NO166178C - PROCEDURE FOR THE PREPARATION OF SYMETRIC 1,4-DIHYDROPYRIDINES. - Google Patents
PROCEDURE FOR THE PREPARATION OF SYMETRIC 1,4-DIHYDROPYRIDINES.Info
- Publication number
- NO166178C NO166178C NO841142A NO841142A NO166178C NO 166178 C NO166178 C NO 166178C NO 841142 A NO841142 A NO 841142A NO 841142 A NO841142 A NO 841142A NO 166178 C NO166178 C NO 166178C
- Authority
- NO
- Norway
- Prior art keywords
- formula
- see diagramm
- dihydropyridines
- preparation
- degrees
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Manufacture Of Tobacco Products (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Ceramics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Air Supply (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Mechanical Coupling Of Light Guides (AREA)
- Steroid Compounds (AREA)
Abstract
1. Processs for the preparation of symmetrical 1,4-dihydropyridines of the formula I see diagramm : EP0124742,P6,F1 in which R represents a phenyl radical which is optionally mono- or disubstituted by nitro and/or chlorine, and R1 represents a C1 -C4 -alkyl radical which is optionally substituted by a C1 -C4 -alkoxy group, by reaction of an ylidene compound of the formula II see diagramm : EP0124742,P6,F2 with an enamine compound of the formula III see diagramm : EP0124742,P6,F3 characterized in that the ylidene compound of the formula II is prepared by reaction of a ketocarboxylic ester of the formula IV see diagramm : EP0124742,P6,F4 with an aldehyde of the formula RCHO in a solvent, in the presence of catalytic amounts of piperidine acetate, at temperatures from - 10 degrees C and up to 100 degrees C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3312216A DE3312216A1 (en) | 1983-04-05 | 1983-04-05 | METHOD FOR PRODUCING SYMMETRIC 1,4-DIHYDROPYRIDINE CARBONIC ACID ESTERS |
Publications (3)
Publication Number | Publication Date |
---|---|
NO841142L NO841142L (en) | 1984-10-08 |
NO166178B NO166178B (en) | 1991-03-04 |
NO166178C true NO166178C (en) | 1991-06-19 |
Family
ID=6195495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO841142A NO166178C (en) | 1983-04-05 | 1984-03-22 | PROCEDURE FOR THE PREPARATION OF SYMETRIC 1,4-DIHYDROPYRIDINES. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0124742B1 (en) |
JP (1) | JPH0662564B2 (en) |
KR (2) | KR900004038B1 (en) |
AT (1) | ATE36849T1 (en) |
AU (1) | AU558122B2 (en) |
CA (1) | CA1234573A (en) |
DE (2) | DE3312216A1 (en) |
DK (1) | DK160488C (en) |
ES (1) | ES8501752A1 (en) |
FI (1) | FI78471C (en) |
GR (1) | GR81898B (en) |
HU (1) | HU192546B (en) |
IE (1) | IE57181B1 (en) |
IL (1) | IL71425A (en) |
NO (1) | NO166178C (en) |
PH (1) | PH20992A (en) |
PT (1) | PT78365B (en) |
ZA (1) | ZA842510B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3312283A1 (en) * | 1983-04-05 | 1984-10-18 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING UNBALANCED 1,4-DIHYDROPYRIDINE CARBONIC ACID ESTERS |
DE3508533A1 (en) * | 1985-03-09 | 1986-09-11 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING BENZYLIDE COMPOUNDS |
US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
DE4423445A1 (en) * | 1994-07-05 | 1996-01-11 | Bayer Ag | Rapid high yield prodn. of nifedipin |
DE19727350C1 (en) | 1997-06-27 | 1999-01-21 | Bayer Ag | Process for the preparation of nifedipine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1792764C3 (en) * | 1967-03-20 | 1981-04-23 | Bayer Ag, 5090 Leverkusen | Coronary drugs |
DE1670824C3 (en) * | 1967-03-20 | 1978-08-03 | Bayer Ag, 5090 Leverkusen | 1,4-Dihydropyridine-33-dicarboxylic acid alkyl ester |
DE2335466A1 (en) * | 1973-07-12 | 1975-01-30 | Bayer Ag | ALCOXY ALKYL-1,4-DIHYDROPYRIDINE, THE METHOD FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT |
US4370334A (en) * | 1975-07-02 | 1983-01-25 | Fujisawa Pharmaceutical Co., Ltd. | 1,4-Dihydro-pyridine derivatives and methods of using same |
DE2549568C3 (en) * | 1975-11-05 | 1981-10-29 | Bayer Ag, 5090 Leverkusen | 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl) -1,4-dihydropyridine-5-carboxylic acid isobutyl ester, several processes for its preparation and pharmaceuticals containing it |
JPS5936896B2 (en) * | 1976-10-21 | 1984-09-06 | 住友化学工業株式会社 | α-acetyl cinnamic acid ester derivatives, their production methods, and herbicides comprising the compounds |
CA1117117A (en) * | 1978-10-10 | 1982-01-26 | Fujisawa Pharmaceutical Co., Ltd. | 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same |
JPS5529990A (en) * | 1979-03-19 | 1980-03-03 | Wako Pure Chem Ind Ltd | Activity measurement of monoamine oxidase (mao) |
-
1983
- 1983-04-05 DE DE3312216A patent/DE3312216A1/en not_active Withdrawn
-
1984
- 1984-03-22 NO NO841142A patent/NO166178C/en not_active IP Right Cessation
- 1984-03-26 AT AT84103304T patent/ATE36849T1/en not_active IP Right Cessation
- 1984-03-26 EP EP84103304A patent/EP0124742B1/en not_active Expired
- 1984-03-26 DE DE8484103304T patent/DE3473756D1/en not_active Expired
- 1984-04-02 IL IL71425A patent/IL71425A/en not_active IP Right Cessation
- 1984-04-02 JP JP59063438A patent/JPH0662564B2/en not_active Expired - Lifetime
- 1984-04-03 CA CA000451158A patent/CA1234573A/en not_active Expired
- 1984-04-03 FI FI841336A patent/FI78471C/en not_active IP Right Cessation
- 1984-04-03 PT PT78365A patent/PT78365B/en unknown
- 1984-04-03 GR GR74294A patent/GR81898B/el unknown
- 1984-04-03 PH PH30491A patent/PH20992A/en unknown
- 1984-04-03 ES ES531236A patent/ES8501752A1/en not_active Expired
- 1984-04-04 IE IE828/84A patent/IE57181B1/en not_active IP Right Cessation
- 1984-04-04 KR KR1019840001767A patent/KR900004038B1/en not_active Application Discontinuation
- 1984-04-04 AU AU26416/84A patent/AU558122B2/en not_active Expired
- 1984-04-04 KR KR1019840001767A patent/KR840008647A/en not_active IP Right Cessation
- 1984-04-04 DK DK178584A patent/DK160488C/en not_active IP Right Cessation
- 1984-04-04 ZA ZA842510A patent/ZA842510B/en unknown
- 1984-04-05 HU HU841337A patent/HU192546B/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |