacture thereof
FR2485000B1 (fi)
JPS6419063A (en) Novel heterocyclic compound and use thereof
NO154496C (no) Analogifremgangsmaate ved fremstilling av terapeutisk virksomme nb-kvartaere derivater av sandwicin og isosandwicin.
NO974458L (no) Fremstilling av cis-4-O-beskyttede-2-cyklopentenolderivater
SE8802162L (sv) Nya aminoacylater av glycerolacetal
JPS5283367A (en) Synthesis of 2-pyrrolidone derivatives
JPS5479289A (en) Uracil derivative and its preparation
JPS5718614A (en) Cholagogue

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN JULY 2002