DK178584D0 - METHOD OF PREPARING SYMMETRIC 1,4-DIHYDROPYRIDINES - Google Patents
METHOD OF PREPARING SYMMETRIC 1,4-DIHYDROPYRIDINESInfo
- Publication number
- DK178584D0 DK178584D0 DK1785/84A DK178584A DK178584D0 DK 178584 D0 DK178584 D0 DK 178584D0 DK 1785/84 A DK1785/84 A DK 1785/84A DK 178584 A DK178584 A DK 178584A DK 178584 D0 DK178584 D0 DK 178584D0
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- see diagramm
- dihydropyridines
- degrees
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Manufacture Of Tobacco Products (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Mechanical Coupling Of Light Guides (AREA)
- Air Supply (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Magnetic Ceramics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
1. Processs for the preparation of symmetrical 1,4-dihydropyridines of the formula I see diagramm : EP0124742,P6,F1 in which R represents a phenyl radical which is optionally mono- or disubstituted by nitro and/or chlorine, and R1 represents a C1 -C4 -alkyl radical which is optionally substituted by a C1 -C4 -alkoxy group, by reaction of an ylidene compound of the formula II see diagramm : EP0124742,P6,F2 with an enamine compound of the formula III see diagramm : EP0124742,P6,F3 characterized in that the ylidene compound of the formula II is prepared by reaction of a ketocarboxylic ester of the formula IV see diagramm : EP0124742,P6,F4 with an aldehyde of the formula RCHO in a solvent, in the presence of catalytic amounts of piperidine acetate, at temperatures from - 10 degrees C and up to 100 degrees C.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3312216 | 1983-04-05 | ||
DE3312216A DE3312216A1 (en) | 1983-04-05 | 1983-04-05 | METHOD FOR PRODUCING SYMMETRIC 1,4-DIHYDROPYRIDINE CARBONIC ACID ESTERS |
Publications (4)
Publication Number | Publication Date |
---|---|
DK178584D0 true DK178584D0 (en) | 1984-04-04 |
DK178584A DK178584A (en) | 1984-10-06 |
DK160488B DK160488B (en) | 1991-03-18 |
DK160488C DK160488C (en) | 1991-08-26 |
Family
ID=6195495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK178584A DK160488C (en) | 1983-04-05 | 1984-04-04 | METHOD OF PREPARING SYMMETRIC 1,4-DIHYDROPYRIDINES |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0124742B1 (en) |
JP (1) | JPH0662564B2 (en) |
KR (2) | KR840008647A (en) |
AT (1) | ATE36849T1 (en) |
AU (1) | AU558122B2 (en) |
CA (1) | CA1234573A (en) |
DE (2) | DE3312216A1 (en) |
DK (1) | DK160488C (en) |
ES (1) | ES531236A0 (en) |
FI (1) | FI78471C (en) |
GR (1) | GR81898B (en) |
HU (1) | HU192546B (en) |
IE (1) | IE57181B1 (en) |
IL (1) | IL71425A (en) |
NO (1) | NO166178C (en) |
PH (1) | PH20992A (en) |
PT (1) | PT78365B (en) |
ZA (1) | ZA842510B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3312283A1 (en) * | 1983-04-05 | 1984-10-18 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING UNBALANCED 1,4-DIHYDROPYRIDINE CARBONIC ACID ESTERS |
DE3508533A1 (en) * | 1985-03-09 | 1986-09-11 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING BENZYLIDE COMPOUNDS |
US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
DE4423445A1 (en) * | 1994-07-05 | 1996-01-11 | Bayer Ag | Rapid high yield prodn. of nifedipin |
DE19727350C1 (en) * | 1997-06-27 | 1999-01-21 | Bayer Ag | Process for the preparation of nifedipine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1792764C3 (en) * | 1967-03-20 | 1981-04-23 | Bayer Ag, 5090 Leverkusen | Coronary drugs |
DE1670824C3 (en) * | 1967-03-20 | 1978-08-03 | Bayer Ag, 5090 Leverkusen | 1,4-Dihydropyridine-33-dicarboxylic acid alkyl ester |
DE2335466A1 (en) * | 1973-07-12 | 1975-01-30 | Bayer Ag | ALCOXY ALKYL-1,4-DIHYDROPYRIDINE, THE METHOD FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT |
US4370334A (en) * | 1975-07-02 | 1983-01-25 | Fujisawa Pharmaceutical Co., Ltd. | 1,4-Dihydro-pyridine derivatives and methods of using same |
DE2549568C3 (en) * | 1975-11-05 | 1981-10-29 | Bayer Ag, 5090 Leverkusen | 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl) -1,4-dihydropyridine-5-carboxylic acid isobutyl ester, several processes for its preparation and pharmaceuticals containing it |
JPS5936896B2 (en) * | 1976-10-21 | 1984-09-06 | 住友化学工業株式会社 | α-acetyl cinnamic acid ester derivatives, their production methods, and herbicides comprising the compounds |
CA1117117A (en) * | 1978-10-10 | 1982-01-26 | Fujisawa Pharmaceutical Co., Ltd. | 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same |
JPS5529990A (en) * | 1979-03-19 | 1980-03-03 | Wako Pure Chem Ind Ltd | Activity measurement of monoamine oxidase (mao) |
-
1983
- 1983-04-05 DE DE3312216A patent/DE3312216A1/en not_active Withdrawn
-
1984
- 1984-03-22 NO NO841142A patent/NO166178C/en not_active IP Right Cessation
- 1984-03-26 EP EP84103304A patent/EP0124742B1/en not_active Expired
- 1984-03-26 AT AT84103304T patent/ATE36849T1/en not_active IP Right Cessation
- 1984-03-26 DE DE8484103304T patent/DE3473756D1/en not_active Expired
- 1984-04-02 IL IL71425A patent/IL71425A/en not_active IP Right Cessation
- 1984-04-02 JP JP59063438A patent/JPH0662564B2/en not_active Expired - Lifetime
- 1984-04-03 ES ES531236A patent/ES531236A0/en active Granted
- 1984-04-03 FI FI841336A patent/FI78471C/en not_active IP Right Cessation
- 1984-04-03 PH PH30491A patent/PH20992A/en unknown
- 1984-04-03 PT PT78365A patent/PT78365B/en unknown
- 1984-04-03 CA CA000451158A patent/CA1234573A/en not_active Expired
- 1984-04-03 GR GR74294A patent/GR81898B/el unknown
- 1984-04-04 ZA ZA842510A patent/ZA842510B/en unknown
- 1984-04-04 AU AU26416/84A patent/AU558122B2/en not_active Expired
- 1984-04-04 DK DK178584A patent/DK160488C/en not_active IP Right Cessation
- 1984-04-04 KR KR1019840001767A patent/KR840008647A/en not_active IP Right Cessation
- 1984-04-04 KR KR1019840001767A patent/KR900004038B1/en not_active Application Discontinuation
- 1984-04-04 IE IE828/84A patent/IE57181B1/en not_active IP Right Cessation
- 1984-04-05 HU HU841337A patent/HU192546B/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |