HUT38315A - New process for preparing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acid - Google Patents
New process for preparing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acidInfo
- Publication number
- HUT38315A HUT38315A HU340284A HU340284A HUT38315A HU T38315 A HUT38315 A HU T38315A HU 340284 A HU340284 A HU 340284A HU 340284 A HU340284 A HU 340284A HU T38315 A HUT38315 A HU T38315A
- Authority
- HU
- Hungary
- Prior art keywords
- dihydropyridine
- substd
- opt
- dicarboxylic acid
- new process
- Prior art date
Links
Landscapes
- Hydrogenated Pyridines (AREA)
Abstract
Asymmetrical 1,4-dihydro pyridines of formula (I) R = phenyl, opt. substd. by 1 or 2 nitro groups and/or chlorine atoms, R1 = 1-4C alkyl, opt. substd. by 1-4C alkoxy R2 = 1-12C alkyl, opt. substd. by 1l4C alkoxy, CF3, or (C6H5)(CH3)N such that R1 and R2 are not the same, are prepared by reacting (VI) and (VIII) with RCHO to form (II) or (III). The reaction is effected in a solvent in the presence of an amine acetate as catalyst at -10 to +100 deg. C. - The amine acetate may be derived from piperidine, morpholine, piperazine, pyrrolidone, and their alkyl derivatives. The preferred catalyst is piperidine acetate. Pref. 0.01-0.7 moles of catalyst is used per mole of ylidene of formula (II) or (III).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU340284A HU192992B (en) | 1984-09-07 | 1984-09-07 | Process for preparing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU340284A HU192992B (en) | 1984-09-07 | 1984-09-07 | Process for preparing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT38315A true HUT38315A (en) | 1986-05-28 |
| HU192992B HU192992B (en) | 1987-08-28 |
Family
ID=10963900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU340284A HU192992B (en) | 1984-09-07 | 1984-09-07 | Process for preparing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acid |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HU192992B (en) |
-
1984
- 1984-09-07 HU HU340284A patent/HU192992B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU192992B (en) | 1987-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HPC4 | Succession in title of patentee |
Owner name: BAYER HEALTHCARE AG., DE |
|
| HPC4 | Succession in title of patentee |
Owner name: BAYER HEALTHCARE AG., DE |