DK410184A - PROCEDURE FOR THE PREPARATION OF UNYMMETRIC 1,4-DIHYDROPYRIDE INDICARBOXYLIC ACID ESTERS - Google Patents
PROCEDURE FOR THE PREPARATION OF UNYMMETRIC 1,4-DIHYDROPYRIDE INDICARBOXYLIC ACID ESTERS Download PDFInfo
- Publication number
- DK410184A DK410184A DK410184A DK410184A DK410184A DK 410184 A DK410184 A DK 410184A DK 410184 A DK410184 A DK 410184A DK 410184 A DK410184 A DK 410184A DK 410184 A DK410184 A DK 410184A
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- DK
- Denmark
- Prior art keywords
- formula
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- group
- denotes
- optionally substituted
- Prior art date
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- Hydrogenated Pyridines (AREA)
Abstract
Asymmetric 1,4-dihydropyridinedicarboxylic acid esters of the formula <IMAGE> where R denotes a phenyl group which is optionally substituted once or twice by nitro and/or chloro, R1 denotes a C1-C4-alkyl group which is optionally substituted by a C1-C4-alkoxy group, and R2 denotes a C1- C12-alkyl group which is optionally substituted by a C1- C4-alkoxy group, a trifluoromethyl group or the group [C6H5CH2][CH3]N, with the groups R1 and R2 not being identical, are prepared by reacting an ylidene compound of the formula II or III <IMAGE> with an enamine compound of the formula IV or V <IMAGE> with the ylidene compound of the formula II or III being prepared by reacting a ketocarboxylic acid ester of the formula VI or VII <IMAGE> with an aldehyde of the formula RCHO in a solvent in the presence of catalytic quantities of acetate salts of amines at temperatures of from -10 degree C to 100 degree C. The yield in this process is higher than in the known methods, and it is not necessary to subject the isolated end product to any further purification step.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK410184A DK161701C (en) | 1984-08-28 | 1984-08-28 | PROCEDURE FOR THE PREPARATION OF UNYMMETRIC 1,4-DIHYDROPYRIDE INDICARBOXYLIC ACID ESTERS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK410184A DK161701C (en) | 1984-08-28 | 1984-08-28 | PROCEDURE FOR THE PREPARATION OF UNYMMETRIC 1,4-DIHYDROPYRIDE INDICARBOXYLIC ACID ESTERS |
DK410184 | 1984-08-28 |
Publications (4)
Publication Number | Publication Date |
---|---|
DK410184D0 DK410184D0 (en) | 1984-08-28 |
DK410184A true DK410184A (en) | 1986-03-01 |
DK161701B DK161701B (en) | 1991-08-05 |
DK161701C DK161701C (en) | 1992-01-27 |
Family
ID=8130191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK410184A DK161701C (en) | 1984-08-28 | 1984-08-28 | PROCEDURE FOR THE PREPARATION OF UNYMMETRIC 1,4-DIHYDROPYRIDE INDICARBOXYLIC ACID ESTERS |
Country Status (1)
Country | Link |
---|---|
DK (1) | DK161701C (en) |
-
1984
- 1984-08-28 DK DK410184A patent/DK161701C/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK161701C (en) | 1992-01-27 |
DK161701B (en) | 1991-08-05 |
DK410184D0 (en) | 1984-08-28 |
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Legal Events
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PUP | Patent expired |