KR860002467A - Process for preparing asymmetric 1,4-dihydropyridinedicarboxylic acid ester - Google Patents

Process for preparing asymmetric 1,4-dihydropyridinedicarboxylic acid ester Download PDF

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Publication number
KR860002467A
KR860002467A KR1019840005483A KR840005483A KR860002467A KR 860002467 A KR860002467 A KR 860002467A KR 1019840005483 A KR1019840005483 A KR 1019840005483A KR 840005483 A KR840005483 A KR 840005483A KR 860002467 A KR860002467 A KR 860002467A
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South Korea
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mole
general formula
per mole
acid ester
aldehyde
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KR1019840005483A
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Korean (ko)
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KR900009008B1 (en
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텔러 베르너
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원본미기재
바이엘 아크티엔 게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음No content

Description

비대칭 1,4-디하이드로피리딘디카복실산 에스테르의 제조방법Process for preparing asymmetric 1,4-dihydropyridinedicarboxylic acid ester

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (7)

일반식(Ⅱ)또는 (Ⅲ)의 일리덴 화합물을 일반식(Ⅳ) 또는 (Ⅴ)의 엔아민 화합물과 반응시켜 일반식(Ⅰ)의 비대칭 1,4-디하이드로피리딘을 제조함에 있어서, 일반식(Ⅱ) 또는 (Ⅲ)의 일리덴 화합물을, 촉매량의 아민 아세테이트 염 존재하의 -10℃ 내지 100℃용매중에서, 일반식 (Ⅵ) 또는(Ⅶ)의 케토카복실산 에스테르와 일반식 RCHO의 알데하이드를 반응시켜 수득함을 특징으로 하는 방법.In preparing the asymmetric 1,4-dihydropyridine of the general formula (I) by reacting the iridene compound of the general formula (II) or (III) with the enamine compound of the general formula (IV) or (V), In the solvent of -10 ° C. to 100 ° C. in the presence of a catalytic amount of amine acetate salt, an aldehyde of the general formula (VI) or (iii) and the aldehyde of general formula RCHO Obtained by reaction. 상기식에서, R은 니트로 및/또는 염소로 임의로 일 또는 이 치환된 페닐라디칼을 나타내고, R1은 C1-C4알콕시 그룹으로 임의 치환된 C1-C4-알킬 라디칼을 나타내며, R2는 C1-C4-알콕시 그룹, 트리플루오로 메틸그룹 또는 라디칼[C6H5CH2][CH2]N으로 임의 치환된 C1-C12-알킬라디칼을 나타내고, 라디칼 R1및 R2는 같지 않다.Wherein, R is nitro and / or represents one or two substituted phenyl radical optionally substituted with chlorine, R 1 is C 1 -C 4 optionally substituted with C 1 -C 4 alkoxy group - wherein the alkyl radical, R 2 is C 1 -C 4 -alkoxy group, trifluoro methyl group or C 1 -C 12 -alkyl radical optionally substituted with radical [C 6 H 5 CH 2 ] [CH 2 ] N, and represents radicals R 1 and R 2 Is not the same. 제1항에 있어서, 20 내지 60℃에서 반응을 수행함을 특징으로 하는 방법.The process according to claim 1, wherein the reaction is carried out at 20 to 60 ° C. 제1항에 있어서, 일리덴 화합물 몰당 촉매 0.01 내지 0.7몰을 사용함을 특징으로 하는 방법.The method of claim 1 wherein 0.01 to 0.7 mole of catalyst is used per mole of iridene compound. 제1항에 있어서, 일리덴 화합물 몰당 촉매 0.02 내지 0.2몰을 사용함을 특징으로 하는 방법.The process of claim 1 wherein from 0.02 to 0.2 mole of catalyst per mole of iridene compound is used. 제1항에 있어서, 일리덴 화합물 몰당 촉매 0.04내지 0.2몰을 사용함을 특징으로 하는 방법.The process of claim 1 wherein from 0.04 to 0.2 mole of catalyst per mole of iridene compound is used. 제1항에 있어서, 케토카복실산 에스테르 몰당 알데하이드 1 내지 2몰을 사용함을 특징으로 하는 방법.The method of claim 1 wherein 1 to 2 moles of aldehyde per mole of ketocarboxylic acid ester are used. 제1항에 있어서, 케토카복실산 에스테르 몰당 알데하이드 1몰을 사용함을 특징으로 하는 방법.The method of claim 1 wherein 1 mole of aldehyde per mole of ketocarboxylic acid ester is used. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840005483A 1984-09-07 1984-09-07 Process for preparing unsymmetrical 1,4-dihydropyridine dicarboxylic esters KR900009008B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840005483A KR900009008B1 (en) 1984-09-07 1984-09-07 Process for preparing unsymmetrical 1,4-dihydropyridine dicarboxylic esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019840005483A KR900009008B1 (en) 1984-09-07 1984-09-07 Process for preparing unsymmetrical 1,4-dihydropyridine dicarboxylic esters

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KR860002467A true KR860002467A (en) 1986-04-26
KR900009008B1 KR900009008B1 (en) 1990-12-17

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KR1019840005483A KR900009008B1 (en) 1984-09-07 1984-09-07 Process for preparing unsymmetrical 1,4-dihydropyridine dicarboxylic esters

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