NO141343B - Fremgangsmaate till fremstilling av aminoglykosid-antibiotika, betegnet xk-88-1,-2, og -5 (seldomyciner). - Google Patents
Fremgangsmaate till fremstilling av aminoglykosid-antibiotika, betegnet xk-88-1,-2, og -5 (seldomyciner). Download PDFInfo
- Publication number
- NO141343B NO141343B NO743760A NO743760A NO141343B NO 141343 B NO141343 B NO 141343B NO 743760 A NO743760 A NO 743760A NO 743760 A NO743760 A NO 743760A NO 141343 B NO141343 B NO 141343B
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- Norway
- Prior art keywords
- methanol
- sulfate
- water
- concentrated
- column
- Prior art date
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- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- WZDRWYJKESFZMB-FQSMHNGLSA-N kanamycin C Chemical compound O([C@H]1[C@H](N)C[C@@H]([C@H]([C@@H]1O)O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)N)N)[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O WZDRWYJKESFZMB-FQSMHNGLSA-N 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 125000001477 organic nitrogen group Chemical group 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960003485 ribostamycin Drugs 0.000 description 1
- NSKGQURZWSPSBC-NLZFXWNVSA-N ribostamycin Chemical compound N[C@H]1[C@H](O)[C@@H](O)[C@H](CN)O[C@@H]1O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](CO)O2)O)[C@H](O)[C@@H](N)C[C@H]1N NSKGQURZWSPSBC-NLZFXWNVSA-N 0.000 description 1
- 229930190553 ribostamycin Natural products 0.000 description 1
- NSKGQURZWSPSBC-UHFFFAOYSA-N ribostamycin A Natural products NC1C(O)C(O)C(CN)OC1OC1C(OC2C(C(O)C(CO)O2)O)C(O)C(N)CC1N NSKGQURZWSPSBC-UHFFFAOYSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- PNGLEYLFMHGIQO-UHFFFAOYSA-M sodium;3-(n-ethyl-3-methoxyanilino)-2-hydroxypropane-1-sulfonate;dihydrate Chemical compound O.O.[Na+].[O-]S(=O)(=O)CC(O)CN(CC)C1=CC=CC(OC)=C1 PNGLEYLFMHGIQO-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11893273A JPS5615232B2 (es) | 1973-10-24 | 1973-10-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO743760L NO743760L (es) | 1975-05-20 |
| NO141343B true NO141343B (no) | 1979-11-12 |
Family
ID=14748770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO743760A NO141343B (no) | 1973-10-24 | 1974-10-17 | Fremgangsmaate till fremstilling av aminoglykosid-antibiotika, betegnet xk-88-1,-2, og -5 (seldomyciner). |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3939043A (es) |
| JP (1) | JPS5615232B2 (es) |
| AR (1) | AR205726A1 (es) |
| AT (1) | AT332547B (es) |
| AU (1) | AU496758B2 (es) |
| BE (1) | BE821441A (es) |
| CA (1) | CA1032100A (es) |
| CH (1) | CH606425A5 (es) |
| DE (1) | DE2450411B2 (es) |
| DK (1) | DK139588B (es) |
| FR (1) | FR2248850B1 (es) |
| GB (1) | GB1479179A (es) |
| IN (1) | IN140482B (es) |
| NL (1) | NL7413859A (es) |
| NO (1) | NO141343B (es) |
| ZA (1) | ZA746606B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5315343A (en) * | 1976-07-27 | 1978-02-13 | Kyowa Hakko Kogyo Co Ltd | Novel antibiotic derivatives and their preparation |
| US4187372A (en) * | 1976-09-08 | 1980-02-05 | Abbott Laboratories | Seldomycin factor 5 derivative |
| US4218441A (en) * | 1979-03-29 | 1980-08-19 | Abbott Laboratories | O-Demethylseldomycin factor 5 |
| US4239752A (en) * | 1979-03-29 | 1980-12-16 | Abbott Laboratories | O-Demethylseldomycin factor 5 derivatives |
| JPH07116209B2 (ja) * | 1986-04-11 | 1995-12-13 | メクト株式会社 | シアロシルセラミド類及びその製造方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652536A (en) * | 1969-06-02 | 1972-03-28 | Upjohn Co | Novenamine compounds and derivatives |
-
1973
- 1973-10-24 JP JP11893273A patent/JPS5615232B2/ja not_active Expired
-
1974
- 1974-01-01 AR AR256247A patent/AR205726A1/es active
- 1974-10-16 ZA ZA00746606A patent/ZA746606B/xx unknown
- 1974-10-17 NO NO743760A patent/NO141343B/no unknown
- 1974-10-21 US US05/516,816 patent/US3939043A/en not_active Expired - Lifetime
- 1974-10-22 GB GB45689/74A patent/GB1479179A/en not_active Expired
- 1974-10-23 DE DE19742450411 patent/DE2450411B2/de active Granted
- 1974-10-23 DK DK555974AA patent/DK139588B/da unknown
- 1974-10-23 FR FR7435608A patent/FR2248850B1/fr not_active Expired
- 1974-10-23 CH CH1420474A patent/CH606425A5/xx not_active IP Right Cessation
- 1974-10-23 CA CA212,117A patent/CA1032100A/en not_active Expired
- 1974-10-23 NL NL7413859A patent/NL7413859A/xx not_active Application Discontinuation
- 1974-10-23 AT AT853374A patent/AT332547B/de not_active IP Right Cessation
- 1974-10-23 AU AU74636/74A patent/AU496758B2/en not_active Expired
- 1974-10-24 BE BE149851A patent/BE821441A/xx unknown
- 1974-11-12 IN IN2493/CAL/74A patent/IN140482B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3939043A (en) | 1976-02-17 |
| DE2450411C3 (es) | 1978-03-09 |
| ZA746606B (en) | 1975-12-31 |
| DE2450411B2 (de) | 1977-07-21 |
| DK555974A (es) | 1975-07-14 |
| AR205726A1 (es) | 1976-05-31 |
| DK139588C (es) | 1979-08-20 |
| BE821441A (fr) | 1975-04-24 |
| FR2248850B1 (es) | 1978-07-21 |
| DE2450411A1 (de) | 1975-04-30 |
| JPS5615232B2 (es) | 1981-04-09 |
| AU496758B2 (en) | 1978-10-26 |
| DK139588B (da) | 1979-03-12 |
| NL7413859A (nl) | 1975-04-28 |
| GB1479179A (en) | 1977-07-06 |
| CA1032100A (en) | 1978-05-30 |
| ATA853374A (de) | 1976-01-15 |
| IN140482B (es) | 1976-11-20 |
| JPS5070590A (es) | 1975-06-12 |
| NO743760L (es) | 1975-05-20 |
| AT332547B (de) | 1976-10-11 |
| FR2248850A1 (es) | 1975-05-23 |
| CH606425A5 (es) | 1978-10-31 |
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