NO130939B - - Google Patents
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- Publication number
- NO130939B NO130939B NO141370A NO141370A NO130939B NO 130939 B NO130939 B NO 130939B NO 141370 A NO141370 A NO 141370A NO 141370 A NO141370 A NO 141370A NO 130939 B NO130939 B NO 130939B
- Authority
- NO
- Norway
- Prior art keywords
- protamine
- zinc
- insulin
- suspension
- amount
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 130
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 104
- 102000007327 Protamines Human genes 0.000 claims description 93
- 108010007568 Protamines Proteins 0.000 claims description 93
- 229940048914 protamine Drugs 0.000 claims description 93
- 102000004877 Insulin Human genes 0.000 claims description 65
- 108090001061 Insulin Proteins 0.000 claims description 65
- 229940125396 insulin Drugs 0.000 claims description 65
- 239000011701 zinc Substances 0.000 claims description 54
- 229910052725 zinc Inorganic materials 0.000 claims description 54
- 238000002360 preparation method Methods 0.000 claims description 33
- 239000000725 suspension Substances 0.000 claims description 31
- 239000013078 crystal Substances 0.000 claims description 24
- 239000008363 phosphate buffer Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 229910019142 PO4 Inorganic materials 0.000 description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 10
- 239000010452 phosphate Substances 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 8
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 7
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 7
- 229940100630 metacresol Drugs 0.000 description 7
- 239000001488 sodium phosphate Substances 0.000 description 6
- 229910000162 sodium phosphate Inorganic materials 0.000 description 6
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 6
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 5
- 239000000872 buffer Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000011592 zinc chloride Substances 0.000 description 3
- 235000005074 zinc chloride Nutrition 0.000 description 3
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 3
- 229910000165 zinc phosphate Inorganic materials 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 108010000947 protamine zinc Proteins 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229910021653 sulphate ion Inorganic materials 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 150000003751 zinc Chemical class 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 108010066090 neutral insulin Proteins 0.000 description 1
- -1 pH = 6-8 Chemical compound 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229940077935 zinc phosphate Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B17/00—Sulfur; Compounds thereof
- C01B17/48—Sulfur dioxide; Sulfurous acid
- C01B17/50—Preparation of sulfur dioxide
- C01B17/56—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Treating Waste Gases (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1207769A SE338036B (index.php) | 1969-09-01 | 1969-09-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO130939B true NO130939B (index.php) | 1974-12-02 |
| NO130939C NO130939C (index.php) | 1975-03-12 |
Family
ID=20295108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO141370A NO130939C (index.php) | 1969-09-01 | 1970-04-15 |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE2025388C3 (index.php) |
| FI (1) | FI58109C (index.php) |
| NO (1) | NO130939C (index.php) |
| SE (1) | SE338036B (index.php) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE975974C (de) * | 1951-04-06 | 1962-12-27 | Zieren Chemiebau Gmbh Dr A | Verfahren zum Waschen und Kuehlen von schwefeldioxydhaltigen Roest- und Verbrennungsgasen |
| DE1264422C2 (de) * | 1965-12-07 | 1978-01-19 | Norddeutsche Affinene, 2000 Hamburg | Verfahren zum waschen und kuehlen von arsenik enthaltenden roestgasen |
-
1969
- 1969-09-01 SE SE1207769A patent/SE338036B/xx unknown
-
1970
- 1970-04-15 NO NO141370A patent/NO130939C/no unknown
- 1970-05-05 FI FI126270A patent/FI58109C/fi active
- 1970-05-25 DE DE19702025388 patent/DE2025388C3/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE338036B (index.php) | 1971-08-30 |
| DE2025388C3 (de) | 1986-02-13 |
| FI58109C (fi) | 1980-12-10 |
| DE2025388B2 (de) | 1977-02-10 |
| DE2025388A1 (en) | 1971-03-04 |
| FI58109B (fi) | 1980-08-29 |
| NO130939C (index.php) | 1975-03-12 |
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