NO152560C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive heterocyklisk substituerte pyrazinoylguanidiner - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive heterocyklisk substituerte pyrazinoylguanidiner

Info

Publication number
NO152560C
NO152560C NO800878A NO800878A NO152560C NO 152560 C NO152560 C NO 152560C NO 800878 A NO800878 A NO 800878A NO 800878 A NO800878 A NO 800878A NO 152560 C NO152560 C NO 152560C
Authority
NO
Norway
Prior art keywords
preparation
pyrazinoylguanidines
therapeutically active
heterocyclic substituted
analogy procedure
Prior art date
Application number
NO800878A
Other languages
English (en)
Other versions
NO800878L (no
NO152560B (no
Inventor
Edward J Cragoe Jr
Otto W Woltersdorf Jr
Susan Jane Desolms
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO800878L publication Critical patent/NO800878L/no
Publication of NO152560B publication Critical patent/NO152560B/no
Publication of NO152560C publication Critical patent/NO152560C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO800878A 1979-03-27 1980-03-26 Analogifremgangsmaate ved fremstilling av terapeutisk aktive heterocyklisk substituerte pyrazinoylguanidiner NO152560C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/024,293 US4246406A (en) 1979-03-27 1979-03-27 Heterocyclic substituted pyrazinoylguanidines

Publications (3)

Publication Number Publication Date
NO800878L NO800878L (no) 1980-09-29
NO152560B NO152560B (no) 1985-07-08
NO152560C true NO152560C (no) 1985-10-16

Family

ID=21819847

Family Applications (1)

Application Number Title Priority Date Filing Date
NO800878A NO152560C (no) 1979-03-27 1980-03-26 Analogifremgangsmaate ved fremstilling av terapeutisk aktive heterocyklisk substituerte pyrazinoylguanidiner

Country Status (10)

Country Link
US (1) US4246406A (no)
EP (1) EP0017152B1 (no)
JP (2) JPS55130965A (no)
AT (1) ATE2323T1 (no)
AU (1) AU533298B2 (no)
DE (1) DE3061733D1 (no)
DK (1) DK129180A (no)
IE (1) IE49578B1 (no)
NO (1) NO152560C (no)
ZA (1) ZA801770B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
US4496573A (en) * 1982-08-24 1985-01-29 William H. Rorer, Inc. 1-Pyridylmethyl-3-acyl guanidines
US4512991A (en) * 1982-12-27 1985-04-23 Merck & Co., Inc. 3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
AU2003295402A1 (en) * 2002-11-06 2004-06-03 Bristol-Myers Squibb Company Acyl guanidine compounds and use thereof
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7064129B2 (en) * 2003-08-18 2006-06-20 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7399766B2 (en) * 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
PL2155721T3 (pl) 2007-05-07 2011-07-29 Novartis Ag Związki organiczne
WO2009074575A2 (en) 2007-12-10 2009-06-18 Novartis Ag Organic compounds
MX2012004792A (es) 2009-10-22 2013-02-01 Vertex Pharma Composiciones para el tratamiento de fibrosis quistica y otras enfermedades cronicas.
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
US9593084B2 (en) 2012-12-17 2017-03-14 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
WO2014099673A1 (en) 2012-12-17 2014-06-26 Parion Sciences, Inc. 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639386A (no) * 1962-10-30
NL6409714A (no) * 1962-10-30 1965-10-01
US3328404A (en) * 1966-08-25 1967-06-27 Merck & Co Inc Derivatives of pyrazine
NL6707564A (no) * 1966-08-25 1968-02-26
US3432502A (en) * 1966-08-25 1969-03-11 Merck & Co Inc Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products
US4087526A (en) * 1976-07-23 1978-05-02 Merck & Co., Inc. (3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens

Also Published As

Publication number Publication date
IE49578B1 (en) 1985-10-30
AU533298B2 (en) 1983-11-17
DK129180A (da) 1980-09-28
EP0017152A1 (en) 1980-10-15
EP0017152B1 (en) 1983-01-26
NO800878L (no) 1980-09-29
JPS55130965A (no) 1980-10-11
IE800608L (en) 1980-09-27
ZA801770B (en) 1981-11-25
JPS56158771A (en) 1981-12-07
NO152560B (no) 1985-07-08
ATE2323T1 (de) 1983-02-15
AU5653680A (en) 1980-10-02
US4246406A (en) 1981-01-20
DE3061733D1 (en) 1983-03-03

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