ATE2323T1 - Heterocyclisch substituierte pyrazinoylguanidine, verfahren zur herstellung und eine sie enthaltende pharmazeutische zusammensetzung. - Google Patents

Heterocyclisch substituierte pyrazinoylguanidine, verfahren zur herstellung und eine sie enthaltende pharmazeutische zusammensetzung.

Info

Publication number
ATE2323T1
ATE2323T1 AT80101589T AT80101589T ATE2323T1 AT E2323 T1 ATE2323 T1 AT E2323T1 AT 80101589 T AT80101589 T AT 80101589T AT 80101589 T AT80101589 T AT 80101589T AT E2323 T1 ATE2323 T1 AT E2323T1
Authority
AT
Austria
Prior art keywords
preparation
pharmaceutical composition
pyrazinoylguanidines
composition containing
heterocyclically substituted
Prior art date
Application number
AT80101589T
Other languages
English (en)
Inventor
Edward J. Cragoe Jr.
Otto W. Woltersdorf Jr.
Susan Jane De Solms
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Application granted granted Critical
Publication of ATE2323T1 publication Critical patent/ATE2323T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT80101589T 1979-03-27 1980-03-26 Heterocyclisch substituierte pyrazinoylguanidine, verfahren zur herstellung und eine sie enthaltende pharmazeutische zusammensetzung. ATE2323T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/024,293 US4246406A (en) 1979-03-27 1979-03-27 Heterocyclic substituted pyrazinoylguanidines
EP80101589A EP0017152B1 (de) 1979-03-27 1980-03-26 Heterocyclisch substituierte Pyrazinoylguanidine, Verfahren zur Herstellung und eine sie enthaltende pharmazeutische Zusammensetzung

Publications (1)

Publication Number Publication Date
ATE2323T1 true ATE2323T1 (de) 1983-02-15

Family

ID=21819847

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80101589T ATE2323T1 (de) 1979-03-27 1980-03-26 Heterocyclisch substituierte pyrazinoylguanidine, verfahren zur herstellung und eine sie enthaltende pharmazeutische zusammensetzung.

Country Status (10)

Country Link
US (1) US4246406A (de)
EP (1) EP0017152B1 (de)
JP (2) JPS55130965A (de)
AT (1) ATE2323T1 (de)
AU (1) AU533298B2 (de)
DE (1) DE3061733D1 (de)
DK (1) DK129180A (de)
IE (1) IE49578B1 (de)
NO (1) NO152560C (de)
ZA (1) ZA801770B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
US4496573A (en) * 1982-08-24 1985-01-29 William H. Rorer, Inc. 1-Pyridylmethyl-3-acyl guanidines
US4512991A (en) * 1982-12-27 1985-04-23 Merck & Co., Inc. 3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
WO2004043362A2 (en) * 2002-11-06 2004-05-27 Bristol-Myers Squibb Company Acyl guanidine compounds and use thereof
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
AU2004266704B2 (en) * 2003-08-18 2012-02-23 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7399766B2 (en) * 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
EP2332933A1 (de) 2007-05-07 2011-06-15 Novartis AG Epithelial Natrium-Kanal Inhibitoren
BRPI0820669A2 (pt) 2007-12-10 2020-08-04 Novartis Ag compostos orgânicos
AU2010310449A1 (en) 2009-10-22 2012-05-03 Vertex Pharmaceuticals Incorporated Compositions for treatment of cystic fibrosis and other chronic diseases
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
HUE032891T2 (hu) 2012-12-17 2017-11-28 Parion Sciences Inc Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére
RU2671976C2 (ru) 2012-12-17 2018-11-08 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
WO2025133218A1 (en) * 2023-12-21 2025-06-26 Phamri Norden Ab Pyrazine derivatives for the treatment of skin disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299931A (de) * 1962-10-30
NL6409714A (de) * 1962-10-30 1965-10-01
US3432502A (en) * 1966-08-25 1969-03-11 Merck & Co Inc Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products
US3328404A (en) * 1966-08-25 1967-06-27 Merck & Co Inc Derivatives of pyrazine
NL6707564A (de) * 1966-08-25 1968-02-26
US4087526A (en) * 1976-07-23 1978-05-02 Merck & Co., Inc. (3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens

Also Published As

Publication number Publication date
JPS55130965A (de) 1980-10-11
NO152560B (no) 1985-07-08
IE800608L (en) 1980-09-27
ZA801770B (en) 1981-11-25
DE3061733D1 (en) 1983-03-03
NO800878L (no) 1980-09-29
AU5653680A (en) 1980-10-02
US4246406A (en) 1981-01-20
IE49578B1 (en) 1985-10-30
NO152560C (no) 1985-10-16
EP0017152B1 (de) 1983-01-26
DK129180A (da) 1980-09-28
AU533298B2 (en) 1983-11-17
EP0017152A1 (de) 1980-10-15
JPS56158771A (en) 1981-12-07

Similar Documents

Publication Publication Date Title
DE3061733D1 (en) Novel heterocyclic substituted pyrazinoylguanidines, processes for preparing and a pharmaceutical composition containing the same
ES539678A0 (es) Procedimiento para preparar un polipeptido ciclico
DE3885366D1 (de) Verfahren zur Herstellung von Pyrrolo-(3,4-c)pyrrolen.
ATA425280A (de) Verfahren zur herstellung von neuen 2-phenyl-imidazo(2.1-b)-benzothiazolderivaten
ATE2953T1 (de) 2-imidazolinderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzung.
ATE2327T1 (de) Pyrazincarboxamide, verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATA183279A (de) Verfahren zur herstellung von neuen 1-oxo-1hpyrimido(6,1-b)benzthiazol-derivaten und von deren salzen
AT363487B (de) Verfahren zum herstellen von neuen amino-pyrazolo(1,5-a)s.triazinen
ATE3422T1 (de) Tetrahydrochinolinderivate, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen.
AT376970B (de) Verfahren zur herstellung von 2,3-dihydro-2,2dimethyl-7-hydroxybenzofuran
AT367050B (de) Verfahren zur herstellung von neuen pyrido (2,1-b) chinazolinderivaten und deren salzen
ATA570780A (de) Verfahren zur herstellung von neuen 1-oxo-1hthiazolo(3,2-a)pyrimidin-2-carboxamiden
NL184780C (nl) Op de plaats 5 door een 6-ring gesubstitueerde 1,1,3-trialkylbiureetverbindingen, werkwijze ter bereiding daarvan, werkwijze ter bereiding van farmaceutische preparaten, die deze verbindingen bevatten, alsmede farmaceutische voorwerpen.
ATA95880A (de) Verfahren zur herstellung der (2,2-dimethyl--1,2dihydro-chinolin-4-yl)-methyl-sulfon-s[ureund von deren salzen
AT375941B (de) Verfahren zur herstellung von neuen 1-aminopyrazolo (1,5-c) chinazolinderivaten
AT357167B (de) Verfahren zur herstellung von neuen 1-(4- phenoxy-phenyl)-1,3,5-triazin-derivaten und deren physiologisch vertraeglichen salzen
AT360519B (de) Verfahren zur herstellung von neuen 6-(m- -aminophenyl)-2,3,5,6-tetrahydroimidazo(2,1-b) thiazolderivaten und von deren salzen
ATA247680A (de) Verfahren zur herstellung von -9-hydrazono-6,7,8, 9-tetravaydro-4h-pyrido/1,2-a/ pyrimidin-4-on- derivaten sowie von deren physiologisch vertraeglichen salzen, hydraten und isomeren
DD129902A5 (de) Verfahren zur herstellung von 1-substituierten 2,2-diphenylcyclopropanderivaten
ATA489981A (de) Verfahren zur herstellung von neuen pyrido(2,1-b) chinazolinderivaten und von deren salzen
PT71284A (de) Verfahren zur herstellung von n-dialkylaminomethyl-s,s-diaryl-suldoximiden
AT375371B (de) Verfahren zur herstellung von neuen pyrido(3,2-e)-as-triazin-derivaten
IT1209343B (it) Derivati piperazinici accrescenti la circolazione sanguigna, metodo per la loro preparazione e composizioni contenenti tali derivati.
ATA489681A (de) Verfahren zur herstellung von neuen pyrido(2,1-b) chinazolinderivaten und von deren salzen
ATE3980T1 (de) Verfahren zur herstellung von riboflavin.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee