NO158016C - Fremgangsmaate for fremstilling av (-)-2-(1-(2,6-diklor-fenoksy)-etyl)-1,3-diazacyklopent-2-en. - Google Patents

Fremgangsmaate for fremstilling av (-)-2-(1-(2,6-diklor-fenoksy)-etyl)-1,3-diazacyklopent-2-en.

Info

Publication number
NO158016C
NO158016C NO824148A NO824148A NO158016C NO 158016 C NO158016 C NO 158016C NO 824148 A NO824148 A NO 824148A NO 824148 A NO824148 A NO 824148A NO 158016 C NO158016 C NO 158016C
Authority
NO
Norway
Prior art keywords
diazacyclopent
dichloro
phenoxy
ethyl
procedure
Prior art date
Application number
NO824148A
Other languages
English (en)
Norwegian (no)
Other versions
NO158016B (no
NO824148L (no
Inventor
Juergen Biedermann
Gerrit Prop
Ille-Stephanie Doppelfeld
Original Assignee
Nattermann A & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nattermann A & Cie filed Critical Nattermann A & Cie
Publication of NO824148L publication Critical patent/NO824148L/no
Publication of NO158016B publication Critical patent/NO158016B/no
Publication of NO158016C publication Critical patent/NO158016C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
NO824148A 1981-12-10 1982-12-09 Fremgangsmaate for fremstilling av (-)-2-(1-(2,6-diklor-fenoksy)-etyl)-1,3-diazacyklopent-2-en. NO158016C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813149009 DE3149009A1 (de) 1981-12-10 1981-12-10 (-)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3-diazacyclopent-2-en, dessen herstellung und seine verwendung in pharmazeutischen praeparaten

Publications (3)

Publication Number Publication Date
NO824148L NO824148L (no) 1983-06-13
NO158016B NO158016B (no) 1988-03-21
NO158016C true NO158016C (no) 1988-06-29

Family

ID=6148418

Family Applications (1)

Application Number Title Priority Date Filing Date
NO824148A NO158016C (no) 1981-12-10 1982-12-09 Fremgangsmaate for fremstilling av (-)-2-(1-(2,6-diklor-fenoksy)-etyl)-1,3-diazacyklopent-2-en.

Country Status (19)

Country Link
US (1) US4518783A (cs)
EP (1) EP0081748B1 (cs)
JP (1) JPS58105968A (cs)
AR (1) AR242192A1 (cs)
AT (1) ATE25520T1 (cs)
AU (1) AU553892B2 (cs)
CA (1) CA1176641A (cs)
DD (1) DD205682A5 (cs)
DE (2) DE3149009A1 (cs)
DK (1) DK548182A (cs)
ES (1) ES518033A0 (cs)
FI (1) FI73980C (cs)
GR (1) GR77767B (cs)
IE (1) IE54222B1 (cs)
NO (1) NO158016C (cs)
PT (1) PT75961B (cs)
SU (1) SU1241989A3 (cs)
YU (1) YU273682A (cs)
ZA (1) ZA828743B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3407509A1 (de) * 1984-03-01 1985-09-05 A. Nattermann & Cie GmbH, 5000 Köln Neue arzneimittelkombination zur behandlung von bluthochdruck und thromboembolischen erkrankungen
US4801617A (en) * 1987-04-06 1989-01-31 Leclerc Gerard Iminoimidazolidines useful in lowering intraocular pressure
FR2642422A1 (fr) * 1988-12-22 1990-08-03 Roussel Uclaf Nouvelles polyamines acylees, leur procede de preparation et leur application comme fongicides
JP2011530504A (ja) * 2008-08-08 2011-12-22 アジーン リミテッド ライアビリティー カンパニー Ｃｎｓ疾患及び病理の治療に用いるロフェキシジンエナンチオマー、並びにそのキラル合成法
US8101779B2 (en) * 2008-10-06 2012-01-24 University Of Kentucky Research Foundation Enantioselective synthesis of (+) and (–)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene
IT201900009777A1 (it) 2019-06-21 2020-12-21 Procos Spa Processo per la sintesi di lofexidina
WO2021209617A1 (en) 2020-04-17 2021-10-21 Medichem, S.A. Process for the synthesis of lofexidine
CN111393369B (zh) * 2020-05-13 2022-12-16 宁夏大学 一种2-己基咪唑的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1695555A1 (de) * 1967-02-23 1970-07-16 Nordmark Werke Gmbh Neue Aryloxy-isoalkyl-delta2-imidazoline und deren Saeureadditionssalze sowie Verfahren zu ihrer Herstellung
US3966757A (en) * 1967-02-23 1976-06-29 A. Nattermann & Cie Gmbh Imidazoline derivatives and processes for the production thereof
US4025639A (en) * 1967-02-23 1977-05-24 A. Nattermann & Cie Gmbh Blood pressure lowering in human mammals
AU3546478A (en) * 1977-04-29 1979-11-01 Ciba Geigy Ag Ectoparasiticides

Also Published As

Publication number Publication date
DE3275466D1 (en) 1987-04-02
ZA828743B (en) 1983-09-28
FI73980C (fi) 1987-12-10
AU553892B2 (en) 1986-07-31
EP0081748A2 (de) 1983-06-22
DK548182A (da) 1983-06-11
ATE25520T1 (de) 1987-03-15
FI73980B (fi) 1987-08-31
AR242192A1 (es) 1993-03-31
SU1241989A3 (ru) 1986-06-30
ES8401947A1 (es) 1984-01-01
PT75961A (en) 1983-01-01
NO158016B (no) 1988-03-21
IE54222B1 (en) 1989-07-19
CA1176641A (en) 1984-10-23
GR77767B (cs) 1984-09-25
PT75961B (en) 1985-10-04
DE3149009A1 (de) 1983-06-23
AU9105982A (en) 1983-06-16
EP0081748B1 (de) 1987-02-25
NO824148L (no) 1983-06-13
US4518783A (en) 1985-05-21
EP0081748A3 (en) 1984-03-07
ES518033A0 (es) 1984-01-01
YU273682A (en) 1985-04-30
DD205682A5 (de) 1984-01-04
IE822812L (en) 1983-06-10
FI824216L (fi) 1983-06-11
JPS58105968A (ja) 1983-06-24
FI824216A0 (fi) 1982-12-08

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